A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma

Carcinogenesis

Volumn 19, Issue 12, 1998, Pages 2129-2132

  Chen, Jia ^a,c,d   Giovannucci, Edward ^a,c   Hankinson, Susan E ^a,c   Ma, Jing ^c   Willett, Walter C ^a,c   Spiegelman, Donna ^a   Kelsey, Karl T ^a,b,c   Hunter, David J ^a,b,c  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD CENTER FOR CANCER PREVENTION   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ALCOHOL; METHIONINE; METHIONINE SYNTHASE;

ADENOMA; ADULT; ALCOHOL CONSUMPTION; ARTICLE; CANCER RISK; COLORECTAL CANCER; CONTROLLED STUDY; DIET; DNA POLYMORPHISM; FEMALE; HUMAN; MALIGNANT TRANSFORMATION; NORMAL HUMAN; PRIORITY JOURNAL;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; ADENOMA; ADULT; COLORECTAL NEOPLASMS; ETHANOL; FEMALE; FOLIC ACID; HUMANS; METHIONINE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; POLYMORPHISM, GENETIC; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 0032434823     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/19.12.2129     Document Type: Article

References (22)

1. Giovannucci,E., Rimm,E.B., Ascherio,A., Stampfer,M.J., Colditz,G.A. and Willett,W.C. (1995) Alcohol, low-methionine-low-folate diets and risk of colon cancer in men. J. Natl Cancer Inst., 87, 265-273.
2. Giovannucci,E., Stampfer,M.J., Colditz,G.A., Rimm,E.B., Trichopoulos,D., Rosner,B.A., Speizer,F.E. and Willett,W.C. (1993) Folate, methionine and alcohol intake and risk of colorectal adenoma. J. Natl Cancer Inst., 85, 875-883.
3. Benito,E., Stiggelbout,A., Bosch,F.X., Obrador,A., Kaldor,J., Mulet,M. and Munoz,N. (1991) Nutritional factors in colorectal cancer risk: a case-control study in Majorca. Int. J. Cancer, 49, 161-167.
4. Benito,E., Cabeza,E., Moreno,V., Obrador,A. and Bosch,F.X. (1993) Diet and colorectal adenomas: a case-control study in Majorca. Int. J. Cancer, 55, 213-219.
5. Ferraroni,M., La Vecchia,C., D'Avanzo,B., Negri,E., Franceschi,S. and Decarli,A. (1994) Selected micronutrient intake and the risk of colorectal cancer. Br. J. Cancer, 70, 1150-1155.
6. Freudenheim,J.L., Graham,S., Marshall,J.R. and Haughey,B.P., Cholewinski,S. and Wilkinson,G. (1991) Folate intake and carcinogenesis of the colon and rectum. Int. J. Epidemiol., 20, 368-374.
7. Frosst,P., Blom,H.J., Milos,R. et al. (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nature Genet., 10, 111-113.
8. Jacques,P.F, Bstom,A.G., Williams,R.R., Ellison,R.C, Eckfeldt,J.H., Rosenberg,R.H., Selhub,J. and Rozen,R. (1996) Relation between folate status, a common mutation in methylenetetrahydrofolate reductase and plasma homocysteine concentrations. Circulation, 93, 7-9.
9. Chen,J., Giovannucci,E., Kelsey,K., Rimm,E.B., Stampfer,M.J., Colditz,G.A., Spiegelman,D., Willett,W.C. and Hunter,D.J. (1996) A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. Cancer Res., 56, 4862-4864.
10. Ma,J., Stampfer,M.J., Giovannucci,E. et al. (1997) Methylenetetrahydrofolate reductase polymorphism, dietary interactions and risk of colorectal cancer. Cancer Res., 57, 1098-1102.
11. Kim,Y.I., Pogribny,I.P., Basnakian,A.G., Miller,J.W, Selhub,J., James,S.J. and Mason,J.B. (1997) Folate deficiency in rats induces DNA strand breaks and hypomethylation within p53 tumor suppressor gene. Am. J. Clin. Nutr., 65, 46-52.
12. Blount,B.C., Mack,M.M., Wehr,C.M., MacGregor,J.T., Hiatt,R.A., Wang,G., Wickramasinghe,S.N., Everson,R.B. and Ames,B.N. (1997) Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc. Natl Acad. Sci. USA, 94, 3290-3295.
13. Fearon,E.R. and Vogelstein,B.A. (1990) A genetic model for colorectal tumorigenesis. Cell, 61, 759-767.
14. Issa,J-P, Ottaviano,Y.L., Celano,P, Hamilton,S.R., Davidson,N.E. and Baylin,S.B. (1994) Methylation of the oestrogen receptor CpG island links aging and neoplasia in human colon. Nature Genet., 7, 536-540.
15. Li,Y.N., Gulati,S., Baker,P.J., Brody,L.C., Banerjee,R. and Kruger,W.D. (1996) Cloning, mapping and RNA analysis of the human methionine synthase gene. Hum. Mol. Genet., 5, 1852-1859.
16. Leclerc,D., Campeau,E., Goyette,P. et al. (1996) Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/colalamin disorders. Hum. Mol. Genet., 5, 1867-1874.
17. Chen,L.H., Liu,M.L., Huang,H.Y. Chen,L.S., Korenberg,J. and Shane,B. (1997) Human methionine synthase: cDNA cloning, gene localization and expression. J. Biol. Chem., 272, 3628-3634.
18. Hunter,D.J., Hankinson,S.E., Hough,H. et al. (1997) A prospective study of NAT2 acetylation genotype, cigarette smoking and risk of breast cancer. Carcinogenesis, 18, 2127-2132.
19. van der Put,N.M.J., Steegers-Theunissen,R.P.M., Frosst,P. et al. (1995) Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet, 346, 1070-1071.
20. Morson,B.C. (1984) The evolution of colorectal carcinoma, Clin. Radiol., 35, 425-431.
21. Rhys,C.M. and Bohr,V.A. (1996) Mammalian DNA repair responses and genomic instability. EXS, 77, 289-305.
22. Usmani,B.A. (1993) Genomic instability and metastatic progression. Pathobiology, 61, 109-116.