The IN-PANCIA Study: Clinical Evaluation of Gastrointestinal Dysfunction and Failure, Multiple Organ Failure, and Levels of Citrulline in Critically Ill Patients

Journal of Intensive Care Medicine

Volumn 35, Issue 3, 2020, Pages 279-283

  Fagoni, Nazzareno ^a,b   Piva, Simone ^a   Marino, Rosella ^a   Chiarini, Giovanni ^a   Ferrari, Daniela ^a   Grespi, Eleonora ^a   Bertuetti, Rita ^a   Barbieri, Silvia ^a   Latronico, Nicola ^a,b   Rasulo, Frank ^a,b  

^a SPEDALI CIVILI   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

Author keywords

arginine; citrulline; gastrointestinal dysfunction or failure; glutamine; intra abdominal hypertension; multiple organ failure

Indexed keywords

AMINO ACID; ARGININE; CITRULLINE; GLUTAMINE; BIOLOGICAL MARKER;

ABDOMINAL PRESSURE; APACHE; ARTICLE; ARTIFICIAL VENTILATION; BODY MASS; CLINICAL EVALUATION; CONTROLLED STUDY; DIGESTIVE SYSTEM FUNCTION DISORDER; ENTERIC FEEDING; FEMALE; GLASGOW COMA SCALE; HUMAN; INTENSIVE CARE UNIT; KIDNEY FUNCTION; MALE; MULTIPLE ORGAN FAILURE; OBSERVATIONAL STUDY; PARENTERAL NUTRITION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RETROSPECTIVE STUDY; SCORING SYSTEM; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; UREA NITROGEN BLOOD LEVEL; AGED; BLOOD; COMPLICATION; CRITICAL ILLNESS; GASTROINTESTINAL DISEASE; INTRAABDOMINAL HYPERTENSION; MIDDLE AGED; MORTALITY; ORGAN DYSFUNCTION SCORE;

AGED; ARGININE; BIOMARKERS; CITRULLINE; CRITICAL ILLNESS; FEMALE; GASTROINTESTINAL DISEASES; GLUTAMINE; HUMANS; INTENSIVE CARE UNITS; INTRA-ABDOMINAL HYPERTENSION; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; ORGAN DYSFUNCTION SCORES; PROSPECTIVE STUDIES;

EID: 85041625296     PISSN: 08850666     EISSN: 15251489     Source Type: Journal    
DOI: 10.1177/0885066617742594     Document Type: Article

References (19)

1. Mentec H, Dupont H, Bocchetti M, Cani P, Ponche F, Bleichner G. Upper digestive intolerance during enteral nutrition in critically ill patients: frequency, risk factors, and complications. Crit Care Med. 2001;29(10):1955–1961.
2. Montejo JC. Enteral nutrition-related gastrointestinal complications in critically ill patients: a multicenter study. The Nutritional and Metabolic Working Group of the Spanish Society of Intensive Care Medicine and Coronary Units. Crit Care Med. 1999;27(8):1447–1453.
3. Piton G, Manzon C, Monnet E, et al. Plasma citrulline kinetics and prognostic value in critically ill patients. Intensive Care Med. 2010;36(4):702–706.
4. Reintam A, Parm P, Kitus R, Starkopf J, Kern H. Gastrointestinal failure score in critically ill patients: a prospective observational study. Crit Care. 2008;12(4):R90.
5. Sertaridou E, Papaioannou V, Kolios G, Pneumatikos I. Gut failure in critical care: old school versus new school. Ann Gastroenterol. 2015;28(3):309–322.
6. Louis K, Netea MG, Carrer DP, et al. Bacterial translocation in an experimental model of multiple organ dysfunctions. J Surg Res. 2013;183(2):686–694.
7. Reintam Blaser A, Malbrain MLNG, Starkopf J, et al. Gastrointestinal function in intensive care patients: terminology, definitions and management. Recommendations of the ESICM Working Group on Abdominal Problems. Intensive Care Med. 2012;38(3):384–394.
8. Chen H, Zhang H, Li W, Wu S, Wang W. Acute gastrointestinal injury in the intensive care unit: a retrospective study. Ther Clin Risk Manag. 2015;11:1523–1529.
9. Piton G, Manzon C, Cypriani B, Carbonnel F, Capellier G. Acute intestinal failure in critically ill patients: is plasma citrulline the right marker? Intensive Care Med. 2011;37(6):911–917.
10. Noordally SO, Sohawon S, Semlali H, Michely D, Devriendt J, Gottignies P. Is there a correlation between circulating levels of citrulline and intestinal dysfunction in the critically ill? Nutr Clin Pract. 2012;27(4):527–532.
11. Wernerman J. Glutamine supplementation. Ann Intensive Care. 2011;1(1):25.
12. Vincent JL, de Mendonça A, Cantraine F, et al. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on “sepsis-related problems” of the European Society of Intensive Care Medicine Crit Care Med. 1998;26(11):1793–1800.
13. Crenn P, Coudray-Lucas C, Thuillier F, Cynober L, Messing B. Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans. Gastroenterology. 2000;119(6):1496–1505.
14. Crenn P, Messing B, Cynober L. Citrulline as a biomarker of intestinal failure due to enterocyte mass reduction. Clin Nutr. 2008;27(3):328–339.
15. Murcia-Sáez IM, Sobrino-Hernandez ML, García-Lopez F, et al. Usefulness of intra-abdominal pressure in a predominantly medical intensive care unit. J Crit Care. 2010;25(1):175e1–e6.
16. Cothren CC, Moore EE, Ciesla DJ, et al. Postinjury abdominal compartment syndrome does not preclude early enteral feeding after definitive closure. Am J Surg. 2004;188(6):653–658.
17. Reintam Blaser A, Parm P, Kitus R, Starkopf J. Intra-abdominal hypertension and gastrointestinal symptoms in mechanically ventilated patients. Crit Care Res Pract. 2011; 2011: 982507.
18. Soler Morejón Cde D, Tamargo Barbeito TO. Effect of mechanical ventilation on intra-abdominal pressure in critically ill patients without other risk factors for abdominal hypertension: an observational multicenter epidemiological study. Ann Intensive Care. 2012;2(suppl 1):S22.
19. Reintam Blaser A, Poeze M, Malbrain ML, Björck M, Oudemans-van Straaten HM, Starkopf J,; Gastro-Intestinal Failure Trial Group. Gastrointestinal symptoms during the first week of intensive care are associated with poor outcome: a prospective multicentre study. Intensive Care Med. 2013;39(5):899–909.