Metabolism of amiodarone: II. High-performance liquid chromatographic assay for mono-N-desethylamiodarone hydroxylation in liver microsomes

Journal of Chromatography B: Biomedical Sciences and Applications

Volumn 757, Issue 2, 2001, Pages 309-315

  Ha, Huy Riem ^a   Kozlik, Peter ^a   Stieger, Bruno ^b   Bigler, Laurent ^c   Follath, Ferenc ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Amiodarone; Hydroxylation; Mono N desethylamiodarone

Indexed keywords

BIOASSAY; DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; METABOLISM;

LIVER MICROSOMES;

CHROMATOGRAPHIC ANALYSIS;

AMIODARONE; DEETHYLAMIODARONE; DRUG METABOLITE; N 3' HYDROXYBUTYL N DESETHYLAMIODARONE; OXYGENASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; DRUG METABOLISM; DRUG STRUCTURE; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; HYDROXYLATION; LIVER MICROSOME; MALE; MICHAELIS MENTEN KINETICS; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RABBIT; RAT; SPECIES DIFFERENCE; STRUCTURE ANALYSIS;

AMIODARONE; ANIMALS; ANTI-ARRHYTHMIA AGENTS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; HYDROXYLATION; MICROSOMES, LIVER; RABBITS; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0035877292     PISSN: 13872273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(01)00165-7     Document Type: Article

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