A phosphorylation-driven ubiquitination switch for cell-cycle control

Trends in Cell Biology

Volumn 12, Issue 3, 2002, Pages 104-107

  Harper, J Wade ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGASE; UBIQUITIN;

CELL CYCLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; REVIEW;

CDC28 PROTEIN KINASE, S CEREVISIAE; CELL CYCLE PROTEINS; ENZYME INHIBITORS; FEEDBACK, BIOCHEMICAL; FUNGAL PROTEINS; PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE PROTEINS; UBIQUITINS; YEASTS;

EID: 0036498527     PISSN: 09628924     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0962-8924(01)02238-3     Document Type: Review

References (20)

1. Building a cellular switch: More lessons from a good egg
2. Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication
3. SIC1 controls the G1 to S transition in S. cerevisiae
4. How the cyclin became a cyclin: Regulated proteolysis in the cell cycle
5. SCF and Cullin/Ring H2-based ubiquitin ligases
6. A complex of Cdc4p, Skp1p, and Cdc53p/Cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p
7. F-box proteins are components of E3 complexes and act as receptors to recruit phosphorylated substrates for ubiquitination
8. Cdc53/Cullin and the essential hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme cdc34
9. Grr1 and Rbx1
10. SKP1 connects cell cycle regulation to the ubiquitin proteolysis machinery through a novel motif, the F-box
11. Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase
12. Rapid degradation of the G1 cyclin Cln2 induced by CDK-dependent phosphorylation
13. Degradation of the transcription factor Gcn4 requires the kinase Pho85 and the SCF (CDC4) ubiquitin-ligase complex
14. Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase
15. Fbw7 ubiquitin ligase
16. Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line
17. Archipelago regulates cyclin E levels in Drosophila and is mutated in human cancer cell lines
18. Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex
19. Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus
20. Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex