Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay

Antiviral Research

Volumn 144, Issue , 2017, Pages 330-339

  Aouadi, Wahiba ^a   Eydoux, Cécilia ^a   Coutard, Bruno ^a   Martin, Baptiste ^a   Debart, Françoise ^b   Vasseur, Jean Jacques ^b   Contreras, Jean Marie ^c   Morice, Christophe ^c   Quérat, Gilles ^d   Jung, Marie Louise ^c   Canard, Bruno ^a   Guillemot, Jean Claude ^a   Decroly, Etienne ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b UNIVERSITÉ DE MONTPELLIER   (France)

^c Prestwick Chemical   (France)

^d Aix Marseille University IRD 190 Inserm 1207   (France)

Author keywords

Antiviral; Coronavirus; Flavivirus; HTRF; Inhibitor; Methyltransferase

Indexed keywords

ANTIVIRUS AGENT; GUANINE; METHYLTRANSFERASE INHIBITOR; NSP14 PROTEIN; SINEFUNGIN; UNCLASSIFIED DRUG; VIRAL PROTEIN; VIRUS RNA; EXORIBONUCLEASE; METHYLTRANSFERASE; NSP14 PROTEIN, SARS CORONAVIRUS;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG SCREENING; DRUG SPECIFICITY; ENZYME INHIBITION; FLUORESCENCE ANALYSIS; HIGH THROUGHPUT SCREENING; HOMOGENOUS TIME RESOLVED FLUORESCENCE; IC50; NONHUMAN; PRIORITY JOURNAL; RNA METHYLATION; RNA STRUCTURE; SARS CORONAVIRUS; VIRUS CAPSID; VIRUS REPLICATION; ANTAGONISTS AND INHIBITORS; ENZYMOLOGY; FLUOROMETRY; HUMAN; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; PRECLINICAL STUDY; PROCEDURES;

ANTIVIRAL AGENTS; DRUG EVALUATION, PRECLINICAL; EXORIBONUCLEASES; FLUOROMETRY; HUMANS; INHIBITORY CONCENTRATION 50; METHYLTRANSFERASES; MICROBIAL SENSITIVITY TESTS; SARS VIRUS; VIRAL NONSTRUCTURAL PROTEINS;

EID: 85021847233     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2017.06.021     Document Type: Article

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