"Catch 222," the effects of symmetry on ligand binding and catalysis in R67 dihydrofolate reductase as determined by mutations at Tyr-69

Journal of Biological Chemistry

Volumn 279, Issue 45, 2004, Pages 47003-47009

  Stinnett, Lori G ^a   Smiley, R Derike ^a   Hicks, Stephanie N ^a   Howell, Elizabeth E ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALORIMETRY; CATALYSIS; CHEMICAL BONDS; MUTAGENESIS; REACTION KINETICS; TITRATION;

DIHYDROFOLATE; LIGAND BINDING;

ENZYMES;

AMINO ACID; DIHYDROFOLATE REDUCTASE; HYDROXYL GROUP; LEUCINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TYROSINE;

ARTICLE; CALORIMETRY; CATALYSIS; GENE MUTATION; LIGAND BINDING; MUTANT; NONHUMAN; PRIORITY JOURNAL; STEADY STATE; TITRIMETRY; WILD TYPE;

BINDING SITES; CALORIMETRY; CATALYSIS; DIMERIZATION; ESCHERICHIA COLI; HYDROGEN-ION CONCENTRATION; IONS; KINETICS; LEUCINE; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; NADP; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TETRAHYDROFOLATE DEHYDROGENASE; THERMODYNAMICS; TYROSINE;

EID: 8744228147     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M404485200     Document Type: Article

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