FKBP12-binding domain analogues of FK506 are potent, nonimmunosuppressive neurotrophic agents in vitro and promote recovery in a mouse model of Parkinson's disease

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 13, 1997, Pages 1785-1790

  Hamilton, G S ^a   Huang, W ^a   Connolly, M A ^a   Ross, D T ^a   Guo, H ^a   Valentine, H L ^a   Suzdak, P D ^a   Steiner, J P ^a  

^a GUILFORD PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3,3 DIMETHYL 1,2 DIOXOPENTYL) 2 PYRROLIDINECARBOXYLIC ACID 3 (3 PYRIDYL)PROPYL ESTER; CALCINEURIN; CYCLOPHILIN A; CYCLOSPORIN; FK 506 BINDING PROTEIN; GLYOXYLIC ACID DERIVATIVE; IMMUNOPHILIN; ISOMERASE; PIPECOLIC ACID DERIVATIVE; RAPAMYCIN; RECEPTOR PROTEIN; TACROLIMUS; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN PROTECTION; CONTROLLED STUDY; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SYNTHESIS; MOUSE; NERVE DEGENERATION; NERVE FIBER GROWTH; NONHUMAN; PARKINSON DISEASE; PROTEIN DOMAIN; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALIA;

EID: 0030762067     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00304-1     Document Type: Article

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