Metabolism of antiarrhythmics

Current Drug Metabolism

Volumn 5, Issue 6, 2004, Pages 543-571

  Ha, Huy Riem ^a   Follath, Ferenc ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

Amiodarone; Antiarrhythmic; Carvedilol; Drug metabolism; Lidocaine; Metoprolol; Procainamide; Propafenone; Quinidine; Verapamil

Indexed keywords

AMIODARONE; AMITRIPTYLINE; ANTIARRHYTHMIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CARVEDILOL; CHLORTALIDONE; CIMETIDINE; DEETHYLAMIODARONE; DIGOXIN; DRUG METABOLIZING ENZYME; FLUOXETINE; HYDRALAZINE; HYDROCHLOROTHIAZIDE; HYDROXYCHLOROQUINE; LIDOCAINE; METOPROLOL; METOPROLOL TARTRATE; NICARDIPINE; NIFEDIPINE; PHENPROCOUMON; PHENYTOIN; PROCAINAMIDE; PROPAFENONE; PROPRANOLOL; QUINIDINE; RIFAMPICIN; TORASEMIDE; UNINDEXED DRUG; VERAPAMIL; WARFARIN;

ANTIARRHYTHMIC ACTIVITY; AREA UNDER THE CURVE; BRADYCARDIA; CARDIOTOXICITY; CONGESTIVE HEART FAILURE; CYTOTOXICITY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG GLUCURONIDATION; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG STRUCTURE; DRUG TISSUE LEVEL; DRUG TRANSFORMATION; ENZYME INHIBITION; GASTROINTESTINAL SYMPTOM; HEART ARRHYTHMIA; HEART BLOCK; HUMAN; HYPOTENSION; LIVER METABOLISM; LUNG TOXICITY; NEUROTOXICITY; NONHUMAN; REVIEW; SPECIES DIFFERENCE; STEREOCHEMISTRY;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; CYTOCHROME P-450 ENZYME SYSTEM; DRUG INTERACTIONS; HUMANS; MICROSOMES, LIVER;

EID: 8844286030     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389200043335351     Document Type: Review

References (308)

1. Northrop, D.A. (1998) J. Chem. Ed. 75(9), 1153-1157.
2. Van Schepdael, J. and Solvay, H. (1970) Presse Med. 78(42), 1849-1850.
3. Rosenbaum, M.B., Chiale, P. A., Halpern, M. S., Nau, G. J., Przybylski, J., Levi, R. J., Lazzari, J. O., and Elizari, M. V. (1976) Am. J. Cardiol. 38(7), 934-944.
4. Young, R.A. and Mehendale, H. M. (1986) Drug Metab. Dispos. 14(4), 423-429.
5. Young, R.A. and Mehendale, H. M. (1987) Drug Metab. Dispos. 15(4), 511-517.
6. Al-Dabbagh, S.G., Idle, J. R., and Smith, R. L. (1981) J. Pharm. Pharmacol. 33, 161-164.
7. Yamamoto Y., Tasaki, T., Nakamura, A., Iwata, H., Kazusaka, A., Gonzalez, F. J., and Fujita, S. (1998) Pharmacokinetics 8 1), 73-82.
8. Trivier, J.M., Pommery, J., Libersa, C., Caron, J., and Lhermitte, M. (1992) J. Chromatogr. 579(2), 269-276.
9. Ha, H.R., Bigler, L., Binder, M., Kozlik, P., Stieger, B., Hesse, M., Altorfer, H. R., and Follath, F. (2001) Drug Metab. Dispos. 29(2), 152-158.
10. Wendt, B., Ha, H. R., and Hesse, M. (2002) Helv. Chim. Acta 85(9), 2990-3001.
11. Ha, H.R., Kozlik, P., Stieger, B., Bigler, L., and Follath, F. (2001) J. Chromatogr. B Biomed Sci. Appl. 757(2), 309-315.
12. Kozlik, P., Ha, H. R., Stieger, B., Bigler, L., and Follath , F. (2001) Xenobiolica 31 (5), 239-248.
13. Trivier, J.M., Libersa, C., Belloc, C., and Lhermitte, M. (1993) Life Sci. 52(10), L91-L96.
14. Ha, H.R., Candinas, R., Stieger, B., Meyer, U. A., and Follath, F. (1996) J. Cardiovasc. Pharmacol. 28(4), 533-539.
15. Ohyama, K., Nakajima, M., Nakamura, S., Shimada, N., Yamazaki, H., and Yokoi, T. (2000) Drug Metab. Dispos. 28 11), 1303-1310.
16. Fabre, G., Julian, B., Saint-Aubert, B., Joyeux, H., and Berger, Y. (1993) Drug Metab. Dispos. 21(6), 978-985.
17. Ha, H. R., Wyss, P. A., Stieger, B., Meyer, U. A., and Follath, F. (1992) FASEB J. 6, A1845.
18. Adams, P.C., Holt, D. W., Storey, G. C., Morley, A. R., Callaghan, J., and Campbell, R. W. (1985) Circulation 72(5 , 1064-1075.
19. Kozlik, P. (2003) Ph.D.Thesis Nr.15287, ETH Zurich, Switzerland.
20. Broekhuysen, J., Laruel, R., and Sion, R. (1969) Arch. Int. Pharmacodyn. Ther. 177(2), 340-359.
21. Flanagan, R.J., Storey, G. C., Holt, D. W., and Farmer, P. B. (1982) J. Pharm. Pharmacol. 34(10), 638-643.
22. Bandyopadhyay, S. and Somani, P. (1987) J. Cardiovasc. Pharmacol. 10(4), 379-388.
23. Kannan, R., Miller, S., and Singh, B. N. (1985) Drug Metab. Dispos. 13(6), 646-650.
24. Kannan, R., Sarma, J. S., Guha, M., and Venkataraman, K. (1989) Fundam. Appl. Toxicol. 13(4), 793-803.
25. Latini, R., Reginato, R., Burlingame, A. L., and Kates, R. E. (1984) Biomed. Mass Spectrom. 11(9), 466-471.
26. Plomp, T.A., Wiersinga, W. M., and Maes, R. A. (1985) Arzneimittelforschung 35(1), 122-129.
27. Plomp, T.A., Wiersinga, W. M., and Maes, R. A. (1985) Arzneimittelforschung 35(12), 1805-1810.
28. Storey, G.C., Adams, P. C., Campbell, R. W., and Holt, D. W. (1983) J. Clin. Pathol. 36(7), 785-789.
29. Harris, L. and Roncucci, R. (1986) in Amiodarone, Pharmacology-Pharmacokinetics-Toxicology-Clinical effects. Paris, pp. 46-91.
30. Staubli, M., Troendle, A., Schmid, B., Balmer, P., Kohler, B., Studer, H., and Bircher, J. (1985) Eur. J. Clin. Pharmacol. 29(4), 417-423.
31. Ha, H.R., Stieger, B., Grassi, G., Altorfer, H. R., and Follath, F. (2000) Eur. J. Clin. Pharmacol. 55(11-12), 807-814.
32. Nattel, S., Davies, M., and Quantz, M. (1988) Circulation 77(1), 200-208.
33. Talajic, M., DeRoode, M. R., and Nattel, S. (1987) Circulation 75(1), 265-271.
34. Charlier, R., Deltour, G., Baudine, A., and Chaillet, F. (1968) Arzneimittelforschung 18(11), 1408-1417.
35. Marcus, F.I. (1984) Ann. N. Y. Acad. Sci. 427, 112-126.
36. Singh, B.N. (1983) Am. Heart J. 106(4 Pt 2), 788-797.
37. Ikeda, N., Nademanee, K., Kannan, R., and Singh, B. N. (1984) Am. Heart J. 108(4 Pt 1), 890-898.
38. Candinas, R., Frielingsdorf, J., Ha, H. R., Carrel, T., Turina, M., and Follath, F. (1998) Eur. J. Clin. Pharmacol. 53 5), 331-336.
39. Nattel, S. (1986) J. Cardiovasc. Pharmacol. 8(4), 771-777.
40. Staubli, M., Bircher, J., Galeazzi, R. L., Remund, H., and Studer, H. (1983) Eur. J. Clin. Pharmacol. 24(4), 485-494.
41. Haffajee, C.I., Love, J. C., Canada, A. T., Lesko, L. J., Asdourian, G., and Alpert, J. S. (1983) Circulation 67(6), 1347-1355.
42. Mostow, N.D., Rakita, L., Vrobel, T. R., Noon, D. L., and Blumer, J. (1984) Am. J. Cardiol. 54(6), 569-574.
43. Beddows, S.A., Page, S. R., Taylor, A. H., McNerney, R., Whitley, G. S., Johnstone, A. P., and Nussey, S. S. (1989) Biochem. Pharmacol. 38(24), 4397-4403.
44. Gross, S.A., Bandyopadhyay, S., Klaunig, J. E., and Somani, P. (1989) Proc. Soc. Exp. Biol. Med. 190(2), 163-169.
45. Bolt, M.W., Racz, W. J., Brien, J. F., and Massey, T. E. (2001) Toxicology 166(3), 109-118.
46. Wilson, B.D. and Lippmann, M. L. (1990) Am. Rev. Respir. Dis. 141(6), 1553-1558.
47. Wilson, B.D., Clarkson, C. E., and Lippmann, M. L. (1991) Am. Rev. Respir. Dis. 143(5 Pt 1), 1110-1114.
48. Daniels, J.M., Brien, J. F., and Massey, T. E. (1989) Toxicol. Appl. Pharmacol. 100(2), 350-359.
49. Larrey, D., Tinel, M., Letteron, P., Geneve, J., Descatoire, V., and Pessayre, D. (1986) Biochem. Pharmacol. 35(13), 2213-2220.
50. Grech-Belanger, O. (1984) Res. Commun. Chem. Pathol. Pharmacol. 44(1), 15-30.
51. Ohyama, K., Nakajima, M., Suzuki, M., Shimada, N., Yamazaki, H., and Yokoi, T. (2000) Br. J. Clin. Pharmacol. 49(3), 244-253.
52. Nolan, P.-E.J., Marcus, F. I., Hoyer, G. L., Bliss, M., and Gear, K. (1989) Clin. Pharmacol. Ther. 46(1), 43-50.
53. Nolan, P.-E.J., Marcus, F. I., Karol, M. D., Hoyer, G. L., and Gear, K. (1990) J. Clin. Pharmacol. 30(12), 1112-1119.
54. Heimark, L.D., Wienkers, L., Kunze, K., Gibaldi, M., Eddy, A. C., Trager, W. F., O'Reilly, R. A., and Goulart, D. A. (1992) Clin. Pharmacol. Ther. 51(4), 398-407.
55. Fenster, P.E., White, N.-W. J., and Hanson, C. D. (1985) J. Am. Coll. Cardiol. 5(1), 108-112.
56. Nichols, A.J., Gellai, M., and Ruffolo, R.-R. J. (1991) Fundam. Clin. Pharmacol. 5(1), 25-38.
57. Yue, T.L., Cheng, H. Y., Lysko, P. G., McKenna, P. J., Feuerstein, R., Gu, J. L., Lysko, K. A., Davis, L. L., and Feuerstein, G. (1992) J. Pharmacol. Exp. Ther. 263(1), 92-98.
58. Ruffolo, R.-R.J., Gellai, M., Hieble, J. P., Willette, R. N., and Nichols, A. J. (1990) Eur. J. Clin. Pharmacol. 38(2), S82-S88.
59. Cleland, J.G. and Swedberg, K. (1996) Lancet 347 9010), 1199-1201.
60. Fujimaki, M. (1994) Drug Metab. Dispos. 22(5), 700-708.
61. Schaefer, W.H. (1992) Drug Metab. Dispos. 20(1), 130-133.
62. Oldham, H.G. and Clarke, S. E. (1997) Drug Metab. Dispos. 25(8), 970-977.
63. Fisher, C.W., Caudle, D. L., Martin-Wixtrom, C., Quattrochi, L. C., Tukey, R. H., Waterman, M. R., and Estabrook, R. W. (1992) FASEB J. 6(2), 759-764.
64. Guengerich, F.P., Martin, M. V., Beaune, P. H., Kremers, P., Wolff, T., and Waxman, D. J. (1986) J. Biol. Chem. 261(11), 5051-5060.
65. Goldstein, J.A., Faletto, M. B., Romkes-Sparks, M., Sullivan, T., Kitareewan, S., Raucy, J. L., Lasker, J. M., and Ghanayem, B. I. (1994) Biochemistry 33(7), 1743-1752.
66. Fujimaki, M. and Hakusui, H. (1990) Xenobiotica 20 10), 1025-1034.
67. Fujimaki, M., Shintani, S., and Hakusui, H. (1991) Drug Metab. Dispos. 19(4), 749-753.
68. Fujimaki, M., Murakoshi, Y., and Hakusui, H. (1990) J. Pharm. Sci. 79(7), 568-572.
69. Fujimaki, M. and Hakusui, H. (1989) Yakubulu Dotai 4 667-671.
70. Schaefer, W.H., Politowski, J., Hwang, B., Dixon, F. J., Goalwin, A., Gutzait, L., Anderson, K., DeBrosse, C., Bean, M., and Rhodes, G. R. (1998) Drug Metab. Dispos. 26(10), 958-969.
71. Neugebauer, G. and Neubert, P. (1991) Eur. J. Drug Metab. Pharmacokinet. 16(4), 257-260.
72. Neugebauer, G., Akpan, W., von Mollendorff, E., Neubert, P., and Reiff, K. (1987) J. Cardiovasc. Pharmacol. 10(11), S85-S88.
73. Neugebauer, G., Akpan, W., Kaufmann, B., and Reiff, K. (1990) Eur. J. Clin. Pharmacol. 38(2), S108-S111.
74. Zhou, H.H. and Wood, A. J. (1995) Clin. Pharmacol. Ther. 57(5), 518-524.
75. Stoschitzky, K., Koshucharova, G., Zweiker, R., Maier, R., Watzinger, N., Fruhwald, F. M., and Klein, W. (2001) Eur. J. Heart Fail. 3(3), 343-349.
76. Nichols, A.J., Sulpizio, A. C., Ashton, D. J., Hieble, J. P., and Ruffolo, R.-R. J. (1989) Chiralily 1(4), 265-270.
77. Bartsch, W., Sponer, G., Strein, K., Muller-Beckmann, B., Kling, L., Bohm, E., Martin, U., and Borbe, H. O. (1990) Eur. J. Clin. Pharmacol. 38(2), S104-S107.
78. Christopher, T.A., Lopez, B. L., Ma, X. L., Feuerstein, G. Z., Ruffolo, R.-R. J., and Yue, T. L. (1998) Br. J. Pharmacol. 123(2), 292-298.
79. Yue, T.L., McKenna, P. J., Lysko, P. G., Gu, J. L., Lysko, K. A., Ruffolo, R.-R. J., and Feuerstein, G. Z. (1994) Eur. J. Pharmacol. 251(2-3), 237-243.
80. Graff, D.W., Williamson, K. M., Pieper, J. A., Carson, S. W., Adams, K.-F. J., Cascio, W. E., and Patterson, J. H. (2001) J. Clin. Pharmacol. 41(1), 97-106.
81. Hokama, N., Hobara, N., Sakai, M., Kameya, H., Ohshiro, S., and Sakanashi, M. (2002) J. Pharm. Pharmacol. 54(6), 821-825.
82. Wermeling, D.P., Field, C. J., Smith, D. A., Chandler, M. H., Clifton, G. D., and Boyle, D. A. (1994) Pharmacotherapy 14 5), 600-606.
83. Oda, Y., Imaoka, S., Nakahira, Y., Asada, A., Fujimori, M., Fujita, S., and Funae, Y. (1989) Biochem. Pharmacol. 38(24 , 4439-4444.
84. Hermansson, J., Glaumann, H., Karlen, B., and von Bahr, C. (1980) Acta Pharmacol. Toxicol. (Copenh) 47(1), 49-52.
85. Suzuki, T., Ishida, R., Matsui, S., Masubuchi, Y., and Narimatzu, S. (1993) Biochem. Pharmacol. 45(7), 1528-1530.
86. Alexson, S.E., Diczfalusy, M., Halldin, M., and Swedmark, S. (2002) Drug Metab. Dispos. 30(6), 643-647.
87. Suzuki, T., Fujita, S., and Kawai, R. (1984) J. Pharm. Sci. 73(1), 136-138.
88. Nakamoto, T., Oda, Y., Imaoka, S., Funae, Y., and Fujimori, M. (1997) Drug Metab. Dispos. 25(3), 296-300.
89. Masubuchi, Y., Umeda, S., Chiba, M., Fujita, S., and Suzuki, T. (1991) Biochem. Pharmacol. 42(3), 693-695.
90. Bargetzi, M.J., Aoyama, T., Gonzalez, F. J., and Meyer, U. A. (1989) Clin. Pharmacol. Ther. 46(5), 521-527.
91. Imaoka, S., Enomoto, K., Oda, Y., Asada, A., Fujimori, M., Shimada, T., Fujita, S., Guengerich, F. P., and Funae, Y. (1990) J. Pharmacol. Exp. Ther. 255(3), 1385-1391.
92. Wang, J.S., Backman, J. T., Taavitsainen, P., Neuvonen, P. J., and Kivisto, K. T. (2000) Drug Metab. Dispos. 28(8), 959-965.
93. Keenaghan, J. B. and Boyes, R. N. (1972) J. Pharmacol. Exp. Ther. 180(2), 454-463.
94. Coutts, R.T., Torok-Both, G. A., Chu, L. V., Tam, Y. K., and Pasutto, F. M. (1987) J. Chromatogr. 421(2), 267-280.
95. Thomas, J. and Meffin, P. (1972) J. Med. Chem. 15 10), 1046-1049.
96. Nelson, S.D., Garland, W. A., Breck, G. D., and Trager, W. F. (1977) J. Pharm. Sci. 66(8), 1180-1190.
97. Smith, E.R. and Duce, B. R. (1971) J. Pharmacol. Exp. Ther. 179(3), 580-585.
98. Blumer, J., Strong, J. M., and Atkinson, A.-J. J. (1973) J. Pharmacol. Exp. Ther. 186(1), 31-36.
99. Brunvand, H., Liu, G., Ma, X. L., Yue, T. L., Ruffolo, R.-R. J., and Feuerstein, G. Z. (1998) Eur. J. Pharmacol. 356(2-3), 193-198.
100. Nation, R.L., Triggs, E. J., and Selig, M. (1977) Br. J. Clin. Pharmacol. 4(4), 439-448.
101. Strong, J.M., Parker, M., and Atkinson, A.-J. J. (1973) Clin. Pharmacol. Ther. 14(1), 67-72.
102. Halkin, H., Meffin, P., Melmon, K. L., and Rowland, M. (1975) Clin. Pharmacol. Ther. 17(6), 669-676.
103. Boyes, R.N., Scott, D. B., Jebson, P. J., Godman, M. J., and Julian, D. G. (1971) Clin. Pharmacol. Ther. 12(1), 105-116.
104. Narang, P.K., Crouthamel, W. G., Carliner, N. H., and Fisher, M. L. (1978) Clin. Pharmacol. Ther. 24(6), 654-662.
105. Drayer, D.E., Lorenzo, B., Werns, S., and Reidenberg, M. M. (1983) Clin. Pharmacol. Ther. 34(1), 14-22.
106. Prescott, L.F., Adjepon-Yamoah, K. K., and Talbot, R. G. (1976) Br. Med. J. 1(6015), 939-941.
107. Bauer, L.A., Brown, T., Gibaldi, M., Hudson, L., Nelson, S., Raisys, V., and Shea, J. P. (1982) Clin. Pharmacol. Ther. 31 4), 433-437.
108. Nattel, S., Talajic, M., Beaudoin, D., Matthews, C., and Roy, D. (1994) Am. J. Cardiol. 73(1), 92-94.
109. Ha, H.R., Candinas, R., Stieger, B., Meyer, U. A., and Follath, F. (1996) J. Cardiovasc. Pharmacol. 28(4), 533-539.
110. Siegmund, J.B., Wilson, J. H., and Imhoff, T. E. (1993) J. Cardiovasc. Pharmacol. 21(4), 513-515.
111. Ochs, H.R., Carstens, G., and Greenblatt, D. J. (1980) N. Engl. J. Med. 303(7), 373-377.
112. Conrad, K.A., Byers, J. M., Finley, P. R., and Burnham, L. (1983) Clin. Pharmacol. Ther. 33(2), 133-138.
113. Bax, N.D., Tucker, G. T., Lennard, M. S., and Woods, H. F. (1985) Br. J. Clin. Pharmacol. 19(5), 597-603.
114. Feely, J., Wilkinson, G. R., McAllister, C. B., and Wood, A. J. (1982) Ann. Intern. Med. 96(5), 592-594.
115. Bauer, L.A., Edwards, W. A., Randolph, F. P., and Blouin, R. A. (1984) Am. Heart J. 108(2), 413-415.
116. Powell, J.R., Foster, J., Patterson, J. H., Cross, R., and Wargin, W. (1986) Clin. Pharm. 5(12), 993-998.
117. Michalets, E.L. (1998) Pharmacotherapy 18(1), 84-112.
118. Li, A.P., Rasmussen, A., Xu, L., and Kaminski, D. L. (1995) J. Pharmacol. Exp. Ther. 274(2), 673-677.
119. Perucca, E. and Richens, A. (1979) Br. J. Clin. Pharmacol. 8(1), 21-31.
120. Arfwidsson, A., Borg, K. O., Hoffmann, K. J., and Skanberg, I. (1976) Xenobiotica 6(11), 691-711.
121. Lennard, M.S., Crewe, H. K., Tucker, G. T., and Woods, H. F. (1986) Biochem. Pharmacol. 35(16), 2757-2761.
122. Barham, H.M., Lennard, M. S., and Tucker, G. T. (1994) Biochem. Pharmacol. 47(8), 1295-1307.
123. Lancaster, D.L., Adio, R. A., Tai, K. K., Simooya, O. O., Broadhead, G. D., Tucker, G. T., and Lennard, M. S. (1990) J. Pharm. Pharmacol. 42(4), 267-271.
124. Kobayashi, S., Murray, S., Watson, D., Sesardic, D., Davies, D. S., and Boobis, A. R. (1989) Biochem. Pharmacol. 38(17), 2795-2799.
125. Otton, S.V., Crewe, H. K., Lennard, M. S., Tucker, G, T., and Woods, H. F. (1988) J. Pharmacol. Exp. Ther. 247(1), 242-247.
126. Belpaire, F.M., Wijnant, P., Temmerman, A., Rasmussen, B. B., and Brosen, K. (1998) Eur. J. Clin. Pharmacol. 54(3), 261-264.
127. Tu, Z.G. and Zhao, L. L. (1995) Zhongguo Yao Li Xue. Bao 16(4), 325-329.
128. Hemeryck, A., De Vriendt, C. A., and Belpaire, F. M. (2001) Drug Metab. Dispos. 29(5), 656-663.
129. Kim, M., Shen, D. D., Eddy, A. C., Nelson, W. L., and Roskos, L. K. (1993) Drug Metab. Dispos. 21(2), 309-317.
130. Borg, K.O., Carlsson, E., Hoffmann, K. J., Jonsson, T. E., Thorin, H., and Wallin, B. (1975) Acta Pharmacol. Toxicol. (Copenh 36(5), 125-135.
131. Murthy, S.S., Nelson, W. L., Shen, D. D., Power, J. M., Cahill, C. M., and McLean, A. J. (1991) Drug Metab. Dispos. 19 6), 1093-1100.
132. Madani, S., Paine, M. F., Lewis, L., Thummel, K. E., and Shen, D. D. (1999) Pharm. Res. 16(8), 1199-1205.
133. Lennard, M.S., Tucker, G. T., Silas, J. H., Freestone, S., Ramsay, L, E., and Woods, H. F. (1983) Clin. Pharmacol. Ther. 34 6), 732-737.
134. Lennard, M.S., Silas, J. H., Freestone, S., and Trevethick, J. (1982) Br. J. Clin. Pharmacol. 14(2), 301-303.
135. Lennard, M.S., Silas, J. H., Freestone, S., Ramsay, L. E., Tucker, G. T., and Woods, H. F. (1982) N. Engl. J. Med. 307 25), 1558-1560.
136. Lennard, M.S., Tucker, G. T., Silas, J. H., and Woods, H. F. (1986) Xenobiotica 16(5), 435-447.
137. McGourty, J.C., Silas, J. H., Lennard, M. S., Tucker, G. T., and Woods, H. F. (1985) Br. J. Clin. Pharmacol. 20(6), 555-566.
138. Silas, J.H., McGourty, J. C., Lennard, M. S., Tucker, G. T., and Woods, H. F. (1985) Eur. J. Clin. Pharmacol. 28 Suppl., 85-88.
139. Bozkurt, A., Basci, N. E., Isimer, A., Sayal, A., and Kayaalp, S. O. (1996) Eur. J. Drug Metab. Pharmacokinet. 21 4), 309-314.
140. Jack, D.B., Wilkins, M., and Quarterman, C. P. (1983) Br. J. Clin. Pharmacol. 16(2), 188-190.
141. Iyun, A.O., Lennard, M. S., Tucker, G. T., and Woods, H. F. (1986) Clin. Pharmacol. Ther. 40(4), 387-394.
142. Sommers, D.K., Moncrieff, J., and Avenant, J. (1989) Hum. Toxicol. 8(1), 39-43.
143. Sommers, D.K., Moncrieff, J., and Avenant, J. (1989) Hum. Toxicol. 8(5), 365-368.
144. Lennard, M.S., Iyun, A. O., Jackson, P. R., Tucker, G. T., and Woods, H. F. (1992) Pharmacogenetics 2(2), 89-92.
145. Simooya, O.O., Njunju, E., Hodjegan, A. R., Lennard, M. S., and Tucker, G. T. (1993) Pharmacogenetics 3(4), 205-208.
146. Johnson, J.A. and Burlew, B. S. (1996) Drug Metab. Dispos. 24(3), 350-355.
147. Setiabudy, R., Kusaka, M., Chiba, K., Darmansjah, I., and Ishizaki, T. (1994) Clin. Pharmacol. Ther. 56(2), 142-153.
148. Sohn, D.R., Shin, S. G., Park, C. W., Kusaka, M., Chiba, K., and Ishizaki, T. (1991) Br. J. Clin. Pharmacol. 32(4), 504-507.
149. Harron, D.W., Balnave, K., Kinney, C. D., Wilson, R., Russell, C. J., and Shanks, R. G. (1981) Clin. Pharmacol. Ther. 29(3), 295-302.
150. Wahlund, G., Nerme, V., Abrahamsson, T., and Sjoquist, P. O. (1990) Br. J. Pharmacol. 99(3), 592-596.
151. Hoffmann, K.J., Regardh, C. G., Aurell, M., Ervik, M., and Jordo, L. (1980) Clin. Pharmacokinet. 5(2), 181-191.
152. Regardh, C.G., Ek, L., and Hoffmann, K. J. (1979) J. Pharmacokinet. Biopharm. 7(5), 471-479.
153. Strauss, W.E. and Parisi, A. F. (1988) Ann. Intern. Med. 109(7), 570-581.
154. McLean, A.J., Knight, R., Harrison, P. M., and Harper, R. W. (1985) Am. J. Cardiol. 55(13 Pt 1), 1628-1629.
155. Keech, A.C., Harper, R. W., Harrison, P. M., Pitt, A., and McLean, A. J. (1986) Am. J. Cardiol. 58(6), 551-552.
156. Jack, D.B., Kendall, M. J., Dean, S., Laugher, S. J., Zaman, R., and Tenneson, M. E. (1982) Biopharm. Drug Dispos. 3(1), 47-54.
157. Walley, T., Pirmohamed, M., Proudlove, C., and Maxwell, D. (1993) Lancet 341(8850), 967-968.
158. Somer, M., Kallio, J., Pesonen, U., Pyykko, K., Huupponen, R., and Scheinin, M. (2000) Br. J. Clin. Pharmacol. 49(6), 549-554.
159. Bennett, P.N., John, V. A., and Whitmarsh, V. B. (1982) Br. J. Clin. Pharmacol. 13(3), 387-391.
160. Spahn, H., Kirch, W., Mutschler, E., Ohnhaus, E. E., Kitteringham, N. R., Logering, H. J., and Paar, D. (1984) Br. J. Clin. Pharmacol. 17(1), 97S-102S.
161. Godbillon, J., Gerardin, A., John, V. A., and Theobald, W. (1983) Eur. J. Clin. Pharmacol. 24(5), 655-660.
162. Houtzagers, J.J., Streurman, O., and Regardh, C. G. (1982) Br. J. Clin. Pharmacol. 14(1), 67-72.
163. Kirch, W., Spahn, H., Kohler, H., Ohnhaus, E. E., and Mutschler, E. (1982) Klin. Wochenschr. 60(22), 1401-1407.
164. Kirch, W., Spahn, H., Kitteringham, N. R., Hutt, H. J., Mutschler, E., and Ohnhaus, E. E. (1984) Br. J. Clin. Pharmacol. 17(1), 65S-68S.
165. Uetrecht, J.P., Woosley, R. L., Freeman, R. W., Sweetman, B. J., and Oates, J. A. (1981) Drug Metab. Dispos. 9(3), 183-187.
166. Tabor, H., Mehler, A. H., and Stadtman, E. R. (1953) J. Biol. Chem. 1204, 127-138.
167. Kang, E.S., Deaton, P. R., Epstein, D., Ingram, L. A., and Mirvis, D. M. (1989) Gen. Pharmacol. 20(2), 223-227.
168. Schneck, D.W., Sprouse, J. S., Hayes, A.-H. J., and Shiroff R. A. (1978) J. Pharmacol. Exp. Ther. 204(1), 212-218.
169. Okumura, K., Kita, T., Chikazawa, S., Komada, F., Iwakawa, S., and Tanigawara, Y. (1997) Clin. Pharmacol. Ther. 61(5), 509-517.
170. Hickman, D., Palamanda, J. R., Unadkat, J. D., and Sim, E. (1995) Biochem. Pharmacol. 50(5), 697-703.
171. Zschieschang, P., Hiepe, F., Gromnica-Ihle, E., Roots, I., and Cascorbi, I. (2002) Pharmacogenetics 12(7), 559-563.
172. Freeman, R.W., Woosley, R. L., Oates, J. A., and Harbison, R. D. (1979) Toxicol. Appl. Pharmacol. 50(1), 9-16.
173. Freeman, R.W., Uetrecht, J. P., Woosley, R. L., Oates, J. A., and Harbison, R. D. (1981) Drug Metab. Dispos. 9(3), 188-192.
174. Uetrecht, J.P., Sweetman, B. J., Woosley, R. L., and Oates, J. A. (1984) Drug Metab. Dispos. 12(1), 77-81.
175. Uetrecht, J.P. (1985) J. Pharmacol. Exp. Ther. 232 2), 420-425.
176. Uetrecht, J. P., Freeman, R. W., and Woosley, R. L. (1981) Arthritis Rheum. 24(8), 994-1003.
177. Budinsky, R.A., Roberts, S. M., Coats, E. A., Adams, L., and Hess, E. V. (1987) Drug Metab. Dispos. 15(1), 37-43.
178. Lessard, E., Fortin, A., Belanger, P. M., Beaune, P., Hamelin, B. A., and Turgeon, J. (1997) Pharmacogenetics 7(5), 381-390.
179. Lessard, E., Hamelin, B. A., Labbe, L., O'Hara, G., Belanger, P. M., and Turgeon, J. (1999) Pharmacogenetics 9(6), 683-696.
180. Uetrecht, J., Zahid, N., and Rubin, R. (1988) Chem. Res. Toxicol. 1(1), 74-78.
181. Goebel, C., Vogel, C., Wulferink, M., Mittmann, S., Sachs, B., Schraa, S., Abel, J., Degen, G., Uetrecht, J., and Gleichmann, E. (1999) Chem. Res. Toxicol. 12(6), 488-500.
182. Schneck, D.W., Grove, K., Dewitt, F. O., Shiroff, R. A., and Hayes, A.-H. J. (1978) J. Pharmacol. Exp. Ther. 204(1), 219-225.
183. Dreyfuss, J., Ross, J.-J. J., and Schreiber, E. C. (1971) Arzneimittelforschung. 21(7), 948-951.
184. Dreyfuss, J., Bigger, J.-T. J., Cohen, A. I., and Schreiber, E. C. (1972) Clin. Pharmacol. Ther. 13(3), 366-371.
185. Drayer, D.E., Lowenthal, D. T., Woosley, R. L., Nies, A. S., Schwartz, A., and Reidenberg, M. M. (1977) Clin. Pharmacol. Ther. 22(1), 63-69.
186. Connolly, S.J. and Kates, R. E. (1982) Clin. Pharmacokinet. 7(3), 206-220.
187. Giardina, E.G., Dreyfuss, J., Bigger, J.-T. J., Shaw, J. M., and Schreiber, E. C. (1976) Clin. Pharmacol. Ther. 19(3), 339-351.
188. Taber, D.F., Jernigan, J. D., Watson, J. T., Carr, K., and Woosley, R. L. (1979) Drug Metab. Dispos. 7(5), 346.
189. Ruo, T.I., Morita, Y., Atkinson, A.-J. J., Henthorn, T., and Thenot, J. P. (1981) J. Pharmacol. Exp. Ther. 216(2), 357-362.
190. Ruo, T.I., Thenot, J. P., Stec, G. P., and Atkinson, A.-J. J. (1981) Ther. Drug Monit. 3(3), 231-237.
191. Lee, W.K., Strong, J. M., Kehoe, R. F., Dutcher, J. S., and Atkinson, A.-J. J. (1976) Clin. Pharmacol. Ther. 19(5 Pt 1 , 508-514.
192. Gibson, T.P., Atkinson, A.-J. J., Matusik, E., Nelson, L. D., and Briggs, W. A. (1977) Kidney Int. 12(6), 422-429.
193. Reidenberg, M.M., Drayer, D. E., Levy, M., and Warner, H. (1975) Clin. Pharmacol. Ther. 17(6), 722-730.
194. Karlsson, E. and Molin, L. (1975) Acta Med. Scand. 197(4), 299-302.
195. Lima, J.J. and Jusko, W. J. (1978) Clin. Pharmacol. Ther. 23(1), 25-29.
196. Woosley, R.L., Drayer, D. E., Reidenberg, M. M., Nies, A. S., Carr, K., and Oates, J. A. (1978) N. Engl. J. Med. 298(21), 1157-1159.
197. Roden, D.M., Reele, S. B., Higgins, S. B., Wilkinson, G. R., Smith, R. F., Oates, J. A., and Woosley, R. L. (1980) Am. J. Cardiol. 46(3), 463-468.
198. Jaillon, P. and Winkle, R. A. (1979) Circulation 60 6), 1385-1394.
199. Giardina, E.G. (1984) Ann. N. Y. Acad. Sci. 432, 177-198.
200. Coyle, J.D., Carnes, C. A., Schaal, S. F., and Muir, W. W. (1992) J. Cardiovasc. Pharmacol. 20(2), 197-205.
201. Boucher, M., Dubray, C., Paire, M., and Duchene-Marullaz, P. (1987) J. Cardiovasc. Pharmacol. 10(5), 562-567.
202. Winkle, R.A., Jaillon, P., Kates, R. E., and Peters, F. (1981) Am. J. Cardiol. 47(1), 123-130.
203. Cote, P., Harrison, D. C., Basile, J., and Schroeder, J. S. (1973) Am. J. Cardiol. 32(7), 937-942,
204. Lai, M.Y., Jiang, F. M., Chung, C. H., Chen, H. C., and Chao, P. D. (1988) Int. J. Clin. Pharmacol. Ther. Toxicol. 26(3), 118-121.
205. Ochs, H.R., Carstens, G., Roberts, G. M., and Greenblatt, D. J. (1983) J. Cardiovasc. Pharmacol. 5(3), 392-395.
206. Morita, K., Mizuochi, M., Yamaji, A., and Yokoyama, T. (1994) Biol. Pharm. Bull. 17(4), 531-534.
207. Zhou, Q., Yao, T. W., and Zeng, S. (2001) World J. Gastroenterol. 7(6), 830-835.
208. Kroemer, H.K., Mikus, G., Kronbach, T., Meyer, U. A., and Eichelbaum, M. (1989) Clin. Pharmacol. Ther. 45(1), 28-33.
209. Siddoway, L.A., Thompson, K. A., McAllister, C. B., Wang, T., Wilkinson, G. R., Roden, D. M., and Woosley, R. L. (1987) Circulation 75(4), 785-791.
210. Kroemer, H.K., Fischer, C., Meese, C. O., and Eichelbaum, M. (1991) Mol. Pharmacol. 41(1), 135-142.
211. Botsch, S., Gautier, J. C., Beaune, P., Eichelbaum, M., and Kroemer, H. K. (1993) Mol. Pharmacol. 43(1), 120-126.
212. Hege, H.G., Hollmann, M., Kaumeier, S., and Lietz, H. (1984) Eur. J. Drug Metab. Pharmacokinet. 9(1), 41-55.
213. Hollmann, M., Brode, E., Hotz, D., Kaumeier, S., and Kehrhahn, O. H. (1983) Arzneimittelforschung. 33(5), 763-770,
214. Connolly, S., Lebsack, C., Winkle, R. A., Harrison, D. C., and Kates, R. E. (1984) Clin. Pharmacol. Ther. 36(2), 163-168.
215. Zoble, R.G., Kirsten, E. B., and Brewington, J. (1989) Clin. Pharmacol. Ther. 45(5), 535-541.
216. Vozeh, S., Haefeli, W., Ha, H. R., Vlcek, J., and Follath, F. (1990) Eur. J. Clin. Pharmacol. 38(5), 509-513.
217. Giani, P., Landolina, M., Giudici, V., Bianchini, C., Ferrario, G., Marchi, S., Riva, E., and Latini, R. (1988) Eur. J. Clin. Pharmacol. 34(2), 187-194.
218. Brode, E., Muller-Peltzer, H., and Hollmann, M. (1988) Methods Find. Exp. Clin. Pharmacol. 10(11), 717-727.
219. Kroemer, H.K., Funck-Brentano, C., Silberstein, D. J., Wood, A. J., Eichelbaum, M., Woosley, R. L., and Roden, D. M. (1989) Circulation 79(5), 1068-1076.
220. Thompson, K.A., Iansmith, D. H., Siddoway, L. A., Woosley, R. L., and Roden, D. M. (1988) J. Pharmacol. Exp. Ther. 244(3 , 950-955.
221. Stoschitzky, K., Klein, W., Stark, G., Stark, U., Zernig, G., Graziadei, I., and Lindner, W. (1990) Clin. Pharmacol. Ther. 47 6), 740-746.
222. Li, G., Gong, P. L., Qiu, J., Zeng, F. D., and Klotz, U. (1998) Br. J. Clin. Pharmacol. 46(5), 441-445.
223. von Philipsborn, G., Gries, J., Hofmann, H. P., Kreiskott, H., Kretzschmar, R., Muller, C. D., Raschack, M., and Teschendorf, H. J. (1984) Arzneimittelforschung. 34(11), 1489-1497.
224. Oti-Amoako, K., Vozeh, S., Ha, H. R., and Follath, F. (1990) J. Cardiovasc. Pharmacol. 15(1), 75-81.
225. Funck-Brentano, C., Kroemer, H. K., Lee, J. T., and Roden, D. M. (1990) N. Engl. J. Med. 322(8), 518-525.
226. Funck-Brentano, C., Kroemer, H. K., Pavlou, H., Woosley, R. L., and Roden, D. M. (1989) Br. J. Clin. Pharmacol. 27(4), 435-444.
227. Morike, K.E. and Roden, D. M. (1994) Clin. Pharmacol. Ther. 55(1), 28-34.
228. Lee, J.T., Kroemer, H. K., Silberstein, D. J., Funck-Brentano, C., Lineberry, M. D., Wood, A. J., Roden, D. M., and Woosley, R. L. (1990) N. Engl. J. Med. 322(25), 1764-1768.
229. Haefeli, E.W., Vozeh, S., Ha, H. R., and Follath, F. (1990) Clin. Pharmacol. Ther. 48(3), 245-254.
230. Hii, J.T., Duff, H. J., and Burgess, E. D. (1991) Clin. Pharmacokinet. 21(1), 1-10.
231. Nolan, P.-E.J., Marcus, F. I., Erstad, B. L., Hoyer, G. L., Furman, C., and Kirsten, E. B. (1989) J. Clin. Pharmacol. 29 1), 46-52.
232. Kates, R.E., Yee, Y. G., and Kirsten, E. B. (1987) Clin. Pharmacol. Ther. 42(3), 305-311.
233. Wagner, F., Kalusche, D., Trenk, D., Jahnchen, E., and Roskamm, H. (1987) Br. J. Clin. Pharmacol. 24(2), 213-220.
234. Kowey, P.R., Kirsten, E. B., Fu, C. H., and Mason, W. D. (1989) J. Clin. Pharmacol. 29(6), 512-517.
235. Rakhit, A. and Mico, B. (1985) Res. Commun. Chem. Pathol. Pharmacol. 49(1), 109-124.
236. Guengerich, F.P., Muller-Enoch, D., and Blair, I. A. (1986) Mol. Pharmacol. 30(3), 287-295.
237. Otton, S.V., Inaba, T., and Kalow, W. (1984) Life Sci. 34(1), 73-80.
238. Otton, S.V., Brinn, R. U., and Gram, L. F. (11988) Drug Metab. Dispos. 16(1), 15-17.
239. Ching, M.S., Blake, C. L., Ghabrial, H., Ellis, S. W., Lennard, M. S., Tucker, G. T., and Smallwood, R. A. (1995) Biochem. Pharmacol. 50(6), 833-837.
240. Ching, M.S., Blake, C. L., Malek, N. A., Angus, P. W., and Ghabrial, H. (2001) Xenobiotica 31(11), 757-767.
241. Nielsen, T.L., Rasmussen, B. B., Flinois, J. P., Beaune, P., and Brosen, K. (1999) J. Pharmacol. Exp. Ther. 289(1), 31-37.
242. Ngui, J.S., Chen, Q., Shou, M., Wang, R. W., Stearns, R. A., Baillie, T. A., and Tang, W. (2001) Drug Metab. Dispos. 29 6), 877-886.
243. Ngui, J.S., Tang, W., Stearns, R. A., Shou, M., Miller, R. R., Zhang, Y., Lin, J. H., and Baillie, T. A. (2000) Drug Metab. Dispos. 28(9), 1043-1050.
244. Tang, W., Stearns, R. A., Kwei, G. Y., Iliff, S. A., Miller, R. R., Egan, M. A., Yu, N. X., Dean, D. C., Kumar, S., Shou, M., Lin, J. H., and Baillie, T. A. (1999) J. Pharmacol. Exp. Ther. 291 3), 1068-1074.
245. Barrow, S.E., Taylor, A. A., Horning, E. C., and Horning, M. G. (1980) J. Chromatogr. 181(2), 219-226.
246. Brodie, B.B., Baer, J. E., and Craig, L. C. (1951) J. Biol. Chem. 188, 567-581.
247. Palmer, K.H., Martin, B., Baggett, B., and Wall, M. E. (1969) Biochem. Pharmacol. 18(8), 8145-8160.
248. Carroll, F.I., Smith, D., and Wall, M. E. (1974) J. Med. Chem. 17(9), 985-987.
249. Beermann, B., Leander, K., and Lindstrom, B. (1976) Acta Chem. Scand. B 30(5), 465.
250. Drayer, D.E., Lowenthal, D. T., Restivo, K. M., Schwartz, A., Cook, C. E., and Reidenberg, M. M. (1978) Clin. Pharmacol. Ther. 24(1), 31-39.
251. Guentert, T.W., Coates, P. E., Upton, R. A., Combs, D. L., and Riegelman, S. (1979) J. Chromatogr. 162(1), 59-70.
252. Guentert, T.W., Daly, J. J., and Riegelman, S. (1982) Eur. J. Drug Metab. Pharmacokinet. 7(1), 31-38.
253. Rakhit, A., Holford, N. H., Guentert, T. W., Maloney, K., and Riegelman, S. (1984) J. Pharmacokinet. Biopharm. 12(1), 1-21.
254. Damkier, P. and Brosen, K. (2000), Clin. Pharmacol. Ther. 68(2), 199-209.
255. Ackerman, B.H., Olsen, K. M., and Pappas, A. A. (1991) DICP 25(7-8), 867-869.
256. Brosen, K., Gram, L. F., Haghfelt, T., and Bertilsson, L. (1987) Pharmacol. Toxicol. 60(4), 312-314.
257. Speirs, C.J., Murray, S., Boobis, A. R., Seddon, C. E., and Davies, D. S. (1986) Br. J. Clin. Pharmacol. 22(6), 739-743.
258. Brinn, R., Brosen, K., Gram, L. F., Haghfelt, T., and Otton, S. V. (1986) Br. J. Clin. Pharmacol. 22(2), 194-197.
259. Inaba, T., Tyndale, R. E., and Mahon, W. A. (1986) Br. J. Clin. Pharmacol. 22(2), 199-200.
260. Funck-Brentano, C., Kroemer, H. K., Pavlou, H., Woosley, R. L., and Roden, D. M. (1989) Br. J. Clin. Pharmacol. 27(4), 435-444.
261. Vozeh, S., Oti-Amoako, K., Uematsu, T., and Follath, F. (1987) J. Pharmacol. Exp. Ther. 243(1), 297-301.
262. Thompson, K.A., Blair, I. A., Woosley, R. L., and Roden, D. M. (1987) J. Pharmacol. Exp. Ther. 241(1), 84-90.
263. Fautrez, V.M., Adamantidis, M. M., Caron, J. F., Libersa, C. C., and Dupuis, B. A. (1992) J. Cardiovasc. Pharmacol. 19(3), 308-318.
264. Vozeh, S., Uematsu, T., Guentert, T. W., Ha, H. R., and Follath, F. (1985) Clin. Pharmacol. Ther. 37(5), 575-581.
265. Kavanagh, K.M., Wyse, D. G., Mitchell, L. B., Gilhooly, T., Gillis, A. M., and Duff, H. J. (1989) Clin. Pharmacol. Ther. 46 3), 352-358.
266. Camsonne, R., Moulin, M. A., Charbonneau, P., and Bazin, C. (1985) Int. J. Clin. Pharmacol. Ther. Toxicol. 23(2), 74-75.
267. Killeen, A.A. and Bowers, L. D. (1987) Obstet. Gynecol. 70(3 Pt 2), 445-449.
268. Bowers, L.D., Nelson, K. M., Connor, R., Lais, C. J., and Krauss, E. (1985) Ther. Drug Monit. 7(3), 308-312.
269. Ha, H.R,, Vozeh, S., Uematsu, T., Guentert, T. W., and Follath, F. (1987) Clin. Pharmacol. Ther. 42(3), 341-345.
270. Dahlqvist, R., Ejvinsson, G., and Schenck-Gustafsson, K. (1980) Br. J. Clin. Pharmacol. 9(4), 413-418.
271. Belz, G.G., Doering, W., Munkes, R., and Matthews, J. (1983) Clin. Pharmacol. Ther. 33(4), 410-417.
272. Angelin, B., Arvidsson, A., Dahlqvist, R., Hedman, A., and Schenck-Gustafsson, K. (1987) Eur. J. Clin. Invest 17(3), 262-265.
273. Rameis, H. (1985) Int. J. Clin. Pharmacol. Ther. Toxicol. 23(3), 145-153.
274. Su, S.F. and Huang, J. D. (1996) Drug Metab. Dispos. 24(2), 142-147.
275. Fromm, M.F., Kim, R. B., Stein, C. M., Wilkinson, G. R., and Roden, D. M. (1999) Circulation 99(4), 552-557.
276. Spinler, S.A., Cheng, J. W., Kindwall, K. E., and Charland, S. L. (1995) Clin. Pharmacol. Ther. 57(1), 89-94.
277. Edwards, D.J., Lavoie, R., Beckman, H., Blevins, R., and Rubenfire, M. (1987) Clin. Pharmacol. Ther. 41(1), 68-73.
278. Ha, H.R., Chen, J., Leuenberger, P. M., Freiburghaus, A. U., and Follath, F. (1995) Eur. J. Clin. Pharmacol. 48(5), 367-371.
279. Min, D.I., Ku, Y. M., Geraets, D. R., and Lee, H. (1996) J. Clin. Pharmacol. 36(5), 469-476.
280. Hughes, B., Dyer, J. E., and Schwartz, A. B. (1987) Am. Heart J. 114(4 Pt 1), 908-909.
281. Yamada, K., Yasuhara, M., Yatsuzuka, A., Okumura, K., Sakurai, T., Kawai, C., and Hori, R. (1992) Chem. Pharm. Bull. (Tokyo 40(7), 1876-1879.
282. Nelson, W.L., Olsen, L. D., Beitner, D. B., and Pallow, R.-J. J. (1988) Drug Metab. Dispos. 16(2), 184-188.
283. Nelson, W.L. and Olsen, L. D. (1988) Drug Metab. Dispos. 16(6), 834-841.
284. Walles, M., Thum, T., Levsen, K., and Borlak, J. (2001) Drug Metab. Dispos. 29(5), 761-768.
285. Kroemer, H.K., Gautier, J. C., Beaune, P., Henderson, C., Wolf, C. R., and Eichelbaum, M. (1993) Naunyn Schmiedebergs Arch. Pharmacol. 348(3), 332-337.
286. Tracy, T.S., Korzekwa, K. R., Gonzalez, F. J., and Wainer, I. W. (1999) Br. J. Clin. Pharmacol. 47(5), 545-552.
287. Busse, D., Cosme, J., Beaune, P., Kroemer, H. K., and Eichelbaum, M. (1995) Naunyn Schmiedebergs Arch. Pharmacol. 353 1), 116-121.
288. Koch, R.L. and Palicharla, P. (1990) J. Pharmacol. Exp. Ther. 254(2), 612-615.
289. McIlhenny, H.M. (1971) J. Med. Chem. 14(12), 1178-1184.
290. Eichelbaum, M., Ende, M., Remberg, G., Schomerus, M., and Dengler, H. J. (1979) Drug Metab. Dispos. 7(3), 145-148.
291. Remberg, G., Ende, M., Eichelbaum, M., and Schomerus, M. (1980) Arzneimittelforschung 30(3), 398-401.
292. Vogelgesang, B., Echizen, H., Schmidt, E., and Eichelbaum, M. (1984) Br. J. Clin. Pharmacol. 18(5), 733-740.
293. Eichelbaum, M., Mikus, G., and Vogelgesang, B. (1984) Br. J. Clin. Pharmacol. 17(4), 453-458.
294. Echizen, H., Vogelgesang, B., and Eichelbaum, M. (1985) Clin. Pharmacol. Ther. 38(1), 71-76.
295. Barbieri, E., Padrini, R., Piovan, D., Toffoli, M., Cargnelli, G., Trevi, G., and Ferrari, M. (1985) Int. J. Clin. Pharmacol. Res. 5(2), 99-107.
296. Neugebauer, G. (1978) Cardiovasc. Res. 12(4), 247-254.
297. Padrini, R., Barbieri, E., Piovan, D., Toffoli, M., Motta, A., Trevi, G. P., and Ferrari, M. (1985) Eur. J. Clin. Pharmacol. 28(6), 653-657.
298. Klein, H.O., Lang, R., Weiss, E., Di Segni, E., Libhaber, C., Guerrero, J., and Kaplinsky, E. (1982) Circulation 65(5), 998-1003.
299. Verschraagen, M., Koks, C. H., Schellens, J. H., and Beijnen, J. H. (1999) Pharmacol. Res. 40(4), 301-306.
300. Tallman, R.-D.J., Rosenblatt, R. M., Weaver, J. M., and Wang, Y. L. (1988) J. Clin. Pharmacol. 28(4), 317-321.
301. Mikus, G., Eichelbaum, M., Fischer, C., Gumulka, S., Klotz, U., and Kroemer, H. K. (1990) J. Pharmacol. Exp. Ther. 253 3), 1042-1048.
302. Carruthers, S.G., Freeman, D. J., and Bailey, D. G. (1989) Clin. Pharmacol. Ther. 46(4), 469-477.
303. McCourty, J.C., Silas, J. H., Tucker, G. T., and Lennard, M. S. (1988) Br. J. Clin. Pharmacol. 25(3), 349-357.
304. Murdoch, D.L., Thomson, G. D., Thompson, G. G., Murray, G. D., Brodie, M. J., and McInnes, G. T. (1991) Br. J. Clin. Pharmacol. 31(3), 323-332.
305. Hiroi, T., Imaoka, S., Chow, T., and Funae, Y. (1998) Biochim. Biophys. Acta 1380(3), 305-312.
306. Hiroi, T., Chow, T., Imaoka, S., and Funae, Y. (2002) Drug Metab. Dispos. 30(9), 970-976.
307. Smith, D.A. (1991) Drug Metab. Rev. 23(3-4), 355-373.
308. Lu, C. and Li, A. P. (2001) Chem. Biol. Interact. 134(3), 271-281.