Conserved MicroRNA miR-8/miR-200 and Its Target USH/FOG2 Control Growth by Regulating PI3K

Cell

Volumn 139, Issue 6, 2009, Pages 1096-1108

  Hyun, Seogang ^a   Lee, Jung Hyun ^a   Jin, Hua ^a   Nam, JinWu ^a   Namkoong, Bumjin ^a   Lee, Gina ^b   Chung, Jongkyeong ^b   Kim, V Narry ^a  

^a Seoul National University   (South Korea)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

HUMDISEASE; RNA; SIGNALING

Indexed keywords

INSULIN; MICRORNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; TRANSCRIPTION FACTOR FOXO; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; ZINC FINGER PROTEIN M2;

ADIPOCYTE; ADIPOSE TISSUE; ADOLESCENT DEVELOPMENT; AGING; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BODY SIZE; CARCINOGENESIS; CELL GROWTH; CONTROLLED STUDY; DROSOPHILA; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; ENZYME SUBUNIT; ENZYME SYNTHESIS; FAT BODY; GROWTH REGULATION; HUMAN; HUMAN CELL; LIVER PARENCHYMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN TARGETING; REGULATORY MECHANISM; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

EID: 71149108895     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2009.11.020     Document Type: Article

References (54)

1. Arden K.C. FOXO animal models reveal a variety of diverse roles for FOXO transcription factors. Oncogene 27 (2008) 2345-2350
2. Asha H., Nagy I., Kovacs G., Stetson D., Ando I., and Dearolf C.R. Analysis of Ras-induced overproliferation in Drosophila hemocytes. Genetics 163 (2003) 203-215
3. Baker J., Liu J.P., Robertson E.J., and Efstratiadis A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75 (1993) 73-82
4. Bartel D.P. MicroRNAs: target recognition and regulatory functions. Cell 136 (2009) 215-233
5. Bielinska M., Genova E., Boime I., Parviainen H., Kiiveri S., Leppaluoto J., Rahman N., Heikinheimo M., and Wilson D.B. Gonadotropin-induced adrenocortical neoplasia in NU/J nude mice. Endocrinology 146 (2005) 3975-3984
6. Biggs III W.H., Meisenhelder J., Hunter T., Cavenee W.K., and Arden K.C. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc. Natl. Acad. Sci. USA 96 (1999) 7421-7426
7. Brennecke J., Stark A., Russell R.B., and Cohen S.M. Principles of microRNA-target recognition. PLoS Biol. 3 (2005) e85
8. Britton J.S., Lockwood W.K., Li L., Cohen S.M., and Edgar B.A. Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions. Dev. Cell 2 (2002) 239-249
9. Caldwell P.E., Walkiewicz M., and Stern M. Ras activity in the Drosophila prothoracic gland regulates body size and developmental rate via ecdysone release. Curr. Biol. 15 (2005) 1785-1795
10. Choi P.S., Zakhary L., Choi W.Y., Caron S., Alvarez-Saavedra E., Miska E.A., McManus M., Harfe B., Giraldez A.J., Horvitz R.H., et al. Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron 57 (2008) 41-55
11. Clugston R.D., Zhang W., and Greer J.J. Gene expression in the developing diaphragm: significance for congenital diaphragmatic hernia. Am. J. Physiol. Lung Cell. Mol. Physiol. 294 (2008) L665-L675
12. Colombani J., Bianchini L., Layalle S., Pondeville E., Dauphin-Villemant C., Antoniewski C., Carre C., Noselli S., and Leopold P. Antagonistic actions of ecdysone and insulins determine final size in Drosophila. Science 310 (2005) 667-670
13. Colombani J., Raisin S., Pantalacci S., Radimerski T., Montagne J., and Leopold P. A nutrient sensor mechanism controls Drosophila growth. Cell 114 (2003) 739-749
14. Cubadda Y., Heitzler P., Ray R.P., Bourouis M., Ramain P., Gelbart W., Simpson P., and Haenlin M. u-shaped encodes a zinc finger protein that regulates the proneural genes achaete and scute during the formation of bristles in Drosophila. Genes Dev. 11 (1997) 3083-3095
15. Dykxhoorn D.M., Wu Y., Xie H., Yu F., Lal A., Petrocca F., Martinvalet D., Song E., Lim B., and Lieberman J. miR-200 enhances mouse breast cancer cell colonization to form distant metastases. PLoS One 4 (2009) e7181
16. Edgar B.A. How flies get their size: genetics meets physiology. Nat. Rev. Genet. 7 (2006) 907-916
17. Flynt A.S., Thatcher E.J., Burkewitz K., Li N., Liu Y., and Patton J.G. miR-8 microRNAs regulate the response to osmotic stress in zebrafish embryos. J. Cell Biol. 185 (2009) 115-127
18. Fossett N., and Schulz R.A. Conserved cardiogenic functions of the multitype zinc-finger proteins: U-shaped and FOG-2. Trends Cardiovasc. Med. 11 (2001) 185-190
19. Fossett N., Tevosian S.G., Gajewski K., Zhang Q., Orkin S.H., and Schulz R.A. The Friend of GATA proteins U-shaped, FOG-1, and FOG-2 function as negative regulators of blood, heart, and eye development in Drosophila. Proc. Natl. Acad. Sci. USA 98 (2001) 7342-7347
20. Fuss B., Becker T., Zinke I., and Hoch M. The cytohesin Steppke is essential for insulin signalling in Drosophila. Nature 444 (2006) 945-948
21. Garriga-Canut M., and Orkin S.H. Transforming acidic coiled-coil protein 3 (TACC3) controls friend of GATA-1 (FOG-1) subcellular localization and regulates the association between GATA-1 and FOG-1 during hematopoiesis. J. Biol. Chem. 279 (2004) 23597-23605
22. Gregory P.A., Bracken C.P., Bert A.G., and Goodall G.J. MicroRNAs as regulators of epithelial-mesenchymal transition. Cell Cycle 7 (2008) 3112-3118
23. Holmes M., Turner J., Fox A., Chisholm O., Crossley M., and Chong B. hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation. J. Biol. Chem. 274 (1999) 23491-23498
24. Ikeya T., Galic M., Belawat P., Nairz K., and Hafen E. Nutrient-dependent expression of insulin-like peptides from neuroendocrine cells in the CNS contributes to growth regulation in Drosophila. Curr. Biol. 12 (2002) 1293-1300
25. Iorio M.V., Visone R., Di Leva G., Donati V., Petrocca F., Casalini P., Taccioli C., Volinia S., Liu C.G., Alder H., et al. MicroRNA signatures in human ovarian cancer. Cancer Res. 67 (2007) 8699-8707
26. John B., Enright A.J., Aravin A., Tuschl T., Sander C., and Marks D.S. Human MicroRNA targets. PLoS Biol. 2 (2004) e363
27. Karres J.S., Hilgers V., Carrera I., Treisman J., and Cohen S.M. The conserved microRNA miR-8 tunes atrophin levels to prevent neurodegeneration in Drosophila. Cell 131 (2007) 136-145
28. Kaufman C.K., Zhou P., Pasolli H.A., Rendl M., Bolotin D., Lim K.C., Dai X., Alegre M.L., and Fuchs E. GATA-3: an unexpected regulator of cell lineage determination in skin. Genes Dev. 17 (2003) 2108-2122
29. Kennell J.A., Gerin I., MacDougald O.A., and Cadigan K.M. The microRNA miR-8 is a conserved negative regulator of Wnt signaling. Proc. Natl. Acad. Sci. USA 105 (2008) 15417-15422
30. Kim S.K., Nam J.W., Rhee J.K., Lee W.J., and Zhang B.T. miTarget: microRNA target gene prediction using a support vector machine. BMC Bioinformatics 7 (2006) 411
31. Kiriakidou M., Nelson P.T., Kouranov A., Fitziev P., Bouyioukos C., Mourelatos Z., and Hatzigeorgiou A. A combined computational-experimental approach predicts human microRNA targets. Genes Dev. 18 (2004) 1165-1178
32. Krek A., Grun D., Poy M.N., Wolf R., Rosenberg L., Epstein E.J., MacMenamin P., da Piedade I., Gunsalus K.C., Stoffel M., et al. Combinatorial microRNA target predictions. Nat. Genet. 37 (2005) 495-500
33. Landgraf P., Rusu M., Sheridan R., Sewer A., Iovino N., Aravin A., Pfeffer S., Rice A., Kamphorst A.O., Landthaler M., et al. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 129 (2007) 1401-1414
34. Layalle S., Arquier N., and Leopold P. The TOR pathway couples nutrition and developmental timing in Drosophila. Dev. Cell 15 (2008) 568-577
35. Lee Y., Lee J., Bang S., Hyun S., Kang J., Hong S.T., Bae E., Kaang B.K., and Kim J. Pyrexia is a new thermal transient receptor potential channel endowing tolerance to high temperatures in Drosophila melanogaster. Nat. Genet. 37 (2005) 305-310
36. Leopold P., and Perrimon N. Drosophila and the genetics of the internal milieu. Nature 450 (2007) 186-188
37. Lewis B.P., Burge C.B., and Bartel D.P. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120 (2005) 15-20
38. Lu J.R., McKinsey T.A., Xu H., Wang D.Z., Richardson J.A., and Olson E.N. FOG-2, a heart- and brain-enriched cofactor for GATA transcription factors. Mol. Cell. Biol. 19 (1999) 4495-4502
39. Mirth C., Truman J.W., and Riddiford L.M. The role of the prothoracic gland in determining critical weight for metamorphosis in Drosophila melanogaster. Curr. Biol. 15 (2005) 1796-1807
40. Mirth C.K., and Riddiford L.M. Size assessment and growth control: how adult size is determined in insects. Bioessays 29 (2007) 344-355
41. Nam E.J., Yoon H., Kim S.W., Kim H., Kim Y.T., Kim J.H., Kim J.W., and Kim S. MicroRNA expression profiles in serous ovarian carcinoma. Clin. Cancer Res. 14 (2008) 2690-2695
42. Nanni S., Priolo C., Grasselli A., D'Eletto M., Merola R., Moretti F., Gallucci M., De Carli P., Sentinelli S., Cianciulli A.M., et al. Epithelial-restricted gene profile of primary cultures from human prostate tumors: a molecular approach to predict clinical behavior of prostate cancer. Mol. Cancer Res. 4 (2006) 79-92
43. Park S.Y., Lee J.H., Ha M., Nam J.W., and Kim V.N. miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Nat. Struct. Mol. Biol. 16 (2009) 23-29
44. Pollak M. Insulin and insulin-like growth factor signalling in neoplasia. Nat. Rev. Cancer 8 (2008) 915-928
45. Puig O., and Tjian R. Transcriptional feedback control of insulin receptor by dFOXO/FOXO1. Genes Dev. 19 (2005) 2435-2446
46. Rulifson E.J., Kim S.K., and Nusse R. Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science 296 (2002) 1118-1120
47. Smibert P., and Lai E.C. Lessons from microRNA mutants in worms, flies and mice. Cell Cycle 7 (2008) 2500-2508
48. Sorrentino R.P., Tokusumi T., and Schulz R.A. The Friend of GATA protein U-shaped functions as a hematopoietic tumor suppressor in Drosophila. Dev. Biol. 311 (2007) 311-323
49. Stark A., Brennecke J., Russell R.B., and Cohen S.M. Identification of Drosophila MicroRNA targets. PLoS Biol. 1 (2003) E60
50. Svensson E.C., Tufts R.L., Polk C.E., and Leiden J.M. Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes. Proc. Natl. Acad. Sci. USA 96 (1999) 956-961
51. Takata K., Yoshida H., Yamaguchi M., and Sakaguchi K. Drosophila damaged DNA-binding protein 1 is an essential factor for development. Genetics 168 (2004) 855-865
52. Tevosian S.G., Deconinck A.E., Cantor A.B., Rieff H.I., Fujiwara Y., Corfas G., and Orkin S.H. FOG-2: A novel GATA-family cofactor related to multitype zinc-finger proteins Friend of GATA-1 and U-shaped. Proc. Natl. Acad. Sci. USA 96 (1999) 950-955
53. Wachi S., Yoneda K., and Wu R. Interactome-transcriptome analysis reveals the high centrality of genes differentially expressed in lung cancer tissues. Bioinformatics 21 (2005) 4205-4208
54. Zinke I., Kirchner C., Chao L.C., Tetzlaff M.T., and Pankratz M.J. Suppression of food intake and growth by amino acids in Drosophila: the role of pumpless, a fat body expressed gene with homology to vertebrate glycine cleavage system. Development 126 (1999) 5275-5284