Polyketide Bioderivatization Using the Promiscuous Acyltransferase KirCII

ACS Synthetic Biology

Volumn 6, Issue 3, 2017, Pages 421-427

  Musiol Kroll, Ewa M ^a,b,c   Zubeil, Florian ^c   Schafhauser, Thomas ^c   Härtner, Thomas ^c   Kulik, Andreas ^c   McArthur, John ^d   Koryakina, Irina ^d   Wohlleben, Wolfgang ^b,c   Grond, Stephanie ^c   Williams, Gavin J ^d   Lee, Sang Yup ^a,e   Weber, Tilmann ^a,b,c  

^a Chalmers University of Technology   (Denmark)

^b German Centre for Infection Research (DZIF)   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d NORTH CAROLINA STATE UNIVERSITY   (United States)

^e Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

antibiotic; click chemistry; engineering; kirromycin; polyketide synthase; trans acyltransferase

Indexed keywords

MOCIMYCIN; NEW DRUG; POLYKETIDE; ACYLTRANSFERASE; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; POLYKETIDE SYNTHASE; PYRIDONE DERIVATIVE;

ANTIMICROBIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CLICK CHEMISTRY; CONTROLLED STUDY; CYCLOADDITION; DERIVATIZATION; DRUG MECHANISM; DRUG PURIFICATION; DRUG SYNTHESIS; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MOLECULAR PROBE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REGIOSELECTIVITY; BACTERIUM; METABOLISM;

ACYLTRANSFERASES; ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL PROTEINS; POLYKETIDE SYNTHASES; POLYKETIDES; PYRIDONES;

EID: 85017588486     PISSN: None     EISSN: 21615063     Source Type: Journal    
DOI: 10.1021/acssynbio.6b00341     Document Type: Article

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