The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity

Frontiers in Microbiology

Volumn 10, Issue , 2019, Pages

  Ogando, Natacha S ^a   Ferron, Francois ^b,c   Decroly, Etienne ^b   Canard, Bruno ^b   Posthuma, Clara C ^a   Snijder, Eric J ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b AIX MARSEILLE UNIVERSITY   (France)

^c European Virus Bioinformatics Center (EVBC)   (Germany)

Author keywords

coronavirus; exoribonuclease; N7 methyltransferase; nidovirus; non structural protein 14; proofreading

Indexed keywords

AURINTRICARBOXYLIC ACID; BETA INTERFERON; DNA DIRECTED DNA POLYMERASE BETA; EXONUCLEASE; EXORIBONUCLEASE; METHYLTRANSFERASE; NONSTRUCTURAL PROTEIN 1; NUCLEOTIDYLTRANSFERASE; RNA DIRECTED RNA POLYMERASE; RNA POLYMERASE; S ADENOSYLMETHIONINE; SINDBIS VIRUS NONSTRUCTURAL PROTEIN 4; ZINC BINDING PROTEIN;

ALANINE-SCANNING MUTAGENESIS; ARTERIVIRUS; CORONAVIRIDAE INFECTION; DOUBLE-STRANDED RNA VIRUS; ENZYME ACTIVITY; GENE EXPRESSION; GENE KNOCKOUT; GENOME ANALYSIS; HUMAN; IMMUNE EVASION; INNATE IMMUNITY; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; MURINE HEPATITIS VIRUS; NIDOVIRALES; NIDOVIRALES INFECTION; NONHUMAN; PATHOGENESIS; PHENOTYPIC VARIATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; RNA CAPPING; RNA REPLICATION; RNA SYNTHESIS; SARS CORONAVIRUS; SEQUENCE ALIGNMENT; SEVERE ACUTE RESPIRATORY SYNDROME; SITE DIRECTED MUTAGENESIS; VIRUS CELL INTERACTION; VIRUS GENOME;

EID: 85072725123     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2019.01813     Document Type: Review

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