Cytosine, but not adenine, base editors induce genome-wide off-target mutations in rice

Science

Volumn 364, Issue 6437, 2019, Pages 292-295

  Jin, Shuai ^a,b   Zong, Yuan ^a,b   Gao, Qiang ^a   Zhu, Zixu ^a,b   Wang, Yanpeng ^a   Qin, Peng ^c   Liang, Chengzhi ^a,b   Wang, Daowen ^a,b   Qiu, Jin Long ^a   Zhang, Feng ^d   Gao, Caixia ^a,b  

^a INSTITUTE OF GENETICS AND DEVELOPMENTAL BIOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c SICHUAN AGRICULTURAL UNIVERSITY   (China)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; CYTOSINE; PLANT RNA; SINGLE GUIDE RNA; THYMINE; UNCLASSIFIED DRUG;

AMINO ACID; BIOTECHNOLOGY; DISEASE TREATMENT; GENOME; GENOMICS; INDUCED RESPONSE; MUTATION; RICE;

ARTICLE; BASE EDITING; GENE EDITING; GENE MUTATION; GENETIC ANALYSIS; NONHUMAN; PRIORITY JOURNAL; RICE; SINGLE NUCLEOTIDE POLYMORPHISM; WHOLE GENOME SEQUENCING; AGROBACTERIUM; DNA MUTATIONAL ANALYSIS; GENETICS; MICROBIOLOGY; MUTATION; ORYZA; PROCEDURES;

ADENINE; AGROBACTERIUM; CYTOSINE; DNA MUTATIONAL ANALYSIS; GENE EDITING; MUTATION; ORYZA; POLYMORPHISM, SINGLE NUCLEOTIDE; WHOLE GENOME SEQUENCING;

EID: 85063014306     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaw7166     Document Type: Article

References (17)

1. M. J. Landrum et al., Nucleic Acids Res. 44, D862-D868 (2016).
2. S. Henikoff, L. Comai, Annu. Rev. Plant Biol. 54, 375-401 (2003).
3. A. C. Komor, Y. B. Kim, M. S. Packer, J. A. Zuris, D. R. Liu, Nature 533, 420-424 (2016).
4. K. Nishida et al., Science 353, aaf8729 (2016).
5. N. M. Gaudelli et al., Nature 551, 464-471 (2017).
6. H. A. Rees, D. R. Liu, Nat. Rev. Genet. 19, 770-788 (2018).
7. D. Kim et al., Nat. Biotechnol. 35, 475-480 (2017).
8. P. Liang et al., Nat. Commun. 10, 67 (2019).
9. H. K. Lee et al., Nat. Commun. 9, 4804 (2018).
10. H. A. Rees et al., Nat. Commun. 8, 15790 (2017).
11. J. M. Gehrke et al., Nat. Biotechnol. 36, 977-982 (2018).
12. S. Bae, J. Park, J. S. Kim, Bioinformatics 30, 1473-1475 (2014).
13. R. S. Harris, S. K. Petersen-Mahrt, M. S. Neuberger, Mol. Cell 10, 1247-1253 (2002).
14. I. B. Rogozin et al., Nat. Immunol. 8, 647-656 (2007).
15. E. H. Radany et al., Mutat. Res. 461, 41-58 (2000).
16. E. Zuo et al., Science 364, 289-292 (2019).
17. Y. B. Kim et al., Nat. Biotechnol. 35, 371-376 (2017).