FK506-binding protein mutational analysis: Defining the active-site residue contributions to catalysis and the stability of ligand complexes

Protein Engineering

Volumn 9, Issue 2, 1996, Pages 173-180

  DeCenzo, Maureen T ^a   Park, Steven T ^a,b   Jarrett, Beth P ^a,c   Aldape, Robert A ^a   Futer, Olga ^a   Murcko, Mark A ^a   Livingston, David J ^a  

^a VERTEX PHARMACEUTICALS   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

FK506; FKBP; Peptidyl prolyl; PPIase; Rapamycin

Indexed keywords

DRUG BINDING PROTEIN; ISOMERASE; MUTANT PROTEIN; RAPAMYCIN; TACROLIMUS;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CATALYSIS; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME STABILITY; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

EID: 0029874581     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/9.2.173     Document Type: Article

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