Effect of tolerating macronutrient deficit on the development of intensive-care unit acquired weakness: A subanalysis of the EPaNIC trial

The Lancet Respiratory Medicine

Volumn 1, Issue 8, 2013, Pages 621-629

  Hermans, Greet ^a,b   Casaer, Michael P ^a,b   Clerckx, Beatrix ^a,b   Güiza, Fabian ^b   Vanhullebusch, Tine ^b   Derde, Sarah ^b   Meersseman, Philippe ^a,b   Derese, Inge ^b   Mesotten, Dieter ^a,b   Wouters, Pieter J ^a,b   Van Cromphaut, Sophie ^a,b   Debaveye, Yves ^a,b   Gosselink, Rik ^c   Gunst, Jan ^a,b   Wilmer, Alexander ^a   Van den Berghe, Greet ^a,b   Vanhorebeek, Ilse ^b  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ATROGIN 1; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN; MUSCLE PROTEIN; MUSCLE RING FINGER 1 PROTEIN; MYOSIN HEAVY CHAIN; PROTEASOME; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; ACTIN; CARDIAC MYOSIN; FBXO32 PROTEIN, HUMAN; LIGHT CHAIN 3, HUMAN; MAP1LC3A PROTEIN, HUMAN; MYC PROTEIN; MYH7 PROTEIN, HUMAN; MYOSIN IIA; TRIM63 PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE;

ADULT; AGED; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CLINICAL ASSESSMENT; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DIET SUPPLEMENTATION; ENTERIC FEEDING; FEMALE; GENE EXPRESSION; GENETIC CODE; HUMAN; HUMAN TISSUE; INTENSIVE CARE UNIT; LIGHT CHAIN; MACRONUTRIENT; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MUSCLE ATROPHY; MUSCLE BIOPSY; MUSCLE MASS; MUSCLE WEAKNESS; NUTRITIONAL DEFICIENCY; PARENTERAL NUTRITION; PHYSICAL TOLERANCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SKELETAL MUSCLE; ATROPHY; CALORIC INTAKE; CHEMISTRY; CLINICAL TRIAL; CONVALESCENCE; GENETICS; INTENSIVE CARE; LENGTH OF STAY; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; TIME;

ACTINS; AGED; ATROPHY; AUTOPHAGY; CARDIAC MYOSINS; ENERGY INTAKE; FEMALE; HUMANS; INTENSIVE CARE; LENGTH OF STAY; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; MUSCLE FIBERS, SKELETAL; MUSCLE PROTEINS; MUSCLE WEAKNESS; MUSCLE, SKELETAL; MYOSIN HEAVY CHAINS; NONMUSCLE MYOSIN TYPE IIA; PARENTERAL NUTRITION; PROSPECTIVE STUDIES; PROTO-ONCOGENE PROTEINS C-MYC; RECOVERY OF FUNCTION; RNA, MESSENGER; SKP CULLIN F-BOX PROTEIN LIGASES; TIME FACTORS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 84885071396     PISSN: 22132600     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2213-2600(13)70183-8     Document Type: Article

References (37)

1. Stevens RD, Dowdy DW, Michaels RK, Mendez-Tellez PA, Pronovost PJ, Needham DM Neuromuscular dysfunction acquired in critical illness: a systematic review. Intensive Care Med 2007, 33:1876-1891.
2. Latronico N, Bolton CF Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis. Lancet Neurol 2011, 10:931-941.
3. De Jonghe B, Bastuji-Garin S, Durand MC, et al. Respiratory weakness is associated with limb weakness and delayed weaning in critical illness. Crit Care Med 2007, 35:2007-2015.
4. De Jonghe B, Bastuji-Garin S, Sharshar T, Outin H, Brochard L Does ICU-acquired paresis lengthen weaning from mechanical ventilation?. Intensive Care Med 2004, 30:1117-1121.
5. Herridge MS, Tansey CM, Matte A, et al. Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med 2011, 364:1293-1304.
6. Vanhorebeek I, Van den Berghe G Hormonal and metabolic strategies to attenuate catabolism in critically ill patients. Curr Opin Pharmacol 2004, 4:621-628.
7. Plank LD, Hill GL Similarity of changes in body composition in intensive care patients following severe sepsis or major blunt injury. Ann N Y Acad Sci 2000, 904:592-602.
8. Friedlander AL, Braun B, Pollack M, et al. Three weeks of caloric restriction alters protein metabolism in normal-weight, young men. Am J Physiol Endocrinol Metab 2005, 289:E446-E455.
9. Villet S, Chiolero RL, Bollmann MD, et al. Negative impact of hypocaloric feeding and energy balance on clinical outcome in ICU patients. Clin Nutr 2005, 24:502-509.
10. Masiero E, Agatea L, Mammucari C, et al. Autophagy is required to maintain muscle mass. Cell Metab 2009, 10:507-515.
11. Derde S, Hermans G, Derese I, et al. Muscle atrophy and preferential loss of myosin in prolonged critically ill patients. Crit Care Med 2012, 40:79-89.
12. Vanhorebeek I, Gunst J, Derde S, et al. Insufficient activation of autophagy allows cellular damage to accumulate in critically ill patients. J Clin Endocrinol Metab 2011, 96:E633-E645.
13. Derde S, Vanhorebeek I, Güiza F, et al. Early parenteral nutrition evokes a phenotype of autophagy deficiency in liver and skeletal muscle of critically ill rabbits. Endocrinology 2012, 153:2267-2276.
14. Glick D, Barth S, Macleod KF Autophagy: cellular and molecular mechanisms. J Pathol 2010, 221:3-12.
15. Meijer AJ Amino acid regulation of autophagosome formation. Methods Mol Biol 2008, 445:89-109.
16. Moruno-Manchon JF, Pérez-Jiménez E, Knecht E Glucose induces autophagy under starvation conditions by a p38 MAPK-dependent pathway. Biochem J 2013, 449:497-506.
17. Casaer MP, Mesotten D, Hermans G, et al. Early versus late parenteral nutrition in critically ill adults. N Engl J Med 2011, 365:506-517.
18. Casaer MP, Hermans G, Wilmer A, Van den Berghe G Impact of early parenteral nutrition completing enteral nutrition in adult critically ill patients (EPaNIC trial): a study protocol and statistical analysis plan for a randomized controlled trial. Trials 2011, 12:21-31.
19. Hermans G, Clerckx B, Vanhullebusch T, et al. Interobserver agreement of medical research council sum-score and handgrip strength in the intensive care unit. Muscle Nerve 2012, 45:18-25.
20. De Jonghe B, Sharshar T, Lefaucheur JP, et al. Paresis acquired in the intensive care unit: a prospective multicenter study. JAMA 2002, 288:2859-2867.
21. Burtin C, Clerckx B, Robbeets C, et al. Early exercise in critically ill patients enhances short-term functional recovery. Crit Care Med 2009, 37:2499-2505.
22. Gosselink R, Clerckx B, Robbeets C, et al. Physiotherapy in the intensive care unit. Neth J Crit Care 2011, 15:66-75.
23. Ali NA, O'Brien JM, Hoffmann SP, et al. Acquired weakness, handgrip strength, and mortality in critically ill patients. Am J Respir Crit Care Med 2008, 178:261-268.
24. Hermans G, Wilmer A, Meersseman W, et al. Impact of intensive insulin therapy on neuromuscular complications and ventilator-dependency in MICU. Am J Respir Crit Care Med 2007, 175:480-489.
25. Recommendations on uniform color spaces, color difference equations, psychometric color terms. Supplement No 2 to CIE Publication No 15, Colorimetry 1978, Commission International de l'Eclairage (CIE), Bureau Central de la CIE, Paris.
26. Behan WMH, Cossar DW, Madden HA, McKay IC Validation of a simple, rapid and economical technique for distinguishing type 1 and 2 fibres in fixed and frozen skeletal muscle. J Clin Pathol 2002, 55:375-380.
27. Choi AMK, Ryter SW, Levine B Autophagy in human health and disease. N Engl J Med 2013, 368:651-662.
28. Bjorkoy G, Lamark T, Pankiv S, et al. Monitoring autophagic degradation of p62/SQSTM1. Methods Enzymol 2009, 452:181-197.
29. Cahill GF Starvation in man. N Engl J Med 1970, 282:668-675.
30. Dulloo AG, Jacquet J The control of partitioning between protein and fat during human starvation: its internal determinants and biological significance. Br J Nutr 1999, 82:339-356.
31. Heidegger CP, Berger MM, Graf S, et al. Optimisation of energy provision with supplemental parenteral nutrition in critically ill patients: a randomised controlled clinical trial. Lancet 2013, 381:385-393.
32. Doig GS, Simpson F, Sweetman EA, et al. Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a randomized controlled trial. JAMA 2013, 309:2130-2138.
33. Wilmore DW Catabolic illness: strategies for enhancing recovery. N Engl J Med 1991, 325:695-702.
34. Gunst J, Vanhorebeek I, Casaer MP, et al. Impact of early parenteral nutrition on metabolism and kidney injury. J Am Soc Nephrol 2013, 24:995-1005.
35. Klionsky DJ, Abdalla FC, Abeliovich H, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012, 8:445-544.
36. Casaer MP, Langouche L, Coudyzer W, et al. Impact of early parenteral nutrition on muscle volume and integrity during the first week of critical illness. Crit Care Med 2013, published online July 15. 10.1097/CCM.0b013e31828cef02.
37. Reid MB, Moylan JS Beyond atrophy: redox mechanisms of muscle dysfunction in chronic inflammatory disease. J Physiol 2011, 589:2171-2179.