Physicochemical determinants of passive membrane permeability: Role of solute hydrogen-bonding potential and volume

Journal of Medicinal Chemistry

Volumn 44, Issue 22, 2001, Pages 3721-3729

  Goodwin, J T ^a   Conradi, R A ^a   Ho, N F H ^a   Burton, P S ^a  

^a Drug Absorption and Transport   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE;

ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DIFFUSION; HYDROGEN BOND; INTESTINE MUCOSA; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MOLECULAR MODEL; NONHUMAN; PARTITION COEFFICIENT; PHYSICAL CHEMISTRY; PROTEIN DOMAIN; PROTEIN STRUCTURE;

CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; HUMANS; HYDROGEN BONDING; MODELS, BIOLOGICAL; MOLECULAR MIMICRY; OCTANOLS; PHENYLALANINE; SOLUBILITY; WATER;

EID: 0035950120     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010253i     Document Type: Article

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