-
1
-
-
84877329207
-
PPARγ signaling and metabolism: the good, the bad and the future
-
Ahmadian M, et al. PPARγ signaling and metabolism: the good, the bad and the future. Nat Med. 2013;19(5):557-566.
-
(2013)
Nat Med
, vol.19
, Issue.5
, pp. 557-566
-
-
Ahmadian, M1
-
2
-
-
28944446431
-
The many faces of PPARgamma
-
Lehrke M, Lazar MA. The many faces of PPARgamma. Cell. 2005;123(6):993-999.
-
(2005)
Cell
, vol.123
, Issue.6
, pp. 993-999
-
-
Lehrke, M1
Lazar, MA.2
-
3
-
-
84862886329
-
Thiazolidinedione safety
-
Kung J, Henry RR. Thiazolidinedione safety. Expert Opin Drug Saf. 2012;11(4):565-579.
-
(2012)
Expert Opin Drug Saf
, vol.11
, Issue.4
, pp. 565-579
-
-
Kung, J1
Henry, RR.2
-
4
-
-
34250212715
-
Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
-
Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med. 2007;356(24):2457-2471.
-
(2007)
N Engl J Med
, vol.356
, Issue.24
, pp. 2457-2471
-
-
Nissen, SE1
Wolski, K.2
-
5
-
-
67149146438
-
Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial
-
Home PD, et al. Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial. Lancet. 2009;373(9681):2125-2135.
-
(2009)
Lancet
, vol.373
, Issue.9681
, pp. 2125-2135
-
-
Home, PD1
-
6
-
-
84907990392
-
Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes
-
Soccio RE, Chen ER, Lazar MA. Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes. Cell Metab. 2014;20(4):573-591.
-
(2014)
Cell Metab
, vol.20
, Issue.4
, pp. 573-591
-
-
Soccio, RE1
Chen, ER2
Lazar, MA.3
-
7
-
-
24044476859
-
Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice
-
Duan SZ, Ivashchenko CY, Russell MW, Milstone DS, Mortensen RM. Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice. Circ Res. 2005;97(4):372-379.
-
(2005)
Circ Res
, vol.97
, Issue.4
, pp. 372-379
-
-
Duan, SZ1
Ivashchenko, CY2
Russell, MW3
Milstone, DS4
Mortensen, RM.5
-
8
-
-
1242337440
-
An antidiabetic thiazolidinedione induces eccentric cardiac hypertrophy by cardiac volume overload in rats
-
Arakawa K, Ishihara T, Aoto M, Inamasu M, Kitamura K, Saito A. An antidiabetic thiazolidinedione induces eccentric cardiac hypertrophy by cardiac volume overload in rats. Clin Exp Pharmacol Physiol. 2004;31(1-2):8-13.
-
(2004)
Clin Exp Pharmacol Physiol
, vol.31
, Issue.1-2
, pp. 8-13
-
-
Arakawa, K1
Ishihara, T2
Aoto, M3
Inamasu, M4
Kitamura, K5
Saito, A.6
-
9
-
-
84892147447
-
Diuretics prevent thiazolidinedione-induced cardiac hypertrophy without compromising insulin-sensitizing effects in mice
-
Chang CS, et al. Diuretics prevent thiazolidinedione-induced cardiac hypertrophy without compromising insulin-sensitizing effects in mice. Am J Pathol. 2014;184(2):442-453.
-
(2014)
Am J Pathol
, vol.184
, Issue.2
, pp. 442-453
-
-
Chang, CS1
-
10
-
-
66049138419
-
Rosiglitazone-induced heart remodelling is associated with enhanced turnover of myofibrillar protein and mTOR activation
-
Festuccia WT, et al. Rosiglitazone-induced heart remodelling is associated with enhanced turnover of myofibrillar protein and mTOR activation. J Mol Cell Cardiol. 2009;47(1):85-95.
-
(2009)
J Mol Cell Cardiol
, vol.47
, Issue.1
, pp. 85-95
-
-
Festuccia, WT1
-
11
-
-
84890026574
-
Metabonomic profiling revealed an alteration in purine nucleotide metabolism associated with cardiac hypertrophy in rats treated with thiazolidinediones
-
Liu Y, et al. Metabonomic profiling revealed an alteration in purine nucleotide metabolism associated with cardiac hypertrophy in rats treated with thiazolidinediones. J Proteome Res. 2013;12(12):5634-5641.
-
(2013)
J Proteome Res
, vol.12
, Issue.12
, pp. 5634-5641
-
-
Liu, Y1
-
12
-
-
33748323383
-
Regulation of cardiac hypertrophy by intracellular signalling pathways
-
Heineke J, Molkentin JD. Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol. 2006;7(8):589-600.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, Issue.8
, pp. 589-600
-
-
Heineke, J1
Molkentin, JD.2
-
13
-
-
34948910262
-
Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction in mice
-
Son NH, et al. Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction in mice. J Clin Invest. 2007;117(10):2791-2801.
-
(2007)
J Clin Invest
, vol.117
, Issue.10
, pp. 2791-2801
-
-
Son, NH1
-
14
-
-
84896479122
-
Rosiglitazone causes cardiotoxicity via peroxisome proliferator-activated receptor γ-independent mitochondrial oxidative stress in mouse hearts
-
He H, et al. Rosiglitazone causes cardiotoxicity via peroxisome proliferator-activated receptor γ-independent mitochondrial oxidative stress in mouse hearts. Toxicol Sci. 2014;138(2):468-481.
-
(2014)
Toxicol Sci
, vol.138
, Issue.2
, pp. 468-481
-
-
He, H1
-
15
-
-
84871536826
-
Adipose tissue biology and cardiomyopathy: translational implications
-
Turer AT, Hill JA, Elmquist JK, Scherer PE. Adipose tissue biology and cardiomyopathy: translational implications. Circ Res. 2012;111(12):1565-1577.
-
(2012)
Circ Res
, vol.111
, Issue.12
, pp. 1565-1577
-
-
Turer, AT1
Hill, JA2
Elmquist, JK3
Scherer, PE.4
-
16
-
-
84902300494
-
Activation of hypoxia-inducible factor-2 in adipocytes results in pathological cardiac hypertrophy
-
Lin Q, et al. Activation of hypoxia-inducible factor-2 in adipocytes results in pathological cardiac hypertrophy. J Am Heart Assoc. 2013;2(6):e000548.
-
(2013)
J Am Heart Assoc
, vol.2
, Issue.6
, pp. e000548
-
-
Lin, Q1
-
17
-
-
84892727198
-
What we talk about when we talk about fat
-
Rosen ED, Spiegelman BM. What we talk about when we talk about fat. Cell. 2014;156(1-2):20-44.
-
(2014)
Cell
, vol.156
, Issue.1-2
, pp. 20-44
-
-
Rosen, ED1
Spiegelman, BM.2
-
18
-
-
77955415911
-
Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation
-
Ogawa R, et al. Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation. Biochem Biophys Res Commun. 2010;398(4):723-729.
-
(2010)
Biochem Biophys Res Commun
, vol.398
, Issue.4
, pp. 723-729
-
-
Ogawa, R1
-
19
-
-
3042767202
-
MicroRNAs: small RNAs with a big role in gene regulation
-
He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet. 2004;5(7):522-531.
-
(2004)
Nat Rev Genet
, vol.5
, Issue.7
, pp. 522-531
-
-
He, L1
Hannon, GJ.2
-
20
-
-
79958282599
-
Role of microRNAs in cardiac remodeling and heart failure
-
Topkara VK, Mann DL. Role of microRNAs in cardiac remodeling and heart failure. Cardiovasc Drugs Ther. 2011;25(2):171-182.
-
(2011)
Cardiovasc Drugs Ther
, vol.25
, Issue.2
, pp. 171-182
-
-
Topkara, VK1
Mann, DL.2
-
21
-
-
84897647778
-
Multifaceted roles of miR-1s in repressing the fetal gene program in the heart
-
Wei Y, et al. Multifaceted roles of miR-1s in repressing the fetal gene program in the heart. Cell Res. 2014;24(3):278-292.
-
(2014)
Cell Res
, vol.24
, Issue.3
, pp. 278-292
-
-
Wei, Y1
-
22
-
-
70349202176
-
MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice
-
Callis TE, et al. MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J Clin Invest. 2009;119(9):2772-2786.
-
(2009)
J Clin Invest
, vol.119
, Issue.9
, pp. 2772-2786
-
-
Callis, TE1
-
23
-
-
84899128394
-
Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy
-
Bang C, et al. Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy. J Clin Invest. 2014;124(5):2136-2146.
-
(2014)
J Clin Invest
, vol.124
, Issue.5
, pp. 2136-2146
-
-
Bang, C1
-
24
-
-
84856695673
-
Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease?
-
Creemers EE, Tijsen AJ, Pinto YM. Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease? Circ Res. 2012;110(3):483-495.
-
(2012)
Circ Res
, vol.110
, Issue.3
, pp. 483-495
-
-
Creemers, EE1
Tijsen, AJ2
Pinto, YM.3
-
25
-
-
48749122914
-
Circulating microRNAs as stable blood-based markers for cancer detection
-
Mitchell PS, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A. 2008;105(30):10513-10518.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.30
, pp. 10513-10518
-
-
Mitchell, PS1
-
26
-
-
53349177819
-
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases
-
Chen X, et al. Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 2008;18(10):997-1006.
-
(2008)
Cell Res
, vol.18
, Issue.10
, pp. 997-1006
-
-
Chen, X1
-
27
-
-
34249302620
-
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
-
Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9(6):654-659.
-
(2007)
Nat Cell Biol
, vol.9
, Issue.6
, pp. 654-659
-
-
Valadi, H1
Ekström, K2
Bossios, A3
Sjöstrand, M4
Lee, JJ5
Lötvall, JO.6
-
28
-
-
84857708170
-
Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs
-
Hergenreider E, et al. Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nat Cell Biol. 2012;14(3):249-256.
-
(2012)
Nat Cell Biol
, vol.14
, Issue.3
, pp. 249-256
-
-
Hergenreider, E1
-
29
-
-
84866093563
-
Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway
-
Zhuang G, et al. Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway. EMBO J. 2012;31(17):3513-3523.
-
(2012)
EMBO J
, vol.31
, Issue.17
, pp. 3513-3523
-
-
Zhuang, G1
-
30
-
-
77954257796
-
Secreted monocytic miR-150 enhances targeted endothelial cell migration
-
Zhang Y, et al. Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell. 2010;39(1):133-144.
-
(2010)
Mol Cell
, vol.39
, Issue.1
, pp. 133-144
-
-
Zhang, Y1
-
31
-
-
84880272931
-
Regulation of vascular smooth muscle cell turnover by endothelial cell-secreted microRNA-126: role of shear stress
-
Zhou J, et al. Regulation of vascular smooth muscle cell turnover by endothelial cell-secreted microRNA-126: role of shear stress. Circ Res. 2013;113(1):40-51.
-
(2013)
Circ Res
, vol.113
, Issue.1
, pp. 40-51
-
-
Zhou, J1
-
32
-
-
44449161481
-
The TSC1-TSC2 complex: a molecular switchboard controlling cell growth
-
Huang J, Manning BD. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J. 2008;412(2):179-190.
-
(2008)
Biochem J
, vol.412
, Issue.2
, pp. 179-190
-
-
Huang, J1
Manning, BD.2
-
34
-
-
33746699629
-
Inhibition of mTOR reduces chronic pressure-overload cardiac hypertrophy and fibrosis
-
Gao XM, et al. Inhibition of mTOR reduces chronic pressure-overload cardiac hypertrophy and fibrosis. J Hypertens. 2006;24(8):1663-1670.
-
(2006)
J Hypertens
, vol.24
, Issue.8
, pp. 1663-1670
-
-
Gao, XM1
-
35
-
-
79952577412
-
Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin
-
Malhowski AJ, et al. Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin. Hum Mol Genet. 2011;20(7):1290-1305.
-
(2011)
Hum Mol Genet
, vol.20
, Issue.7
, pp. 1290-1305
-
-
Malhowski, AJ1
-
36
-
-
84862821627
-
Pro-inflammatory role of microrna-200 in vascular smooth muscle cells from diabetic mice
-
Reddy MA, et al. Pro-inflammatory role of microrna-200 in vascular smooth muscle cells from diabetic mice. Arterioscler Thromb Vasc Biol. 2012;32(3):721-729.
-
(2012)
Arterioscler Thromb Vasc Biol
, vol.32
, Issue.3
, pp. 721-729
-
-
Reddy, MA1
-
37
-
-
78649326868
-
Diabetic Cardiomyopathy: Mechanisms and Therapeutic Targets
-
Battiprolu PK, Gillette TG, Wang ZV, Lavandero S, Hill JA. Diabetic Cardiomyopathy: Mechanisms and Therapeutic Targets. Drug Discov Today Dis Mech. 2010;7(2):e135-e143.
-
(2010)
Drug Discov Today Dis Mech
, vol.7
, Issue.2
, pp. e135-e143
-
-
Battiprolu, PK1
Gillette, TG2
Wang, ZV3
Lavandero, S4
Hill, JA.5
-
38
-
-
0016251063
-
Role of diabetes in congestive heart failure: the Framingham study
-
Kannel WB, Hjortland M, Castelli WP. Role of diabetes in congestive heart failure: the Framingham study. Am J Cardiol. 1974;34(1):29-34.
-
(1974)
Am J Cardiol
, vol.34
, Issue.1
, pp. 29-34
-
-
Kannel, WB1
Hjortland, M2
Castelli, WP.3
-
39
-
-
0015498586
-
New type of cardiomyopathy associated with diabetic glomerulosclerosis
-
Rubler S, Dlugash J, Yuceoglu YZ, Kumral T, Branwood AW, Grishman A. New type of cardiomyopathy associated with diabetic glomerulosclerosis. Am J Cardiol. 1972;30(6):595-602.
-
(1972)
Am J Cardiol
, vol.30
, Issue.6
, pp. 595-602
-
-
Rubler, S1
Dlugash, J2
Yuceoglu, YZ3
Kumral, T4
Branwood, AW5
Grishman, A.6
-
40
-
-
84863283393
-
Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice
-
Battiprolu PK, et al. Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice. J Clin Invest. 2012;122(3):1109-1118.
-
(2012)
J Clin Invest
, vol.122
, Issue.3
, pp. 1109-1118
-
-
Battiprolu, PK1
-
41
-
-
71149108895
-
Conserved microRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K
-
Hyun S, et al. Conserved microRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K. Cell. 2009;139(6):1096-1108.
-
(2009)
Cell
, vol.139
, Issue.6
, pp. 1096-1108
-
-
Hyun, S1
-
42
-
-
79960391940
-
miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells
-
Eades G, Yao Y, Yang M, Zhang Y, Chumsri S, Zhou Q. miR-200a regulates SIRT1 expression and epithelial to mesenchymal transition (EMT)-like transformation in mammary epithelial cells. J Biol Chem. 2011;286(29):25992-26002.
-
(2011)
J Biol Chem
, vol.286
, Issue.29
, pp. 25992-26002
-
-
Eades, G1
Yao, Y2
Yang, M3
Zhang, Y4
Chumsri, S5
Zhou, Q.6
-
43
-
-
78449241484
-
Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR
-
Liu M, et al. Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR. J Biol Chem. 2010;285(47):36387-36394.
-
(2010)
J Biol Chem
, vol.285
, Issue.47
, pp. 36387-36394
-
-
Liu, M1
-
44
-
-
77950127881
-
SIRT1 negatively regulates the mammalian target of rapamycin
-
Ghosh HS, McBurney M, Robbins PD. SIRT1 negatively regulates the mammalian target of rapamycin. PLoS ONE. 2010;5(2):e9199.
-
(2010)
PLoS ONE
, vol.5
, Issue.2
, pp. e9199
-
-
Ghosh, HS1
McBurney, M2
Robbins, PD.3
-
45
-
-
78650172708
-
Silent information regulator 1 protects the heart from ischemia/reperfusion
-
Hsu CP, et al. Silent information regulator 1 protects the heart from ischemia/reperfusion. Circulation. 2010;122(21):2170-2182.
-
(2010)
Circulation
, vol.122
, Issue.21
, pp. 2170-2182
-
-
Hsu, CP1
-
46
-
-
67651005839
-
Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart
-
Zhou B, et al. Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest. 2009;119(6):1462-1476.
-
(2009)
J Clin Invest
, vol.119
, Issue.6
, pp. 1462-1476
-
-
Zhou, B1
-
47
-
-
23644439061
-
Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure
-
Shiojima I, et al. Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J Clin Invest. 2005;115(8):2108-2118.
-
(2005)
J Clin Invest
, vol.115
, Issue.8
, pp. 2108-2118
-
-
Shiojima, I1
-
48
-
-
0037151104
-
Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart
-
Matsui T, et al. Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J Biol Chem. 2002;277(25):22896-22901.
-
(2002)
J Biol Chem
, vol.277
, Issue.25
, pp. 22896-22901
-
-
Matsui, T1
-
49
-
-
33646458252
-
Akt signaling and growth of the heart
-
Walsh K. Akt signaling and growth of the heart. Circulation. 2006;113(17):2032-2034.
-
(2006)
Circulation
, vol.113
, Issue.17
, pp. 2032-2034
-
-
Walsh, K.1
-
50
-
-
79955694276
-
Brain PPAR-γ promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones
-
Lu M, et al. Brain PPAR-γ promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones. Nat Med. 2011;17(5):618-622.
-
(2011)
Nat Med
, vol.17
, Issue.5
, pp. 618-622
-
-
Lu, M1
-
51
-
-
79960018147
-
Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice
-
Wong WT, et al. Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice. Cell Metab. 2011;14(1):104-115.
-
(2011)
Cell Metab
, vol.14
, Issue.1
, pp. 104-115
-
-
Wong, WT1
-
52
-
-
70350542786
-
Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance
-
Deng ZB, et al. Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance. Diabetes. 2009;58(11):2498-2505.
-
(2009)
Diabetes
, vol.58
, Issue.11
, pp. 2498-2505
-
-
Deng, ZB1
-
53
-
-
76049086229
-
PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization
-
Sugii S, et al. PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization. Proc Natl Acad Sci U S A. 2009;106(52):22504-22509.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.52
, pp. 22504-22509
-
-
Sugii, S1
-
54
-
-
84859715525
-
Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease
-
Sheikh F, et al. Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease. J Clin Invest. 2012;122(4):1209-1221.
-
(2012)
J Clin Invest
, vol.122
, Issue.4
, pp. 1209-1221
-
-
Sheikh, F1
-
55
-
-
0021136310
-
Primary culture of isolated adipocytes. A new model to study insulin receptor regulation and insulin action
-
Marshall S, Garvey WT, Geller M. Primary culture of isolated adipocytes. A new model to study insulin receptor regulation and insulin action. J Biol Chem. 1984;259(10):6376-6384.
-
(1984)
J Biol Chem
, vol.259
, Issue.10
, pp. 6376-6384
-
-
Marshall, S1
Garvey, WT2
Geller, M.3
-
56
-
-
16644369330
-
Primary culture and differentiation of human adipocyte precursor cells
-
van Harmelen V, Skurk T, Hauner H. Primary culture and differentiation of human adipocyte precursor cells. Methods Mol Med. 2005;107:125-135.
-
(2005)
Methods Mol Med
, vol.107
, pp. 125-135
-
-
van Harmelen, V1
Skurk, T2
Hauner, H.3
|