Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress

Molecular Cell

Volumn 9, Issue 6, 2002, Pages 1307-1317

  Proft, Markus ^a   Struhl, Kevin ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE ACETYLTRANSFERASE; PHOSPHOTRANSFERASE;

ARTICLE; CONTROLLED STUDY; GENE CONTROL; GENE REPRESSION; NONHUMAN; NUCLEOSOME; OSMOTIC STRESS; PROMOTER REGION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION; YEAST;

EID: 0036289351     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(02)00557-9     Document Type: Article

References (53)

1. Stress-induced MAP kinase Hog1 is part of transcription activation complexes
2. Three subunits of the RNA polymerase II mediator complex are involved in glucose repression
3. Elimination of false positives that arise in using the two-hybrid system
4. SAGA is an essential in vivo target of the yeast acidic activator Gal4p
5. Recruitment of the yeast Tup1p-Ssn6p repressor is associated with localized decreases in histone acetylation
6. Recruitment of HAT complexes by direct activator interactions with the ATM-related Tra1 subunit
7. The Tup1-Cyc8 protein complex can shift from a transcriptional co-repressor to a transcriptional co-activator
8. Ordered recruitment of transcription and chromatin remodeling factors to a cell cycle- and developmentally regulated promoter
9. Regulated nuclear translocation of the Mig1 glucose repressor
10. Histone acetylation at promoters is differentially affected by activators and repressors
11. Targeted recruitment of Rpd3 histone deacetylase represses transcription by inhibiting recruitment of Swi/Snf, SAGA, and TBP
12. Exploring the metabolic and genetic control of gene expression on a genomic scale
13. Repression domain of the yeast global repressor TUP1 interacts directly with histones H3 and H4
14. Regulated nucleo-cytoplasmic exchange of HOG1 MAPK requires the importin β homologs NMD5 and XPO1
15. Aca1 and Aca2, ATF/CREB activators in Saccharomyces cerevisiae, are important for carbon-source utilization but not the response to stress
16. A novel and conserved salt-induced protein is an important determinant of salt tolerance in yeast
17. Srb7p is a physical and physiological target of Tup1p
18. A new efficient gene disruption cassette for repeated use in budding yeast
19. MAP kinase pathways in the yeast Saccharomyces cerevisiae
20. Med9/Cse2 and Gal11 modules are required for transcriptional repression of distinct group of genes
21. The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor
22. Absolute mRNA levels and transcriptional initiation rates in Saccharomyces cerevisiae
23. Degradation signal masking by heterodimerization of MATa2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway
24. Ssn6-Tup1 is a general repressor of transcription in yeast
25. The WD repeats of Tup1 interact with the homeo domain protein a2
26. Functional relationships of Srb10-Srb11 kinase, carboxy-terminal domain kinase CTDK-1, and transcriptional corepressor Ssn6-Tup1
27. Cyclin-dependent protein kinase and cyclin homologs SSN3 and SSN8 contribute to transcriptional control in yeast
28. Gcn4 activator targets Gcn5 histone acetyltransferase to specific promoters independently of transcription
29. Binding of TBP to promoters in vivo is stimulated by activators and requires Pol II holoenzyme
30. The S. cerevisiae SAGA complex functions in vivo as a coactivator for transcriptional activation by Gal4
31. Transcriptional activation by Gcn4 involves independent interactions with the Swi/Snf complex and the Srb/mediator
32. Activation domain-mediated targeting of the SWI/SNF complex to promoters stimulates transcription from nucleosome arrays
33. Yeast SKO1 gene encodes a bZIP protein that binds to the CRE motif and acts as a repressor of transcription
34. Hrs1/Med3: A Cyc8-Tup1 corepressor target in the RNA polymerase II holoenzyme
35. Permanently bound corepressor complex facilitates SAGA-mediated transcriptional activation
36. Multiple levels of control regulate the yeast cAMP-response-element-binding protein repressor Sko1p in response to stress
37. Sko1p-repressor and Gcn4p-activator antagonistically modulate stress-regulated transcription in Saccharomyces cerevisiae
38. Repressors and upstream repressing sequences of the stress-regulation ENA1 gene in Saccharomyces cerevisiae: BZIP protein Sko1p confers HOG-dependent osmotic regulation
39. Regulation of the Sko1 transcriptional repressor by the Hog MAP kinase in response to osmotic stress
40. Kinase activity-dependent nuclear export opposes stress-induced nuclear accumulation and retention of Hog1 mitogen-activated protein kinase in the budding yeast Saccharomyces cerevisiae
41. Osmotic stress-induced gene expression in Saccharomyces cerevisiae requires Msn1p and the novel nuclear factor Hot1p
42. The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway-dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage
43. Use of polymerase chain reaction epitope tagging for protein tagging in Saccharomyces cerevisiae
44. Turning genes off by Ssn6-Tup1: A conserved system of transcriptional repression in eukaryotes
45. SSN genes that affect transcriptional repression in Saccharomyces cerevisiae encode SIN4, ROX3 and SRB proteins associated with RNA polymerase II
46. Functional dissection of the yeast Cyc8-Tup1 transcriptional corepressor complex
47. Distinct TPR motifs of Cyc8 are involved in recruiting the Cyc8-Tup1 co-repressor complex to differentially regulated promoters
48. ACR1, a yeast ATF/CREB repressor
49. Identification of genes required for a2 repression in Saccharomyces cerevisiae
50. Ssn6-Tup1 interacts with class I histone deacetylases required for repression
51. TUP1 utilizes histone H3/H2B-specific HDA1 deacetylase to repress gene activity in yeast
52. Recruitment of the SWI/SNF chromatin remodeling complex by transcriptional activators
53. Interaction of a transcriptional repressor with the RNA polymerase II holoenzyme plays a crucial role in repression