Intravenous amino acid therapy for kidney function in critically ill patients: a randomized controlled trial

Intensive Care Medicine

Volumn 41, Issue 7, 2015, Pages 1197-1208

  Doig, Gordon S ^a,f   Simpson, Fiona ^a   Bellomo, Rinaldo ^b   Heighes, Philippa T ^a   Sweetman, Elizabeth A ^a   Chesher, Douglas ^a,e   Pollock, Carol ^a   Davies, Andrew ^b   Botha, John ^b   Harrigan, Peter ^c   Reade, Michael C ^d  

^a UNIVERSITY OF SYDNEY   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c JOHN HUNTER HOSPITAL   (Australia)

^d UNIVERSITY OF QUEENSLAND   (Australia)

^e New South Wales School of Space Science   (Australia)

^f ROYAL NORTH SHORE HOSPITAL   (Australia)

Author keywords

Acute kidney injury; Amino acids; Clinical trial; Nutrition; Protein

Indexed keywords

AMINO ACID; CREATININE; CYSTATIN C; UREA; VASOACTIVE AGENT;

ADULT; APACHE; ARTICLE; ARTIFICIAL VENTILATION; AUSTRALIA AND NEW ZEALAND; BODY MASS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CRITICALLY ILL PATIENT; ENTERIC FEEDING; FEMALE; FLUID BALANCE; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY FAILURE; KIDNEY FUNCTION; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OUTCOME ASSESSMENT; PARENTERAL NUTRITION; PHASE 2 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; RENAL REPLACEMENT THERAPY; RESPIRATORY FAILURE; TERTIARY CARE CENTER; UREA BLOOD LEVEL; URINE VOLUME; ACUTE KIDNEY INJURY; AGED; BLOOD; CRITICAL ILLNESS; INTENSIVE CARE UNIT; MIDDLE AGED;

ACUTE KIDNEY INJURY; AGED; AMINO ACIDS; CREATININE; CRITICAL ILLNESS; CYSTATIN C; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED;

EID: 84933279377     PISSN: 03424642     EISSN: 14321238     Source Type: Journal    
DOI: 10.1007/s00134-015-3827-9     Document Type: Article

References (36)

1. Bagshaw SM, George C, Dinu I, Bellomo R (2008) A multi-centre evaluation of the RIFLE criteria for early acute kidney injury in critically ill patients. Nephrol Dial Transpl 23:1203–1210
2. Bagshaw SM, George C, Bellomo R (2008) Early acute kidney injury and sepsis: a multicentre evaluation. Crit Care 12:R47
3. Rewa O, Bagshaw SM (2014) Acute kidney injury-epidemiology, outcomes and economics. Nat Rev Nephrol 10:193–207
4. Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S et al (2005) Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA 294:813–818
5. Prowle JR, Ishikawa K, May CN, Bellomo R (2010) Renal plasma flow and glomerular filtration rate during acute kidney injury in man. Ren Fail 32:349–355
6. Bove T, Zangrillo A, Guarracino F (2014) Effect of fenoldopam on use of renal replacement therapy among patients with acute kidney injury after cardiac surgery: a randomized clinical trial. JAMA 312:2244–2253
7. Bellomo R, Chapman M, Finfer S, Hickling K, Myburgh J (2000) Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Lancet 356:2139–2143
8. Woods LL (1993) Mechanisms of renal hemodynamic regulation in response to protein feeding. Kidney Int 44:659–675
9. Sharma A, Mucino MJ, Ronco C (2014) Renal Functional reserve and renal recovery after acute kidney injury. Nephron Clin Pract 127:94–100
10. Meyer TW, Ichikawa I, Zatz R, Brenner BM (1983) The renal hemodynamic response to amino acid infusion in the rat. Trans Assoc Am Physicians 96:76–83
11. Roberts PR, Black KW, Zaloga GP (1997) Enteral feeding improves outcome and protects against glycerol-induced acute renal failure in the rat. Am J Respir Crit Care Med 156:1265–1269
12. Abel RM, Beck CH Jr, Abbott WM, Ryan JA Jr, Barnett GO, Fischer JE (1973) Improved survival from acute renal failure after treatment with intravenous essential L-amino acids and glucose. Results of a prospective, double-blind study. N Engl J Med 288:695–699
13. Singer P (2007) High-dose amino acid infusion preserves diuresis and improves nitrogen balance in non-oliguric acute renal failure. Wien Klin Wochenschr 119:218–222
14. Doig GS, Simpson F, Finfer S, Delaney A, Davies AR, Mitchell I et al (2008) Effect of evidence-based feeding guidelines on mortality of critically ill adults: a cluster randomized controlled trial. JAMA 300:2731–2741
15. Doig GS, Simpson F, Bellomo R, The ANZICSCTG (2009) Improved nutritional support is associated with reduced renal dysfunction in critical illness: a post hoc exploratory subgroup analysis. Am J Respir Crit Care Med 179:A1567
16. Schulz KF, Grimes DA (2002) Allocation concealment in randomised trials: defending against deciphering. Lancet 359:614–618
17. Knaus WA, Draper EA, Wagner DP, Zimmerman JE (1985) APACHE II: a severity of disease classification system. Crit Care Med 13:818–829
18. Simpson F, Sweetman EA, Doig GS (2010) A systematic review of techniques and interventions for improving adherence to inclusion and exclusion criteria during enrolment into randomised controlled trials. Trials 11:17
19. Bernard GR, Doig GS, Hudson LD, Lemeshow S, Marshall JC, Russel J et al (1995) Quantification of organ failure for clinical trials and clinical practice. Am J Respir Crit Care Med 151:A323
20. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF III, Feldman HI et al (2009) A new equation to estimate glomerular filtration rate. Ann Intern Med 150:604–612
21. Stevens LA, Coresh J, Schmid CH, Feldman HI, Froissart M, Kusek J et al (2008) Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3418 individuals with CKD. Am J Kidney Dis 51:395–406
22. Zubrod C, Schneiderman MA, Frei E, Brindley C, Gold GL, Shnider B et al (1960) Appraisal of methods for the study of chemotherapy of cancer in man: comparative therapeutic trial of nitrogen mustard and triethylene thiophosphoramide. J Chronic Dis 11:7–33
23. Ware JE Jr, Sherbourne CD (1992) The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 30:473–483
24. Haybittle JL (1971) Repeated assessment of results in clinical trials of cancer treatment. Br J Radiol 44:793–797
25. Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV et al (1976) Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design. Br J Cancer 34:585–612
26. Doig GS, Simpson F, Sweetman EA, Heighes PT, on behalf of the Nephro-Protective Trial Management Committee (2013) Statistical analysis plan for a multi-centre randomised controlled trial: nephro-protective effects of L-amino acids in critically ill patients. EvidenceBased.net, Sydney
27. Delanaye P, Cavalier E, Morel J, Mehdi M, Maillard N, Claisse G et al (2014) Detection of decreased glomerular filtration rate in intensive care units: serum cystatin C versus serum creatinine. BMC Nephrol 15:9
28. Carlier M, Dumoulin AF, Janssen AF, Picavet S, Vanthuyne S, Vanthuyne S, Van Eynde R, Van Eynde RF et al (2015) Comparison of different equations to assess glomerular filtration in critically ill patients. Intensive Care Med 41:427–435
29. Woods LL, Smith BE, De Young DR (1993) Regulation of renal hemodynamics after protein feeding: effects of proximal and distal diuretics. Am J Physiol 264:R337–R344
30. Juraschek SP, Appel LJ, Anderson CA, Miller ER III (2013) Effect of a high-protein diet on kidney function in healthy adults: results from the OmniHeart trial. Am J Kidney Dis 61:547–554
31. Finfer S, Bellomo R, Boyce N, French J, Myburgh J, Norton R (2004) A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med 350:2247–2256
32. Wiedemann HP, Wheeler AP, Bernard GR, Thompson BT, Hayden D, deBoisblanc B et al (2006) Comparison of two fluid-management strategies in acute lung injury. N Engl J Med 354:2564–2575
33. Dickerson RN, Medling TL, Smith AC, Maish GO III, Croce MA, Minard G et al (2013) Hypocaloric, high-protein nutrition therapy in older vs. younger critically ill patients with obesity. J Parenter Enteral Nutr 37:342–351
34. Bagshaw SM, Uchino S, Kellum JA, Morimatsu H, Morgera S, Schetz M et al (2013) Association between renal replacement therapy in critically ill patients with severe acute kidney injury and mortality. J Crit Care 28:1011–1018
35. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P (2004) Acute renal failure—definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 8:R204–R212
36. Bellomo R, Cass A, Cole L, Finfer S, Gallagher M, Lo S et al (2009) Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med 361:1627–1638