Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2′-o-methyltransferase nsp10/nsp16 complex

PLoS Pathogens

Volumn 7, Issue 5, 2011, Pages

  Decroly, Etienne ^a   Debarnot, Claire ^a   Ferron, François ^a   Bouvet, Mickael ^a   Coutard, Bruno ^a   Imbert, Isabelle ^a   Gluais, Laure ^a   Papageorgiou, Nicolas ^a   Sharff, Andrew ^b   Bricogne, Gérard ^b   Ortiz Lombardia, Miguel ^a   Lescar, Julien ^a,c   Canard, Bruno ^a  

^a CNRS   (France)

^b GLOBAL PHASING LTD   (United Kingdom)

^c NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLTRANSFERASE; RNA; S ADENOSYLMETHIONINE; SARS CORONAVIRUS RNA CAP 2' O METHYLTRANSFERASE NSP10 NSP16 COMPLEX; SINEFUNGIN; UNCLASSIFIED DRUG; ADENOSINE; CAPPED RNA; DRUG DERIVATIVE; MAGNESIUM; NSP10 PROTEIN, SARS VIRUS; NSP16 PROTEIN, SARS VIRUS; RNA 2' O METHYLTRANSFERASE; RNA 2'-O-METHYLTRANSFERASE; VIRUS PROTEIN; VIRUS RNA;

ARTICLE; BINDING SITE; CATALYSIS; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVITY; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RNA BINDING; RNA CAPPING; SARS CORONAVIRUS; CHEMISTRY; GENETICS; METABOLISM; MUTATION; PLASMID;

RNA VIRUSES; SARS CORONAVIRUS;

ADENOSINE; CRYSTALLIZATION; MAGNESIUM; METHYLTRANSFERASES; MUTATION; PLASMIDS; PROTEIN BINDING; RNA CAPS; RNA, VIRAL; S-ADENOSYLMETHIONINE; SARS VIRUS; VIRAL NONSTRUCTURAL PROTEINS;

EID: 79958067824     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002059     Document Type: Article

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