Effects of vitamin E on cytotoxicity of amiodarone and N-desethylamiodarone in isolated hamster lung cells

Toxicology

Volumn 166, Issue 3, 2001, Pages 109-118

  Bolt, M W ^a   Racz, W J ^a   Brien, J F ^a   Massey, T E ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Alveolar macrophages; Alveolar type II cells; Amiodarone; Clara cells; Desethylamiodarone; Isoprostanes; Lipid peroxidation; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; AMIODARONE; CARBON TETRACHLORIDE; DEETHYLAMIODARONE; ISOPROSTANE; TRYPAN BLUE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DEATH; CELL FRACTIONATION; CELL ISOLATION; CELL LEVEL; CELL PROTECTION; CELL TYPE; CELL VIABILITY; CLARA CELL; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG INDUCED DISEASE; HAMSTER; INCUBATION TIME; LIPID PEROXIDATION; LUNG ALVEOLUS CELL TYPE 2; LUNG ALVEOLUS MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL;

AMIODARONE; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ANTIOXIDANTS; BRONCHI; BRONCHOALVEOLAR LAVAGE FLUID; CARBON TETRACHLORIDE; CELL SEPARATION; CELL SURVIVAL; CELLS, CULTURED; CRICETINAE; EPITHELIAL CELLS; FREE RADICAL SCAVENGERS; LIPID PEROXIDATION; LUNG; MACROPHAGES, ALVEOLAR; MALE; MESOCRICETUS; VITAMIN E;

CRICETINAE;

EID: 0035949811     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(01)00451-6     Document Type: Article

References (49)

1. Antiarrhythmic effects of desethylamiodarone in dogs with subacute myocardial infarction and inducible ventricular arrhythmias
2. Amiodarone and its desethyl metabolite: Tissue distribution and morphologic changes during long-term therapy
3. Acute pulmonary inflammation in hamsters following intratracheal administration of amiodarone
4. Effects of vitamin E on Desethylamiodarone Cytotoxicity in isolated hamster lung cells
5. Effects of vitamin E on desethylamiodarone cytotoxicity in isolated hamster lung cells
6. Distribution of amiodarone and its metabolite, desethylamiodarone in human tissues
7. Pulmonary sequestration of amiodarone and desethylamiodarone
8. Increased synthesis of elastin in amiodarone-induced pulmonary fibrosis
9. Amiodarone-induced disruption of hamster lung and liver mitochondrial function: Lack of association with thiobarbituric acid-reactive substance production
10. Effects of dietary vitamin E supplementation on pulmonary morphology and collagen deposition in amiodarone- and vehicle-treated hamsters
11. Evidence-based analysis of amiodarone efficacy and safety
12. Pulmonary fibrosis induced in the hamster by amiodarone and desethylamiodarone
13. Alveolar type II and Clara cells: Isolation and xenobiotic metabolism
14. Isolation and identification of Clara cells from rabbit lung
15. Toxicity of amiodarone on mouse pulmonary endothelial cells cultured with or without alveolar macrophages
16. Amiodarone and desethylamiodarone toxicity in isolated hepatocytes in culture
17. Lipd peroxidation: Its mechanism, measurement, and significance
18. Vitamin E reduces accumulation of amiodarone and desethylamiodarone and inhibits phospholipidosis in cultured human cells
19. Randomised trial of effect of amiodarone on mortality in patients with left-ventricular dysfunction after recent myocardial infarction: EMIAT
20. Amiodarone-induced injury of human pulmonary artery endothelial cells: Protection by α-tocopherol
21. Tissue drug accumulation and ultrastructural changes during amiodarone administration in rats
22. Clinical aspects of amiodarone pulmonary toxicity
23. The type II epithelial cell of the lung. I. Method of isolation
24. Resistance of the hamster to amiodarone-induced pulmonary toxicity following repeated intraperitoneal administration
25. Evaluation of reactive oxygen species involvement in amiodarone pulmonary toxicity in vivo and in vitro
26. Spectroscopic studies of cutaneous photosensitizing agents-IX. A spin trapping study of the photolysis of amiodarone and desethylamiodarone
27. Neutrality of amiodarone on the initiation and propagation of membrane lipid peroxidation
28. Amiodarone pulmonary toxicity: Recognition and pathogenesis (Part I)
29. Isolation and use of lung cells in toxicology
30. The 1994 Veylien Henderson Award of the Society of Toxicology of Canada. Mechanisms in the pathogenesis of amiodarone-induced pulmonary toxicity
31. Amiodarone induces cytochrome c release and apoptosis through an iodine-independent mechanism
32. Measurement of lipid peroxidation
33. The isoprostanes: Unique bioactive products of lipid peroxidation
34. Bioactivation of halogenated hydrocarbons by rabbit pulmonary cells
35. Response of alveolar macrophages to amiodarone and desethylamiodarone, in vitro
36. Clara cells
37. An evaluation of possible mechanisms underlying amiodarone-induced pulmonary toxicity
38. Evaluation of amiodarone free radical toxicity in rat hepatocytes
39. Lung injury, inflammatory mediators, and fibroblast activation in fibrosing alveolitis
40. Antiarrhythmic actions of amiodarone: A profile of a paradoxical agent
41. Pulmonary effects of low dose amiodarone: A review of the risks and recommendations for surveillance
42. Intratracheal amiodarone administration to Fisher 344 rats causes acute damage to airways and parenchymal cells; the possible role of free radical generation
43. Cytotoxicity measures: Choices and methods
44. Membrane-stabilizing effects of vitamin E: Effect of α-tocopherol and its model compounds on fluidity of lecithin liposomes
45. The role of free radicals in the pathogenesis of amiodarone toxicity
46. The role of oxidative stress, caused by amiodarone, in the side effects of the drug
47. Pulmonary accumulation of amiodarone and N-desethylamiodarone: Relationship to the development of pulmonary toxicity