Relevance of folate metabolism in the pathogenesis of colorectal cancer

Journal of Laboratory and Clinical Medicine

Volumn 138, Issue 3, 2001, Pages 164-176

  Ryan, Barbara M ^a   Weir, Donald G ^a  

^a ST JAMES S HOSPITAL   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CLONE; COLORECTAL CANCER; ENZYME METABOLISM; FOLATE METABOLISM; NUTRIENT DEFICIENCY; NUTRITIONAL VALUE; PATHOGENICITY;

EID: 0034868436     PISSN: 00222143     EISSN: None     Source Type: Journal    
DOI: 10.1067/mlc.2001.117161     Document Type: Article

References (117)

1. Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study
2. Folate levels and neural tube defects. Implications for prevention
3. Maternal plasma folate and vitamin B 12 are independent risk factors for neural tube defects
4. Clinical implications of hyperhomocysteinaemia
5. Relationship between homocysteine and thrombotic diseases
6. Homocyteine and cardiovascular diseases
7. The "thermolabile" variant of methylenetetrahydrofolate reductase and neural tube defects: An evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother
8. Folate, vitamin B 12 and total homocysteine levels in confirmed Alzheimer disease
9. Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study
10. Colonic mucosal folate concentrations and their association with colorectal cancer
11. Folic acid, homocysteine and one-carbon metabolism: A review of the essential biochemistry
12. Folate and neural tube defects
13. Methylenetetrahydrofolate reductase thermolabile variant and oral clefts
14. The bioavailability of folate
15. Transport of folate compounds into cells
16. Folate chemistry and metabolism
17. Gastric intrinsic factor and its receptor
18. Vitamin B 12 "Cobalamin."
19. Mechanism of the antimicrobial drug trimethoprim revisited
20. Inhibition of glycine N-methyltransferase by folate derivatives: Implications for regulation of methyl group metabolism
21. Mammalian methylenetetrahydrofolate reductase. Partial purification, properties and inhibition by S-adenosylmethionine
22. Methionine metabolism in mammals
23. The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human homocysteinemia
24. Thermolabile methylenetetrahydrofolate reductase in patients with coronary artery disease
25. Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida
26. The common "thermolabile" variant of methylenetetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia
27. Is the common C677T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A circle analysis
28. Hyperhomocysteinaemia as a risk factor for occlusive vascular disease
29. Genetic analysis of thermolabile methylenetetrahydrofolate reductase as a risk factor for myocardial infarction
30. A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase
31. The impaired functioning of thermolabile methylene-tetrahydrofolate reductase (MTHFR) is dependent upon riboflavin status: Implications for riboflavin requirements
32. A second common mutation in the methylenetetrahydrofolate reductase gene: An additional risk for neural tube defects
33. Folate, methionine and alcohol intake and risk of colorectal adenoma
34. Alcohol, low-methionine-low-folate diets, and risk of colon cancer in men
35. Selected micronutrient intake and the risk of colorectal cancer
36. Diet and colorectal adenomas: A case-control study in Majorca
37. Folate intake, alcohol consumption, cigarette smoking, and risk of colorectal adenomas
38. Nutritional factors in colorectal cancer risk: A case-control study in Majorca
39. Relationship between vitamin and calcium supplement use and colon cancer
40. Folate and alcohol intakes: Related or independent roles in the adenoma-carcinoma sequence
41. The effect of ethanol on one-carbon metabolism: Increased methionine catabolism and lipotrope methy-group wastage
42. Microbially produced acataldehyde from ethanol may increase the risk of colon cancer via folate deficiency
43. The effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis: A case-control study
44. Red blood cell folate is associated with the development of dysplasia and cancer in ulcerative colitis
45. Colorectal cancer in ulcerative colitis: A cohort study of primary referrals from three centres
46. Ulcerative colitis and colorectal cancer: A population-based study
47. The effect of folate supplementation on the risk for cancer or dysplasia in ulcerative colitis
48. Colorectal cancer and folate status: A nested case-control study among male smokers
49. Lower colonic mucosal folate concentrations in patients with adenomatous polyps: Possible implications for the development of colorectal cancer
50. Epithelial cell folate depletion occurs in neoplastic but not adjacent normal colon mucosa
51. Folate status and adenomatous colonic polyps: A colonoscopically controlled study
52. Red cell and plasma folate, folate consumption, and the risk of colorectal adenomatous polyps
53. Colonic mucosal concentrations of folate correlate well with blood measurements of folate status in persons with colorectal polyps
54. Esophageal cancer: Vitamin and lipotrope deficiencies in an at-risk South African population
55. Epidemiology of esophageal cancer in China
56. Association of esophageal cytological abnormalities with vitamin and lipotrope deficiencies in populations at risk for esophageal cancer
57. Oesophageal carcinoma: Cytopathology and nutritional aspects in aetiology
58. Smoking, dietary fat, fiber and vitamins influence the progression of chronic gastritis to distal gastric cancer: A case-control study
59. Selected micronutrient intake and the risk of gastric cancer
60. Folate deficiency and cervical dysplasia
61. A case-control study of nutrient status and invasive cervical cancer. I. Dietary indicators
62. Folate, vitamin C and cervical intraepithelial neoplasia
63. A case-control study of diet and invasive cervical cancer
64. Diet and alcohol consumption and lung cancer risk in the New York State Cohort
65. Chemoprevention effects of bronchial squamous metaplasia by folate and vitamin B 12 in heavy smokers
66. Folic acid supplementation and cell kinetics of rectal mucosa in patients with ulcerative colitis
67. DNA methylation as an intermediate biomarker in colorectal cancer: Modulation by folic acid supple-mentation
68. Folate status, DNA methylation and colon cancer risk in inflammatory bowel disease
69. Folate supplementation and adenomatous colonic polyps
70. Dietary folate protects against the development of macroscopic colonic neoplasia in a dose responsive manner in rats
71. Folate deficiency enhances the development of colonic neoplasia in dimethylhydrazine-treated rats
72. Inhibition of progression of aberrant crypt foci and colon tumor development by vitamin E and beta-carotene in rats on a high-risk diet
73. Potential chemopreventive activity of perrilyl alcohol and enhancement of experimental colon carcinogenesis by folic acid and genistein
74. Aberrant crypts as a biomarker for colon cancer: Evaluation of potential chemopreventive agents in the rat
75. Effects of folate deficiency and supplementation on methylnitrosurea-induced rat mammary tumors
76. High-affinity folate receptor in human ovary, serous ovarian adenocarcinoma, and ascites: Radioligand binding mechanism, molecular size, ionic properties, hydrophobic domain, and immunoreactivity
77. Expression of folate receptor type alpha in relation to cell type, malignancy, and differentiation in ovary, uterus, and cervix
78. Modulation of glutathione content and the effect on methionine auxotrophy and cellular distribution of homocysteine and cysteine in mouse cell lines
79. Methioninase: A therapeutic for diseases related to altered methionine metabolism and transmethylation: Cancer, heart disease, obesity, aging, and Parkinson's disease
80. Misincorporation of uracil into the DNA of folate- and B 12-deficient HL60 cells
81. In vitro folate deficiency induces deoxynucleotide pool imbalance, apoptosis and mutagenesis in Chinese hamster ovary cells
82. Presence and consequence of uracil in preneoplastic DNA from folate/ methyl-deficient rats
83. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage
84. Apoptosis and proliferation under conditions of deoxynucleotide pool imbalance in liver of folate/methyl deficient rats
85. Pathways and regulation of homocysteine metabolism in mammals
86. Folate deficiency in rats induces DNA strand breaks and hypomethylation within p53 tumor suppressor gene
87. Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl deficient rats
88. Cancer epigenetics comes of age
89. DNA hypermethylation in tumorigenesis
90. A genetic model for colorectal tumorigenesis
91. Hypomethylation of DNA from benign and malignant human colon neoplasms
92. Folate, epithelial dysplasia and colon cancer
93. Genetic alterations during colorectal-tumor development
94. Altered expression of chondroitin sulfate proteoglycan in the stroma of human colon carcinoma
95. Hypomethylation of the decorin proteoglycan gene in human colon cancer
96. Hypomethylation of DNA in human cancer cells: A site specific change in the c-myc oncogene
97. Hypomethylation of ras oncogenes in primary human cancers
98. Patterns of methylation of the c-myc gene in human colorectal cancer progression
99. Effects of dietary folate on DNA strand breaks within mutation-prone exons of the p53 gene in the rat colon
100. Keeping an old friend under control: Regulation of p53 stability
101. DNA methylation affects the formation of active chromatin
102. DNA methylation and chromatin structure
103. Methylenetetrahydrofolate reductase polymorphisms, plasma folate, homocysteine and risk of myocardial infarction in US physicians
104. Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: Implications for folate intake recommendations
105. Methylenetetrahydrofolate reductase, diet, and risk of colon cancer
106. Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer
107. Germ line polymorphisms in cytochrome-P450 1A1 (C4887 CYP1A1) and methylenetetrahydrofolate reductase (MTHFR) genes and endometrial cancer susceptibility
108. A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma
109. A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer
110. MTHFR polymorphism, methyl-replete diets and the risk of colorectal carcinoma and adenoma among US men. Men and women: An example of gene-environment interactions in colorectal tumorigenesis
111. Colorectal adenomas and the C677T MTHFR polymorphism: Evidence for gene-environment interaction
112. Lack of association between the C677T MTHFR polymorphism and colorectal hyperplastic polyps
113. Methylenetetrahydrofolate reductase polymorphism and the risk of colorectal adenomas
114. Loss of heterozygosity of methylenetetrahydrofolate reductase in colon carcinomas
115. Riboflavin as a determinant of plasma total homocysteine: Effect modification by the methylenetetrahydrofolate reductase C677T polymorphism