Intensive care unit–acquired weakness: unanswered questions and targets for future research: .

F1000Research

Volumn 8, Issue , 2019, Pages

  Piva, Simone ^a,b   Fagoni, Nazzareno ^a,b   Latronico, Nicola ^a,b  

^a UNIVERSITY OF BRESCIA   (Italy)

^b SPEDALI CIVILI   (Italy)

Author keywords

Critical Illness Myopathy; Critical Illness Polyneuromyopathy; Critical Illness Polyneuropathy; ICU acquired weakness; Muscle atrophy CRIMYNE; Muscle weakness

Indexed keywords

ARTIFICIAL FEEDING; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; DELIRIUM; DIAGNOSTIC TEST; DIAPHRAGM DISEASE; GRIP STRENGTH; HUMAN; INTENSIVE CARE UNIT ACQUIRED WEAKNESS; LIMB WEAKNESS; MOBILIZATION; MUSCLE ATROPHY; MUSCLE METABOLISM; MUSCLE STRENGTH; MUSCLE WEAKNESS; MYOPATHY; POLYNEUROPATHY; REVIEW; ARTIFICIAL VENTILATION; COMPLICATION; DIAPHRAGM; HAND STRENGTH; INTENSIVE CARE UNIT; MUSCLE DISEASE; PATHOPHYSIOLOGY;

CRITICAL ILLNESS; DIAPHRAGM; HAND STRENGTH; HUMANS; INTENSIVE CARE UNITS; MUSCLE WEAKNESS; MUSCULAR ATROPHY; MUSCULAR DISEASES; POLYNEUROPATHIES; RESPIRATION, ARTIFICIAL;

EID: 85065675950     PISSN: None     EISSN: 20461402     Source Type: Journal    
DOI: 10.12688/f1000research.17376.1     Document Type: Review

References (86)

1. Stevens RD, Marshall SA, Cornblath DR: A framework for diagnosing and classifying intensive care unit-acquired weakness. Crit Care Med. 2009;37(10 Suppl):S299–308. 20046114 10.1097/CCM.0b013e3181b6ef67
2. Latronico N, Bolton CF: Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis. Lancet Neurol. 2011;10(10):931–41. 21939902 10.1016/S1474-4422(11)70178-8
3. Fan E, Cheek F, Chlan L: An official American Thoracic Society Clinical Practice guideline: the diagnosis of intensive care unit-acquired weakness in adults. Am J Respir Crit Care Med. 2014;190(12):1437–46. 25496103 10.1164/rccm.201411-2011ST
4. Latronico N, Herridge M, Hopkins RO: The ICM research agenda on intensive care unit-acquired weakness. Intensive Care Med. 2017;43(9):1270–81. 28289812 10.1007/s00134-017-4757-5
5. Kelmenson DA, Held N, Allen RR: Outcomes of ICU Patients With a Discharge Diagnosis of Critical Illness Polyneuromyopathy: A Propensity-Matched Analysis. Crit Care Med. 2017;45(12):2055–60. 29019851 10.1097/CCM.0000000000002763 5693740 F1000 Recommendation
6. Latronico N, Rasulo FA: Presentation and management of ICU myopathy and neuropathy. Curr Opin Crit Care. 2010;16(2):123–7. 20075723 10.1097/MCC.0b013e328336a229
7. Sharshar T, Citerio G, Andrews PJ: Neurological examination of critically ill patients: a pragmatic approach. Report of an ESICM expert panel. Intensive Care Med. 2014;40(4):484–95. 24522878 10.1007/s00134-014-3214-y
8. Latronico N, Gosselink R: A guided approach to diagnose severe muscle weakness in the intensive care unit. Rev Bras Ter Intensiva. 2015;27(3):199–201. 26376161 10.5935/0103-507X.20150036 4592111
9. Dres M, Goligher EC, Heunks LMA: Critical illness-associated diaphragm weakness. Intensive Care Med. 2017;43(10):1441–52. 28917004 10.1007/s00134-017-4928-4 F1000 Recommendation
10. Batt J, Herridge M, Dos Santos C: Mechanism of ICU-acquired weakness: skeletal muscle loss in critical illness. Intensive Care Med. 2017;43(12):1844–6. 28283700 10.1007/s00134-017-4758-4 F1000 Recommendation
11. Renaud G, Llano-Diez M, Ravara B: Sparing of muscle mass and function by passive loading in an experimental intensive care unit model. J Physiol. 2013;591(5):1385–402. 23266938 10.1113/jphysiol.2012.248724 3607878
12. Hermans G, Clerckx B, Vanhullebusch T: Interobserver agreement of Medical Research Council sum-score and handgrip strength in the intensive care unit. Muscle Nerve. 2012;45(1):18–25. 22190301 10.1002/mus.22219
13. Parry SM, Berney S, Granger CL: A new two-tier strength assessment approach to the diagnosis of weakness in intensive care: an observational study. Crit Care. 2015;19:52. 25882719 10.1186/s13054-015-0780-5 4344764 F1000 Recommendation
14. Hough CL, Lieu BK, Caldwell ES: Manual muscle strength testing of critically ill patients: feasibility and interobserver agreement. Crit Care. 2011;15(1):R43. 21276225 10.1186/cc10005 3221972 F1000 Recommendation
15. Leijten FS, Harinck-de Weerd JE, Poortvliet DC: The role of polyneuropathy in motor convalescence after prolonged mechanical ventilation. JAMA. 1995;274(15):1221–5. 7563512 10.1001/jama.1995.03530150045032
16. Latronico N, Bertolini G, Guarneri B: Simplified electrophysiological evaluation of peripheral nerves in critically ill patients: the Italian multi-centre CRIMYNE study. Crit Care. 2007;11(1):R11. 17254336 10.1186/cc5671 2151880
17. Latronico N, Nattino G, Guarneri B: Validation of the peroneal nerve test to diagnose critical illness polyneuropathy and myopathy in the intensive care unit: the multicentre Italian CRIMYNE-2 diagnostic accuracy study [version 1; peer review: awaiting peer review]. F1000Res. 2014;3:127. 25309729.1 10.12688/f1000research.3933.1
18. Kelmenson DA, Quan D, Moss M: What is the diagnostic accuracy of single nerve conduction studies and muscle ultrasound to identify critical illness polyneuromyopathy: a prospective cohort study. Crit Care. 2018;22(1):342. 30558638 10.1186/s13054-018-2281-9 6296115 F1000 Recommendation
19. Moss M, Yang M, Macht M: Screening for critical illness polyneuromyopathy with single nerve conduction studies. Intensive Care Med. 2014;40(5):683–90. 24623137 10.1007/s00134-014-3251-6
20. Kelmenson DA, Quan D, Nordon-Craft A: Electrophysiological abnormalities can differentiate pre-hospital discharge functional status in critically ill patients with normal strength. Intensive Care Med. 2016;42(9):1504–5. 27334267 10.1007/s00134-016-4425-1 4992460 F1000 Recommendation
21. Hermans G, Van Mechelen H, Bruyninckx F: Predictive value for weakness and 1-year mortality of screening electrophysiology tests in the ICU. Intensive Care Med. 2015;41(12):2138–48. 26266842 10.1007/s00134-015-3979-7
22. Rafferty G, Moxham J: Assessment of peripheral and respiratory muscle strength in ICU. In Textbook of Post-ICU Medicine: The Legacy of Critical Care(eds. Stevens RD., Hart N. & Herridge MS.) (Oxford University Press).2014;530–547. 10.1093/med/9780199653461.003.0047
23. Latronico N, Fagoni N, Gobbo M: Neuromuscular Electrical Stimulation in Critically Ill Patients. Essentials of Neuroanesthesia.2017;771–781. 10.1016/B978-0-12-805299-0.00046-4
24. Mourtzakis M, Parry S, Connolly B: Skeletal Muscle Ultrasound in Critical Care: A Tool in Need of Translation. Ann Am Thorac Soc. 2017;14(10):1495–503. 28820608 10.1513/AnnalsATS.201612-967PS 5718569 F1000 Recommendation
25. Witteveen E, Sommers J, Wieske L: Diagnostic accuracy of quantitative neuromuscular ultrasound for the diagnosis of intensive care unit-acquired weakness: a cross-sectional observational study. Ann Intensive Care. 2017;7(1):40. 28382599 10.1186/s13613-017-0263-8 5382120 F1000 Recommendation
26. Jung B, Moury PH, Mahul M: Diaphragmatic dysfunction in patients with ICU-acquired weakness and its impact on extubation failure. Intensive Care Med. 2016;42(5):853–61. 26572511 10.1007/s00134-015-4125-2 F1000 Recommendation
27. Telleman JA, Stellingwerff MD, Brekelmans GJ: Nerve ultrasound: A useful screening tool for peripheral nerve sheath tumors in NF1? Neurology. 2017;88(17):1615–22. 28341644 10.1212/WNL.0000000000003870 F1000 Recommendation
28. Demoule A, Jung B, Prodanovic H: Diaphragm dysfunction on admission to the intensive care unit. Prevalence, risk factors, and prognostic impact-a prospective study. Am J Respir Crit Care Med. 2013;188(2):213–9. 23641946 10.1164/rccm.201209-1668OC
29. Bolton CF, Gilbert JJ, Hahn AF: Polyneuropathy in critically ill patients. J Neurol Neurosurg Psychiatry. 1984;47(11):1223–31. 6094735 10.1136/jnnp.47.11.1223 1028091
30. Dres M, Dubé BP, Mayaux J: Coexistence and Impact of Limb Muscle and Diaphragm Weakness at Time of Liberation from Mechanical Ventilation in Medical Intensive Care Unit Patients. Am J Respir Crit Care Med. 2017;195(1):57–66. 27310484 10.1164/rccm.201602-0367OC F1000 Recommendation
31. Schreiber A, Bertoni M, Goligher EC: Avoiding Respiratory and Peripheral Muscle Injury During Mechanical Ventilation: Diaphragm-Protective Ventilation and Early Mobilization. Crit Care Clin. 2018;34(3):357–81. 29907270 10.1016/j.ccc.2018.03.005 F1000 Recommendation
32. Goligher EC, Fan E, Herridge MS: Evolution of Diaphragm Thickness during Mechanical Ventilation. Impact of Inspiratory Effort. Am J Respir Crit Care Med. 2015;192(9):1080–8. 26167730 10.1164/rccm.201503-0620OC
33. Supinski GS, Morris PE, Dhar S: Diaphragm Dysfunction in Critical Illness. Chest. 2018;153(4):1040–51. 28887062 10.1016/j.chest.2017.08.1157 6026291 F1000 Recommendation
34. Petrof BJ: Diaphragm Weakness in the Critically Ill: Basic Mechanisms Reveal Therapeutic Opportunities. Chest. 2018;154(6):1395–403. 30144420 10.1016/j.chest.2018.08.1028 F1000 Recommendation
35. 2 modulates infection-induced diaphragm dysfunction. Am J Physiol Lung Cell Mol Physiol. 2016;310(10):L975–84. 26968769 10.1152/ajplung.00312.2015 4896095 F1000 Recommendation
36. Callahan LA, Nethery D, Stofan D: Free radical-induced contractile protein dysfunction in endotoxin-induced sepsis. Am J Respir Cell Mol Biol. 2001;24(2):210–7. 11159056 10.1165/ajrcmb.24.2.4075
37. Jaber S, Petrof BJ, Jung B: Rapidly progressive diaphragmatic weakness and injury during mechanical ventilation in humans. Am J Respir Crit Care Med. 2011;183(3):364–71. 20813887 10.1164/rccm.201004-0670OC F1000 Recommendation
38. Levine S, Nguyen T, Taylor N: Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans. N Engl J Med. 2008;358(13):1327–35. 18367735 10.1056/NEJMoa070447 F1000 Recommendation
39. Picard M, Jung B, Liang F: Mitochondrial dysfunction and lipid accumulation in the human diaphragm during mechanical ventilation. Am J Respir Crit Care Med. 2012;186(11):1140–9. 23024021 10.1164/rccm.201206-0982OC
40. Hussain SN, Cornachione AS, Guichon C: Prolonged controlled mechanical ventilation in humans triggers myofibrillar contractile dysfunction and myofilament protein loss in the diaphragm. Thorax. 2016;71(5):436–45. 27033022 10.1136/thoraxjnl-2015-207559 F1000 Recommendation
41. Latronico N, Fenzi F, Recupero D: Critical illness myopathy and neuropathy. Lancet. 1996;347(9015):1579–82. 8667865 10.1016/S0140-6736(96)91074-0
42. Puthucheary ZA, Rawal J, McPhail M: Acute skeletal muscle wasting in critical illness. JAMA. 2013;310(15):1591–600. 24108501 10.1001/jama.2013.278481 F1000 Recommendation
43. Zambon M, Greco M, Bocchino S: Assessment of diaphragmatic dysfunction in the critically ill patient with ultrasound: a systematic review. Intensive Care Med. 2017;43(1):29–38. 27620292 10.1007/s00134-016-4524-z F1000 Recommendation
44. Medrinal C, Prieur G, Frenoy É: Respiratory weakness after mechanical ventilation is associated with one-year mortality - a prospective study. Crit Care. 2016;20(1):231. 27475524 10.1186/s13054-016-1418-y 4967510
45. Elkins M, Dentice R: Inspiratory muscle training facilitates weaning from mechanical ventilation among patients in the intensive care unit: a systematic review. J Physiother. 2015;61(3):125–34. 26092389 10.1016/j.jphys.2015.05.016
46. Bissett BM, Leditschke IA, Neeman T: Inspiratory muscle training to enhance recovery from mechanical ventilation: a randomised trial. Thorax. 2016;71(9):812–9. 27257003 10.1136/thoraxjnl-2016-208279 5013088
47. Supinski GS, Callahan LA: β-Hydroxy-β-methylbutyrate (HMB) prevents sepsis-induced diaphragm dysfunction in mice. Respir Physiol Neurobiol. 2014;196:63–8. 24632527 10.1016/j.resp.2014.02.015 4049168
48. Doorduin J, Sinderby CA, Beck J: The calcium sensitizer levosimendan improves human diaphragm function. Am J Respir Crit Care Med. 2012;185(1):90–5. 21960535 10.1164/rccm.201107-1268OC F1000 Recommendation
49. Pandharipande PP, Ely EW, Arora RC: The intensive care delirium research agenda: a multinational, interprofessional perspective. Intensive Care Med. 2017;43(9):1329–39. 28612089 10.1007/s00134-017-4860-7 5709210 F1000 Recommendation
50. Salluh JIF, Latronico N: Does this critically ill patient with delirium require any drug treatment? Intensive Care Med. 2019;45(4):501–504. 30043275 10.1007/s00134-018-5310-x
51. Pandharipande PP, Girard TD, Jackson JC: Long-term cognitive impairment after critical illness. N Engl J Med. 2013;369(14):1306–16. 24088092 10.1056/NEJMoa1301372 3922401 F1000 Recommendation
52. Yang T, Li Z, Jiang L: Risk factors for intensive care unit-acquired weakness: A systematic review and meta-analysis. Acta Neurol Scand. 2018;138(2):104–14. 29845614 10.1111/ane.12964 F1000 Recommendation
53. Devlin JW, Skrobik Y, Gélinas C: Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU. Crit Care Med. 2018;46(9):e825–e873. 30113379 10.1097/CCM.0000000000003299 F1000 Recommendation
54. Urazaev AK, Magsumov ST, Poletayev GI: Muscle NMDA receptors regulate the resting membrane potential through NO-synthase. Physiol Res. 1995;44(3):205–8. 8869279
55. Malomouzh AI, Nurullin LF, Arkhipova SS: NMDA receptors at the endplate of rat skeletal muscles: precise postsynaptic localization. Muscle Nerve. 2011;44(6):987–9. 22102472 10.1002/mus.22250
56. Druml W, Heinzel G, Kleinberger G: Amino acid kinetics in patients with sepsis. Am J Clin Nutr. 2001;73(5):908–13. 11333844 10.1093/ajcn/73.5.908
57. Fagoni N, Piva S, Marino R: The IN-PANCIA Study: Clinical Evaluation of Gastrointestinal Dysfunction and Failure, Multiple Organ Failure, and Levels of Citrulline in Critically Ill Patients. J Intensive Care Med. 2017; 885066617742594. 29141526 10.1177/0885066617742594
58. Hermans G, Casaer MP, Clerckx B: Effect of tolerating macronutrient deficit on the development of intensive-care unit acquired weakness: a subanalysis of the EPaNIC trial. Lancet Respir Med. 2013;1(8):621–9. 24461665 10.1016/S2213-2600(13)70183-8
59. Doig GS, Simpson F, Bellomo R: Intravenous amino acid therapy for kidney function in critically ill patients: a randomized controlled trial. Intensive Care Med. 2015;41(7):1197–208. 25925203 10.1007/s00134-015-3827-9
60. Clifton GL, Robertson CS, Contant CF: Enteral hyperalimentation in head injury. J Neurosurg. 1985;62(2):186–93. 3918145 10.3171/jns.1985.62.2.0186
61. Rugeles S, Villarraga-Angulo LG, Ariza-Gutiérrez A: High-protein hypocaloric vs normocaloric enteral nutrition in critically ill patients: A randomized clinical trial. J Crit Care. 2016;35:110–4. 27481744 10.1016/j.jcrc.2016.05.004
62. Allingstrup MJ, Kondrup J, Wiis J: Early goal-directed nutrition versus standard of care in adult intensive care patients: the single-centre, randomised, outcome assessor-blinded EAT-ICU trial. Intensive Care Med. 2017;43(11):1637–47. 28936712 10.1007/s00134-017-4880-3 F1000 Recommendation
63. Thiessen SE, Derde S, Derese I: Role of Glucagon in Catabolism and Muscle Wasting of Critical Illness and Modulation by Nutrition. Am J Respir Crit Care Med. 2017;196(9):1131–43. 28475354 10.1164/rccm.201702-0354OC F1000 Recommendation
64. Puthucheary ZA, Astin R, Mcphail MJW: Metabolic phenotype of skeletal muscle in early critical illness. Thorax. 2018;73(10):926–35. 29980655 10.1136/thoraxjnl-2017-211073 F1000 Recommendation
65. Latronico N, Friedrich O: Electrophysiological investigations of peripheral nerves and muscles: a method for looking at cell dysfunction in the critically ill patients. Crit Care. 2019;23(1):33. 30696473 10.1186/s13054-019-2331-y 6350331
66. Wright SE, Thomas K, Watson G: Intensive versus standard physical rehabilitation therapy in the critically ill (EPICC): a multicentre, parallel-group, randomised controlled trial. Thorax. 2018;73(3):213–21. 28780504 10.1136/thoraxjnl-2016-209858 5870467 F1000 Recommendation
67. Denehy L, Lanphere J, Needham DM: Ten reasons why ICU patients should be mobilized early. Intensive Care Med. 2017;43(1):86–90. 27562244 10.1007/s00134-016-4513-2 F1000 Recommendation
68. Hodgson CL, Stiller K, Needham DM: Expert consensus and recommendations on safety criteria for active mobilization of mechanically ventilated critically ill adults. Crit Care. 2014;18(6):658. 25475522 10.1186/s13054-014-0658-y 4301888
69. Gosselink R, Bott J, Johnson M: Physiotherapy for adult patients with critical illness: recommendations of the European Respiratory Society and European Society of Intensive Care Medicine Task Force on Physiotherapy for Critically Ill Patients. Intensive Care Med. 2008;34(7):1188–99. 18283429 10.1007/s00134-008-1026-7
70. Nydahl P, Sricharoenchai T, Chandra S: Safety of Patient Mobilization and Rehabilitation in the Intensive Care Unit. Systematic Review with Meta-Analysis. Ann Am Thorac Soc. 2017;14(5):766–77. 28231030 10.1513/AnnalsATS.201611-843SR F1000 Recommendation
71. Tipping CJ, Harrold M, Holland A: The effects of active mobilisation and rehabilitation in ICU on mortality and function: a systematic review. Intensive Care Med. 2017;43(2):171–83. 27864615 10.1007/s00134-016-4612-0 F1000 Recommendation
72. Schaller S, Nydahl P, Blobner M: What does the EPICC trial really tell us? Thorax. 2018. Reference Source
73. Moss M, Nordon-Craft A, Malone D: A Randomized Trial of an Intensive Physical Therapy Program for Patients with Acute Respiratory Failure. Am J Respir Crit Care Med. 2016;193(10):1101–10. 26651376 10.1164/rccm.201505-1039OC 4872662
74. Fossat G, Baudin F, Courtes L: Effect of In-Bed Leg Cycling and Electrical Stimulation of the Quadriceps on Global Muscle Strength in Critically Ill Adults: A Randomized Clinical Trial. JAMA. 2018;320(4):368–78. 30043066 10.1001/jama.2018.9592 F1000 Recommendation
75. Walsh TS, Salisbury LG, Merriweather JL: Increased Hospital-Based Physical Rehabilitation and Information Provision After Intensive Care Unit Discharge: The RECOVER Randomized Clinical Trial. JAMA Intern Med. 2015;175(6):901–10. 25867659 10.1001/jamainternmed.2015.0822
76. Morris PE, Berry MJ, Files DC: Standardized Rehabilitation and Hospital Length of Stay Among Patients With Acute Respiratory Failure: A Randomized Clinical Trial. JAMA. 2016;315(24):2694–702. 27367766 10.1001/jama.2016.7201
77. Gruther W, Pieber K, Steiner I: Can Early Rehabilitation on the General Ward After an Intensive Care Unit Stay Reduce Hospital Length of Stay in Survivors of Critical Illness?: A Randomized Controlled Trial. Am J Phys Med Rehabil. 2017;96(9):607–15. 28181920 10.1097/PHM.0000000000000718 F1000 Recommendation
78. AVERT Trial Collaboration group: Efficacy and safety of very early mobilisation within 24 h of stroke onset (AVERT): a randomised controlled trial. Lancet. 2015;386(9988):46–55. 25892679 10.1016/S0140-6736(15)60690-0 F1000 Recommendation
79. Bernhardt J, Churilov L, Ellery F: Prespecified dose-response analysis for A Very Early Rehabilitation Trial (AVERT). Neurology. 2016;86(23):2138–45. 26888985 10.1212/WNL.0000000000002459 4898313
80. Titsworth WL, Hester J, Correia T: The effect of increased mobility on morbidity in the neurointensive care unit. J Neurosurg. 2012;116(6):1379–88. 22462507 10.3171/2012.2.JNS111881
81. Piva S, Dora G, Minelli C: The Surgical Optimal Mobility Score predicts mortality and length of stay in an Italian population of medical, surgical, and neurologic intensive care unit patients. J Crit Care. 2015;30(6):1251–7. 26315654 10.1016/j.jcrc.2015.08.002
82. Schaller SJ, Scheffenbichler FT, Bose S: Influence of the initial level of consciousness on early, goal-directed mobilization: a post hoc analysis. Intensive Care Med. 2019;45(2):201–10. 30666366 10.1007/s00134-019-05528-x
83. Compher C, Chittams J, Sammarco T: Greater Protein and Energy Intake May Be Associated With Improved Mortality in Higher Risk Critically Ill Patients: A Multicenter, Multinational Observational Study. Crit Care Med. 2017;45(2):156–63. 28098623 10.1097/CCM.0000000000002083 F1000 Recommendation
84. Arabi YM, Casaer MP, Chapman M: The intensive care medicine research agenda in nutrition and metabolism. Intensive Care Med. 2017;43(9):1239–56. 28374096 10.1007/s00134-017-4711-6 5569654 F1000 Recommendation
85. Needham DM, Sepulveda KA, Dinglas VD: Core Outcome Measures for Clinical Research in Acute Respiratory Failure Survivors. An International Modified Delphi Consensus Study. Am J Respir Crit Care Med. 2017;196(9):1122–30. 28537429 10.1164/rccm.201702-0372OC 5694837 F1000 Recommendation
86. Pun BT, Balas MC, Barnes-Daly MA: Caring for Critically Ill Patients with the ABCDEF Bundle: Results of the ICU Liberation Collaborative in Over 15,000 Adults. Crit Care Med. 2019;47(1):3–14. 30339549 10.1097/CCM.0000000000003482 6298815 F1000 Recommendation