The stress response in the yeast Saccharomyces cerevisiae;La respuesta a estrés en la levadura Saccharomyces cerevisiae

Revista Latinoamericana de Microbiologia

Volumn 46, Issue 1-2, 2004, Pages 24-46

  Folch Mallol, Jorge Luis ^b   Garay Arroyo, Adriana ^a   Lledías, Fernando ^a   Covarrubias Robles, Alejandra A ^a,c  

^a INSTITUTO DE CIENCIAS FÍSICAS   (Mexico)

^b UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MORELOS   (Mexico)

^c INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

Author keywords

Signal transduction; Stress response; Transcriptional regulation

Indexed keywords

ASCORBIC ACID; CATALASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUTATHIONE; GUANOSINE TRIPHOSPHATASE; HEAT SHOCK PROTEIN; HOG KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; PROTEIN KINASE; PROTEIN TYROSINE PHOSPHATASE; RAS PROTEIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ACE1P; TRANSCRIPTION FACTOR GCN4P; TRANSCRIPTION FACTOR HAP1P; TRANSCRIPTION FACTOR HOT1P; TRANSCRIPTION FACTOR MAC1P; TRANSCRIPTION FACTOR MSN1P; TRANSCRIPTION FACTOR MSN2P; TRANSCRIPTION FACTOR MSN4P; TRANSCRIPTION FACTOR SGD1P; TRANSCRIPTION FACTOR SKN7P; TRANSCRIPTION FACTOR SKO1P; TRANSCRIPTION FACTOR SMP1P; TRANSCRIPTION FACTOR YAP1P; TRANSCRIPTION FACTOR YAP2P; UNCLASSIFIED DRUG;

FUNGAL GENETICS; GENE EXPRESSION; GENETIC TRANSCRIPTION; HEAT STRESS; NONHUMAN; OSMOTIC STRESS; OXIDATIVE STRESS; REVIEW; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; STRESS; TRANSCRIPTION REGULATION; YEAST;

CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE EXPRESSION REGULATION, FUNGAL; GLYCEROL; HEAT; HEAT-SHOCK PROTEINS; HOT TEMPERATURE; ION TRANSPORT; MITOGEN-ACTIVATED PROTEIN KINASES; OSMOSIS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SALTS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

SACCHAROMYCES CEREVISIAE;

EID: 9244239705     PISSN: 01874640     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (147)

1. Akhtar, N., A.K. Pahlman., K. Larsson., A.M., Corbett & L. Adler. 2000. SGD1 encodes an essential nuclear protein of Saccharomyces cerevisiae that affects expression of the GPD1 gene for glycerol 3-phosphate dehydrogenase. FEBS Lett. 483(2-3):87-92.
2. Albertyn, J., Hohmann, S., Thevelein, J.M. & B.A. Prior. 1994. GPD1, which encodes glycerol-3-phosphate dehydrogenase, is essential for growth under osmotic stress in Saccharomyces cerevisiae, and its expression is regulated by the high-osmolarity glycerol response pathway. Mol Cell Biol 14(6):4135-44.
3. Alepuz, P.M., Cunningham, K.W. & F. Estruch. 1997. Glucose repression affects ion homeostasis in yeast through the regulation of stress-activated ENA1 gene. Mol. Microbiol. 26:91-98.
4. Alepuz, P., Jovanovic, A., Reiser, V., & G. Ammerer. 2001. Stress-induced map kinase Hog1 is part of transcription activation complexes. Mol Cell. 7(4):767-77.
5. +-dependent glycerol 3-phosphate dehydrogenase encoded by GPD1 and GPD2 have distinct roles in osmoadaptation and redox regulation. EMBO J 16(9):2179-87.
6. Balasundaram, D., Tabor, C.W. & H. Tabor. 1991. Spermidine or spermine is essential for the aerobic growth of Saccharomyces cerevisiae. Proc. Natl Acad. Sci 88:5872-5876.
7. Beck T., & M.N. Hall. 1999. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature 402(6762):689-92.
8. +) in acquired osmotolerance of Saccharomyces cerevisiae. J Bacteriol. 171(2):1087-92.
9. Blomberg, A. 2000. Metabolic surprises in Saccharomyces cerevisiae during adaptation to saline conditions: questions, some answers and a model. FEMS Microbiol Lett. 182(1):1-8.
10. Boutelet F., P.A., & F. Hilger. 1985. Yeast cdc35 mutants are defective in adenylate cyclase and are allelic with cyr1 mutants while CAS1, a new gene, is involved in the regulation of adenylate cyclase. EMBO J. 4(10):2635-41.
11. Boy-Marcotte, E., Perrot, M., Bussereau, F., Boucherie, H., & M. Jacquet. 1998. Msn2p and Msn4p control a large number of genes induced at the diuxic transition which are repressed by cyclic AMP in Saccharomyces cerevisiae. J. Bacteriol. 180:1044-1052.
12. Brewster, J.L., de Valoir, T., Dwyer, N.D., Winter, E., & Gustin, M.C. 1993. An osmosensing signal transduction pathway in yeast. Science 259(5102):1760-3.
13. Camus, C., Geymonat, M., Garreau, H., Baudet-Nessler, S. & M. Jacquet. 1997. Dimerization of Cdc25p, the guanine-nucleotide exchange factor for Ras from Saccharomyces cerevisiae, and its interaction with Sdc25p. Eur. J. Biochem 247:703-708.
14. Causton, H., Ren, B., Koh, S.S., Harbison, C.T., Kanin, E., Jennings, E.G., Lee, T.I., True, H.L., Lander, E.S., & R.A. Young. 2001. Remodeling of yeast genome expression in response to environmental changes. Mol Biol Cell. 12(2):323-37.
15. Chen, T., & C.S. Parker. 2002. Dynamic association of transcriptional activation domains and regulatory regions in Saccharomyces heat shock factor. PNAS 99(3):1200-1205.
16. Clos J., W.J., Becker P.B., Wilson S., Lambert K., & C., Wu. 1990. Molecular cloning and expression of a hexameric Drosophila heat shock factor subject to negative regulation. Cell 63(5):1085-97.
17. Colledge, M., & J.D. Scott. 1999. AKAPs: from structure to function. Trends Cell Biol. 9:216-221.
18. Collinson, L.P. & I.W. Dawes. 1995. Isolation, characterization and overexpression of the yeast gene, GLR1, encoding glutathione reductase. Genes Dev. 156:123-127.
19. Colombo, S., Ma, P., Cauwenberg, L., Winderickx, J., Crauwels, M., Teunissen, A., Nauwelaers, D., de Winde, J.H., Gorwa, M.-F., Colavizza, D., & J.M. Thevelein. 1998. Involvement of distinct G-proteins, Gpa2 and Ras, in glucose-and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae. EMBO J. 17:3326-3341.
20. Craig, E.A., Baxter, B.K., Becker, J., Halladay, J. & T. Zigelhoffer. 1994. Is Hsp70 the cellular thermometer? Trends Biochem. Sci. 16:135-140.
21. Crespo, J.L., Powers, T., Fowler, B., & M.N. Hall. 2002. The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine. Proc. Natl. Acad. Sci. USA 99(10):6784-6789.
22. Damak, F., Boy-Marcotte E., Le-Roscouet, D., Guilbaud, R. & M. Jacquet. 1991. 5DC25, a CDC25-like gene which contains a RAS activating domain and is a dispensable gene of Saccharomyces cerevisiae. Mol. Cell Biol 11:202-212.
23. Davidson, J.F., Whyte, B., Bissinger, P.H. & R.H. Schiestl. 1996. Oxidative stress is involved in heat-induced cell death in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 93:5116-5121.
24. 2 sensing through oxidation of the Yap1 transcription factor. EMBO J. 19(19):5157-66.
25. 2 receptor and redox-transducer in gene activation. Cell 111(4):471-81.
26. DeLuna, A., Avendaño, A., Riego, L., & A. Gonzalez. 2001. NADP-glutamate dehydrogenase isoenzymes of Saccharomyces cerevisiae. Purification, kinetic properties, and physiological roles. J Biol Chem. 276(47):43775-83.
27. Dichtl, B., Stevens, A., & D. Tollervey. 1997. Lithium toxicity in yeast is due to the inhibition of RNA processing enzymes. EMBO J. 16(23):7184-95.
28. Dihazi H., Kessler, R., & K. Escnrich. 2003. Glucose-induced stimulation of the Ras-cAMP pathway in yeast leads to multiple phosphorylations and activation of 6-phosphofructo-2-kinase. Biochemistry 42(20):6275-82.
29. Estruch, F. 2000. Stress-controlled transcription factors, stress-induced genes and stress tolerance in budding yeast. FEMS Microbiol Rev. 24:469-486.
30. Fedor-Chaiken, M., Deschenes, R.J. & J.R. Broach. 1990. SVR2, a gene required for RAS activation of adenylate cyclase. Cell 61:329-340.
31. Fernandes, L., Rodrigues-Pousada, C. & K. Struhl. 1997. Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions. Mol. Cell Biol. 17:6982-6993.
32. Flattery-O'Brien, J., Grant, C.M. & I.W. Dawes. 1997. Stationary-phase regulation of the Saccharomyces cerevisiae SOD2 gene is dependent on the additive effects of HAP2/3//4/5- and STRE binding elements. Mol. Microbiol. 23:303-312.
33. Furst, P., Hu, S., Hackett, R. & D. Hamer. 1988. Copper activates metallothionein gene transcription by altering the conformation of a specific DNA binding protein. Cell 55:705-717.
34. Garay-Arroyo, A., Lledias, F., Hansberg, W., & A.A. Covarrubias. 2003. Cu,Zn-superoxide dismutase of Saccharomyces cerevisiae is required for resistance to hyperosmosis. FEBS Lett. 539(1-3):68-72.
35. Garciadeblas, B., Rubio, F., Quintero, F.J., Bafiuelos, M.A., Haro, R., & A. Rodríguez-Navarro. 1993. Differential expression of two genes encoding isoforms of the ATPase involved in sodium efflux in Saccharomyces cerevisiae. Mol Gen Genet 236:363-368.
36. Garreau, H., Hasan, R.N., Renault, G., Estruch, F., Boy-Marcotte, E., & M. Jacquet. 2000. Hyperphosphorylation of Msn2p and Msn4p in response to heat shock and the diauxic shift is inhibited by cAMP in Saccharomyces cerevisiae. Microbiology 146:2113-20.
37. Garrido, E., & C.M. Grant. 2002. Role of thioredoxins in the response of Saccharomyces cerevisiae to oxidative stress induced by hydroperoxides. Mol Microbiol. 43(4):993-1003.
38. Gasch, A., Spellman, P.T., Kao, C.M., Carmel-Harel, O., Eisen, M.B., Storz, G., Botstein, D., & P.O. Brown. 2000. Genomic expression programs in the response of yeast cells to environmental changes. Mol Biol Cell. 11(12):4241-4257.
39. Gaxiola, R.A., Rao, R., Sherman, A., Grisafi, P., Alper, S.L., & G.R. Fink. 1999. The Arabidopsis thaliana proton transporters, At-Nhx1 and Avp1, can function in cation detoxification in yeast. Proc Natl Acad Sci USA. 96(4):1480-5.
40. Geymonat, M., Wang, L., Carreau, H. & M. Jacquet. 1998. Ssa1p chaperone interacts with the guanine exchange factor of ras Cdc25p and controls the cAMP pathway in Saccharomyces cerevisiae. Mol. Microbiol. 30:855-864.
41. 2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity. Genes Dev. 12:586-597.
42. Gralla, E. & J.S. Vallentine. 1991. Null mutants of Saccharomyces cerevisiae Cu, Zn Superoxide dismutase: characterization and spontaneous mutation rates. J. Bacteriol. 173:5918-5920.
43. Grey, M. & M. Brendel. 1994. Overexpression of the SNQ3/YAP1 gene confers hyperresistance to nitrosoguanidine in Saccharomyces cerevisiae via a glutathione-independent mechanism. Curr. Genet. 25:469-471.
44. Griffioen, G., Anghileri, P., Imre E., Baroni, M.D. & H. Ruis. 2000. Nutritional control of nucleocytoplasmic localization of cAMP-dependent protein kinase catalytic and regulatory subunits in Saccharomyces cerevisiae. J. Biol. Chem. 275:1449-1456.
45. Griffioen, G., Branduardi, P., Ballarini, A., Anghileri, P., Norbeck, J., Baroni, M.D., & R. Ruis. 2001. Nucleocytoplasmic distribution of budding yeast protein kinase A regulatory subunit Bcy1 requires Zds1 and is regulated by Yak1-dependent phosphorylation of its targeting domain. Mol. Cell Biol. 21:511-523.
46. Griffioen, G., & J.M. Thevelein. 2002. Molecular mechanisms controlling the localization of protein kinase A. Curr Genet. 41(4):199-207.
47. Gross, E., Goldberg, D. & A. Levitzki. 1992. Phosphorylation of the Saccharomyces cerevisiae Cdc25p in response to glucose results in its dissociation from Ras. Nature 360:762-765.
48. Halliwell, B. & M.C. Gutteridge. 1999. Free Radicals in Biology and Medicine. London, Oxford University Press.
49. Hamer, D. 1986. Metallothionein. Ann. Rev. Biochem 55:913-951.
50. Hardy, J.A., Walsh, S.T. & H.C. Nelson. 2000. Role of an alpha-helical bulge in the yeast heat shock transcription factor. J Mol Biol. 295(3):393-409.
51. Hinnebusch, A., & K. Natarajan. 2002. Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress. Eukaryot Cell. 1(1):22-32.
52. Hohmann, S. & W. Mager. 1997. Shaping up: The responses of yeast to osmotic stress. Yeast stress responses. S. Hohmann and W. Mager. U.S.A., Chapman & Hall:101-146.
53. Hohmann, S. 2003. The osmotic stress response of Saccharomyces cerevisiae. Yeast stress responses. S. Hohmann and W. Mager. Germany, Springer: 121-200.
54. Holst, B., Lunde, C., Lages, F., Oliveira, R., Lucas, C., & M.C. Kielland-Brandt. 2000 GUP1 and its close homologue GUP2, encoding multimembrane-spanning proteins involved in active glycerol uptake in Saccharomyces cerevisiae. Mol Microbiol. 37(1):108-24.
55. Hon, T., Hach, A., Lee, H.C., Cheng, T., & L. Zhang. 2000. Functional analysis of heme regulatory elements of the transcriptional activator Hap1. Biochem Biophys Res Commun. 273(2):584-91.
56. Iida, H. & I. Yahara. 1984. A heat shock-resistant mutant of Saccharomyces cerevisiae shows constitutive synthesis of two heat shock proteins and altered growth. J. Cell. Biol. 99:1441-1450.
57. Inoue, Y., Matsuda, T., Sugiyama, K., Izawa, S., & A. Kimura. 1999. Genetic analysis of glutathione peroxidase in oxidative stress response of Saccharomyces cerevisiae. J Biol Chem. 274(38):27002-9.
58. Inouye, S., K.K., Izu, H., Fujimoto, M., Sugahara, K., Yamada, S., Shinkai, Y., Oka, Y., Katoh, Y., & A. Nakai. 2003. Activation of heat shock genes is not necessary for protection by heat shock transcription factor 1 against cell death due to a single exposure to high temperatures. Mol. Cel. Biol. 23(16):5882-95.
59. Jacobsen, B. & H.R. Pelham. 1988. Constitutive binding of yeast heat shock factor to DNA in vivo. Mol. Cell. Biol. 8:5040-5042.
60. Jamieson, D., Rivers, S.L. & D.W.S. Stephen. 1994. Analysis of Saccharomyces cerevisiae proteins induced by peroxide and super-oxide stress. Microbiology. 140:3277-3283.
61. Juhnke, J., Krems, B., Kotter, P. & K.D. Entian. 1996. Mutants that show increased sensitivity to hydrogen peroxide reveal an important role for the pentose phosphate pathway in protection of yeast against oxidative stress. Mol. Gen. Genet 252:456-464.
62. Jungmann, J., Reins, H.A., Lee, J., Romeo, A.R., Kosman, D. & S. Jentsch. 1993. MAC1, a nuclear regulatory protein related to Cu-dependent transcription factors and is involved in Cu/Fe utilization and stress resistance in yeast. EMBO J. 12:5051-5056.
63. Kim, S., Huh, W.k., Kim, J.Y., Huang, S.W. & S.O. Kang. 1996. D-arabinose dehydrogenase and biosynthesis of erythroascorbic acid in Candida albicans. Biochim. Biophys. Acta 1297:1-8.
64. Kingston, R.E., Schuetz, T., & Z. Larin. 1987. Heat-inducible human factor that binds to a human hsp70 promoter. Mol Cell Biol. 7(4):1530-4.
65. Kobayashi, N. & K. McEntee. 1990. Evidence for heat shock transcription factor-independent mechanism for heat shock induction of transcription in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 87:6550-6554.
66. Kobayashi, N. & K. McEntee. 1993. Identification of cis and trans components of a novel heat shock stress regulatory pathway in Saccharomyces cerevisiae. Mol. Cell. Biol. 13:248-256.
67. Kraakman, L., Lemarie, K., Ma, P., Teunissen, A.W.R.H., Donaton, M.C.V., VanDijck, P., Winderickx, J., de Winde, J.H., & J.M. Thevelein, 1999. A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose. Mol. Microbiol 32:1002-1012.
68. Kurtz, S., Rossi, J., Petko, L., & S. Lindquist. 1986. An ancient developmental induction: heat shock proteins induced in sporulation and oogenesis. Science 231:1154-1157.
69. Larcher, W. 1995. Physiological Plant Ecology. Berlin, Springer-Verlag.
70. Larsson, K., Ansell, R., Eriksson, P., & L. Adler. 1993. A gene encoding sn-glycerol 3-phosphate dehydrogenase (NAD+) complements an osmosensitive mutant of Saccharomyces cerevisiae. Mol Microbiol 10(5):1101-11.
71. Li, S., Ault, A., Malone, C.L., Raitt, D., Dean, S., Johnston, L.H., Deschenes, R.J., & J.S. Fassler. 1998. The yeast histidine protein kinase, SIn1p, mediates phosphotransfer to two response regulators, Ssk1p and Skn7p. EMBO J. 17(23):6952-62.
72. Li, S., Dean, S., Li, Z., Horecka, J., Deschenes, R.J., & J.S. Fassler. 2002. The eukaryotic two-component histidine kinase Sln1p regulates OCH1 via the transcription factor, Skn7p. Mol Biol Cell. 13(2):412-24.
73. Lindquist, S. 1992. Heat shock proteins and stress tolerance in microorganisms. Curr. Opin. Genet. Dev. 2:748-755.
74. Liu, X.D. & D.J. Thielle. 1996. Oxidative stress induced heat shock factor phosphorilation and HSF-dependent activation of yeast metallothioprotein gene transcription. Genes Dev. 10:592-603.
75. Luikenhuis, S., Perrone, G., Dawes, I.W. & C.M. Grant. 1998. The yeast Saccharomyces cerevisiae contains two glutaredoxin genes that are required for protection against reactive oxygen species. Mol. Biol. Cell 9:1081-1091.
76. Luyten, K., Albertyn, J., Skibbe, W.F., Prior, B.A., Ramos, J., Thevelein, J.M., & S. Hohmann. 1995. Fps1, a yeast member of the MIP family of channel proteins, is a facilitator for glycerol uptake and efflux and is inactive under osmotic stress. EMBO J. 14(7):1360-71.
77. Ma, P., Wera, S., Van Dick, P. & J.M. Thevelein. 1999. The PDE1 encoded low-affinity phosphodiesterase in the yeast Saccharomyces cerevisiae has a specific function in controlling agonist-induced cAMP signalling. Mol. Biol. Cell. 10:91-104.
78. Maeda, T., Wurgler-Murphy, S.M., & H. Saito. 1994. A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Nature 369(6477):242-5.
79. Maeda, T., Takekawa, M., & H. Saito. 1995. Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor. Science 269(5223):554-8.
80. Mager W.H., & A.J. De Kruijff. 1995. Stress-induced transcriptional activation. Microbiol Rev 59(3):506-31.
81. Marchler, G., Schuller, C., Adam, G., & H. Ruis. 1993. A Saccharomyces cerevisiae UAS element controlled by protein kinase A activates transcription in response to a variety of stress conditions. EMBO J 12(5):1997-2003.
82. Martinez-Pastor, M.T., Marchler, G., Schuller, C., Marchler-Bauer, A., Ruis, H. & F. Estruch. 1996. The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE). EMBO J. 15:2227-2235.
83. Márquez, J. A., Pascual-Ahuir, A., Proft, M., & R. Serrano. 1998. The Ssn6-Tup1 repressor complex of Saccharomyces cerevisiae is involved in the osmotic induction of HOG-dependent and -independent genes. EMBO J. 17(9):2543-2553.
84. Moskvina, E. Schuller, C., Maurer, C.T., Mager, W.H. & H. Ruis. 1998. A search in the genome of Saccharomyces cerevisiae for genes regulated via stress response elements. Yeast 14:1041-1050.
85. Moye-Rowley W.S. 2002. Transcription factors regulating the response to oxidative stress in yeast. Antioxid Redox Signal. 4(1):123-40.
86. Muller, E. 1991. Thioredoxin deficiency in yeast prolongs S phase and shortens the G1 interval of the cell cycle. J. Biol. Chem. 266:9194-9202.
87. Murguia, J.R., Belles, J.M., & R. Serrano. 1996. The yeast HAL2 nucleotidase is an in vivo target of salt toxicity. J Biol Chem. 271(46):29029-33.
88. Pahlman, A., Granath, K., Ansell, R., Hohmann, S., & L. Adler. 2001. The yeast glycerol 3-phosphatases Gpp1p and Gpp2p are required for glycerol biosynthesis and differentially involved in the cellular responses to osmotic, anaerobic, and oxidative stress. J Biol Chem. 276(5):3555-63.
89. Park, S.K., Cha, M.K., Jeong, W., & I.H. Kim. 2000. Distinct physiological functions of thiol peroxidase isoenzymes in Saccharomyces cerevisiae J. Biol. Chem. 275(8):5723-5732.
90. Pascual-Ahuir, A., Posas, F., Serrano, R., & M. Proft. 2001a. Multiple levels of control regulate the yeast cAMP-response element-binding protein repressor Sko1p in response to stress. J Biol Chem. 276(40):37373-8.
91. Pascual-Ahuir, A., Serrano, R., & M. Proft. 2001b. The Sko1p repressor and Gcn4p activator antagonistically modulate stress-regulated transcription in Saccharomyces cerevisiae. Mol Cell Biol. 21(1):16-25.
92. Pawson, T., & J.D. Scott. 1997. Signaling through scaffold, anchoring, and adaptor proteins. Science. 278(5346):2075-80.
93. Peteranderl, R. & H.C. Nelsson. 1992. Trimerization of the heat shock transcription factor by a triple-stranded alpha-helical coiled-coil. Biochemistry 31(48):12272-6.
94. Piper, P. 1997. The Heat Shock response. Heidelberg, Springer-Verlag.
95. Portela, P., Howell, S., Moreno, S., & S. Rossi. 2002. In vivo and in vitro Phosphorylation of Two Isoforms of Yeast Pyruvate Kinase by Protein Kinase A. Journal of Biological Chemistry 277(34):30477-30487.
96. Posas, F., Camps, M., & J. Arino. 1995. The PPZ protein phosphatases are important determinants of salt tolerance in yeast cells. J. Biol Chem. 270(22):13036-41.
97. Prior, C., Potier, S., Souciet, J.L., & H. Sychrova. 1996. Characterization of the NHA1 gene encoding a Na+/H+-antiporter of the yeast Saccharomyces cerevisiae. FEBS Lett. 387(1):89-93.
98. Proft, M., & R. Serrano. 1999. Repressors and upstream repressing sequences of the stress-regulated ENA1 gene in Saccharomyces cerevisiae: bZIP protein Sko1p confers HOG-dependent osmotic regulation. Mol Cell Biol. 19(1):537-46.
99. Proft, M., Pascual-Ahuir, A., de Nadal, E., Arino, J., Serrano, R., & F. Posas. 2001. Regulation of the Sko1 transcriptional repressor by the Hog1 MAP kinase in response to osmotic stress. EMBO J. 20(5):1123-33.
100. Proft, M. & Struhl, K. 2002. Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SW1/SNF in response to osmotic stress. Mol Cell. 9(6):1307-17.
101. Raitt, D., Posas, F., & H. Saito. 2000. Yeast Cdc42 GTPase and Ste20 PAK-like kinase regulate Sho1-dependent activation of the Hog1 MAPK pathway. EMBO J. 19(17):4623-31.
102. Reinders, A., Bürckert, N., Boiler, T., Wiemken, A., & C. De Virgilio. 1998. Saccharomyces cerevisiae cAMP-dependent protein kinase controls entry into stationary phase through the Rim15p protein kinase. Genes Dev. 12:2943-2955.
103. Reiser, V., Salah, S.M., Ammerer, G. 2000. Polarized localization of yeast Pbs2 depends on osmostress, the membrane protein Sho1 and Cdc42. Nat Cell Biol. 2(9):620-7.
104. Rep, M., Reiser, V., Gartner, U., Thevelein, J.M., Hohmann, S., Ammerer, G. & H. Ruis. 1999. Osmotic Stress-Induced Gene Expression in Saccharomyces cerevisiae Requires Msn1p and the Novel Nuclear Factor Hot1p. Mol Cell Biol 19(8):5474-5485.
105. Rep, M., Krantz, M., Thevelein, J.M., & S. Hohmann. 2000. The transcriptional response of Saccharomyces cerevisiae to osmotic shock. Hot1p and Msn2p/Msn4p are required for the induction of subsets of high osmolarity glycerol pathway-dependent genes. J Biol Chem 275(12):8290-300.
106. Rohde, J., Heitman, J., & M.E. Cardenas. 2001. The TOR kinases link nutrient sensing to cell growth. J Biol Chem 276(13):9583-6.
107. Ruis, H. & B. Hamilton. 1992. Regulation of yeast catalase genes. In Molecular Biology of Free Radical Scavenging Systems, CSH Press: 153-172.
108. Ruis, H. & C. Schüller. 1995. Stress signaling in yeast. Bioessays 17:959-966.
109. Sánchez, Y. & S. Lindquist. 1990. HSP104 is required for induced thermotolerance. Science 248:1112-1115
110. Santoro, N., Johansson, N. and & D.J. Thiele. 1998. Heat shock element architecture is an important determinant in the temperature and transactivation domain requirements for heat shock transcription factor. Mol. Cell. Biol. 18:6340-6352.
111. Schnell, N., Krems, B. & K.D. Entian. 1992. The PAR1 (YAP1/SNQ3) gene of Saccharomyces cerevisiae, a c-Jun homologue, is involved in oxygen metabolism. Curr. Genet. 21:269-273.
112. Serrano, R. 1996 Salt tolerance in plants and microorganisms: toxicity targets and defense responses. Int. Rev. of Cyt. 165:1-52.
113. Shi, Y., Mosser, D.D. & R.I. Morimoto. 1998. Molecular chaperones as HSF1-specific transcriptional repressors. Genes Dev. 12(5):654-66.
114. Singer M.A. & S. Lindquist. 1998. Thermotolerance in Saccharomyces cerevisiae: the Yin and Yang of trehalose. Trends Biotechnol. 16(11):460-8.
115. Slekar, K., Kosman, D.J. & V.C. Culotta. 1996. The yeast copper/zinc Superoxide dismutase and the pentose phosphate pathway play overlapping roles in oxidative stress protection. J. Biol. Chem. 271:28831-28836.
116. Smith, B.J. &. M.P. Yafee. 1991. Uncoupling thermotolerance from the induction of heat shock proteins. Proc Natl Acad Sci U S A 88(24):11091-4.
117. Smith, R., & A.D. Johnson. 2000. Turning genes off by Ssn6-Tup1: a conserved system of transcriptional repression in eukaryotes. Trends Biochem Sci 25(7):325-30.
118. Sorger P., K. & H.C. Nelson. 1989. Trimerization of a yeast transcriptional activator via a coiled-coil motif. Cell 59(5):807-13.
119. Sorger, P.K. 1990. Yeast heat shock factor contains separable transient and sustained response transcriptional activators. Cell 62(4):793-805.
120. Sorger, P.K. 1991. Heat shock factor and heat shock response. Cell 65:363-366
121. Storz, G., Christman, M.F., Sies, H. & B.N. Ames. 1987. Spontaneous mutagenesis and oxidative damage to DNA in Salmonella typhimurium. Proc. Natl Acad. Sci 84:8917-8921.
122. Sutherland, F., Lages, F., Lucas, C., Luyten, K., Albertyn, J., Hohmann, S., Prior, B.A., & S.O. Kilian. 1997. Characteristics of Fps1-dependent and -independent glycerol transport in Saccharomyces cerevisiae. J Bacteriol. 179(24):7790-5.
123. Tamas, M., Rep, M., Thevelein, J.M., & S. Hohmann. 2000. Stimulation of the yeast high osmolarity glycerol (HOG) pathway: evidence for a signal generated by a change in turgor rather than by water stress. FEBS Lett. 472(1):159-65.
124. Tanaka, K., Matsumoto K. & A. Toh-e. 1989. Ira1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae. Mol. Cel. Biol. 9:757-768.
125. Tao, W., Deschenes, R.J., & J.S. Fassler. 1999. Intracellular glycerol levels modulate the activity of Sln1p, a Saccharomyces cerevisiae two-component regulator. J Biol Chem. 274(1):360-367.
126. Tatchell, K. 1993. RAS genes in the budding yeast Saccharomyces cerevisiae. San Diego, Academic Press.
127. Thevelein, J.M. 1994. Signal transduction in yeast. Yeast 10:109-130.
128. Thevelein, J.M., & de J.H. Winde. 1999. Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae. Molecular Microbiology 33(5):904-918.
129. Thevelein, J.M., Cauwenberg, L., Colombo, S., De Winde, J.H., Donation, M., Dumortier, F., Kraakman, L., Lemaire, K., Ma, P., Nauwelaers, D., Rolland, F., Teunissen, A., Van Dijck, P., Versele, M., Wera, S. & J. Winderickx. 2000. Nutrient-induced signal transduction through the protein kinase A pathway and its role in the control of metabolism, stress resistance and growth in yeast. Enzyme and Microbial Technology 26:819-825.
130. Toda, T., Cameron, S., Sass, P., Zoller, M., Scott, J.D., McBullen, B., Hurwitz, M., Krebs, E.G. & M. Wigler. 1987a. Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae. Mol. Cell Biol. 7:1371-1377.
131. Toda, T., Cameron, S., Sass, P., Zoller, M. & P. Wigler. 1987b. Three different genes in Saccharomyces cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell 50:277-287.
132. Tortora J.G., F., R.B., & L.C. Case. 1986. Microbiology. Menlo Prak, CA, USA, Benjamin/Cummings Publishing Company Inc.
133. Treger, J.M., Schmitt, A.P., Simon, J.R. & K. McEntee. 1998a. Transcriptional factor mutations reveal regulatory complexities of heat shock and newly identified stress genes in Saccharomyces cerevisiae. J. Biol. Chem. 273:26875-26879.
134. Treger, J.M., Magee, T.R., & K. McEntee. 1998b. Functional analysis of the stress response element and its role on the multistress response of Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 243:13-19.
135. Vilela, C., Linz, B., Rodrigues-Pousada, C., & J.E. McCarthy. 1998 The yeast transcription factor genes YAP1 and YAP2 are subject to differential control at the levels of both translation and mRNA stability. Nucleic Acids Res. 26(5):1150-9.
136. Vuister, G., Kim, S.J., Orosz, A., Marquardt, J., Wu, C., & A. Bax. 1994. Solution structure of the DNA-binding domain of Drosophila heat shock transcription factor. Nat Struct Biol. 1(9):605-14.
137. Wadskog, I., & L. Adler. 2003. Ion homeostasis in Saccharomyces cerevisiae under NaCl stress. En Yeast Stress Responses. Ed. Hohmann, S. and Mager W.H. 201-440 pp.
138. Weiser, R., Adam, G., Wagner, A., Schuller, C., Marchler, G., Ruis, H., Krewiec, Z. & T. Bilinski. 1991. Heat shock factor-independent heat control of transcription of the CTT1 gene encoding the cytoso-Hc catalase T of Saccharomyces cerevisiae. J. Biol Chem 266:12406-12411.
139. Werner-Washburne, M.B., J., Kosic-Smithers, J. & E.A. Craig. 1989. Yeast HSP70 RNA levels vary in response to the physiological status of the cell. Journal of Bacteriology 171:2680-2688.
140. Werner-Washburne, M., B.E., Johnston G.C., & R.A., Singer. 1993. Stationary phase in the yeast Saccharomyces cerevisiae. Microbiological Reviews 57:383-401.
141. Westwood, J.T., Clos, J. & C. Wu. 1991. Stress-induced oligomerization of heat shock factor. Nature 353:822-827.
142. + pump in the yeast plasma membrane. EMBO J. 14:3870-3882.
143. Wiederrecht G., S.D., & C.S. Parker. 1988. Isolation of the gene encoding the S. cerevisiae heat shock transcription factor. Cell 54(6):841-53.
144. Wu, A. & W.S. Moye-Rowley. 1994. GSH1, which encodes γ-glutamylcysteine synthetase, is a target gene for yAP-1 transcriptional regulation. Mol. Cell Biol. 14:5832-5839.
145. Wu, C. 1995. Heat shock transcription factors: structure and regulation. Annu Rev Cell Dev Biol. 11:441-69.
146. Yancey, P., Clark, M.E., Hand, S.C., Bowlus, R.D., & G.N. Somero. 1982. Living with water stress: evolution of osmolyte systems. Science. 217(4566):1214-22.
147. Zhao, X., Raitt, D., Burke, P.V., Clewell, A.S., Kwast, K.E. & R.O. Poyton. 1996. Function and expression of flavohemoglobin in Saccharomyces cerevisiae. J. Biol. Chem 271:25131-25138.