메뉴 건너뛰기




Volumn 19, Issue 9, 2004, Pages 726-733

Mouse models of tuberous sclerosis complex

Author keywords

[No Author keywords available]

Indexed keywords

HAMARTIN; TUBERIN;

EID: 8844279090     PISSN: 08830738     EISSN: None     Source Type: Journal    
DOI: 10.1177/08830738040190091401     Document Type: Review
Times cited : (20)

References (77)
  • 2
    • 0035833936 scopus 로고    scopus 로고
    • Autism in tuberous sclerosis complex is related to both cortical and subcortical dysfunction
    • Asano E, Chugani DC, Muzik O, et al: Autism in tuberous sclerosis complex is related to both cortical and subcortical dysfunction. Neurology 2001;51:1269-1277.
    • (2001) Neurology , vol.51 , pp. 1269-1277
    • Asano, E.1    Chugani, D.C.2    Muzik, O.3
  • 3
    • 0036263937 scopus 로고    scopus 로고
    • Neuro-epileptic determinants of autisum spectrum disorders in tuberous sclerosis complex
    • Bolton PF, Park RJ, Higgins NP, et al: Neuro-epileptic determinants of autisum spectrum disorders in tuberous sclerosis complex. Brain 2002;125:1247-1255.
    • (2002) Brain , vol.125 , pp. 1247-1255
    • Bolton, P.F.1    Park, R.J.2    Higgins, N.P.3
  • 4
    • 0031054894 scopus 로고    scopus 로고
    • Association of tuberous sclerosis of temporal lobes with autism and atypical autism
    • Bolton PF, Griffiths PD: Association of tuberous sclerosis of temporal lobes with autism and atypical autism. Lancet 1997; 349:392-395.
    • (1997) Lancet , vol.349 , pp. 392-395
    • Bolton, P.F.1    Griffiths, P.D.2
  • 5
    • 0028821190 scopus 로고
    • MR findings in tuberous sclerosis complex and correlation with seizure development and mental impairment
    • Shepard CW, Houser OW, Gomez MR: MR findings in tuberous sclerosis complex and correlation with seizure development and mental impairment. AJNR Am J Neuroradiol 1995;16:149-155.
    • (1995) AJNR Am. J. Neuroradiol , vol.16 , pp. 149-155
    • Shepard, C.W.1    Houser, O.W.2    Gomez, M.R.3
  • 6
    • 12244298162 scopus 로고    scopus 로고
    • Learning disability and epilepsy in an epidemiological sample of individuals with tuberous sclerosis complex
    • Joinson C, O'Callaghan FJ, Osborne JP, et al: Learning disability and epilepsy in an epidemiological sample of individuals with tuberous sclerosis complex. Psychol Med 2003;33:335-344.
    • (2003) Psychol. Med. , vol.33 , pp. 335-344
    • Joinson, C.1    O'Callaghan, F.J.2    Osborne, J.P.3
  • 8
    • 0029849117 scopus 로고    scopus 로고
    • Neurological manifestation of tuberous sclerosis complex
    • Curatolo P: Neurological manifestation of tuberous sclerosis complex. Childs Nerv Syst 1996;12:515-521.
    • (1996) Childs Nerv. Syst. , vol.12 , pp. 515-521
    • Curatolo, P.1
  • 9
    • 0025613368 scopus 로고
    • Topographic comparative study of MRI and EEG in 34 children with tuberous sclerosis
    • Cusmai R, Chiron C, Curatolo P, et al: Topographic comparative study of MRI and EEG in 34 children with tuberous sclerosis. Epilepsia 1990;31:747-755.
    • (1990) Epilepsia , vol.31 , pp. 747-755
    • Cusmai, R.1    Chiron, C.2    Curatolo, P.3
  • 10
    • 0030942875 scopus 로고    scopus 로고
    • Cortical tuber count: A biomarker indicating neurologic severity of tuberous sclerosis complex
    • Goodman M, Lamm SH, Engel A, et al: Cortical tuber count: A biomarker indicating neurologic severity of tuberous sclerosis complex. J Child Neurol 1997;12:85-90.
    • (1997) J. Child Neurol. , vol.12 , pp. 85-90
    • Goodman, M.1    Lamm, S.H.2    Engel, A.3
  • 11
    • 8844280259 scopus 로고    scopus 로고
    • Vigabatrin in the treatment of infantile spasms in tuberous sclerosis: Literature review
    • Hancock E, Osborne JP: Vigabatrin in the treatment of infantile spasms in tuberous sclerosis: Literature review. J Child Neurol 1999;41:123-126.
    • (1999) J. Child Neurol. , vol.41 , pp. 123-126
    • Hancock, E.1    Osborne, J.P.2
  • 12
    • 0027274928 scopus 로고
    • Surgical treatment for epilepsy in cerebral tuberous sclerosis
    • Bebin EM, Kelly PJ, Gomez MR: Surgical treatment for epilepsy in cerebral tuberous sclerosis. Epilepsia 1993;34:651-657.
    • (1993) Epilepsia , vol.34 , pp. 651-657
    • Bebin, E.M.1    Kelly, P.J.2    Gomez, M.R.3
  • 13
    • 0030742270 scopus 로고    scopus 로고
    • Tuberous sclerosis in a 20-week gestation fetus: Immunohistochemical study
    • Park SH, Pepkowitz SH, Kerfoot C, et al: Tuberous sclerosis in a 20-week gestation fetus: Immunohistochemical study. Acta Neuropathol (Berl) 1997;94:180-186.
    • (1997) Acta Neuropathol (Berl.) , vol.94 , pp. 180-186
    • Park, S.H.1    Pepkowitz, S.H.2    Kerfoot, C.3
  • 15
    • 0030954850 scopus 로고    scopus 로고
    • Evidence of abnormal differentiation in giant cells of tuberous sclerosis
    • Yamanouchi H, Jay V, Rutka JT, et al: Evidence of abnormal differentiation in giant cells of tuberous sclerosis. Pediatr Neurol 1997;17:49-53.
    • (1997) Pediatr. Neurol. , vol.17 , pp. 49-53
    • Yamanouchi, H.1    Jay, V.2    Rutka, J.T.3
  • 16
    • 0038754165 scopus 로고    scopus 로고
    • Markers of cellular proliferation are expressed in cortical tubers
    • Lee A, Maldonado M, Baybis M, et al: Markers of cellular proliferation are expressed in cortical tubers. Ann Neurol 2003; 53: 668-673.
    • (2003) Ann. Neurol. , vol.53 , pp. 668-673
    • Lee, A.1    Maldonado, M.2    Baybis, M.3
  • 17
    • 0034778130 scopus 로고    scopus 로고
    • Neuropathology of tuberous sclerosis
    • Mizuguchi M, Takashima S: Neuropathology of tuberous sclerosis. Brain Dev 2001;23:508-515.
    • (2001) Brain Dev. , vol.23 , pp. 508-515
    • Mizuguchi, M.1    Takashima, S.2
  • 18
    • 0025905689 scopus 로고
    • Subependymal giant cell astrocytoma: A clinical, pathologic, and flow cytometry study
    • Shepard CW, Scheithauer BW, Gomez MR, et al: Subependymal giant cell astrocytoma: A clinical, pathologic, and flow cytometry study. Neurosurgery 1991;38:864-869.
    • (1991) Neurosurgery , vol.38 , pp. 864-869
    • Shepard, C.W.1    Scheithauer, B.W.2    Gomez, M.R.3
  • 19
    • 0032856473 scopus 로고    scopus 로고
    • Congenital subependymal giant cell astrocytoma: Case report with prenatal ultrasonogram
    • Mirkin LD, Ey EH, Chaparro M: Congenital subependymal giant cell astrocytoma: Case report with prenatal ultrasonogram. Pediatr Radiol 1999;29:776-780.
    • (1999) Pediatr. Radiol. , vol.29 , pp. 776-780
    • Mirkin, L.D.1    Ey, E.H.2    Chaparro, M.3
  • 20
    • 0028168936 scopus 로고
    • Two loci for tuberous sclerosis: One on 9q34 and one on 16p13
    • Povey S, Burley MW, Attwood J, et al: Two loci for tuberous sclerosis: One on 9q34 and one on 16p13. Ann Hum Genet 1994; 58:107-127.
    • (1994) Ann. Hum. Genet. , vol.58 , pp. 107-127
    • Povey, S.1    Burley, M.W.2    Attwood, J.3
  • 21
    • 0030879277 scopus 로고    scopus 로고
    • Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34
    • van Slegtenhorst M, de Hoogt R, Hermans C, et al: Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science 1997;277:805-808.
    • (1997) Science , vol.277 , pp. 805-808
    • van Slegtenhorst, M.1    de Hoogt, R.2    Hermans, C.3
  • 22
    • 0027770784 scopus 로고
    • Identification and characterization of the tuberous sclerosis gene on chromosome 16
    • European Chromosome 16 Tuberous Sclerosis Consortium
    • European Chromosome 16 Tuberous Sclerosis Consortium: Identification and characterization of the tuberous sclerosis gene on chromosome 16. Cell 1993;75:1305-1315.
    • (1993) Cell , vol.75 , pp. 1305-1315
  • 23
    • 7144255533 scopus 로고    scopus 로고
    • Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products
    • van Slegtenhorst M, Nellist M, Nagelkerken B, et al: Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products. Hum Mol Genet 1998;7:1053-1057.
    • (1998) Hum. Mol. Genet. , vol.7 , pp. 1053-1057
    • van Slegtenhorst, M.1    Nellist, M.2    Nagelkerken, B.3
  • 24
    • 0032213545 scopus 로고    scopus 로고
    • Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles
    • Plank TL, Yeung RS, Henske EP: Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles. Cancer Res 1998;58:4766-4770.
    • (1998) Cancer Res. , vol.58 , pp. 4766-4770
    • Plank, T.L.1    Yeung, R.S.2    Henske, E.P.3
  • 25
    • 8844247335 scopus 로고    scopus 로고
    • Pathologic mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin
    • Hodges AK, Li S, Maynard J, et al: Pathologic mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin. Hum Mol Genet 2001;159:217-224.
    • (2001) Hum. Mol. Genet. , vol.159 , pp. 217-224
    • Hodges, A.K.1    Li, S.2    Maynard, J.3
  • 26
    • 0041758428 scopus 로고    scopus 로고
    • Tuberous sclerosis: From tubers to mTOR
    • Kwiatkowski DJ: Tuberous sclerosis: From tubers to mTOR. Ann Hum Genet 2003;67:87-96.
    • (2003) Ann. Hum. Genet. , vol.67 , pp. 87-96
    • Kwiatkowski, D.J.1
  • 28
    • 0029831886 scopus 로고    scopus 로고
    • Allelic loss is frequent in tuberous sclerosis kidney lesions but rare in brain lesions
    • Henske EP, Scheithauer BW, Short MP, et al: Allelic loss is frequent in tuberous sclerosis kidney lesions but rare in brain lesions. Am J Hum Genet 1996;59:400-406.
    • (1996) Am. J. Hum. Genet. , vol.59 , pp. 400-406
    • Henske, E.P.1    Scheithauer, B.W.2    Short, M.P.3
  • 29
    • 0034887907 scopus 로고    scopus 로고
    • Survey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesions
    • Niida Y, Stemmer-Rahamimov AO, Logrip M, et al: Survey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesions. Am J Hum Genet 2001;69:493-503.
    • (2001) Am. J. Hum. Genet. , vol.69 , pp. 493-503
    • Niida, Y.1    Stemmer-Rahamimov, A.O.2    Logrip, M.3
  • 30
    • 17844369428 scopus 로고    scopus 로고
    • The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination
    • Benvenuto G, Li S, Brown SJ, et al: The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination. Oncogene 2000;19:6306-6316.
    • (2000) Oncogene , vol.19 , pp. 6306-6316
    • Benvenuto, G.1    Li, S.2    Brown, S.J.3
  • 31
    • 0033861013 scopus 로고    scopus 로고
    • The TSC1 gene product, hamartin, negatively regulates cell proliferation
    • Miloloza A, Rosner M, Nellist M, et al: The TSC1 gene product, hamartin, negatively regulates cell proliferation. Hum Mol Genet 2000;9:1721-1727.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 1721-1727
    • Miloloza, A.1    Rosner, M.2    Nellist, M.3
  • 32
    • 0032430241 scopus 로고    scopus 로고
    • Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2
    • Soucek T, Yeung RS, Hengstschlager M: Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2. Proc Natl Acad Sci U S A 1998;95:15653-15658.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 15653-15658
    • Soucek, T.1    Yeung, R.S.2    Hengstschlager, M.3
  • 33
    • 0030663735 scopus 로고    scopus 로고
    • Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces cells to enter S phase
    • Soucek T, Pusch O, Wienecke R, et al: Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces cells to enter S phase. J Biol Chem 1997;272:29301-29308.
    • (1997) J. Biol. Chem. , vol.272 , pp. 29301-29308
    • Soucek, T.1    Pusch, O.2    Wienecke, R.3
  • 34
    • 0030853223 scopus 로고    scopus 로고
    • Tuberin immunohistochemistry in brain, kidneys, and heart with or without tuberous sclerosis
    • Mizuguchi M, Kato M, Yamanouchi H, et al: Tuberin immunohistochemistry in brain, kidneys, and heart with or without tuberous sclerosis. Acta Neuropathol (Berl) 1997;94:525-531.
    • (1997) Acta Neuropathol. (Berl.) , vol.94 , pp. 525-531
    • Mizuguchi, M.1    Kato, M.2    Yamanouchi, H.3
  • 35
    • 8844274284 scopus 로고    scopus 로고
    • Expression of the tuberous sclerosis complex gene products, hamartin and tubenin, in central nervous system tissues
    • Gutmann DH, Zhang Y, Hasbani MJ, et al: Expression of the tuberous sclerosis complex gene products, hamartin and tubenin, in central nervous system tissues. Acta Neuropathol (Berl) 2000;5:276-286.
    • (2000) Acta Neuropathol. (Berl.) , vol.5 , pp. 276-286
    • Gutmann, D.H.1    Zhang, Y.2    Hasbani, M.J.3
  • 36
    • 0032580368 scopus 로고    scopus 로고
    • A role of the tuberous sclerosis gene-2 product during neuronal differentiation
    • Soucek T, Holzl G, Bernaschek G, Hengtschlager M: A role of the tuberous sclerosis gene-2 product during neuronal differentiation. Oncogene 1998;16:2197-2204.
    • (1998) Oncogene , vol.16 , pp. 2197-2204
    • Soucek, T.1    Holzl, G.2    Bernaschek, G.3    Hengtschlager, M.4
  • 37
    • 8844243450 scopus 로고    scopus 로고
    • Reduced TSC2 RNA and protein in sporadic astrocytomas and ependymomas
    • Wienecke R, Guha A, Maize JC, et al: Reduced TSC2 RNA and protein in sporadic astrocytomas and ependymomas. Ann Neurol 1997;15:1611-1616.
    • (1997) Ann. Neurol. , vol.15 , pp. 1611-1616
    • Wienecke, R.1    Guha, A.2    Maize, J.C.3
  • 38
    • 0037864533 scopus 로고    scopus 로고
    • Aspects of tuberous sclerosis complex (TSC) protein function in the brain
    • Ramesh V: Aspects of tuberous sclerosis complex (TSC) protein function in the brain. Biochem Soc Trans 2003;31:579-583.
    • (2003) Biochem. Soc. Trans. , vol.31 , pp. 579-583
    • Ramesh, V.1
  • 39
    • 0036943576 scopus 로고    scopus 로고
    • TSC2 null neuroepithelial cells are a model for human tuber giant cells and show activation of an mTOR pathway
    • Onda H, Crino PB, Zhang H, et al: TSC2 null neuroepithelial cells are a model for human tuber giant cells and show activation of an mTOR pathway. Mol Cell Neurosci 2002;21:561-574.
    • (2002) Mol. Cell Neurosci. , vol.21 , pp. 561-574
    • Onda, H.1    Crino, P.B.2    Zhang, H.3
  • 40
    • 0033582748 scopus 로고    scopus 로고
    • Gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle
    • Ito N, Rubin GM: gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle. Cell 1999;96:529-539.
    • (1999) Cell , vol.96 , pp. 529-539
    • Ito, N.1    Rubin, G.M.2
  • 41
    • 0035805162 scopus 로고    scopus 로고
    • Drosophila TSC1 functions with TSC2 to antagonize insulin signaling regulating cell growth, cell proliferation, and organ size
    • Potter CJ, Huang H, Xu T: Drosophila TSC1 functions with TSC2 to antagonize insulin signaling regulating cell growth, cell proliferation, and organ size. Cell 2001;105:357-368.
    • (2001) Cell , vol.105 , pp. 357-368
    • Potter, C.J.1    Huang, H.2    Xu, T.3
  • 43
    • 0034982971 scopus 로고    scopus 로고
    • TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
    • Gao X, Pan D: TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes Dev 2001;5:1383-1392.
    • (2001) Genes Dev. , vol.5 , pp. 1383-1392
    • Gao, X.1    Pan, D.2
  • 44
    • 0033376684 scopus 로고    scopus 로고
    • PTEN affects cell size, cell proliferation, and apoptosis during Drosophila eye development
    • Huang H, Potter CJ, Tao W, et al: PTEN affects cell size, cell proliferation, and apoptosis during Drosophila eye development. Development 1999;126:5365-5372.
    • (1999) Development , vol.126 , pp. 5365-5372
    • Huang, H.1    Potter, C.J.2    Tao, W.3
  • 45
    • 18544375193 scopus 로고    scopus 로고
    • Phosphatidylinositol-3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin
    • Dan HC, Sun M, Yang L, et al: Phosphatidylinositol-3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. J Biol Chem 2002;277:35364-35370.
    • (2002) J. Biol. Chem. , vol.277 , pp. 35364-35370
    • Dan, H.C.1    Sun, M.2    Yang, L.3
  • 46
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling
    • Inoki K, Li Y, Zhu T, et al: TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling. Nat Cell Biol 2002; 4:648-657.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3
  • 47
    • 0037108750 scopus 로고    scopus 로고
    • Tuberous sclerosis complex-1 and 2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
    • Tee AR, Fingar DC, Manning BD, et al: Tuberous sclerosis complex-1 and 2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci U S A 2002;99:13571-13576.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 13571-13576
    • Tee, A.R.1    Fingar, D.C.2    Manning, B.D.3
  • 48
    • 0036714127 scopus 로고    scopus 로고
    • Akt regulates growth by directly phosphorylating TSC2
    • Potter CJ, Pedraza LG, Xu T: Akt regulates growth by directly phosphorylating TSC2. Nat Cell Biol 2002;4:658-665.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 658-665
    • Potter, C.J.1    Pedraza, L.G.2    Xu, T.3
  • 49
    • 0036712905 scopus 로고    scopus 로고
    • Tsc tumor suppressor proteins antagonize amino acid-TOR signaling
    • Gao X, Zhang Y, Arrazola P, et al: Tsc tumor suppressor proteins antagonize amino acid-TOR signaling. Nat Cell Biol 2002;4:699-704.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 699-704
    • Gao, X.1    Zhang, Y.2    Arrazola, P.3
  • 50
    • 0032520009 scopus 로고    scopus 로고
    • 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt (PKB) signaling pathway
    • Gingras A, Kennedy SG, O'Leary MA, et al: 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt (PKB) signaling pathway. Genes Dev 1998;12:502-513.
    • (1998) Genes Dev. , vol.12 , pp. 502-513
    • Gingras, A.1    Kennedy, S.G.2    O'Leary, M.A.3
  • 51
    • 0037097863 scopus 로고    scopus 로고
    • Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
    • Fingar DC, Salama S, Tsou C, et al: Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev 2002;16:1472-1487.
    • (2002) Genes Dev. , vol.16 , pp. 1472-1487
    • Fingar, D.C.1    Salama, S.2    Tsou, C.3
  • 52
    • 0036501277 scopus 로고    scopus 로고
    • A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas and upregulation of p70S6 kinase activity in TSC1 null cells
    • Kwiatkowski DJ, Zhang H, Bandura JL, et al: A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas and upregulation of p70S6 kinase activity in TSC1 null cells. Hum Mol Genet 2002;11:525-534.
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 525-534
    • Kwiatkowski, D.J.1    Zhang, H.2    Bandura, J.L.3
  • 53
    • 0038433304 scopus 로고    scopus 로고
    • Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
    • Garami A, Zwartkruis FJT, Nobukuni T, et al: Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell 2003;11:1457-1466.
    • (2003) Mol. Cell , vol.11 , pp. 1457-1466
    • Garami, A.1    Zwartkruis, F.J.T.2    Nobukuni, T.3
  • 54
    • 0041356888 scopus 로고    scopus 로고
    • Rheb binds TSC2 and promotes S6 kinase activation in a rapamycin and farnesylation-dependent manner
    • Castro AR, Rebhun JF, Clark GJ, Quilliam LA: Rheb binds TSC2 and promotes S6 kinase activation in a rapamycin and farnesylation-dependent manner. J Biol Chem 2003;278:32493-32496.
    • (2003) J. Biol. Chem. , vol.278 , pp. 32493-32496
    • Castro, A.R.1    Rebhun, J.F.2    Clark, G.J.3    Quilliam, L.A.4
  • 55
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • Inoki K, Li Y, Xu T, Guan KL: Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 2003;17:1829-1835.
    • (2003) Genes Dev. , vol.17 , pp. 1829-1835
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.L.4
  • 56
    • 0141925647 scopus 로고    scopus 로고
    • Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K
    • Tabancay AP, Gau CL, Machado IMP, et al: Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K. J Biol Chem 2003;278:39921-39930.
    • (2003) J. Biol. Chem. , vol.278 , pp. 39921-39930
    • Tabancay, A.P.1    Gau, C.L.2    Machado, I.M.P.3
  • 57
    • 0042701991 scopus 로고    scopus 로고
    • Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
    • Tee AR, Manning BD, Roux PP, et al: Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol 2003;13:1259-1268.
    • (2003) Curr. Biol. , vol.13 , pp. 1259-1268
    • Tee, A.R.1    Manning, B.D.2    Roux, P.P.3
  • 58
    • 0038141979 scopus 로고    scopus 로고
    • Rheb is a direct target of the tuberous sclerosis tumor suppressor proteins
    • Zhang Y, Gao X, Saucedo LJ, et al: Rheb is a direct target of the tuberous sclerosis tumor suppressor proteins. Nat Cell Biol 2003;5:578-581.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 578-581
    • Zhang, Y.1    Gao, X.2    Saucedo, L.J.3
  • 59
    • 0041827366 scopus 로고    scopus 로고
    • Drosophila Rheb GTPase is required for cell cycle progression and growth control
    • Patel PH, Thapar N, Guo L, et al: Drosophila Rheb GTPase is required for cell cycle progression and growth control. J Cell Sci 2003;116:3601-3610.
    • (2003) J. Cell Sci. , vol.116 , pp. 3601-3610
    • Patel, P.H.1    Thapar, N.2    Guo, L.3
  • 60
    • 0030888163 scopus 로고    scopus 로고
    • The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation
    • Clark GJ, Kinch MS, Rogers-Graham K, et al: The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation. J Biol Chem 1997;272:10608-10615.
    • (1997) J. Biol. Chem. , vol.272 , pp. 10608-10615
    • Clark, G.J.1    Kinch, M.S.2    Rogers-Graham, K.3
  • 61
    • 0038643484 scopus 로고    scopus 로고
    • Rheb promotes cell growth as a component of the insulin/TOR signaling network
    • Saucedo LJ, Gao X, Chiarelli DA, et al: Rheb promotes cell growth as a component of the insulin/TOR signaling network. Nat Cell Biol 2003;5:566-571.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 566-571
    • Saucedo, L.J.1    Gao, X.2    Chiarelli, D.A.3
  • 62
    • 0038304516 scopus 로고    scopus 로고
    • Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
    • Stocker H, Radimerski, Schindelholz B, et al: Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat Cell Biol 2003;5:559-565.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 559-565
    • Stocker, H.1    Radimerski, A.2    Schindelholz, B.3
  • 64
    • 15844384256 scopus 로고    scopus 로고
    • A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice
    • Fero ML, Rivkin M, Tasch M, et al: A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell 1996;85:733-744.
    • (1996) Cell , vol.85 , pp. 733-744
    • Fero, M.L.1    Rivkin, M.2    Tasch, M.3
  • 65
    • 0027996238 scopus 로고
    • Predisposition to renal carcinoma in the Eker rat is determined by germline mutation of the tuberous sclerosis (TSC2) gene
    • Yeung RS, Xiao GH, Jin F, et al: Predisposition to renal carcinoma in the Eker rat is determined by germline mutation of the tuberous sclerosis (TSC2) gene. Proc Natl Acad Sci U S A 1994;91: 11413-11416.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 11413-11416
    • Yeung, R.S.1    Xiao, G.H.2    Jin, F.3
  • 66
    • 0030663268 scopus 로고    scopus 로고
    • Subependymal astrocytic hamartomas in the Eker rat model of tuberous sclerosis
    • Yeung RS, Katsetos CD, Klein-Szanto A: Subependymal astrocytic hamartomas in the Eker rat model of tuberous sclerosis. Am J Pathol 1997;151:1477-1486.
    • (1997) Am. J. Pathol. , vol.151 , pp. 1477-1486
    • Yeung, R.S.1    Katsetos, C.D.2    Klein-Szanto, A.3
  • 67
    • 0036250938 scopus 로고    scopus 로고
    • Rat genetics: Attaching physiology and pharmacology to the genome
    • Jacob HJ, Kwitek AE: Rat genetics: Attaching physiology and pharmacology to the genome. Nat Rev Genet 2002;3:33-42.
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 33-42
    • Jacob, H.J.1    Kwitek, A.E.2
  • 68
    • 0032954092 scopus 로고    scopus 로고
    • Insights into cancer from transgenic mouse models
    • Macleod KF, Jacks T: Insights into cancer from transgenic mouse models. J Pathol 1999;187:43-60.
    • (1999) J. Pathol. , vol.187 , pp. 43-60
    • Macleod, K.F.1    Jacks, T.2
  • 69
    • 0033559663 scopus 로고    scopus 로고
    • Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice
    • Kobayashi T, Minowa O, Kuno J, et al: Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice. Cancer Res 1999;59: 1206-1211.
    • (1999) Cancer Res. , vol.59 , pp. 1206-1211
    • Kobayashi, T.1    Minowa, O.2    Kuno, J.3
  • 70
    • 0035902509 scopus 로고    scopus 로고
    • A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice
    • Kobayashi T, Minowa O, Sugitani Y, et al: A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice. Proc Natl Acad Sci U S A 2001;98:8762-8767.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 8762-8767
    • Kobayashi, T.1    Minowa, O.2    Sugitani, Y.3
  • 71
    • 0035167932 scopus 로고    scopus 로고
    • Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs
    • Dabora SL, Jozwiak S, Franz DN, et al: Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs. Am J Hum Genet 2001;68:64-80.
    • (2001) Am. J. Hum. Genet. , vol.68 , pp. 64-80
    • Dabora, S.L.1    Jozwiak, S.2    Franz, D.N.3
  • 72
    • 0036713644 scopus 로고    scopus 로고
    • Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures
    • Uhlmann EJ, Wong M, Baldwin RL, et al: Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures. Ann Neurol 2002;53:285-296.
    • (2002) Ann. Neurol. , vol.53 , pp. 285-296
    • Uhlmann, E.J.1    Wong, M.2    Baldwin, R.L.3
  • 73
    • 1842662634 scopus 로고    scopus 로고
    • Expression profiling in tuberous sclerosis (TSC) knockout mouse astrocytes to characterize human TSC brain pathology
    • Ess KC, Uhlmann EJ, Li W, et al: Expression profiling in tuberous sclerosis (TSC) knockout mouse astrocytes to characterize human TSC brain pathology. Glia 2004;46:28-40
    • (2004) Glia , vol.46 , pp. 28-40
    • Ess, K.C.1    Uhlmann, E.J.2    Li, W.3
  • 74
    • 3943106696 scopus 로고    scopus 로고
    • Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation
    • Uhlmann EJ, Li W, Scheidenhelm D, et al: Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation. Glia 2004;47:180-188.
    • (2004) Glia , vol.47 , pp. 180-188
    • Uhlmann, E.J.1    Li, W.2    Scheidenhelm, D.3
  • 75
    • 0041343133 scopus 로고    scopus 로고
    • Impaired astrocyte glutamate transport in a mouse epilepsy model of tuberous sclerosis
    • Wong M, Ess KC, Uhlmann EJ, et al: Impaired astrocyte glutamate transport in a mouse epilepsy model of tuberous sclerosis. Ann Neurol 2003;54:251-256.
    • (2003) Ann. Neurol. , vol.54 , pp. 251-256
    • Wong, M.1    Ess, K.C.2    Uhlmann, E.J.3
  • 76
    • 0346059618 scopus 로고    scopus 로고
    • Optic nerve glioma in mice requires Nf1 gene inactivation and Nf1 brain heterozygosity
    • Bajenaru ML, Hernandez MR, Perry A, et al: Optic nerve glioma in mice requires Nf1 gene inactivation and Nf1 brain heterozygosity. Cancer Res 2003;63:8573-8577.
    • (2003) Cancer Res. , vol.63 , pp. 8573-8577
    • Bajenaru, M.L.1    Hernandez, M.R.2    Perry, A.3
  • 77
    • 0035993192 scopus 로고    scopus 로고
    • Farnesyl transferase inhibitors as anticancer agents
    • Haluska P, Dy GK, Adjei AA: Farnesyl transferase inhibitors as anticancer agents. Eur J Cancer 2002;38:1685-1700.
    • (2002) Eur. J. Cancer , vol.38 , pp. 1685-1700
    • Haluska, P.1    Dy, G.K.2    Adjei, A.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.