Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease

Journal of Clinical Investigation

Volumn 122, Issue 4, 2012, Pages 1209-1221

  Sheikh, Farah ^a   Ouyang, Kunfu ^a   Campbell, Stuart G ^b   Lyon, Robert C ^a   Chuang, Joyce ^a,b   Fitzsimons, Dan ^c   Tangney, Jared ^b   Hidalgo, Carlos G ^d   Chung, Charles S ^d   Cheng, Hongqiang ^a   Dalton, Nancy D ^a   Gu, Yusu ^a   Kasahara, Hideko ^e   Ghassemian, Majid ^f   Omens, Jeffrey H ^a,b   Peterson, Kirk L ^a   Granzier, Henk L ^d   Moss, Richard L ^c   McCulloch, Andrew D ^b   Chen, Ju ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d UNIVERSITY OF ARIZONA   (United States)

^e UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIAC MYOSIN; MYOSIN LIGHT CHAIN 2;

ACTIN MYOSIN INTERACTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE TARGETING; HEART CONTRACTION; HEART FAILURE; HEART LEFT VENTRICLE FAILURE; MOUSE; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE TWITCH; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; THIN FILAMENT;

ACTIN CYTOSKELETON; ACTOMYOSIN; ANIMALS; BIOMECHANICS; CALCIUM SIGNALING; CARDIAC MYOSINS; HEART FAILURE; HEART VENTRICLES; KINETICS; MICE; MICE, MUTANT STRAINS; MODELS, CARDIOVASCULAR; MUSCLE RELAXATION; MYOCARDIAL CONTRACTION; MYOSIN LIGHT CHAINS; PHOSPHORYLATION; PHOSPHOSERINE; PROTEIN PROCESSING, POST-TRANSLATIONAL; STRUCTURE-ACTIVITY RELATIONSHIP; VENTRICULAR DYSFUNCTION, LEFT;

EID: 84859715525     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI61134     Document Type: Article

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