Prolonged controlled mechanical ventilation in humans triggers myofibrillar contractile dysfunction and myofilament protein loss in the diaphragm

Thorax

Volumn 71, Issue 5, 2016, Pages 436-445

  Hussain, Sabah N A ^a,b   Cornachione, Anabelle S ^c   Guichon, Céline ^a   Al Khunaizi, Auday ^a   De Souza Leite, Felipe ^d   Petrof, Basil J ^a   Mofarrahi, Mahroo ^a   Moroz, Nikolay ^a   De Varennes, Benoit ^e   Goldberg, Peter ^a   Rassier, Dilson E ^d  

^a MCGILL UNIVERSITY   (Canada)

^b RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d MCGILL UNIVERSITY   (Canada)

^e MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTIN; ALPHA ACTININ; CONNECTIN; MYOSIN HEAVY CHAIN; NEBULIN; PROTEASOME; TROPOMYOSIN; TROPONIN C; TROPONIN I; TROPONIN T; ACTIN; ACTININ; MUSCLE PROTEIN;

ADULT; AGED; ARTICLE; ARTIFICIAL VENTILATION; CARDIOVASCULAR PARAMETERS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FORCE DEVELOPMENT; FORCE GENERATION; FORCE REDEVELOPMENT; FORCE RELAXATION; HUMAN; IMMUNOBLOTTING; MALE; MIDDLE AGED; MUSCLE BIOPSY; MUSCLE DISEASE; MUSCLE FIBRIL; MYOFIBRILLAR CONTRACTILE DYSFUNCTION; MYOFILAMENT; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; VERY ELDERLY; ADVERSE EFFECTS; BIOPSY; CASE CONTROL STUDY; DIAPHRAGM; DONOR; HEART DISEASES; METABOLISM; MUSCLE ATROPHY; MUSCLE CONTRACTION; PATHOLOGY; PATHOPHYSIOLOGY; RISK FACTOR; TIME FACTOR;

ACTININ; ACTINS; ADULT; AGED; AGED, 80 AND OVER; BIOPSY; CASE-CONTROL STUDIES; CONNECTIN; DIAPHRAGM; FEMALE; HEART DISEASES; HUMANS; MALE; MIDDLE AGED; MUSCLE CONTRACTION; MUSCLE PROTEINS; MUSCULAR ATROPHY; MYOFIBRILS; MYOSIN HEAVY CHAINS; RESPIRATION, ARTIFICIAL; RISK FACTORS; TIME FACTORS; TISSUE DONORS; TROPOMYOSIN; TROPONIN C; TROPONIN I; TROPONIN T;

EID: 84964497102     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thoraxjnl-2015-207559     Document Type: Article

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