Comparative dose-dependence study of FK506 and cyclosporin A on the rate of axonal regeneration in the rat sciatic nerve

Journal of Pharmacology and Experimental Therapeutics

Volumn 282, Issue 2, 1997, Pages 1084-1093

  Wang, M S ^a   Zeleny Pooley, Michelle ^a   Gold, Bruce G ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CYCLOSPORIN A; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; MALE; NERVE FIBER GROWTH; NERVE INJURY; NERVE REGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE;

ANIMALS; AXONS; CYCLOSPORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MICROSCOPY, ELECTRON; NERVE REGENERATION; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE; TACROLIMUS;

EID: 0030839896     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (67)

1. ABE, K., CHU, P. -J., ISHIHARA, A. AND SAITO, H.: Transforming growth factor-β1 promotes re-elongation of injured axons of cultured rat hippocampal neurons. Brain Res. 723: 206-209, 1996.
2. ARMISTEAD, D. M., BADIA, M. C., DEININGER, D. D., DUFFY, J. P., SAUNDERS, J. O., TUNG, R. D., THOMSON, J. A., DECENZO, M. T., FUTER, O., LIVINGSTON, D. J., MURCKO, M. A., YAMASHITA, M. M. AND NAVIA, M. A.: Design, synthesis and structure of non-macrocyclic inhibitors of FKBP12, the major binding protein for the immunosuppressant FK506. Acta Cryst. 51: 522-528, 1995.
3. BATCHELOR, M. J., GILLESPIE, R. J., GOLEC, J. M. C., HEDGECOCK, C. J. R., JONES, S. D. AND MURDOCH, R.: Total synthesis of close analogues of the immunosuppressant FK506. Tetrahedron 50: 809-825, 1994.
4. BRILLANTES, A. M. B., ONDRIAS, K., SCOTT, A., KOBRINSKY, E., ONDRIASOVA, E., MOSCHELLA, M. C., JAYARAMAN, T., LANDERS, M., EHRLICH, B. E. AND MARKS, A. R.: Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein. Cell 77: 513-523, 1994.
5. BRONSTER, D. J., YONOVER, P., STEIN, J., SCELSA, S. N., MILLER, C. M. AND SHEINER, P. A.: Demyelinating sensorimotor polyneuropathy after administration of FK506. Transplantation 59: 1066-1068, 1995.
6. 2+ flux. Cell 83: 463-472, 1995a.
7. CAMERON, A. M., STEINER, J. P., SABATINI, D. M., KAPLIN, A. I., WALENSKY, L. D. AND SNYDER, S. H.: Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux. Proc. Natl. Acad. Sci. U.S.A. 92: 1784-1788, 1995b.
8. CLIPSTONE, N. A. AND CRABTREE, G. R.: Calcineurin is a key signaling enzyme in T lymphocyte activation and the target of the immunosuppressive drugs cyclosporin A and FK506. In Immunosuppressive and Antiinflammatory Drugs, ed. by A. C. Allison, K. J. Lafferty, and H. Fliri. pp. 20-30, The New York Academy of Sciences, New York, NY, 1993.
9. CZAR, M. J., OWENS-GRILLO, J. K., YEM, A. W., LEACH, K. L., DEIBEL, M. R., JR., WELSH, M. J. AND PRATT, W. B.: The hsp56 immunophilin component of untransformed steroid receptor complexes is localized both to microtubules in the cytoplasm and to the same nonrandom regions within the nucleus as the steroid receptor. Mol. Endocrin. 8: 1731-1741, 1994.
10. DAWSON, T. M., STEINER, J. P., LYONS, W. E., FOTUHI, M., BLUE, M. AND SNYDER, S. H.: The immunophilins, FK506 binding protein and cyclophilin, are discretely localized in the brain: Relationship to Calcineurin. Neuroscience 62: 569-580, 1994.
11. DROZ, B. AND WARSHAWSKY, H.: Reliability of the radioautographic technique for the detection of newly synthesized protein. J. Histochem. Cytochem, 11: 426-435, 1963.
12. FUNG, J. J., ELIASZIW, M., TODO, S., JAIN, A., DEMETRIS, A. J., MCMICHAEL, J. P., STARZL, T. E., MEIER, P. AND DONNER, A.: The Pittsburgh randomized trial of tacrolimus compared to cyclosporine for hepatic transplantation. J. Am. Coll. Surg. 183: 117-125, 1996.
13. GOLD, B. G., KATOH, K. AND STORM-DICKERSON, T.: The immunosuppressant FK506 increases the rate of axonal regeneration in rat sciatic nerve. J. Neurosci. 15: 7505-7516, 1995.
14. GOLD, B. G., LAGRANGE, M. AND WANG, M. S.: FK506 increases expression of the heat shock protein-70 (HSP-70) in rat brain: Possible role in its ability to provide neuroprotection against ischemic injury. J. Neuropathol. Exp. Neurol. 55: 622, 1996a.
15. GOLD, B. G., STORM-DICKERSON, T. AND AUSTIN, D. R.: The immunosuppressant FK506 increases functional recovery and nerve regeneration following peripheral nerve injury. Restor. Neurol. Neurosci. 6: 287-296, 1994.
16. GOLD, B. G., WANG, M. S. AND ZELENY-POOLEY, M.: FK506 and cyclosporin A: Comparative dose-dependency studies on the rate of axonal regeneration in the rat sciatic nerve (Abstract). Soc. Neurosci. 22: 264, 1996b.
17. GRIFFITH, J. P., KIM, J. L., KIM, E. E., SINTCHANK, M. D., THOMSON, J. A., FITZGIBBON, M. J., FLEMING, M. A., CARON, P. R., HSIAO, K. AND NAVIA, M. A.: X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex. Cell 82: 507-522, 1995.
18. HARDING, M. W., GALAT, A., UEHLING, D. E. AND SCHREIBER, S. L.: A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase. Nature (Lond.) 341: 758-760, 1989.
19. HEMENWAY, C. S. AND HEITMAN, J.: Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast. J. Biol. Chem. 271: 18527-18534, 1996.
20. HOFFMAN, A. L., MAKOWKA, L., BANNER, B., CAI, X., CRAMER, D. V., PASCUALONE, A., TODO, S. AND STARZL, T. E.: The use of FK-506 for small intestine allotransplantation: Inhibition of acute rejection and prevention of fatal graft-versus-host disease. Transplantation 49: 483-490, 1990.
21. IDE, T., MORIKAWA, E. AND KIRINO, T.: An immunosuppressant, FK506, protects hippocampal neurons from forebrain ischemia in the Mongolian gerbil. Neurosci. Lett. 204: 157-160, 1996.
22. ITOH, S., DECENZO, M. T., LIVINGSTON, D. J., PEARLMAN, D. A. AND NAVIA, M. A.: Conformation of FK506 in x-ray structures of its complexes with human recombinant FKBP12 mutants. Bioorgan. Med. Chem. Lett. 5: 1983-1988, 1995.
23. ITOH, S. AND NAVIA, M. A.: Structure comparison of native and mutant human recombinant FKBP12 complexes with the immunosuppressant drug FK506 (tacrolimus). Protein Science (Wash. DC) 4: 2261-2268, 1995.
24. JAIN, A. B. AND FUNG, J. J.: Cyclosporin and tacrolimus in clinical transplantation. A comparative review. Clin. Immunother. 5: 351-373, 1996.
25. JAP TJOEN SAN, E. R. A., VAN ROZEN, A. J., NIELANDER, H. B., OESTREICHER, A. B., GISPEN, W. H. AND SCHOTMEN, P.: Expression levels of B-50/GAP-43 in PC12 cells are decisive for the complexity of their neuntes and growth cones. J. Mol. Neurosci. 6: 185-200, 1995.
26. JAYARAMAN, T., BRILLANTES, A., TIMERMAN, A. P., FLEISCHER, S., ERDJUMENT-BROMAGE, H., TEMPST, P. AND MARKS, A. R.: FK506 binding protein associated with the calcium release channel (ryanodine receptor). J. Biol. Chem. 267: 9474-9477, 1992.
27. KINO, T., HATANAKA, H., HASHIMOTO, M. AND NISHIYAMA, H.: FK-506, a novel immunosuppressant isolated from a streptomyces. I. Fermentation, isolation, and physiochemical and biological characteristics. J. Antibiot. 40: 1249-1255, 1987a.
28. KINO, T., HATANAKA, H., MIYATA, S., INAMURA, N., NISHIYAMA, M., YAJIMA, T., GOTO, T., OKUHARA, M., KOHSAKA, M., AOKI, H. AND OCHIAI, T.: FK-506, a novel immunosuppressant isolated from a streptomyces. II. Immunosuppressive of FK-506 in vitro. J. Antibiot. 40: 1256-1265, 1987b.
29. KLEE, C. B.: Concerted regulation of protein phosphorylation and dephosphorylation by calmodulin. Neurochem. Res. 16: 1059-1065, 1991.
30. KLINTMALM, G.: The U.S. Multicenter FK 506 Liver Study Group: A comparison of tacrolimus (FK 506) and cyclosporine for immunosuppression in liver transplantation. N. Engl. J. Med. 331: 1110-1115, 1994.
31. LEBEAU, M. C., MASSOL, N., HERRICK, J., FABER, L. E., RENOIN, M. J., RADANYI, C. AND BAULIEU, E. E.: P59, an hsp 90-binding protein. Cloning and sequencing of its cDNA and preparation of a peptide-directed polyclonal antibody. J. Biol. Chem. 267: 4281-4284, 1992.
32. LINDHOLM, D., HENGERER, B., ZAFRA, F. AND THOENEN, H.: Transforming growth factor-β1 stimulates expression of nerve growth factor in the rat CNS. NeuroReport 1: 9-12, 1990.
33. LIU, J., FARMER, J. D., LANE, W. S., FRIEDMAN, J., WEISSMAN, I. AND SCHREIBER, S. L.: Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66: 807-815, 1991.
34. LOPEZ, O. L., MARTINEZ, A. J. AND TORRE-CISNEROS, J.: Neuropathologic findings in liver transplantation: A comparative study of cyclosporine and FK506. Transplant Proc. 23: 3181-3182, 1991.
35. LYONS, W. E., GEORGE, E. B., DAWSON, T. M., STEINER, J. P. AND SNYDER, S. H.: Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia. Proc. Natl. Acad. Sci. U.S.A. 91: 3191-3195, 1994.
36. MEIRI, K. F., BICKERSTAFF, L. E. AND SCHWOB, J. E.: Monoclonal antibodies show that kinase C phosphorylation of GAP-43 during axonogenesis is both spatially and temporally restricted in vivo. J. Cell Biol. 112: 991-1005, 1991.
37. MOUZAKI, A., DAI, Y., WEIL, R. AND RUNGGER, D.: Cyclosporin A and FK506 prevent the derepression of the IL-2 gene in mitogen-induced primary T lympocytes. Cytokine 4: 151-160, 1992.
38. MUELLER, A. R., PLATZ, K.-P., BECHSTEIN, W.-O., SCHATTENFROH, N., STOLTENBURG-DIDINGER, G., BLUMHARDT, G., CHRISTE, W. AND NEUHAUS, P.: Neurotoxicity after orthotopic liver transplantation. A comparison between cyclosporine and FK506. Transplantation 58: 155-169, 1994.
39. NAVIA, M. A. AND CHATURVEDI, P. R.: Design principles for orally bioavailable drugs. Drug Discovery Today 1: 179-189, 1996.
40. NEUHAUS, P., PICHLMAYR, R. AND WILLIAMS, R.: The European FK 506 Multicentre Liver Study Group: Randomised trial comparing tacrolimus (FK 506) and cyclosporin in prevention of liver allograft rejection. Lancet 344: 423-428, 1994.
41. OCHS, S. AND RANISH, N.: Metabolic dependence of fast axoplasmic transport in nerve. Science (Wash. DC) 167: 878-879, 1970.
42. r of 63,000, 56,000, and 50,000. J. Biol. Chem. 266: 6708-6713, 1991.
43. ROKAW, M. D., WEST, M. E., PALEVSKY, P. M. AND JOHNSON, J. P.: FK-506 and rapamycin but not cyclosporin inhibit aldosterone-stimulated sodium transport in A6 cells. Am. J. Physiol. 271: C194-C202, 1996.
44. SCHREIBER, S. L.: Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science (Wash. DC) 251: 283-287, 1991.
45. SCHREIBER, S. L. AND CRABTREE, G. R.: The mechanism of action of cyclosporin A and FK506. Immunol. Today 13: 136-142, 1992.
46. SHARKEY, J. AND BUTCHER, S. P.: Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia. Nature (Lond.) 371: 336-339, 1994.
47. SHUKER, S. B., HAJDUK, P. J., MEADOWS, R. P. AND FESIK, S. W.: Discovering high-affinity ligands for proteins: SAR by NMR. Science (Wash. DC) 274: 1531-1534, 1996.
48. SIEKIERKA, J. J., HUNG, S. H. Y., POE, M., LIN, C. S. AND SIGAL, N. H.: A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin. Nature (Lond.) 341: 755-757, 1989.
49. SKENE, J. H. P.: Axonal growth-associated proteins. Annu. Rev. Neurosci. 12: 127-156, 1989.
50. SKENE, J. H. P. AND WILLARD, M. B.: Changes in axonally transported proteins during axon regeneration in toad retinal ganglion cells. J. Cell. Biol. 89: 86-95, 1981a.
51. SKENE, J. H. P. AND WILLARD, M. B.: Axonally transported proteins associated with growth in rabbit central and peripheral nervous system. J. Cell. Biol. 89: 96-103, 1981b.
52. SNYDER, S. H. AND SABATINI, D. M.: Immunophilins and the nervous system. Nature Med. 1: 32-37, 1995.
53. STARZL, T. E., TODO, S., FUNG, J., DEMETRIS, A. J., VENKATARAMMAN, R. AND JAIN, A.: FK-506 for liver, kidney, and pancreas transplantation. Lancet 2: 1000-1004, 1989.
54. STEINER, J. P., DAWSON, T. M., FOTUHI, C., GLATT, C., SNOWMAN, A. M., COHEN, N. AND SNYDER, S. H.: The immunosuppressant FK-506 enhances phosphorylation of GAP43: Implications for a role in modulation of growth cone function and neurotransmitter release (Abstract). Soc. Neurosci. 18: 603, 1991.
55. STEINER, J. P., DAWSON, T. M., FOTUHI, M., GLATT, C. E., SNOWMAN, A. M. M., COHEN, N. AND SNYDER, S. H.: High brain densities of the immunophilin FKBP colocalized with calcineurin. Nature (Lond.) 358: 584-587, 1992.
56. TAKEI, K., JAY, D. G. AND MIKOSHIBA, K.: Regional laser inactivation of type 1 inositol 1,4,5 trisphosphate receptor affects growth cone morphology and motility in chick DRG neurons (Abstract). Soc. Neurosci. 22: 740, 1996.
57. TANIUCHI, M., CLARK, H. B., SCHWEITZER, J. B. AND JOHNSON, E. M., JR.: Expression of nerve growth factor receptors by Schwann cells of axotomized peripheral nerves: Ultrastructural location, suppression by axonal contact, and binding properties. J. Neurosci. 8: 664-681, 1988.
58. TOCCI, M. J., MATKOVICH, D. A., MATKOVICH, K., COLLIER, K. A., KWOK, P., DUMONT, F., LIN, S., DEGUDICIBUS, S., SIEKERKA, J. J., CHIN, J. AND HUTCHINSON, N. I.: The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes. J. Immunol. 143: 718-726, 1989.
59. TOKIME, T., NOZAKI, K. AND KIKUCHI, H.: Neuroprotective effect of FK506, an immunosuppressant, on transient global ischemia in gerbil. Neurosci. Lett. 206: 81-84, 1996.
60. VINCENTI, F., LASKOW, D. A., NEYLAN, J. F., MENDEZ, R. AND MATAS, A. J.: One-year follow-up of an open-label trial of FK506 for primary kidney transplantation. Transplantation 61: 1576-1581, 1996.
61. WALKER, J. L., RESIG, P., GUARNIERI, S., SISKEN, B. F. AND EVANS, J. M.: Improved footprint analysis using video recording to assess functional recovery following injury to the rat sciatic nerve. Restor. Neurol. Neurosci. 6: 189-193, 1994.
62. WANG, T., DONAHOE, P. K. AND ZERVOS, A. S.: Specific interaction of Type I receptors of the TGF-β family with the immunophilin FKBP-12. Science (Wash. DC) 265: 674-676, 1994.
63. WANG, T., LI, B.-Y., DANIELSON, P. D., ROCKWELL, S., LECHLEIDER, R. J., MARTIN, J., MANGANARO, T. AND DONAHOE, P. K.: The immunophilin FKBP12 functions as a common inhibitor of the TGFβ family type I receptors. Cell 86: 435-444, 1996.
64. WIEDERRECHT, G., LAM, E., HUNG, S., MARTIN, M. AND SIGAL, N.: The mechanism of action of FK-506 and cyclosporin A. Ann. N.Y. Acad. Sci. 696: 9-19, 1993.
65. WIEDERRECHT, G. AND ETZKORN, F.: The immunophilins. Perspectives in Drug Discovery and Design 2: 57-84, 1994.
66. WIJDICKS, E. F. M., WEISNER, R. H., DAHLKE, L. J. AND KROM, R. A. F.: FK506-induced neurotoxicity in liver transplantation. Ann. Neurol. 35: 498-501, 1994.
67. ZHUANG, H.-X., SNYDER, C. K., PU, S.-F. AND ISHII, D. N.: Insulin-like growth factors reverse or arrest diabetic neuropathy: Effects on hyperalgesia and impaired nerve regeneration in rats. Exp. Neurol. 140: 198-205, 1996.