Tissue distributions of CYP2D1, 2D2, 2D3 and 2D4 mRNA in rats detected by RT-PCR

Biochimica et Biophysica Acta - General Subjects

Volumn 1380, Issue 3, 1998, Pages 305-312

  Hiroi, Toyoko ^a   Imaoka, Susumu ^a   Chow, Toshio ^a   Funae, Yoshihiko ^a  

^a Osaka Prefecture University   (Japan)

Author keywords

Cytochrome P450 2D form; Expression; mRNA; RT PCR; Tissue distribution

Indexed keywords

CYTOCHROME P450; DNA; MESSENGER RNA; POLYADENYLIC ACID;

ADRENAL GLAND; ANIMAL TISSUE; ARTICLE; BLADDER; BRAIN; CONTROLLED STUDY; DNA SEQUENCE; ENZYME LOCALIZATION; FEMALE; HEART; KIDNEY; LIVER; LUNG; MALE; NONHUMAN; OVARY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMALL INTESTINE MUCOSA; SPLEEN; TESTIS; TISSUE DISTRIBUTION;

ANIMALS; CYTOCHROME P-450 CYP2D6; DNA PRIMERS; FEMALE; ISOENZYMES; MALE; MULTIGENE FAMILY; ORGAN SPECIFICITY; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY;

EID: 0032496338     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-4165(97)00157-8     Document Type: Article

References (29)

1. Nelson D.R., Koymans L., Kamataki T., Stegeman J.J., Feyereisen R., Waxman D.J., Waterman M.R., Gotoh O., Coon M.J., Estabrook R.W., Gunsalus I.C., Nebert D.W. P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics. 6:1996;1-42.
2. F.J. Gonzalez, The CYP2D subfamily, in: C. Ioannides (Ed.), Cytochromes P450: Metabolic and Toxicological Aspects, CRC Press, New York, 1996, pp. 183-210.
3. Hakkola J., Raunio H., Purkunen R., Pelkonen O., Saarikoski S., Cresteil T., Pasanen M. Detection of cytochrome P450 gene expression in human placenta in first trimester of pregnancy. Biochem. Pharmacol. 52:1996;379-383.
4. Carcillo J.A., Parise R.A., Adedoyin A., Frye R., Branch R.A., Romkes M. CYP2D6 mRNA expression in circulating peripheral blood mononuclear cells correlates with in vivo debrisoquine hydroxylase activity in extensive metabolizers. Res. Commun. Mol. Pathol. 91:1996;149-159.
5. Jiang Q., Voigt J.M., Colby H.D. Molecular cloning and sequencing of a guinea pig cytochrome P4502D (CYP2D16): high-level expression in adrenal microsomes. Biochem. Biophys. Res. Commun. 209:1995;1149-1156.
6. Kawashima H., Strobel H.W. cDNA cloning of a novel rat brain cytochrome P450 belonging to the CYP2D subfamily. Biochem. Biophys. Res. Commun. 209:1995;535-540.
7. Hellmold H., Lamb J.B., Wyss A., Gustafsson J.-Å., Warner M. Development and endocrine regulation of P450 isoforms in rat breast. Mol. Pharmacol. 48:1995;630-638.
8. Zhang Q.-Y., Wikoff F., Dunbar D., Kaminsky L. Characterization of rat small intestine cytochrome P450 composition and inducibility. Drug Metab. Dispos. 24:1996;322-328.
9. Hedlund E., Wyss A., Kainu T., Bacjlund M., Köhler C., Pelto-Huikko M., Gustafsson J.-Å., Warner M. Cytochrome P4502D4 in the brain: specific neuronal regulation by clozapine and toluene. Mol. Pharmacol. 50:1996;342-350.
10. Ohishi N., Imaoka S., Suzuki T., Funae Y. Characterization of two P450 isozymes placed in the rat CYP2D subfamily. Biochim. Biophys. Acta. 1158:1993;227-236.
11. Matsunaga E., Zanger U.M., Hardwick J.P., Gelboin H.V., Meyer U.A., Gonzalez F.J. The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats. Biochemistry. 28:1989;7349-7355.
12. Wyss A., Gustafsson J.-Å., Warner M. Cytochrome P450 of the 2D subfamily in rat brain. Mol. Pharmacol. 47:1995;1148-1155.
13. Komori M. A novel P450 expressed at the high level rat brain. Biochem. Biophys. Res. Commun. 196:1993;721-728.
14. Wan J., Imaoka S., Chow T., Hiroi T., Yabusaki Y., Funae Y. Expression of four rat CYP2D isoforms in Saccharomyces cerevisiae and their catalytic specificity. Arch. Biochem. Biophys. 348:1997;383-390.
15. Gonzalez F.J., Matsunaga T., Nagata K., Meyer U.A., Nerbert D.W., Pastewka J., Kazak C.A., Gillette J., Gelboin H.V., Hardwick J.P. Debrisoquine 4-hydroxylase: characterization of a new P450 gene, subfamily, regulation, chromosomal mapping and molecular analysis of the DA rat polymorphism. DNA. 6:1987;149-161.
16. Matsunaga E., Umeno M., Gonzalez F.J. The rat P450 IID subfamily: complete sequence homologeneity at the heme-binding region of the cytochrome P450 active site. J. Mol. Evol. 30:1990;155-169.
17. Tso J.Y., Sun X.H., Kao T.H., Reece K.S., Wu R. Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene. Nucleic Acids Res. 13:1985;2485-2502.
18. Masubuchi Y., Yamamoto K., Suzuki T., Horie T., Narimatsu S. Characterization of the oxidation reactions catalyzed by CYP2D enzyme in rat renal microsomes. Life Sci. 58:1996;2431-2437.
19. Matsuda T., Imaoka S., Funae Y., Otori K., Fukushima S. Induction of CYP2D isoenzymes in various organs of rats by 3-methylcholanthrene or β-naphthoflavone. Can. Lett. 97:1995;137-143.
20. Arthur F.B., Strobel H.W. Anatomical distribution of NADPH-cytochrome P450 reductase and cytochrome P4502D forms in rat brain: effects of xenobiotics and sex steroids. Mol. Cell. Biochem. 162:1996;31-41.
21. Y. Funae, S. Imaoka, Cytochrome P450 in rodents, in: J.B. Schenkman, H. Greim (Eds.), Handbook of Experimental Pharmacology, Vol. 105, Cytochrome P450, Springer, Berlin, 1993, pp. 221-238.
22. N. Ishida, O. Sugita, The rat cytochrome P450 C-M/F (CYP2D) subfamily: constitutive P450 isozymes in male and female, Regulation of Heme Protein Synthesis, 1994, pp. 89-95.
23. Hiroi T., Ohishi N., Imaoka S., Yabusaki Y., Fukui H., Funae Y. Mepyramine, a histamine H1 receptor antagonist, inhibits the metabolic activity of rat and human P450 2D forms. J. Pharmacol. Exp. Ther. 272:1995;939-944.
24. Iwahashi K., Matsuo Y., Tsuneoka Y., Ichikawa Y., Hosokawa K., Suwaki H. Histamine and 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline are competitive inhibitors of debrisoquine 4-monooxygenase in rat liver. Arch. Toxicol. 67:1993;514-516.
25. Hiroi T., Imaoka S., Chow T., Yabusaki Y., Funae Y. Specific binding of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl propyl) piperazine (GBR-12935), an inhibitor of the dopamine transporter, to human CYP2D6. Biochem. Pharmacol. 53:1997;1937-1939.
26. 3H]GBR-12935 binding to cytochrome P450 in the human brain. J. Neurochem. 62:1994;342-348.
27. 3H]GBR-12935 binding proteins. Arch. Biochem. Biophys. 276:1990;424-432.
28. 3H]dextromethorphan and σ ligands to guinea pig brain. Life Sci. 48:1991;543-550.
29. Zanger R.C., Hernandez M., Novak R.F. Posttranscriptional elevation of cytochrome P450 3A expression. Biochem. Biophys. Res. Commun. 231:1997;203-205.