-
1
-
-
0027122245
-
Crystal structure of transforming growth factor-β2: An unusual fold for the superfamily
-
Daopin, S., Piez, K.A., Ogawa, Y. & Davies, D.R. (1992). Crystal structure of transforming growth factor-β2: an unusual fold for the superfamily. Science 257, 369-373.
-
(1992)
Science
, vol.257
, pp. 369-373
-
-
Daopin, S.1
Piez, K.A.2
Ogawa, Y.3
Davies, D.R.4
-
2
-
-
0026633842
-
An unusual feature revealed by the crystal structure at 2.2 Å resolution of human transforming growth factor-β2
-
Schlunegger, M.P. & Grutter, M.G. (1992). An unusual feature revealed by the crystal structure at 2.2 Å resolution of human transforming growth factor-β2. Nature 358, 430-434.
-
(1992)
Nature
, vol.358
, pp. 430-434
-
-
Schlunegger, M.P.1
Grutter, M.G.2
-
4
-
-
0000116653
-
-
(Sporn, M.B. & Roberts, A.B., eds) Springer-Verlag, Heidelberg
-
Roberts, A.B. & Sporn, M.B. (1990). In Peptide Growth Factors and Their Receptors (Sporn, M.B. & Roberts, A.B., eds) pp. 419-472, Springer-Verlag, Heidelberg.
-
(1990)
Peptide Growth Factors and Their Receptors
, pp. 419-472
-
-
Roberts, A.B.1
Sporn, M.B.2
-
5
-
-
0029904671
-
Serine/threonine kinase receptors: Mediators of transforming growth factor beta family signals
-
Massague, J. & Weis-Garcia, F. (1996). Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals. Cancer Surv. 27, 41-64.
-
(1996)
Cancer Surv.
, vol.27
, pp. 41-64
-
-
Massague, J.1
Weis-Garcia, F.2
-
6
-
-
0030427867
-
Signal transduction by members of the transforming growth factor-beta superfamily
-
Attisano, L. & Wrana, J.L. (1996). Signal transduction by members of the transforming growth factor-beta superfamily. Cytokine Growth Factor Rev. 7, 327-339.
-
(1996)
Cytokine Growth Factor Rev.
, vol.7
, pp. 327-339
-
-
Attisano, L.1
Wrana, J.L.2
-
7
-
-
0027930903
-
Formation of hetero-oligomeric complexes of type I and type Il receptors for transforming growth factor-β
-
Yamashita, H., ten Dijke, P., Franzen, P., Miyazono, K. & Heldin, C.-H. (1994). Formation of hetero-oligomeric complexes of type I and type Il receptors for transforming growth factor-β. J. Biol. Chem. 269, 20172-20178.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 20172-20178
-
-
Yamashita, H.1
Ten Dijke, P.2
Franzen, P.3
Miyazono, K.4
Heldin, C.-H.5
-
8
-
-
0029834231
-
Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor
-
Thomsen, G.H. (1996). Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor. Development 122, 2359-2366.
-
(1996)
Development
, vol.122
, pp. 2359-2366
-
-
Thomsen, G.H.1
-
9
-
-
0029940972
-
Xenopus mad proteins transduce distinct subsets of signals for the TGFβ superfamily
-
Graff, J.M., Bansal, A. & Melton, D.A. (1996). Xenopus mad proteins transduce distinct subsets of signals for the TGFβ superfamily. Cell 85, 479-487.
-
(1996)
Cell
, vol.85
, pp. 479-487
-
-
Graff, J.M.1
Bansal, A.2
Melton, D.A.3
-
10
-
-
0029829230
-
A novel mesoderm inducer, MADR2, functions in the activin signal transduction pathway
-
Baker, J.C. & Harland, R.M. (1996). A novel mesoderm inducer, MADR2, functions in the activin signal transduction pathway. Genes Dev. 10, 1880-1889.
-
(1996)
Genes Dev.
, vol.10
, pp. 1880-1889
-
-
Baker, J.C.1
Harland, R.M.2
-
11
-
-
0029786212
-
Receptor-associated mad homologues synergize as effectors of the TGF-β response
-
Zhang, Y., Feng, X.-H., Wu, R.-Y. & Derynck, R. (1996). Receptor-associated mad homologues synergize as effectors of the TGF-β response. Nature 383, 168-172.
-
(1996)
Nature
, vol.383
, pp. 168-172
-
-
Zhang, Y.1
Feng, X.-H.2
Wu, R.-Y.3
Derynck, R.4
-
12
-
-
0029834067
-
Partnership between DPC4 and SMAD proteins in TGF-β signaling pathways
-
Lagna, G., Hata, A., Hemmati-Brivanlou, A. & Massague, J. (1996). Partnership between DPC4 and SMAD proteins in TGF-β signaling pathways. Nature 383, 832-836.
-
(1996)
Nature
, vol.383
, pp. 832-836
-
-
Lagna, G.1
Hata, A.2
Hemmati-Brivanlou, A.3
Massague, J.4
-
13
-
-
12644260471
-
Vascular MADs: Two novel MAD-related genes selectively inducible by flow in human vascular endothelium
-
Topper, J.N., et al., & Falb, D. (1997). Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Proc. Natl Acad. Sci. USA 94, 9314-9319.
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 9314-9319
-
-
Topper, J.N.1
Falb, D.2
-
14
-
-
0030765945
-
Smad6 inhibits signaling by the TGF-β superfamily
-
Imamura, T., et al., & Miyazono, K. (1997). Smad6 inhibits signaling by the TGF-β superfamily. Nature 389, 622-626.
-
(1997)
Nature
, vol.389
, pp. 622-626
-
-
Imamura, T.1
Miyazono, K.2
-
15
-
-
0030611757
-
Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signaling
-
Nakao, A., et al., & ten Dijke, P. (1997). Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signaling. Nature 389, 631-635.
-
(1997)
Nature
, vol.389
, pp. 631-635
-
-
Nakao, A.1
Ten Dijke, P.2
-
16
-
-
0030886204
-
Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells
-
Liu, X., Sun, Y., Constantinescu, S.N., Karam, E., Weinberg, R.A. & Lodish, H.F. (1997). Transforming growth factor β-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Proc. Natl Acad. Sci. USA 94, 10669-10674.
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 10669-10674
-
-
Liu, X.1
Sun, Y.2
Constantinescu, S.N.3
Karam, E.4
Weinberg, R.A.5
Lodish, H.F.6
-
17
-
-
0030300115
-
MADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling
-
Macias-Silva, M., Abdollah, S., Hoodless, P.A., Pirone, R., Attisano, L. & Wrana, J.L. (1996). MADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell 87, 1215-1224.
-
(1996)
Cell
, vol.87
, pp. 1215-1224
-
-
Macias-Silva, M.1
Abdollah, S.2
Hoodless, P.A.3
Pirone, R.4
Attisano, L.5
Wrana, J.L.6
-
18
-
-
0030768644
-
TGF-β receptor-mediated signaling through Smad2, Smad3 and Smad4
-
Nakao, A., et al., & ten Dijke, P. (1997). TGF-β receptor-mediated signaling through Smad2, Smad3 and Smad4. EMBO J. 16, 5353-5362.
-
(1997)
EMBO J.
, vol.16
, pp. 5353-5362
-
-
Nakao, A.1
Ten Dijke, P.2
-
20
-
-
0029802485
-
A transcriptional partner for MAD proteins in TGF-β signaling
-
Chen, X., Rubock, M.J. & Whitman, M. (1996). A transcriptional partner for MAD proteins in TGF-β signaling. Nature 383, 691-696.
-
(1996)
Nature
, vol.383
, pp. 691-696
-
-
Chen, X.1
Rubock, M.J.2
Whitman, M.3
-
21
-
-
0030961168
-
Smad4 and FAST-1 in the assembly of activin-responsive factor
-
Chen, X., Weisberg, E., Fridmacher, V., Watanabe, M., Naco, G. & Whitman, M. (1997). Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature 389, 85-89.
-
(1997)
Nature
, vol.389
, pp. 85-89
-
-
Chen, X.1
Weisberg, E.2
Fridmacher, V.3
Watanabe, M.4
Naco, G.5
Whitman, M.6
-
22
-
-
0030872367
-
Drosophila mad binds to DNA and directly mediates activation of vestigial by decapentaplegic
-
Kim, J., Johnson, K., Chen, H,J., Carroll, S. & Laughon, A. (1997). Drosophila mad binds to DNA and directly mediates activation of vestigial by decapentaplegic. Nature 388, 304-308.
-
(1997)
Nature
, vol.388
, pp. 304-308
-
-
Kim, J.1
Johnson, K.2
Chen, H.J.3
Carroll, S.4
Laughon, A.5
-
24
-
-
0029941824
-
Interaction of transforming growth factor-β receptor I with farnesyl-protein transferase-α in yeast and mammalian cells
-
Ventura, F., Liu, F., Doody, J, & Massague, J. (1996). Interaction of transforming growth factor-β receptor I with farnesyl-protein transferase-α in yeast and mammalian cells. J. Biol. Chem. 271, 13931-13934.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 13931-13934
-
-
Ventura, F.1
Liu, F.2
Doody, J.3
Massague, J.4
-
25
-
-
0029610361
-
Interaction of the transforming growth factor-β type I receptor with farnesyl-protein transferase-α
-
Kawabata, M., Imamura, T., Miyazono, K., Engel, M.E. & Moses, H.L. (1995). Interaction of the transforming growth factor-β type I receptor with farnesyl-protein transferase-α. J. Biol. Chem. 270, 29628-29631.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 29628-29631
-
-
Kawabata, M.1
Imamura, T.2
Miyazono, K.3
Engel, M.E.4
Moses, H.L.5
-
26
-
-
0028108801
-
Specific interaction of type I receptors of the TGF-β family with the immunophilin FKBP12
-
Wang, T., Donahoe, P.K. & Zervos, A.S. (1994). Specific interaction of type I receptors of the TGF-β family with the immunophilin FKBP12. Science 265, 674-676.
-
(1994)
Science
, vol.265
, pp. 674-676
-
-
Wang, T.1
Donahoe, P.K.2
Zervos, A.S.3
-
27
-
-
0029157432
-
A WD-domain protein that is associated with and phosphorylated by the type II TGF-β receptor
-
Chen, R.-H., Miettinen, P.J., Maruoka, E.M., Choy, L. & Derynck, R. (1995). A WD-domain protein that is associated with and phosphorylated by the type II TGF-β receptor. Nature 377, 548-552.
-
(1995)
Nature
, vol.377
, pp. 548-552
-
-
Chen, R.-H.1
Miettinen, P.J.2
Maruoka, E.M.3
Choy, L.4
Derynck, R.5
-
28
-
-
85101729263
-
The immunophilin FKBP12 functions as a common inhibitor of the TGF-β family type I receptors
-
Wang, T., et al., & Donohoe, P.K. (1996). The immunophilin FKBP12 functions as a common inhibitor of the TGF-β family type I receptors. Cell 86, 1-20.
-
(1996)
Cell
, vol.86
, pp. 1-20
-
-
Wang, T.1
Donohoe, P.K.2
-
29
-
-
0029786480
-
Characterization of the interaction of FKBP12 with the transforming growth factor-β type I receptor in vivo
-
Okadome, T., et al., & Kawabata, M. (1996). Characterization of the interaction of FKBP12 with the transforming growth factor-β type I receptor in vivo. J. Biol. Chem. 271, 21687-21690.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 21687-21690
-
-
Okadome, T.1
Kawabata, M.2
-
30
-
-
0029836237
-
FKBP-12 recognition is dispensable for signal generation by type I transforming growth factor-β receptors
-
Charng, M.-J., Kinnunen, P., Hawkers, J., Brand, T. & Schneider, M.D. (1996). FKBP-12 recognition is dispensable for signal generation by type I transforming growth factor-β receptors. J. Biol. Chem. 271, 22941-22944.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 22941-22944
-
-
Charng, M.-J.1
Kinnunen, P.2
Hawkers, J.3
Brand, T.4
Schneider, M.D.5
-
31
-
-
0030926004
-
Mechanism of TGF-β receptor inhibition by FKBP12
-
Chen, Y.-G., Liu, F. & Massague, J. (1997). Mechanism of TGF-β receptor inhibition by FKBP12. EMBO J. 16, 3866-3876.
-
(1997)
EMBO J.
, vol.16
, pp. 3866-3876
-
-
Chen, Y.-G.1
Liu, F.2
Massague, J.3
-
32
-
-
0026496172
-
TGFβ signals through a heteromeric protein kinase receptor complex
-
Wrana, J.L., et al., & Massague, J. (1992). TGFβ signals through a heteromeric protein kinase receptor complex. Cell 71, 1003-1014.
-
(1992)
Cell
, vol.71
, pp. 1003-1014
-
-
Wrana, J.L.1
Massague, J.2
-
33
-
-
0032543664
-
Probing the role of homomeric and heteromeric receptor interactions in TGF-β signaling using small molecule dimerizers
-
Stockwell, B.R. & Schreiber, S.L. (1998). Probing the role of homomeric and heteromeric receptor interactions in TGF-β signaling using small molecule dimerizers. Curr. Biol. 8, 761-770.
-
(1998)
Curr. Biol.
, vol.8
, pp. 761-770
-
-
Stockwell, B.R.1
Schreiber, S.L.2
-
34
-
-
0027756895
-
Controlling signal transduction with synthetic ligands
-
Spencer, D.M., Wandless, T.J., Schreiber, S.L. & Crabtree, G.R. (1993). Controlling signal transduction with synthetic ligands. Science 262, 1019-1024.
-
(1993)
Science
, vol.262
, pp. 1019-1024
-
-
Spencer, D.M.1
Wandless, T.J.2
Schreiber, S.L.3
Crabtree, G.R.4
-
35
-
-
0027463577
-
A composite FKBP12-FK506 surface that contacts calcineurin
-
Yang, D., Rosen, M.K. & Schreiber, S.L. (1993). A composite FKBP12-FK506 surface that contacts calcineurin. J. Am. Chem. Soc. 115, 819-820.
-
(1993)
J. Am. Chem. Soc.
, vol.115
, pp. 819-820
-
-
Yang, D.1
Rosen, M.K.2
Schreiber, S.L.3
-
36
-
-
0029022221
-
GS domain mutations that constitutively activate TβRI, the downstream signaling component in the TGF-β receptor complex
-
Wieser, R., Wrana, J.L. & Massague, J. (1995). GS domain mutations that constitutively activate TβRI, the downstream signaling component in the TGF-β receptor complex. EMBO J. 14, 2199-2208.
-
(1995)
EMBO J.
, vol.14
, pp. 2199-2208
-
-
Wieser, R.1
Wrana, J.L.2
Massague, J.3
-
37
-
-
0025129867
-
Concomitant loss of transforming growth factor (TGF)-β receptor types I and II in TGF-resistant cell mutants implicates both receptor types in signal transduction
-
Laiho, M., Weis, F.M.B. & Massague, J. (1990). Concomitant loss of transforming growth factor (TGF)-β receptor types I and II in TGF-resistant cell mutants implicates both receptor types in signal transduction. J. Biol. Chem. 265, 18518-18524.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 18518-18524
-
-
Laiho, M.1
Weis, F.M.B.2
Massague, J.3
-
38
-
-
0028972072
-
Transforming growth factor-β (TGF-β)-induced down-regulation of cyclin A expression requires a functional TGF-β receptor complex
-
Feng, X.-H., Filvaroff, E.H. & Derynck, R. (1995). Transforming growth factor-β (TGF-β)-induced down-regulation of cyclin A expression requires a functional TGF-β receptor complex. J. Biol. Chem. 270, 24237-24245.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 24237-24245
-
-
Feng, X.-H.1
Filvaroff, E.H.2
Derynck, R.3
-
39
-
-
0030013607
-
Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins
-
Belshaw, P.J., Ho, S.N., Crabtree, G.R. & Schreiber, S.L. (1996). Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins. Proc. Natl Acad. Sci. USA 93, 4604-4607.
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 4604-4607
-
-
Belshaw, P.J.1
Ho, S.N.2
Crabtree, G.R.3
Schreiber, S.L.4
-
40
-
-
0028170226
-
Mechanism of activation of the TGF-β receptor
-
Wrana, J.L., Attisano, L., Wieser, R., Ventura, F. & Massague, J. (1994). Mechanism of activation of the TGF-β receptor. Nature 370, 341-347.
-
(1994)
Nature
, vol.370
, pp. 341-347
-
-
Wrana, J.L.1
Attisano, L.2
Wieser, R.3
Ventura, F.4
Massague, J.5
-
41
-
-
0032576689
-
Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12
-
Shou, W., et al., & Matzuk, M.M. (1998). Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12. Nature 391, 489-492.
-
(1998)
Nature
, vol.391
, pp. 489-492
-
-
Shou, W.1
Matzuk, M.M.2
-
42
-
-
0028267256
-
A transforming growth factor β type I receptor that signals to activate gene expression
-
Bassing, C.H., et al., & Wang, X.-F. (1994). A transforming growth factor β type I receptor that signals to activate gene expression. Science 263, 87-89.
-
(1994)
Science
, vol.263
, pp. 87-89
-
-
Bassing, C.H.1
Wang, X.-F.2
|