Calcium-dependent phospholipase A2 modulates infection-induced diaphragm dysfunction

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 310, Issue 10, 2016, Pages L975-L984

  Supinski, Gerald S ^a,b   Alimov, Alexander P ^a,b   Wang, Lin ^a,b   Song, Xiao Hong ^a,b   Callahan, Leigh A ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Calpain; CPLA2; Cytokines; Diaphragm weakness; Sepsis

Indexed keywords

3,3' (1,4 PHENYLENE)BIS[N [4 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL]ACRYLAMIDE]; ACONITATE HYDRATASE; CALCIUM DEPENDENT PHOSPHOLIPASE A2; CALPAIN; CALPASTATIN; CASPASE 12; FLUORESCENT DYE; GAMMA INTERFERON; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; PHOSPHOLIPASE A2; REACTIVE OXYGEN METABOLITE; SPHINGOMYELIN PHOSPHODIESTERASE; SUPEROXIDE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; PHOSPHOLIPASE A2 GROUP IV;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CECAL LIGATION AND PUNCTURE-INDUCED SEPSIS; CELL ISOLATION; CELL VIABILITY; CITRIC ACID CYCLE; CONTROLLED STUDY; DIAPHRAGM DISEASE; DIAPHRAGM WEAKNESS; EMBRYO; INFECTION INDUCED DIAPHRAGM DYSFUNCTION; MITOCHONDRION; MOUSE; MUSCLE WEAKNESS; MYOTUBE; NONHUMAN; PERITONITIS; PRIORITY JOURNAL; SKELETAL MUSCLE CELL; TRYPAN BLUE ASSAY; WESTERN BLOTTING; ANIMAL; CELL LINE; DIAPHRAGM; ENZYMOLOGY; METABOLISM; MICROBIOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SEPSIS;

ANIMALS; CELL LINE; DIAPHRAGM; GROUP IV PHOSPHOLIPASES A2; MICE; MUSCLE WEAKNESS; SEPSIS; SUPEROXIDES;

EID: 84984636124     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00312.2015     Document Type: Article

References (40)

1. Badiola N, Penas C, Minano-Molina A, Barneda-Zahonero B, Fado R, Sanchez-Opazo G, Comella JX, Sabria J, Zhu C, Blomgren K, Casas C, Rodriguez-Alvarez J. Induction of ER stress in response to oxygenglucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12. Cell Death Dis 2: e149, 2011.
2. Bhattacharya A, Muller FL, Liu Y, Sabia M, Liang H, Song W, Jang YC, Ran Q, Van Remmen H. Denervation induces cytosolic phospho-lipase A2-mediated fatty acid hydroperoxide generation by muscle mitochondria. J Biol Chem 284: 46-55, 2009.
3. Bulger EM, Jurkovich GJ, Farver CL, Klotz P, Maier RV. Oxandrolone does not improve outcome of ventilator dependent surgical patients. Ann Surg 240: 472-478; discussion 478-480, 2004.
4. Callahan LA, Supinski GS. Sepsis-induced myopathy. Crit Care Med 37: S354-S367, 2009.
5. Chavez AM, Menconi MJ, Hodin RA, Fink MP. Cytokine-induced intestinal epithelial hyperpermeability: role of nitric oxide. Crit Care Med 27: 2246-2251, 1999.
6. Cho S, Szeto HH, Kim E, Kim H, Tolhurst AT, Pinto JT. A novel cell-permeable antioxidant peptide, SS31, attenuates ischemic brain injury by down-regulating CD36. J Biol Chem 282: 4634-4642, 2007.
7. Craft JM, Hallahan D. Towards novel radiosensitizing agents: the role of cytosolic PLA2alpha in combined modality cancer therapy. Future Med Chem 3: 835-843, 2011.
8. Demoule A, Jung B, Prodanovic H, Molinari N, Chanques G, Coirault C, Matecki S, Duguet A, Similowski T, Jaber S. Diaphragm dysfunction on admission to the intensive care unit. Prevalence, risk factors, and prognostic impact-a prospective study. Am J Respir Crit Care Med 188: 213-219, 2013.
9. Divangahi M, Matecki S, Dudley RW, Tuck SA, Bao W, Radzioch D, Comtois AS, Petrof BJ. Preferential diaphragmatic weakness during sustained Pseudomonas aeruginosa lung infection. Am J Respir Crit Care Med 169: 679-686, 2004.
10. Du J, Wang X, Miereles C, Bailey JL, Debigare R, Zheng B, Price SR, Mitch WE. Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions. J Clin Invest 113: 115-123, 2004.
11. Fan J, Wu L, Li G, Tao S, Sheng Z, Meng Q, Li F, Yu L, Li L. Effects of enteral nutrition with parenteral glutamine supplementation on the immunological function in septic rats. Br J Nutr 113: 1712-1722, 2015.
12. Gardner PR, Fridovich I. Inactivation-reactivation of aconitase in Escherichia coli. A sensitive measure of superoxide radical. J Biol Chem 267: 8757-8763, 1992.
13. Hanna RA, Campbell RL, Davies PL. Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin. Nature 456: 409-412, 2008.
14. Hermans G, Agten A, Testelmans D, Decramer M, Gayan-Ramirez G. Increased duration of mechanical ventilation is associated with decreased diaphragmatic force: a prospective observational study. Crit Care 14: R127, 2010.
15. Laghi F, Cattapan SE, Jubran A, Parthasarathy S, Warshawsky P, Choi YS, Tobin MJ. Is weaning failure caused by low-frequency fatigue of the diaphragm? Am J Respir Crit Care Med 167: 120-127, 2003.
16. Linkous AG, Yazlovitskaya EM, Hallahan DE. Cytosolic phospholipase A2 and lysophospholipids in tumor angiogenesis. J Natl Cancer Inst 102: 1398-1412, 2010.
17. Liu Y, Schubert DR. The specificity of neuroprotection by antioxidants. J Biomed Sci 16: 98, 2009.
18. Loweth AC, Scarpello JH, Morgan NG. A specific inhibitor of cytosolic phospholipase A2 activity, AACOCF3, inhibits glucose-induced insulin secretion from isolated rat islets. Biochem Biophys Res Commun 218: 423-427, 1996.
19. Martinez JA, Zhang Z, Svetlov SI, Hayes RL, Wang KK, Larner SF. Calpain and caspase processing of caspase-12 contribute to the ER stress-induced cell death pathway in differentiated PC12 cells. Apoptosis 15: 1480-1493, 2010.
20. Nakagawa T, Yuan J. Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. J Cell Biol 150: 887-894, 2000.
21. Powers SK, Hudson MB, Nelson WB, Talbert EE, Min K, Szeto HH, Kavazis AN, Smuder AJ. Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weakness. Crit Care Med 39: 1749-1759, 2011.
22. Qin YJ, Zhang XL, Yu YQ, Bian XH, Dong SM. Cardioprotective effect of erythropoietin on sepsis-induced myocardial injury in rats. World J Emerg Med 4: 215-222, 2013.
23. Qiu G, Gribbin E, Harrison K, Sinha N, Yin K. Inhibition of gamma interferon decreases bacterial load in peritonitis by accelerating peritoneal fibrin deposition and tissue repair. Infect Immun 71: 2766-2774, 2003.
24. Rabuel C, Samuel JL, Lortat-Jacob B, Marotte F, Lanone S, Keyser C, Lessana A, Payen D, Mebazaa A. Activation of the ubiquitin proteolytic pathway in human septic heart and diaphragm. Cardiovasc Pathol 19: 158-164, 2010.
25. Salazar JJ, Michele DE, Brooks SV. Inhibition of calpain prevents muscle weakness and disruption of sarcomere structure during hindlimb suspension. J Appl Physiol 108: 120-127, 2010.
26. Supinski G, Nethery D, DiMarco A. Effect of free radical scavengers on endotoxin-induced respiratory muscle dysfunction. Am Rev Respir Dis 148: 1318-1324, 1993.
27. Supinski GS, Alimov AP, Wang L, Song XH, Callahan LA. Neutral sphingomyelinase 2 is required for cytokine-induced skeletal muscle calpain activation. Am J Physiol Lung Cell Mol Physiol 309: L614-L624, 2015.
28. Supinski GS, Callahan LA. beta-hydroxy-beta-methylbutyrate (HMB) prevents sepsis-induced diaphragm dysfunction in mice. Respir Physiol Neurobiol 196: 63-68, 2014.
29. Supinski GS, Callahan LA. Calpain activation contributes to endotoxininduced diaphragmatic dysfunction. Am J Respir Cell Mol Biol 42: 80-87, 2010.
30. Supinski GS, Callahan LA. Caspase activation contributes to endotoxininduced diaphragm weakness. J Appl Physiol 100: 1770-1777, 2006.
31. Supinski GS, Callahan LA. Diaphragm weakness in mechanically ventilated critically ill patients. Crit Care 17: R120, 2013.
32. Supinski GS, Callahan LA. Double-stranded RNA-dependent protein kinase activation modulates endotoxin-induced diaphragm weakness. J Appl Physiol 110: 199-205, 2011.
33. Supinski GS, Ji X, Callahan LA. The JNK MAP kinase pathway contributes to the development of endotoxin-induced diaphragm caspase activation. Am J Physiol Regul Integr Comp Physiol 297: R825-R834, 2009.
34. Supinski GS, Ji X, Wang W, Callahan LA. The extrinsic caspase pathway modulates endotoxin-induced diaphragm contractile dysfunction. J Appl Physiol 102: 1649-1657, 2007.
35. Supinski GS, Ji XY, Callahan LA. p38 Mitogen-activated protein kinase modulates endotoxin-induced diaphragm caspase activation. Am J Respir Cell Mol Biol 43: 121-127, 2010.
36. Supinski GS, Vanags J, Callahan LA. Effect of proteasome inhibitors on endotoxin-induced diaphragm dysfunction. Am J Physiol Lung Cell Mol Physiol 296: L994-L1001, 2009.
37. Supinski GS, Wang L, Song XH, Moylan JS, Callahan LA. Musclespecific calpastatin overexpression prevents diaphragm weakness in cecal ligation puncture-induced sepsis. J Appl Physiol (1985) 117: 921-929, 2014.
38. Supinski GS, Wang W, Callahan LA. Caspase and calpain activation both contribute to sepsis-induced diaphragmatic weakness. J Appl Physiol 107: 1389-1396, 2009.
39. Thompson VF, Saldana S, Cong J, Goll DE. A BODIPY fluorescent microplate assay for measuring activity of calpains and other proteases. Anal Biochem 279: 170-178, 2000.
40. Watson AC, Hughes PD, Louise Harris M, Hart N, Ware RJ, Wendon J, Green M, Moxham J. Measurement of twitch transdiaphragmatic, esophageal, and endotracheal tube pressure with bilateral anterolateral magnetic phrenic nerve stimulation in patients in the intensive care unit. Crit Care Med 29: 1325-1331, 2001.