Highly efficient DSB-free base editing for streptomycetes with CRISPR-BEST

Proceedings of the National Academy of Sciences of the United States of America

Volumn 116, Issue 41, 2019, Pages 20366-20375

  Tong, Yaojun ^a   Whitford, Christopher M ^a,b   Robertsen, Helene L ^a   Blin, Kai ^a   Jørgensen, Tue S ^a   Klitgaard, Andreas K ^a   Gren, Tetiana ^a   Jiang, Xinglin ^a   Weber, Tilmann ^a   Lee, Sang Yup ^a,c  

^a Chalmers University of Technology   (Denmark)

^b BIELEFELD UNIVERSITY   (Germany)

^c Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Adenosine deaminase; CRISPR base editor; Cytidine deaminase; Genome editing; Streptomycetes

Indexed keywords

ADENOSINE; ADENOSINE DEAMINASE; CYTIDINE; CYTIDINE DEAMINASE; GUANOSINE; GUIDE RNA; MOCIMYCIN; NUCLEOTIDE; THYMIDINE; BACTERIAL DNA;

AMINO ACID SUBSTITUTION; ARTICLE; BASE PAIRING; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; CRISPR BASE EDITING SYSTEM; DOUBLE STRANDED DNA BREAK; GENE EDITING; GENE INACTIVATION; GENE KNOCKOUT; GENE MUTATION; GENETIC MANIPULATION; GENOME-WIDE ASSOCIATION STUDY; MUTANT; NONHUMAN; PLASMID; PRIORITY JOURNAL; RNA PROCESSING; STOP CODON; STREPTOMYCETACEAE; BACTERIAL GENOME; CRISPR CAS SYSTEM; GENE EXPRESSION REGULATION; GENETICS; STREPTOMYCES COELICOLOR;

CRISPR-CAS SYSTEMS; DNA, BACTERIAL; GENE EDITING; GENE EXPRESSION REGULATION, BACTERIAL; GENOME, BACTERIAL; GENOME-WIDE ASSOCIATION STUDY; PLASMIDS; STREPTOMYCES COELICOLOR;

EID: 85073071217     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1913493116     Document Type: Article

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