Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages

Journal of Nutrition

Volumn 128, Issue 8, 1998, Pages 1336-1341

  Nelen, Willianne L D M ^a   Blom, Henk J ^a   Thomas, Chris M G ^a   Steegers, Eric A P ^a   Boers, Godfried H J ^b   Eskes, Tom K A B ^a  

^a Dept of Obstetrics and Gynecology ^*  (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

5,10 methylenetetrahydrofolate reductase; Folic acid; Homocysteine; Humans; Recurrent miscarriages

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID; HOMOCYSTEINE;

ADULT; ARTICLE; CLINICAL ARTICLE; COMORBIDITY; DIET RESTRICTION; FEMALE; FOLIC ACID DEFICIENCY; GENE MUTATION; GENETIC POLYMORPHISM; HEMATOCRIT; HUMAN; NUCLEIC ACID BASE SUBSTITUTION; PATHOGENESIS; RECURRENT ABORTION;

EID: 0031828880     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/128.8.1336     Document Type: Article

References (33)

1. Boushey, C. J., Beresford, S.A.A., Omenn, G. S. & Motulsky, A. G. (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes, J. Am. Med. Assoc. 274: 1049-1057.
2. Brattström, L., Israelsson, B., Norrving, B., Bergqvist, D., Thorne, J., Hultberg, B. & Hamfelt, A. (1990) Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease. Effects of pyridoxine and folic acid treatment. Atherosclerosis 81: 51-60.
3. Czeizel, A. E. & Dudas, I. (1992) Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N. Engl. J. Med. 327: 1832-1835.
4. Dekker, G. A., De Vries, J. I., Doelitzsch, P. M., Huijgens, P. C., von Blomberg, B. M., Jakobs, C. & Van Geijn, H. P. (1995) Underlying disorders associated with severe early-onset preeclampsia. Am. J. Obstet. Gynecol. 173: 1042-1048.
5. Den Heijer, M., Blom, H. J., Gerrits, W. B., Rosendaal, F. R., Haak, H. L., Wijermans, P. W. & Bos, G. M. (1995) Is hyperhomocysteinaemia a risk factor for recurrent venous thrombosis? Lancet 345: 882-885.
6. Frosst, P., Blom, H. J., Milos, R., Goyette, P., Sheppard, C. A., Matthews, R. G., Boers, G.H.J., Den Heijer, M., Kluijtmans, L.A.J., Van den Heuvel, L.P.W.J. & Rozen, R. (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nature Genet. 10: 111-113.
7. Glueck, C. J., Shaw, P., Lang, J. E., Tracy, T., Sieve Smith, L. & Wang, Y. (1995) Evidence that homocysteine is an independent risk factor for atherosclerosis in hyperlipidemic patients. Am. J. Cardiol. 75: 132-136.
8. Goddijn Wessel, T. A., Wouters, M.G.A.J., Van der Molen, E. F., Spuijbroek, M. D., Steegers-Theunissen, R.P.M., Blom, H. J., Boers, G.H.J. & Eskes, T.K.A.B. (1996) Hyperhomocysteinemia: a risk factor for placental abruption or infarction. Eur. J. Obstet. Gynecol. Reprod. Biol. 66: 23-29.
9. Guttormsen, A. B., Ueland, P. M., Nesthus, I., Nygard, O., Schneede, J., Vollset, S. E. & Refsum, H. (1996) Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (> or = 40 micromol/liter). The Hordaland Homocysteine Study. J. Clin. Invest. 98: 2174-2183.
10. Harmon, D. L., Woodside, J. V., Yarnell, J. W., Mcmaster, D., Young, I. S., McCrum, E. E., Gey, K. F., Whitehead, A. S. & Evans, A. E. (1996) The common 'thermolabile' variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia. Q. J. Med. 89: 571-577.
11. Heseker, H. & Schmitt, G. (1987) Effect of long-term supplementation of folate on folate status in plasma and erythrocytes. J. Nutr. Sci. Vitaminol. (Tokyo) 33: 163-168.
12. Jacques, P. F., Bostom, A. G., Williams, R. R., Ellison, R. C., Eckfeldt, J. H., Rosenberg, I. H., Selhub, J. & Rozen, R. (1996) Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 93: 7-9.
13. Kang, S. S., Wong, P.W.K., Susmano, A., Sora, J., Norusis, M. & Ruggie, N. (1991) Thermolabile methylenetetrahydrofolate reductase: an inherited risk factor for coronary artery disease. Am. J. Hum. Genet. 48: 536-545.
14. Kluijtmans, L.A.J., Kastelein, J.J.P., Lindemans, J., Boers, G.H.J., Heil, S. G., Bruschke, A.V.G., Jukema, J. W., Van den Heuvel, L.P.W.J., Trijbels, F.J.M., Boerma, G.J.M., Verheugt, F.W.A., Willems, F. & Blom, H. J. (1997) Thermolabile methylenetetrahydrofolate reductase in coronary artery disease. Circulation 96: 2573-2577.
15. Landgren, F., Israelsson, B., Lindgren, A., Hultberg, B., Andersson, A. & Brattström, L. (1995) Plasma homocysteine in acute myocardial infarction: homocysteine-lowering effect of folic acid. J. Intern. Med. 237: 381-388.
16. Malinow, M. R., Nieto, F. J., Kruger, W. D., Duell, P. B., Hess, D. L., Gluckman, R. A., Block, P. C., Holzgang, C. R., Anderson, P. H., Seltzer, D., Upson, B. & Lin, Q. R. (1997) The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofoiate reductase genotypes. Arterioscler. Thromb. Vasc. Biol. 17: 1157-1162.
17. Mason, J. B. & Miller, J. W. (1992) The effects of vitamins B12, B6, and folate on blood homocysteine levels. Ann. N. Y. Acad. Sci. 669: 197-203.
18. Mooij, P. N., Thomas, C.M.G., Doesburg, W. H. &Eskes, T.K.A.B. (1991) Multivitamin supplementation in oral contraceptive users. Contraception 44: 277-288.
19. Nelen, W.L.D.M., Steegers, E.A.P., Eskes, T.K.A.B. & Blom, H. J. (1997a) Genetic risk factor for unexplained recurrent early pregnancy loss. Lancet 350: 861.
20. Nelen, W.L.D.M., Van der Molen, E. F., Blom, H. J., Heil, S. G., Steegers, E.A.P. & Eskes, T.K.A.B. (19975) Recurrent early pregnancy loss and genetic-related disturbances in folate and homocysteine metabolism. Br. J. Hosp. Med. 58: 511-513.
21. Schrijver, J., Speek, A. J. & Schreurs, W. H. (1981) Semi-automated fluorometric determination of pyridoxal-5′-phosphate (vitamin B6) in whole blood by high-performance liquid chromatograpny (HPLC). Int. J. Vitam. Nutr. Res. 51: 216-222.
22. Sohda, S., Arinami, T., Hamada, H., Yamada, N., Hamaguchi, H. & Kubo, T. (1997) Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia. J. Med. Genet. 34: 525-526.
23. Steegers-Theunissen, R.P.M., Boers, G.H.J., Trijbels, F.J.M., Finkelstein, J. D., Blom, H. J., Thomas, C.M.G., Borm, G. F., Wouters, M.G.A.J. & Eskes, T.K.A.B. (1994) Maternal hyperhomocysteinemia: a risk factor for neural-tube defects? Metabolism 43: 1475-1480.
24. Te Poele-Pothoff, M. T., Van den Berg, M., Franken, D. G., Boers, G.H.J., Jakobs, C., de Kroon, I. F., Eskes, T.K.A.B., Trijbels, J. M. & Blom, H. J. (1995) Three different methods for the determination of total homocysteine in plasma. Ann. Clin. Biochem. 32: 218-220.
25. Ubbink, J. B., Hayward-Vermaak, W. J., Van der Merwe, A., Becker, P. J., Delport, R. & Potgieter, H. C. (1994) Vitamin requirements for the treatment of hyperhomocysteinemia in humans. J. Nutr. 124: 1927-1933.
26. Ubbink, J. B., Van der Merwe, A., Vermaak, W.J.H. & Delport, R. (1993a) Hyperhomocysteinemia and the response to vitamin supplementation. Clin. Investig. 71: 993-998.
27. Ubbink, J. B., Vermaak, W.J.H., Delport, R., Van der Merwe, A., Becker, P. J. & Potgieter, H. (1995) Effective homocysteine metabolism may protect South African blacks against coronary heart disease. Am. J. Clin. Nutr. 62: 802-808.
28. Ubbink, J. B., Vermaak, W.J.H., Van der Merwe, A. & Becker, P. J. (1993b) Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia. Am. J. Clin. Nutr. 57: 47-53.
29. Van den Berg, M., Boers, G.H.J., Franken, D. G., Blom, H. J., Van Kamp, G. J., Jakobs, C., Rauwerda, J. A., Kluft, C. & Stehouwert, C. D. (1995) Hyperhomocysteinaemia and endothelial dysfunction in young patients with peripheral arterial occlusive disease. Eur. J. Clin. Invest. 25: 176-181.
30. Van der Put, N. M., Steegers-Theunissen, R.P.M., Frosst, P., Trijbels, F. J., Eskes, T.K.A.B., Van den Heuvel, L.P.W.J., Mariman, E. C., Den Heijer, M., Rozen, R. & Blom, H. J. (1995) Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet 346: 1070-1071.
31. Van der Put, N. M., Eskes, T.K.A.B. & Blom, H. J. (1997) Is the common 677C→T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A meta-analysis. Q. J. Med. 90: 111-115.
32. Wouters, M.G.A.J., Boers, G.H.J., Blom, H. J., Trijbels, F.J.M., Thomas, C.M.G., Borm, G. F., Steegers-Theunissen, R.P.M. & Eskes, T.K.A.B. (1993) Hyperhomocysteinemia: a risk factor in women with unexplained recurrent early pregnancy loss. Fertil. Steril. 60: 820-825.
33. Wouters, M.G.A.J., Moorrees, M. T., Van der Mooren, M. J., Blom, H. J., Boers, G.H.J., Schellekens, L. A., Thomas, C.M.G. & Eskes, T.K.A.B. (1995) Plasma homocysteine and menopausal status. Eur. J. Clin. Invest. 25: 801-805.