Effects of single tryptophan mutations on R67 dihydrofolate reductase

Biochemistry

Volumn 39, Issue 13, 2000, Pages 3678-3689

  West, Freddie W ^a   Seo, Han Seok ^a   Bradrick, Thomas D ^b   Howell, Elizabeth E ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; DIMER; TRYPTOPHAN;

ANISOTROPY; ARTICLE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME KINETICS; ENZYME STABILITY; GENE MUTATION; GENE STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING;

BINDING SITES; CHROMATOGRAPHY, GEL; CIRCULAR DICHROISM; ENERGY TRANSFER; HYDROGEN-ION CONCENTRATION; KINETICS; MUTAGENESIS, SITE-DIRECTED; NADP; PHENYLALANINE; PROTEIN FOLDING; QUANTUM THEORY; R FACTORS; SPECTROMETRY, FLUORESCENCE; TETRAHYDROFOLATE DEHYDROGENASE; TRYPTOPHAN;

EID: 0034603784     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi992195x     Document Type: Article

References (49)

1. Eftink, M. R. (1994) Biophys. J. 66, 482-501.
2. Helms, M. K., Hazlett, T. L., Mizuguchi, H., Hasemann, C. A., Uyeda, K., and Jameson, D. M. (1998) Biochemistry 37, 14057-14064.
3. Dijkstra, S. D., Broos, J., Visser, A. J. W. G., van Hock, A., and Robillard, G. T. (1997) Biochemistry 36, 4860-4866.
4. Barry, J. K., and Matthews, K. S. (1997) Biochemistry 36, 15632-15642.
5. Kombo, D. C., Nemethy, G., Gibson, K. D., Ross, A. J. B., Rackovsky, S., and Scheraga, H. A. (1996) J. Protein Chem. 15, 77-86.
6. Vos, R., Engelborghs, Y., Izard, J., and Baty, D. (1995) Biochemistry 34, 1734-1743.
7. Weitzman, C., Consler, T. G., and Kaback, H. R. (1995) Protein Sci. 4, 2310-2318.
8. Szpikowska, B. K., Beechem, J. M., Sherman, M. A., and Mas, M. T. (1994) Biochemistry 33, 2217-2225.
9. Mann, C. J., Royer, C. A., and Matthews, C. R. (1993) Protein Sci. 2, 1853-1861.
10. Royer, C. A., Mann, C. J., and Matthews, C. R. (1993) Protein Sci. 2, 1844-1852.
11. Reece, L. J., Nichols, R., Ogden, R. C., and Howell, E. E. (1991) Biochemistry 30, 10895-10904.
12. Nichols, R., Weaver, C. D., Eisenstein, E., Blakley, R. L., Appleman, J., Huang, T.-H., Huang, F.-Y., and Howell, E. E. (1993) Biochemistry 32, 1695-1706.
13. Zhuang, P., Eisenstein, E., and Howell, E. E. (1994) Biochemistry 33, 4237-4244.
14. Bradrick, T. D., Shattuck, C., Strader, M. B., Wicker, C., Eisenstein, E., and Howell, E. E. (1996) J. Biol. Chem. 271, 28031-28037.
15. Matthews, D. A., Smith, S. L., Baccanari, D. P., Burchall, J. J., Oatley, S. J., and Kraut, J. (1986) Biochemistry 25, 4194-4204.
16. Amyes, S. G. B., and Gemmel, C. G. (1992) J. Med. Microbiol. 36, 4-29.
17. Narayana, N., Matthews, D. A., Howell, E. E., and Xuong, N.-H. (1995) Nat. Struct. Biol. 2, 1018-1025.
18. Zieg, J., Maples, V. F., and Kushner, S. R. (1978) J. Bacteriol. 134, 958-966.
19. Tartof, K. D., and Hobbs, C. A. (1987) BRL Focus 9, 12.
20. Vermersch, P. S., Klass, M. R., and Bennett, G. N. (1986) Gene 41, 289-297.
21. Gornall, A. G., Bardawill, C. J., and David, M. M. (1949) J. Biol. Chem. 177, 751-766.
22. Howell, E. E., Warren, M. S., Booth, C. L. J., Villafranca, J. E., and Kraut, J. (1987) Biochemistry 26, 8591-8598.
23. Ellis, K. J., and Morrison, J. F. (1982) Methods Enzymol. 87, 405-426.
24. Cleland, W. W. (1963) Biochim. Biophys. Acta 67, 104-137.
25. Zhuang, P., Yin, M., Holland, J. C., Peterson, C. B., and Howell, E. E. (1993) J. Biol. Chem. 268, 22672-22679.
26. Dunn, S. M. J., Lanigan, T. M., and Howell, E. E. (1990) Biochemistry 29, 8569-8576.
27. Beddard, G. S., Fleming, G. R., Porter, G., and Robbins, R. I. (1980) Philos. Tran.s R. Soc London A: Math. Phys. Sci. 298, 321-324.
28. Demchenko, A. P. (1986) Ultraviolet Spectroscopy of Proteins, pp 24-24, Springer-Verlag, Berlin and Heidelberg, Germany.
29. Pace, C. N., Shirley, B. A., and Thompson, J. A. (1990) in Protein Structure: A Practical Approach (Creighton, T. E., Ed.) pp 311-330, IRL Press, Oxford, England.
30. Prasad, K., Lippoldt, R. E., and Edelhoch, H. (1985) Biochemistry 24, 6421-6427.
31. Murray, M. B., Tadaki, D. K., Campion, S. R., Lamerdin, J. A., Serpersu, E. H., Bradrick. T. D., and Niyogi, S. K. (1998) Protein Eng. 11, 1041-1050.
32. Provencher, S. W., and Glöckner, J. (1981) Biochemistry 20, 33-37.
33. Green, S. M., Knutson, J. R., and Hensley, P. (1990) Biochemistry 29, 9159-9168.
34. Woody, R. W. (1995) Methods Enzymol. 246, 34-70.
35. Eftink, M. R. (1991) Methods Biochem. Anal. 35, 127-205.
36. Park, H., Zhuang, P., Nichols, R., and Howell, E. E. (1997) J. Biol. Chem. 272, 2252-2258.
37. Kyte, J., and Doolittle, R. F. (1982) J. Mol. Biol. 157, 105-132.
38. Bowie, J. U., Reidhaar-Olson, J. F., Lim, W. A., and Sauer, R. T. (1990) Science 247, 1306-1310.
39. Cordes, M. H. J., and Sauer, R. J. (1999) Protein Sci. 8, 318-325.
40. Chen, Y., and Barkley, M. D. (1998) Biochemistry 37, 9976-9982.
41. Vincent, M., Brochon, J.-C., Merola, F., Jordi, W., and Gallay, J. (1988) Biochemistry 27, 8752-8761.
42. Ross, J. B. A., Rousslang, K. W., and Brand, L. (1981) Biochemistry 20, 4361-4369.
43. Ross, J. B. A., Schmidt, C. J., and Brand, L. (1981) Biochemistry 20, 4369-4377.
44. Davenport, L., Knutson, J. R., and Brand, L. (1986) Faraday Discuss. Chem. Soc. 81, 81-94.
45. Davenport, L., Knutson, J. R., and Brand, L. (1986) Biochemistry 25, 1186-1195.
46. Eftink, M. R., Wasylewski, Z., and Ghiron, C. A. (1987) Biochemistry 26, 8338-8346.
47. Knutson, J. R., Beechem, J. M., and Brand, L. (1983) Chem. Phys. Lett. 102, 501-507.
48. Kim, S.-J., Chowdhury, F. N., Stryjewski, W., Younathan, E. S., Russo, P. S., and Barkley, M. D. (1992) Biophys. J. 65, 215-226.
49. Creighton, T. E. (1993) Proteins W. H. Freemand and Co.: New York; p 4.