-
2
-
-
0035833936
-
Autism in tuberous sclerosis complex is related to both cortical and subcortical dysfunction
-
Asano E, Chugani DC, Muzik O, et al: Autism in tuberous sclerosis complex is related to both cortical and subcortical dysfunction. Neurology 2001;51:1269-1277.
-
(2001)
Neurology
, vol.51
, pp. 1269-1277
-
-
Asano, E.1
Chugani, D.C.2
Muzik, O.3
-
3
-
-
0036263937
-
Neuro-epileptic determinants of autisum spectrum disorders in tuberous sclerosis complex
-
Bolton PF, Park RJ, Higgins NP, et al: Neuro-epileptic determinants of autisum spectrum disorders in tuberous sclerosis complex. Brain 2002;125:1247-1255.
-
(2002)
Brain
, vol.125
, pp. 1247-1255
-
-
Bolton, P.F.1
Park, R.J.2
Higgins, N.P.3
-
4
-
-
0031054894
-
Association of tuberous sclerosis of temporal lobes with autism and atypical autism
-
Bolton PF, Griffiths PD: Association of tuberous sclerosis of temporal lobes with autism and atypical autism. Lancet 1997; 349:392-395.
-
(1997)
Lancet
, vol.349
, pp. 392-395
-
-
Bolton, P.F.1
Griffiths, P.D.2
-
5
-
-
0028821190
-
MR findings in tuberous sclerosis complex and correlation with seizure development and mental impairment
-
Shepard CW, Houser OW, Gomez MR: MR findings in tuberous sclerosis complex and correlation with seizure development and mental impairment. AJNR Am J Neuroradiol 1995;16:149-155.
-
(1995)
AJNR Am. J. Neuroradiol
, vol.16
, pp. 149-155
-
-
Shepard, C.W.1
Houser, O.W.2
Gomez, M.R.3
-
6
-
-
12244298162
-
Learning disability and epilepsy in an epidemiological sample of individuals with tuberous sclerosis complex
-
Joinson C, O'Callaghan FJ, Osborne JP, et al: Learning disability and epilepsy in an epidemiological sample of individuals with tuberous sclerosis complex. Psychol Med 2003;33:335-344.
-
(2003)
Psychol. Med.
, vol.33
, pp. 335-344
-
-
Joinson, C.1
O'Callaghan, F.J.2
Osborne, J.P.3
-
8
-
-
0029849117
-
Neurological manifestation of tuberous sclerosis complex
-
Curatolo P: Neurological manifestation of tuberous sclerosis complex. Childs Nerv Syst 1996;12:515-521.
-
(1996)
Childs Nerv. Syst.
, vol.12
, pp. 515-521
-
-
Curatolo, P.1
-
9
-
-
0025613368
-
Topographic comparative study of MRI and EEG in 34 children with tuberous sclerosis
-
Cusmai R, Chiron C, Curatolo P, et al: Topographic comparative study of MRI and EEG in 34 children with tuberous sclerosis. Epilepsia 1990;31:747-755.
-
(1990)
Epilepsia
, vol.31
, pp. 747-755
-
-
Cusmai, R.1
Chiron, C.2
Curatolo, P.3
-
10
-
-
0030942875
-
Cortical tuber count: A biomarker indicating neurologic severity of tuberous sclerosis complex
-
Goodman M, Lamm SH, Engel A, et al: Cortical tuber count: A biomarker indicating neurologic severity of tuberous sclerosis complex. J Child Neurol 1997;12:85-90.
-
(1997)
J. Child Neurol.
, vol.12
, pp. 85-90
-
-
Goodman, M.1
Lamm, S.H.2
Engel, A.3
-
11
-
-
8844280259
-
Vigabatrin in the treatment of infantile spasms in tuberous sclerosis: Literature review
-
Hancock E, Osborne JP: Vigabatrin in the treatment of infantile spasms in tuberous sclerosis: Literature review. J Child Neurol 1999;41:123-126.
-
(1999)
J. Child Neurol.
, vol.41
, pp. 123-126
-
-
Hancock, E.1
Osborne, J.P.2
-
12
-
-
0027274928
-
Surgical treatment for epilepsy in cerebral tuberous sclerosis
-
Bebin EM, Kelly PJ, Gomez MR: Surgical treatment for epilepsy in cerebral tuberous sclerosis. Epilepsia 1993;34:651-657.
-
(1993)
Epilepsia
, vol.34
, pp. 651-657
-
-
Bebin, E.M.1
Kelly, P.J.2
Gomez, M.R.3
-
13
-
-
0030742270
-
Tuberous sclerosis in a 20-week gestation fetus: Immunohistochemical study
-
Park SH, Pepkowitz SH, Kerfoot C, et al: Tuberous sclerosis in a 20-week gestation fetus: Immunohistochemical study. Acta Neuropathol (Berl) 1997;94:180-186.
-
(1997)
Acta Neuropathol (Berl.)
, vol.94
, pp. 180-186
-
-
Park, S.H.1
Pepkowitz, S.H.2
Kerfoot, C.3
-
15
-
-
0030954850
-
Evidence of abnormal differentiation in giant cells of tuberous sclerosis
-
Yamanouchi H, Jay V, Rutka JT, et al: Evidence of abnormal differentiation in giant cells of tuberous sclerosis. Pediatr Neurol 1997;17:49-53.
-
(1997)
Pediatr. Neurol.
, vol.17
, pp. 49-53
-
-
Yamanouchi, H.1
Jay, V.2
Rutka, J.T.3
-
16
-
-
0038754165
-
Markers of cellular proliferation are expressed in cortical tubers
-
Lee A, Maldonado M, Baybis M, et al: Markers of cellular proliferation are expressed in cortical tubers. Ann Neurol 2003; 53: 668-673.
-
(2003)
Ann. Neurol.
, vol.53
, pp. 668-673
-
-
Lee, A.1
Maldonado, M.2
Baybis, M.3
-
17
-
-
0034778130
-
Neuropathology of tuberous sclerosis
-
Mizuguchi M, Takashima S: Neuropathology of tuberous sclerosis. Brain Dev 2001;23:508-515.
-
(2001)
Brain Dev.
, vol.23
, pp. 508-515
-
-
Mizuguchi, M.1
Takashima, S.2
-
18
-
-
0025905689
-
Subependymal giant cell astrocytoma: A clinical, pathologic, and flow cytometry study
-
Shepard CW, Scheithauer BW, Gomez MR, et al: Subependymal giant cell astrocytoma: A clinical, pathologic, and flow cytometry study. Neurosurgery 1991;38:864-869.
-
(1991)
Neurosurgery
, vol.38
, pp. 864-869
-
-
Shepard, C.W.1
Scheithauer, B.W.2
Gomez, M.R.3
-
19
-
-
0032856473
-
Congenital subependymal giant cell astrocytoma: Case report with prenatal ultrasonogram
-
Mirkin LD, Ey EH, Chaparro M: Congenital subependymal giant cell astrocytoma: Case report with prenatal ultrasonogram. Pediatr Radiol 1999;29:776-780.
-
(1999)
Pediatr. Radiol.
, vol.29
, pp. 776-780
-
-
Mirkin, L.D.1
Ey, E.H.2
Chaparro, M.3
-
20
-
-
0028168936
-
Two loci for tuberous sclerosis: One on 9q34 and one on 16p13
-
Povey S, Burley MW, Attwood J, et al: Two loci for tuberous sclerosis: One on 9q34 and one on 16p13. Ann Hum Genet 1994; 58:107-127.
-
(1994)
Ann. Hum. Genet.
, vol.58
, pp. 107-127
-
-
Povey, S.1
Burley, M.W.2
Attwood, J.3
-
21
-
-
0030879277
-
Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34
-
van Slegtenhorst M, de Hoogt R, Hermans C, et al: Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science 1997;277:805-808.
-
(1997)
Science
, vol.277
, pp. 805-808
-
-
van Slegtenhorst, M.1
de Hoogt, R.2
Hermans, C.3
-
22
-
-
0027770784
-
Identification and characterization of the tuberous sclerosis gene on chromosome 16
-
European Chromosome 16 Tuberous Sclerosis Consortium
-
European Chromosome 16 Tuberous Sclerosis Consortium: Identification and characterization of the tuberous sclerosis gene on chromosome 16. Cell 1993;75:1305-1315.
-
(1993)
Cell
, vol.75
, pp. 1305-1315
-
-
-
23
-
-
7144255533
-
Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products
-
van Slegtenhorst M, Nellist M, Nagelkerken B, et al: Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products. Hum Mol Genet 1998;7:1053-1057.
-
(1998)
Hum. Mol. Genet.
, vol.7
, pp. 1053-1057
-
-
van Slegtenhorst, M.1
Nellist, M.2
Nagelkerken, B.3
-
24
-
-
0032213545
-
Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles
-
Plank TL, Yeung RS, Henske EP: Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles. Cancer Res 1998;58:4766-4770.
-
(1998)
Cancer Res.
, vol.58
, pp. 4766-4770
-
-
Plank, T.L.1
Yeung, R.S.2
Henske, E.P.3
-
25
-
-
8844247335
-
Pathologic mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin
-
Hodges AK, Li S, Maynard J, et al: Pathologic mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin. Hum Mol Genet 2001;159:217-224.
-
(2001)
Hum. Mol. Genet.
, vol.159
, pp. 217-224
-
-
Hodges, A.K.1
Li, S.2
Maynard, J.3
-
26
-
-
0041758428
-
Tuberous sclerosis: From tubers to mTOR
-
Kwiatkowski DJ: Tuberous sclerosis: From tubers to mTOR. Ann Hum Genet 2003;67:87-96.
-
(2003)
Ann. Hum. Genet.
, vol.67
, pp. 87-96
-
-
Kwiatkowski, D.J.1
-
28
-
-
0029831886
-
Allelic loss is frequent in tuberous sclerosis kidney lesions but rare in brain lesions
-
Henske EP, Scheithauer BW, Short MP, et al: Allelic loss is frequent in tuberous sclerosis kidney lesions but rare in brain lesions. Am J Hum Genet 1996;59:400-406.
-
(1996)
Am. J. Hum. Genet.
, vol.59
, pp. 400-406
-
-
Henske, E.P.1
Scheithauer, B.W.2
Short, M.P.3
-
29
-
-
0034887907
-
Survey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesions
-
Niida Y, Stemmer-Rahamimov AO, Logrip M, et al: Survey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesions. Am J Hum Genet 2001;69:493-503.
-
(2001)
Am. J. Hum. Genet.
, vol.69
, pp. 493-503
-
-
Niida, Y.1
Stemmer-Rahamimov, A.O.2
Logrip, M.3
-
30
-
-
17844369428
-
The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination
-
Benvenuto G, Li S, Brown SJ, et al: The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination. Oncogene 2000;19:6306-6316.
-
(2000)
Oncogene
, vol.19
, pp. 6306-6316
-
-
Benvenuto, G.1
Li, S.2
Brown, S.J.3
-
31
-
-
0033861013
-
The TSC1 gene product, hamartin, negatively regulates cell proliferation
-
Miloloza A, Rosner M, Nellist M, et al: The TSC1 gene product, hamartin, negatively regulates cell proliferation. Hum Mol Genet 2000;9:1721-1727.
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 1721-1727
-
-
Miloloza, A.1
Rosner, M.2
Nellist, M.3
-
32
-
-
0032430241
-
Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2
-
Soucek T, Yeung RS, Hengstschlager M: Inactivation of the cyclin-dependent kinase inhibitor p27 upon loss of the tuberous sclerosis complex gene-2. Proc Natl Acad Sci U S A 1998;95:15653-15658.
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 15653-15658
-
-
Soucek, T.1
Yeung, R.S.2
Hengstschlager, M.3
-
33
-
-
0030663735
-
Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces cells to enter S phase
-
Soucek T, Pusch O, Wienecke R, et al: Role of the tuberous sclerosis gene-2 product in cell cycle control. Loss of the tuberous sclerosis gene-2 induces cells to enter S phase. J Biol Chem 1997;272:29301-29308.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 29301-29308
-
-
Soucek, T.1
Pusch, O.2
Wienecke, R.3
-
34
-
-
0030853223
-
Tuberin immunohistochemistry in brain, kidneys, and heart with or without tuberous sclerosis
-
Mizuguchi M, Kato M, Yamanouchi H, et al: Tuberin immunohistochemistry in brain, kidneys, and heart with or without tuberous sclerosis. Acta Neuropathol (Berl) 1997;94:525-531.
-
(1997)
Acta Neuropathol. (Berl.)
, vol.94
, pp. 525-531
-
-
Mizuguchi, M.1
Kato, M.2
Yamanouchi, H.3
-
35
-
-
8844274284
-
Expression of the tuberous sclerosis complex gene products, hamartin and tubenin, in central nervous system tissues
-
Gutmann DH, Zhang Y, Hasbani MJ, et al: Expression of the tuberous sclerosis complex gene products, hamartin and tubenin, in central nervous system tissues. Acta Neuropathol (Berl) 2000;5:276-286.
-
(2000)
Acta Neuropathol. (Berl.)
, vol.5
, pp. 276-286
-
-
Gutmann, D.H.1
Zhang, Y.2
Hasbani, M.J.3
-
36
-
-
0032580368
-
A role of the tuberous sclerosis gene-2 product during neuronal differentiation
-
Soucek T, Holzl G, Bernaschek G, Hengtschlager M: A role of the tuberous sclerosis gene-2 product during neuronal differentiation. Oncogene 1998;16:2197-2204.
-
(1998)
Oncogene
, vol.16
, pp. 2197-2204
-
-
Soucek, T.1
Holzl, G.2
Bernaschek, G.3
Hengtschlager, M.4
-
37
-
-
8844243450
-
Reduced TSC2 RNA and protein in sporadic astrocytomas and ependymomas
-
Wienecke R, Guha A, Maize JC, et al: Reduced TSC2 RNA and protein in sporadic astrocytomas and ependymomas. Ann Neurol 1997;15:1611-1616.
-
(1997)
Ann. Neurol.
, vol.15
, pp. 1611-1616
-
-
Wienecke, R.1
Guha, A.2
Maize, J.C.3
-
38
-
-
0037864533
-
Aspects of tuberous sclerosis complex (TSC) protein function in the brain
-
Ramesh V: Aspects of tuberous sclerosis complex (TSC) protein function in the brain. Biochem Soc Trans 2003;31:579-583.
-
(2003)
Biochem. Soc. Trans.
, vol.31
, pp. 579-583
-
-
Ramesh, V.1
-
39
-
-
0036943576
-
TSC2 null neuroepithelial cells are a model for human tuber giant cells and show activation of an mTOR pathway
-
Onda H, Crino PB, Zhang H, et al: TSC2 null neuroepithelial cells are a model for human tuber giant cells and show activation of an mTOR pathway. Mol Cell Neurosci 2002;21:561-574.
-
(2002)
Mol. Cell Neurosci.
, vol.21
, pp. 561-574
-
-
Onda, H.1
Crino, P.B.2
Zhang, H.3
-
40
-
-
0033582748
-
Gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle
-
Ito N, Rubin GM: gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle. Cell 1999;96:529-539.
-
(1999)
Cell
, vol.96
, pp. 529-539
-
-
Ito, N.1
Rubin, G.M.2
-
41
-
-
0035805162
-
Drosophila TSC1 functions with TSC2 to antagonize insulin signaling regulating cell growth, cell proliferation, and organ size
-
Potter CJ, Huang H, Xu T: Drosophila TSC1 functions with TSC2 to antagonize insulin signaling regulating cell growth, cell proliferation, and organ size. Cell 2001;105:357-368.
-
(2001)
Cell
, vol.105
, pp. 357-368
-
-
Potter, C.J.1
Huang, H.2
Xu, T.3
-
43
-
-
0034982971
-
TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
-
Gao X, Pan D: TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes Dev 2001;5:1383-1392.
-
(2001)
Genes Dev.
, vol.5
, pp. 1383-1392
-
-
Gao, X.1
Pan, D.2
-
44
-
-
0033376684
-
PTEN affects cell size, cell proliferation, and apoptosis during Drosophila eye development
-
Huang H, Potter CJ, Tao W, et al: PTEN affects cell size, cell proliferation, and apoptosis during Drosophila eye development. Development 1999;126:5365-5372.
-
(1999)
Development
, vol.126
, pp. 5365-5372
-
-
Huang, H.1
Potter, C.J.2
Tao, W.3
-
45
-
-
18544375193
-
Phosphatidylinositol-3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin
-
Dan HC, Sun M, Yang L, et al: Phosphatidylinositol-3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. J Biol Chem 2002;277:35364-35370.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 35364-35370
-
-
Dan, H.C.1
Sun, M.2
Yang, L.3
-
46
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling
-
Inoki K, Li Y, Zhu T, et al: TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling. Nat Cell Biol 2002; 4:648-657.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
-
47
-
-
0037108750
-
Tuberous sclerosis complex-1 and 2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
-
Tee AR, Fingar DC, Manning BD, et al: Tuberous sclerosis complex-1 and 2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci U S A 2002;99:13571-13576.
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 13571-13576
-
-
Tee, A.R.1
Fingar, D.C.2
Manning, B.D.3
-
48
-
-
0036714127
-
Akt regulates growth by directly phosphorylating TSC2
-
Potter CJ, Pedraza LG, Xu T: Akt regulates growth by directly phosphorylating TSC2. Nat Cell Biol 2002;4:658-665.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 658-665
-
-
Potter, C.J.1
Pedraza, L.G.2
Xu, T.3
-
49
-
-
0036712905
-
Tsc tumor suppressor proteins antagonize amino acid-TOR signaling
-
Gao X, Zhang Y, Arrazola P, et al: Tsc tumor suppressor proteins antagonize amino acid-TOR signaling. Nat Cell Biol 2002;4:699-704.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 699-704
-
-
Gao, X.1
Zhang, Y.2
Arrazola, P.3
-
50
-
-
0032520009
-
4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt (PKB) signaling pathway
-
Gingras A, Kennedy SG, O'Leary MA, et al: 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt (PKB) signaling pathway. Genes Dev 1998;12:502-513.
-
(1998)
Genes Dev.
, vol.12
, pp. 502-513
-
-
Gingras, A.1
Kennedy, S.G.2
O'Leary, M.A.3
-
51
-
-
0037097863
-
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
-
Fingar DC, Salama S, Tsou C, et al: Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev 2002;16:1472-1487.
-
(2002)
Genes Dev.
, vol.16
, pp. 1472-1487
-
-
Fingar, D.C.1
Salama, S.2
Tsou, C.3
-
52
-
-
0036501277
-
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas and upregulation of p70S6 kinase activity in TSC1 null cells
-
Kwiatkowski DJ, Zhang H, Bandura JL, et al: A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas and upregulation of p70S6 kinase activity in TSC1 null cells. Hum Mol Genet 2002;11:525-534.
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 525-534
-
-
Kwiatkowski, D.J.1
Zhang, H.2
Bandura, J.L.3
-
53
-
-
0038433304
-
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
-
Garami A, Zwartkruis FJT, Nobukuni T, et al: Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell 2003;11:1457-1466.
-
(2003)
Mol. Cell
, vol.11
, pp. 1457-1466
-
-
Garami, A.1
Zwartkruis, F.J.T.2
Nobukuni, T.3
-
54
-
-
0041356888
-
Rheb binds TSC2 and promotes S6 kinase activation in a rapamycin and farnesylation-dependent manner
-
Castro AR, Rebhun JF, Clark GJ, Quilliam LA: Rheb binds TSC2 and promotes S6 kinase activation in a rapamycin and farnesylation-dependent manner. J Biol Chem 2003;278:32493-32496.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 32493-32496
-
-
Castro, A.R.1
Rebhun, J.F.2
Clark, G.J.3
Quilliam, L.A.4
-
55
-
-
0043127125
-
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
Inoki K, Li Y, Xu T, Guan KL: Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 2003;17:1829-1835.
-
(2003)
Genes Dev.
, vol.17
, pp. 1829-1835
-
-
Inoki, K.1
Li, Y.2
Xu, T.3
Guan, K.L.4
-
56
-
-
0141925647
-
Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K
-
Tabancay AP, Gau CL, Machado IMP, et al: Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K. J Biol Chem 2003;278:39921-39930.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 39921-39930
-
-
Tabancay, A.P.1
Gau, C.L.2
Machado, I.M.P.3
-
57
-
-
0042701991
-
Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
-
Tee AR, Manning BD, Roux PP, et al: Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol 2003;13:1259-1268.
-
(2003)
Curr. Biol.
, vol.13
, pp. 1259-1268
-
-
Tee, A.R.1
Manning, B.D.2
Roux, P.P.3
-
58
-
-
0038141979
-
Rheb is a direct target of the tuberous sclerosis tumor suppressor proteins
-
Zhang Y, Gao X, Saucedo LJ, et al: Rheb is a direct target of the tuberous sclerosis tumor suppressor proteins. Nat Cell Biol 2003;5:578-581.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 578-581
-
-
Zhang, Y.1
Gao, X.2
Saucedo, L.J.3
-
59
-
-
0041827366
-
Drosophila Rheb GTPase is required for cell cycle progression and growth control
-
Patel PH, Thapar N, Guo L, et al: Drosophila Rheb GTPase is required for cell cycle progression and growth control. J Cell Sci 2003;116:3601-3610.
-
(2003)
J. Cell Sci.
, vol.116
, pp. 3601-3610
-
-
Patel, P.H.1
Thapar, N.2
Guo, L.3
-
60
-
-
0030888163
-
The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation
-
Clark GJ, Kinch MS, Rogers-Graham K, et al: The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation. J Biol Chem 1997;272:10608-10615.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 10608-10615
-
-
Clark, G.J.1
Kinch, M.S.2
Rogers-Graham, K.3
-
61
-
-
0038643484
-
Rheb promotes cell growth as a component of the insulin/TOR signaling network
-
Saucedo LJ, Gao X, Chiarelli DA, et al: Rheb promotes cell growth as a component of the insulin/TOR signaling network. Nat Cell Biol 2003;5:566-571.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 566-571
-
-
Saucedo, L.J.1
Gao, X.2
Chiarelli, D.A.3
-
62
-
-
0038304516
-
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
-
Stocker H, Radimerski, Schindelholz B, et al: Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat Cell Biol 2003;5:559-565.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 559-565
-
-
Stocker, H.1
Radimerski, A.2
Schindelholz, B.3
-
64
-
-
15844384256
-
A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice
-
Fero ML, Rivkin M, Tasch M, et al: A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell 1996;85:733-744.
-
(1996)
Cell
, vol.85
, pp. 733-744
-
-
Fero, M.L.1
Rivkin, M.2
Tasch, M.3
-
65
-
-
0027996238
-
Predisposition to renal carcinoma in the Eker rat is determined by germline mutation of the tuberous sclerosis (TSC2) gene
-
Yeung RS, Xiao GH, Jin F, et al: Predisposition to renal carcinoma in the Eker rat is determined by germline mutation of the tuberous sclerosis (TSC2) gene. Proc Natl Acad Sci U S A 1994;91: 11413-11416.
-
(1994)
Proc. Natl. Acad. Sci. U. S. A.
, vol.91
, pp. 11413-11416
-
-
Yeung, R.S.1
Xiao, G.H.2
Jin, F.3
-
66
-
-
0030663268
-
Subependymal astrocytic hamartomas in the Eker rat model of tuberous sclerosis
-
Yeung RS, Katsetos CD, Klein-Szanto A: Subependymal astrocytic hamartomas in the Eker rat model of tuberous sclerosis. Am J Pathol 1997;151:1477-1486.
-
(1997)
Am. J. Pathol.
, vol.151
, pp. 1477-1486
-
-
Yeung, R.S.1
Katsetos, C.D.2
Klein-Szanto, A.3
-
67
-
-
0036250938
-
Rat genetics: Attaching physiology and pharmacology to the genome
-
Jacob HJ, Kwitek AE: Rat genetics: Attaching physiology and pharmacology to the genome. Nat Rev Genet 2002;3:33-42.
-
(2002)
Nat. Rev. Genet.
, vol.3
, pp. 33-42
-
-
Jacob, H.J.1
Kwitek, A.E.2
-
68
-
-
0032954092
-
Insights into cancer from transgenic mouse models
-
Macleod KF, Jacks T: Insights into cancer from transgenic mouse models. J Pathol 1999;187:43-60.
-
(1999)
J. Pathol.
, vol.187
, pp. 43-60
-
-
Macleod, K.F.1
Jacks, T.2
-
69
-
-
0033559663
-
Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice
-
Kobayashi T, Minowa O, Kuno J, et al: Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice. Cancer Res 1999;59: 1206-1211.
-
(1999)
Cancer Res.
, vol.59
, pp. 1206-1211
-
-
Kobayashi, T.1
Minowa, O.2
Kuno, J.3
-
70
-
-
0035902509
-
A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice
-
Kobayashi T, Minowa O, Sugitani Y, et al: A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice. Proc Natl Acad Sci U S A 2001;98:8762-8767.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 8762-8767
-
-
Kobayashi, T.1
Minowa, O.2
Sugitani, Y.3
-
71
-
-
0035167932
-
Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs
-
Dabora SL, Jozwiak S, Franz DN, et al: Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs. Am J Hum Genet 2001;68:64-80.
-
(2001)
Am. J. Hum. Genet.
, vol.68
, pp. 64-80
-
-
Dabora, S.L.1
Jozwiak, S.2
Franz, D.N.3
-
72
-
-
0036713644
-
Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures
-
Uhlmann EJ, Wong M, Baldwin RL, et al: Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures. Ann Neurol 2002;53:285-296.
-
(2002)
Ann. Neurol.
, vol.53
, pp. 285-296
-
-
Uhlmann, E.J.1
Wong, M.2
Baldwin, R.L.3
-
73
-
-
1842662634
-
Expression profiling in tuberous sclerosis (TSC) knockout mouse astrocytes to characterize human TSC brain pathology
-
Ess KC, Uhlmann EJ, Li W, et al: Expression profiling in tuberous sclerosis (TSC) knockout mouse astrocytes to characterize human TSC brain pathology. Glia 2004;46:28-40
-
(2004)
Glia
, vol.46
, pp. 28-40
-
-
Ess, K.C.1
Uhlmann, E.J.2
Li, W.3
-
74
-
-
3943106696
-
Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation
-
Uhlmann EJ, Li W, Scheidenhelm D, et al: Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation. Glia 2004;47:180-188.
-
(2004)
Glia
, vol.47
, pp. 180-188
-
-
Uhlmann, E.J.1
Li, W.2
Scheidenhelm, D.3
-
75
-
-
0041343133
-
Impaired astrocyte glutamate transport in a mouse epilepsy model of tuberous sclerosis
-
Wong M, Ess KC, Uhlmann EJ, et al: Impaired astrocyte glutamate transport in a mouse epilepsy model of tuberous sclerosis. Ann Neurol 2003;54:251-256.
-
(2003)
Ann. Neurol.
, vol.54
, pp. 251-256
-
-
Wong, M.1
Ess, K.C.2
Uhlmann, E.J.3
-
76
-
-
0346059618
-
Optic nerve glioma in mice requires Nf1 gene inactivation and Nf1 brain heterozygosity
-
Bajenaru ML, Hernandez MR, Perry A, et al: Optic nerve glioma in mice requires Nf1 gene inactivation and Nf1 brain heterozygosity. Cancer Res 2003;63:8573-8577.
-
(2003)
Cancer Res.
, vol.63
, pp. 8573-8577
-
-
Bajenaru, M.L.1
Hernandez, M.R.2
Perry, A.3
-
77
-
-
0035993192
-
Farnesyl transferase inhibitors as anticancer agents
-
Haluska P, Dy GK, Adjei AA: Farnesyl transferase inhibitors as anticancer agents. Eur J Cancer 2002;38:1685-1700.
-
(2002)
Eur. J. Cancer
, vol.38
, pp. 1685-1700
-
-
Haluska, P.1
Dy, G.K.2
Adjei, A.A.3
|