메뉴 건너뛰기




Volumn 93, Issue 3, 2019, Pages

Two Families of Env Antibodies Efficiently Engage Fc-Gamma Receptors and Eliminate HIV -1-Infected Cells

Author keywords

Adcc; Anti cluster a antibodies; Anticoreceptor binding site antibodies; Cd4 mimetics; Env; Fcriiia; HIV 1; Nonneutralizing antibodies

Indexed keywords

CD16 ANTIGEN; CORECEPTOR BINDING SITE ANTIBODY; FC RECEPTOR; GLYCOPROTEIN GP 120; PROTEIN FC RECEPTOR IIIA; UNCLASSIFIED DRUG; VIRUS ANTIBODY; VIRUS ENVELOPE PROTEIN; EPITOPE; FCGR3A PROTEIN, HUMAN; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; PROTEIN BINDING; RECOMBINANT PROTEIN;

EID: 85060165375     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01823-18     Document Type: Article
Times cited : (41)

References (76)
  • 2
    • 0036435095 scopus 로고    scopus 로고
    • Sustained antibodydependent cell-mediated cytotoxicity (adcc) in siv-infected macaques correlates with delayed progression to AIDS
    • Banks ND, Kinsey N, Clements J, Hildreth JE. 2002. Sustained antibodydependent cell-mediated cytotoxicity (ADCC) in SIV-infected macaques correlates with delayed progression to AIDS. AIDS Res Hum Retroviruses 18:1197-1205. https://doi.org/10.1089/08892220260387940.
    • (2002) AIDS Res Hum, Retroviruses , vol.18 , pp. 1197-1205
    • Banks, N.D.1    Kinsey, N.2    Clements, J.3    Hildreth, J.E.4
  • 5
    • 0033375327 scopus 로고    scopus 로고
    • Antibody-dependent cellular cytotoxicity independently predicts survival in severely immunocompromised human immunodeficiency virus-infected patients
    • Forthal DN, Landucci G, Haubrich R, Keenan B, Kuppermann BD, Tilles JG, Kaplan J. 1999. Antibody-dependent cellular cytotoxicity independently predicts survival in severely immunocompromised human immunodeficiency virus-infected patients. J Infect Dis 180:1338-1341. https://doi.org/10.1086/314988.
    • (1999) J Infect Dis , vol.180 , pp. 1338-1341
    • Forthal, D.N.1    Landucci, G.2    Haubrich, R.3    Keenan, B.4    Kuppermann, B.D.5    Tilles, J.G.6    Kaplan, J.7
  • 6
    • 84864055665 scopus 로고    scopus 로고
    • HIV -specific antibodies capable of adcc are common in breastmilk and are associated with reduced risk of transmission in women with high viral loads
    • Mabuka J, Nduati R, Odem-Davis K, Peterson D, Overbaugh J. 2012. HIV -specific antibodies capable of ADCC are common in breastmilk and are associated with reduced risk of transmission in women with high viral loads. PLoS Pathog 8:e1002739. https://doi.org/10.1371/jouRNAl.ppat.1002739.
    • (2012) PLoS Pathog , vol.8 , pp. e1002739
    • Mabuka, J.1    Nduati, R.2    Odem-Davis, K.3    Peterson, D.4    Overbaugh, J.5
  • 7
    • 79960423934 scopus 로고    scopus 로고
    • Antibody-dependent cell-mediated cytotoxicity in simian immunodeficiency virus-infected rhesus monkeys
    • Sun Y, Asmal M, Lane S, Permar SR, Schmidt SD, Mascola JR, Letvin NL. 2011. Antibody-dependent cell-mediated cytotoxicity in simian immunodeficiency virus-infected rhesus monkeys. J Virol 85:6906-6912. https://doi.org/10.1128/JVI.00326-11.
    • (2011) J Virol , vol.85 , pp. 6906-6912
    • Sun, Y.1    Asmal, M.2    Lane, S.3    Permar, S.R.4    Schmidt, S.D.5    Mascola, J.R.6    Letvin, N.L.7
  • 10
    • 84859301570 scopus 로고    scopus 로고
    • Fc receptor-targeted therapies for the treatment of inflammation, cancer and beyond
    • Hogarth PM, Pietersz GA. 2012. Fc receptor-targeted therapies for the treatment of inflammation, cancer and beyond. Nat Rev Drug Discov 11:311-331. https://doi.org/10.1038/nrd2909.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 311-331
    • Hogarth, P.M.1    Pietersz, G.A.2
  • 11
    • 85025082969 scopus 로고    scopus 로고
    • Antibody functional assays as measures of fc receptor-mediated immunity to HIV -new technologies and their impact on the HIV vaccine field
    • Wines BD, Billings H, McLean MR, Kent SJ, Hogarth PM. 2017. Antibody functional assays as measures of Fc receptor-mediated immunity to HIV -new technologies and their impact on the HIV vaccine field. Curr HIV Res 15:202-215. https://doi.org/10.2174/1570162X15666170320112247.
    • (2017) Curr HIV Res , vol.15 , pp. 202-215
    • Wines, B.D.1    Billings, H.2    McLean, M.R.3    Kent, S.J.4    Hogarth, P.M.5
  • 14
    • 84920439570 scopus 로고    scopus 로고
    • Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against hcv genotypes 1a, 1b, 2a, 2b, 2c, and 3a
    • Carlsen TH, Pedersen J, Prentoe JC, Giang E, Keck ZY, Mikkelsen LS, Law M, Foung SK, Bukh J. 2014. Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against HCV genotypes 1a, 1b, 2a, 2b, 2c, and 3a. Hepatology 60:1551-1562. https://doi.org/10.1002/hep.27298.
    • (2014) Hepatology , vol.60 , pp. 1551-1562
    • Carlsen, T.H.1    Pedersen, J.2    Prentoe, J.C.3    Giang, E.4    Keck, Z.Y.5    Mikkelsen, L.S.6    Law, M.7    Foung, S.K.8    Bukh, J.9
  • 18
    • 85038864598 scopus 로고    scopus 로고
    • Envelope glycoproteins sampling states 2/3 are susceptible to adcc by sera from HIV -1-infected individuals
    • Prevost J, Richard J, Ding S, Pacheco B, Charlebois R, Hahn BH, Kaufmann DE, Finzi A. 2018. Envelope glycoproteins sampling states 2/3 are susceptible to ADCC by sera from HIV -1-infected individuals. Virology 515: 38-45. https://doi.org/10.1016/j.virol.2017.12.002.
    • (2018) Virology , vol.515 , pp. 38-45
    • Prevost, J.1    Richard, J.2    Ding, S.3    Pacheco, B.4    Charlebois, R.5    Hahn, B.H.6    Kaufmann, D.E.7    Finzi, A.8
  • 19
    • 84919429656 scopus 로고    scopus 로고
    • The HIV -1 gp120 cd4-bound conformation is preferentially targeted by antibodydependent cellular cytotoxicity-mediating antibodies in sera from HIV -1-infected individuals
    • Veillette M, Coutu M, Richard J, Batraville LA, Dagher O, BeRNArd N, Tremblay C, Kaufmann DE, Roger M, Finzi A. 2015. The HIV -1 gp120 CD4-bound conformation is preferentially targeted by antibodydependent cellular cytotoxicity-mediating antibodies in sera from HIV -1-infected individuals. J Virol 89:545-551. https://doi.org/10.1128/JVI.02868-14.
    • (2015) J Virol , vol.89 , pp. 545-551
    • Veillette, M.1    Coutu, M.2    Richard, J.3    Batraville, L.A.4    Dagher, O.5    BeRNArd, N.6    Tremblay, C.7    Kaufmann, D.E.8    Roger, M.9    Finzi, A.10
  • 23
    • 38549095979 scopus 로고    scopus 로고
    • Tetherin inhibits retrovirus release and is antagonized by HIV -1 vpu
    • Neil SJ, Zang T, Bieniasz PD. 2008. Tetherin inhibits retrovirus release and is antagonized by HIV -1 Vpu. Nature 451:425-430. https://doi.org/10.1038/nature06553.
    • (2008) Nature , vol.451 , pp. 425-430
    • Neil, S.J.1    Zang, T.2    Bieniasz, P.D.3
  • 24
    • 41849116366 scopus 로고    scopus 로고
    • The interferon-induced protein bst-2 restricts HIV -1 release and is downregulated from the cell surface by the viral vpu protein
    • Van Damme N, Goff D, Katsura C, Jorgenson RL, Mitchell R, Johnson MC, Stephens EB, Guatelli J. 2008. The interferon-induced protein BST-2 restricts HIV -1 release and is downregulated from the cell surface by the viral Vpu protein. Cell Host Microbe 3:245-252. https://doi.org/10.1016/j.chom.2008.03.001.
    • (2008) Cell Host Microbe , vol.3 , pp. 245-252
    • Van Damme, N.1    Goff, D.2    Katsura, C.3    Jorgenson, R.L.4    Mitchell, R.5    Johnson, M.C.6    Stephens, E.B.7    Guatelli, J.8
  • 25
    • 84958062076 scopus 로고    scopus 로고
    • Role of HIV -1 envelope glycoproteins conformation and accessory proteins on adcc responses
    • Veillette M, Richard J, Pazgier M, Lewis GK, Parsons MS, Finzi A. 2016. Role of HIV -1 envelope glycoproteins conformation and accessory proteins on ADCC responses. Curr HIV Res 14:9-23.
    • (2016) Curr HIV Res , vol.14 , pp. 9-23
    • Veillette, M.1    Richard, J.2    Pazgier, M.3    Lewis, G.K.4    Parsons, M.S.5    Finzi, A.6
  • 26
    • 85034733206 scopus 로고    scopus 로고
    • Impact of HIV -1 envelope conformation on adcc responses
    • Richard J, Prevost J, Alsahafi N, Ding S, Finzi A. 2018. Impact of HIV -1 envelope conformation on ADCC responses. Trends Microbiol 26: 253-265. https://doi.org/10.1016/j.tim.2017.10.007.
    • (2018) Trends Microbiol , vol.26 , pp. 253-265
    • Richard, J.1    Prevost, J.2    Alsahafi, N.3    Ding, S.4    Finzi, A.5
  • 27
    • 85055791553 scopus 로고    scopus 로고
    • Antibody-dependent cellular cytotoxicity (adcc) in HIV infection
    • 13 November
    • Forthal DN, Finzi A. 13 November 2018. Antibody-dependent cellular cytotoxicity (ADCC) in HIV infection. AIDS https://doi.org/10.1097/QAD.0000000000002011.
    • (2018) AIDS
    • Forthal, D.N.1    Finzi, A.2
  • 33
    • 85031804948 scopus 로고    scopus 로고
    • Targeting the late stage of HIV -1 entry for antibody-dependent cellular cytotoxicity: Structural basis for env epitopes in the c11 region
    • Tolbert WD, Gohain N, Alsahafi N, Van V, Orlandi C, Ding S, Martin L, Finzi A, Lewis GK, Ray K, Pazgier M. 2017. Targeting the late stage of HIV -1 entry for antibody-dependent cellular cytotoxicity: Structural basis for Env epitopes in the C11 region. Structure 25:1719-1731.e4. https://doi.org/10.1016/j.str.2017.09.009.
    • (2017) Structure , vol.25 , Issue.1719-1731 , pp. e4
    • Tolbert, W.D.1    Gohain, N.2    Alsahafi, N.3    Van, V.4    Orlandi, C.5    Ding, S.6    Martin, L.7    Finzi, A.8    Lewis, G.K.9    Ray, K.10    Pazgier, M.11
  • 34
    • 77749329921 scopus 로고    scopus 로고
    • Topological layers in the HIV -1 gp120 inner domain regulate gp41 interaction and cd4-triggered conformational transitions
    • Finzi A, Xiang SH, Pacheco B, Wang L, Haight J, Kassa A, Danek B, Pancera M, Kwong PD, Sodroski J. 2010. Topological layers in the HIV -1 gp120 inner domain regulate gp41 interaction and CD4-triggered conformational transitions. Mol Cell 37:656-667. https://doi.org/10.1016/j.molcel.2010.02.012.
    • (2010) Mol Cell , vol.37 , pp. 656-667
    • Finzi, A.1    Xiang, S.H.2    Pacheco, B.3    Wang, L.4    Haight, J.5    Kassa, A.6    Danek, B.7    Pancera, M.8    Kwong, P.D.9    Sodroski, J.10
  • 35
    • 79960342938 scopus 로고    scopus 로고
    • An HIV -1 gp120 envelope human monoclonal antibody that recognizes a c1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (adcc) activity and defines a common adcc epitope in human HIV -1 serum
    • Ferrari G, Pollara J, Kozink D, Harms T, Drinker M, Freel S, Moody MA, Alam SM, Tomaras GD, Ochsenbauer C, Kappes JC, Shaw GM, Hoxie JA, Robinson JE, Haynes BF. 2011. An HIV -1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV -1 serum. J Virol 85: 7029-7036. https://doi.org/10.1128/JVI.00171-11.
    • (2011) J Virol , vol.85 , pp. 7029-7036
    • Ferrari, G.1    Pollara, J.2    Kozink, D.3    Harms, T.4    Drinker, M.5    Freel, S.6    Moody, M.A.7    Alam, S.M.8    Tomaras, G.D.9    Ochsenbauer, C.10    Kappes, J.C.11    Shaw, G.M.12    Hoxie, J.A.13    Robinson, J.E.14    Haynes, B.F.15
  • 36
    • 0029119783 scopus 로고
    • Involvement of the v1/v2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding
    • Wyatt R, Moore J, Accola M, Desjardin E, Robinson J, Sodroski J. 1995. Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding. J Virol 69:5723-5733.
    • (1995) J Virol , vol.69 , pp. 5723-5733
    • Wyatt, R.1    Moore, J.2    Accola, M.3    Desjardin, E.4    Robinson, J.5    Sodroski, J.6
  • 37
    • 84983751890 scopus 로고    scopus 로고
    • Dimeric fcgammar ectodomains as probes of the fc receptor function of anti-influenza virus igg
    • Wines BD, Vanderven HA, Esparon SE, Kristensen AB, Kent SJ, Hogarth PM. 2016. Dimeric FcgammaR ectodomains as probes of the Fc receptor function of anti-influenza virus IgG. J Immunol 197:1507-1516. https://doi.org/10.4049/jimmunol.1502551.
    • (2016) J Immunol , vol.197 , pp. 1507-1516
    • Wines, B.D.1    Vanderven, H.A.2    Esparon, S.E.3    Kristensen, A.B.4    Kent, S.J.5    Hogarth, P.M.6
  • 40
    • 85023176913 scopus 로고    scopus 로고
    • Dimeric fcgamma receptor enzyme-linked immunosorbent assay to study HIV -specific antibodies: A new look into breadth of fcgamma receptor antibodies induced by the rv144 vaccine trial
    • McLean MR, Madhavi V, Wines BD, Hogarth PM, Chung AW, Kent SJ. 2017. Dimeric Fcgamma receptor enzyme-linked immunosorbent assay to study HIV -specific antibodies: A new look into breadth of Fcgamma receptor antibodies induced by the RV144 Vaccine Trial. J Immunol 199:816-826. https://doi.org/10.4049/jimmunol.1602161.
    • (2017) J Immunol , vol.199 , pp. 816-826
    • McLean, M.R.1    Madhavi, V.2    Wines, B.D.3    Hogarth, P.M.4    Chung, A.W.5    Kent, S.J.6
  • 43
    • 84924985686 scopus 로고    scopus 로고
    • HIV -1 gp120 dimers decrease the overall affinity of gp120 preparations for cd4-induced ligands
    • Coutu M, Finzi A. 2015. HIV -1 gp120 dimers decrease the overall affinity of gp120 preparations for CD4-induced ligands. J Virol Methods 215-216:37-44. https://doi.org/10.1016/j.jviromet.2015.02.017.
    • (2015) J Virol Methods , vol.215-216 , pp. 37-44
    • Coutu, M.1    Finzi, A.2
  • 46
    • 0035194285 scopus 로고    scopus 로고
    • Effector function activities of a panel of mutants of a broadly neutralizing antibody against human immunodeficiency virus type 1
    • Hezareh M, Hessell AJ, Jensen RC, van de Winkel JG, Parren PW. 2001. Effector function activities of a panel of mutants of a broadly neutralizing antibody against human immunodeficiency virus type 1. J Virol 75:12161-12168. https://doi.org/10.1128/JVI.75.24.12161-12168.2001.
    • (2001) J Virol , vol.75 , pp. 12161-12168
    • Hezareh, M.1    Hessell, A.J.2    Jensen, R.C.3    Van, D.W.J.G.4    Parren, P.W.5
  • 47
    • 84912010283 scopus 로고    scopus 로고
    • Highly reduced binding to high and low affinity mouse fc gamma receptors by l234a/l235a and n297a fc mutations engineered into mouse igg2a
    • Arduin E, Arora S, Bamert PR, Kuiper T, Popp S, Geisse S, Grau R, Calzascia T, Zenke G, Kovarik J. 2015. Highly reduced binding to high and low affinity mouse Fc gamma receptors by L234A/L235A and N297A Fc mutations engineered into mouse IgG2a. Mol Immunol 63:456-463. https://doi.org/10.1016/j.molimm.2014.09.017.
    • (2015) Mol Immunol , vol.63 , pp. 456-463
    • Arduin, E.1    Arora, S.2    Bamert, P.R.3    Kuiper, T.4    Popp, S.5    Geisse, S.6    Grau, R.7    Calzascia, T.8    Zenke, G.9    Kovarik, J.10
  • 51
    • 0032546844 scopus 로고    scopus 로고
    • The HIV -1 envelope glycoproteins: Fusogens, antigens, and immunogens
    • Wyatt R, Sodroski J. 1998. The HIV -1 envelope glycoproteins: Fusogens, antigens, and immunogens. Science 280:1884-1888. https://doi.org/10.1126/science.280.5371.1884.
    • (1998) Science , vol.280 , pp. 1884-1888
    • Wyatt, R.1    Sodroski, J.2
  • 55
    • 84866495323 scopus 로고    scopus 로고
    • Human antibodies that neutralize HIV -1: Identification, structures, and b cell ontogenies
    • Kwong PD, Mascola JR. 2012. Human antibodies that neutralize HIV -1: Identification, structures, and B cell ontogenies. Immunity 37:412-425. https://doi.org/10.1016/j.immuni.2012.08.012.
    • (2012) Immunity , vol.37 , pp. 412-425
    • Kwong, P.D.1    Mascola, J.R.2
  • 60
    • 85048481468 scopus 로고    scopus 로고
    • 13 June,Incomplete downregulation of cd4 expression affects HIV -1 env conformation and antibody-dependent cellular cytotoxicity responses
    • Prevost J, Richard J, Medjahed H, Alexander A, Jones J, Kappes JC, Ochsenbauer C, Finzi A. 13 June 2018. Incomplete downregulation of CD4 expression affects HIV -1 Env conformation and antibody-dependent cellular cytotoxicity responses. J Virol https://doi.org/10.1128/JVI.00484-18.
    • (2018) J Virol
    • Prevost, J.1    Richard, J.2    Medjahed, H.3    Alexander, A.4    Jones, J.5    Kappes, J.C.6    Ochsenbauer, C.7    Finzi, A.8
  • 64
    • 85047463449 scopus 로고    scopus 로고
    • The molecular mechanism of two coreceptor binding site antibodies x5 and 17b neutralizing HIV -1: Insights from molecular dynamics simulation
    • Zhang Y, Guo J, Huang L, Tian J, Yao X, Liu H. 2018. The molecular mechanism of two coreceptor binding site antibodies X5 and 17b neutralizing HIV -1: Insights from molecular dynamics simulation. Chem Biol Drug Des 92:1357-1365. https://doi.org/10.1111/cbdd.13201.
    • (2018) Chem Biol, Drug des , vol.92 , pp. 1357-1365
    • Zhang, Y.1    Guo, J.2    Huang, L.3    Tian, J.4    Yao, X.5    Liu, H.6
  • 68
    • 77954042425 scopus 로고    scopus 로고
    • Few and far between: How HIV may be evading antibody avidity
    • Klein JS, Bjorkman PJ. 2010. Few and far between: How HIV may be evading antibody avidity. PLoS Pathog 6:e1000908. https://doi.org/10.1371/jouRNAl.ppat.1000908.
    • (2010) PLoS, Pathog , vol.6 , pp. e1000908
    • Klein, J.S.1    Bjorkman, P.J.2
  • 69
    • 78650969171 scopus 로고    scopus 로고
    • High expression levels of b lymphocyte stimulator (blys) by dendritic cells correlate with HIV -related b-cell disease progression in humans
    • Fontaine J, Chagnon-Choquet J, Valcke HS, Poudrier J, Roger M. 2011. High expression levels of B lymphocyte stimulator (BLyS) by dendritic cells correlate with HIV -related B-cell disease progression in humans. Blood 117:145-155. https://doi.org/10.1182/blood-2010-08-301887.
    • (2011) Blood , vol.117 , pp. 145-155
    • Fontaine, J.1    Chagnon-Choquet, J.2    Valcke, H.S.3    Poudrier, J.4    Roger, M.5
  • 70
    • 65549123647 scopus 로고    scopus 로고
    • HIV infection affects blood myeloid dendritic cells after successful therapy and despite nonprogressing clinical disease
    • Fontaine J, Coutlee F, Tremblay C, Routy JP, Poudrier J, Roger M. 2009. HIV infection affects blood myeloid dendritic cells after successful therapy and despite nonprogressing clinical disease. J Infect Dis 199: 1007-1018. https://doi.org/10.1086/597278.
    • (2009) J Infect Dis , vol.199 , pp. 1007-1018
    • Fontaine, J.1    Coutlee, F.2    Tremblay, C.3    Routy, J.P.4    Poudrier, J.5    Roger, M.6
  • 71
    • 34250652387 scopus 로고    scopus 로고
    • Functional t cell subsets contribute differentially to HIV peptide-specific responses within infected individuals: Correlation of these functional t cell subsets with markers of disease progression
    • Peretz Y, Ndongala ML, Boulet S, Boulassel MR, Rouleau D, Cote P, Longpre D, Routy JP, Falutz J, Tremblay C, Tsoukas CM, Sekaly RP, BeRNArd NF. 2007. Functional T cell subsets contribute differentially to HIV peptide-specific responses within infected individuals: Correlation of these functional T cell subsets with markers of disease progression. Clin Immunol 124:57-68. https://doi.org/10.1016/j.clim.2007.04.004.
    • (2007) Clin Immunol , vol.124 , pp. 57-68
    • Peretz, Y.1    Ndongala, M.L.2    Boulet, S.3    Boulassel, M.R.4    Rouleau, D.5    Cote, P.6    Longpre, D.7    Routy, J.P.8    Falutz, J.9    Tremblay, C.10    Tsoukas, C.M.11    Sekaly, R.P.12    BeRNArd, N.F.13
  • 74
    • 0032488888 scopus 로고    scopus 로고
    • Crystallographic structure of an intact igg1 monoclonal antibody
    • Harris LJ, Skaletsky E, McPherson A. 1998. Crystallographic structure of an intact IgG1 monoclonal antibody. J Mol Biol 275:861-872. https://doi.org/10.1006/jmbi.1997.1508.
    • (1998) J Mol Biol , vol.275 , pp. 861-872
    • Harris, L.J.1    Skaletsky, E.2    McPherson, A.3
  • 75
    • 0034691322 scopus 로고    scopus 로고
    • The 3.2-a crystal structure of the human igg1 fc fragment-fc gammariii complex
    • Sondermann P, Huber R, Oosthuizen V, Jacob U. 2000. The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex. Nature 406:267-273. https://doi.org/10.1038/35018508.
    • (2000) Nature , vol.406 , pp. 267-273
    • Sondermann, P.1    Huber, R.2    Oosthuizen, V.3    Jacob, U.4
  • 76
    • 84942155315 scopus 로고    scopus 로고
    • Envelope glycoprotein inteRNAlization protects human and simian immunodeficiency virus-infected cells from antibodydependent cell-mediated cytotoxicity
    • von Bredow B, Arias JF, Heyer LN, Gardner MR, Farzan M, Rakasz EG, Evans DT. 2015. Envelope glycoprotein inteRNAlization protects human and simian immunodeficiency virus-infected cells from antibodydependent cell-mediated cytotoxicity. J Virol 89:10648-10655. https://doi.org/10.1128/JVI.01911-15.
    • (2015) J Virol , vol.89 , pp. 10648-10655
    • Von Bredow, B.1    Arias, J.F.2    Heyer, L.N.3    Gardner, M.R.4    Farzan, M.5    Rakasz, E.G.6    Evans, D.T.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.