Functional T cell subsets contribute differentially to HIV peptide-specific responses within infected individuals: Correlation of these functional T cell subsets with markers of disease progression

Clinical Immunology

Volumn 124, Issue 1, 2007, Pages 57-68

  Peretz, Yoav ^a   Ndongala, Michel L ^a   Boulet, Salix ^a   Boulassel, Mohamed R ^b   Rouleau, Danielle ^c   Côté, Pierre ^d   Longpré, Danièle ^e   Routy, Jean Pierre ^a   Falutz, Julian ^a   Tremblay, Cécile ^c   Tsoukas, Christos M ^a   Sékaly, Rafick P ^c   Bernard, Nicole F ^a  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b ROYAL VICTORIA HOSPITAL   (Canada)

^c CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^d Clinique Medicale du Quartier Latin   (Canada)

^e Clinique Medicale l'Actuel   (Canada)

Author keywords

AIDS; Cellular immunology; Disease progression; Dual color ELISPOT; Functional subsets; HIV; Long term non progressors; T cells

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 2;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CELL COUNT; CELL FUNCTION; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE RELEASE; DISEASE COURSE; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; VIREMIA; VIRUS LOAD;

EID: 34250652387     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2007.04.004     Document Type: Article

References (40)

1. Buchbinder S., and Vittinghoff E. HIV-infected long-term nonprogressors: epidemiology, mechanisms of delayed progression, and clinical and research implications. Microbes Infect. 1 (1999) 1113-1120
2. Learmont J., Tindall B., Evans L., Cunningham A., Cunningham P., Wells J., Penny R., Kaldor J., and Cooper D.A. Long-term symptomless HIV-1 infection in recipients of blood products from a single donor. Lancet 340 (1992) 863-867
3. Kirchhoff F., Greenough T.C., Brettler D.B., Sullivan J.L., and Desrosiers R.C. Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N. Engl. J. Med. 332 (1995) 228-232
4. Mariani R., Kirchhoff F., Greenough T.C., Sullivan J.L., Desrosiers R.C., and Skowronski J. High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection. J. Virol. 70 (1996) 7752-7764
5. Connor R.I., Sheridan K.E., Lai C., Zhang L., and Ho D.D. Characterization of the functional properties of env genes from long-term survivors of human immunodeficiency virus type 1 infection. J. Virol. 70 (1996) 5306-5311
6. Learmont J.C., Geczy A.F., Mills J., Ashton L.J., Raynes-Greenow C.H., Garsia R.J., Dyer W.B., McIntyre L., Oelrichs R.B., Rhodes D.I., Deacon N.J., and Sullivan J.S. Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1. A report from the Sydney Blood Bank Cohort. N. Engl. J. Med. 340 (1999) 1715-1722
7. Fauci A.S., Mavilio D., and Kottilil S. NK cells in HIV infection: paradigm for protection or targets for ambush. Nat. Rev., Immunol. 5 (2005) 835-843
8. Kaslow R.A., Carrington M., Apple R., Park L., Munoz A., Saah A.J., Goedert J.J., Winkler C., O'Brien S.J., Rinaldo C., Detels R., Blattner W., Phair J., Erlich H., and Mann D.L. Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection. Nat. Med. 2 (1996) 405-411
9. Martin M.P., and Carrington M. Immunogenetics of viral infections. Curr. Opin. Immunol. 17 (2005) 510-516
10. Martinez-Picado J., Prado J.G., Fry E.E., Pfafferott K., Leslie A., Chetty S., Thobakgale C., Honeyborne I., Crawford H., Matthews P., Pillay T., Rousseau C., Mullins J.I., Brander C., Walker B.D., Stuart D.I., Kiepiela P., and Goulder P. Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1. J. Virol. 80 (2006) 3617-3623
11. Kiepiela P., Ngumbela K., Thobakgale C., Ramduth D., Honeyborne I., Moodley E., Reddy S., de Pierres C., Mncube Z., Mkhwanazi N., Bishop K., van der S.M., Nair K., Khan N., Crawford H., Payne R., Leslie A., Prado J., Prendergast A., Frater J., McCarthy N., Brander C., Learn G.H., Nickle D., Rousseau C., Coovadia H., Mullins J.I., Heckerman D., Walker B.D., and Goulder P. CD8(+) T-cell responses to different HIV proteins have discordant associations with viral load. Nat. Med. 13 (2006) 46-53
12. Addo M.M., Yu X.G., Rathod A., Cohen D., Eldridge R.L., Strick D., Johnston M.N., Corcoran C., Wurcel A.G., Fitzpatrick C.A., Feeney M.E., Rodriguez W.R., Basgoz N., Draenert R., Stone D.R., Brander C., Goulder P.J., Rosenberg E.S., Altfeld M., and Walker B.D. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J. Virol. 77 (2003) 2081-2092
13. Frahm N., Korber B.T., Adams C.M., Szinger J.J., Draenert R., Addo M.M., Feeney M.E., Yusim K., Sango K., Brown N.V., SenGupta D., Piechocka-Trocha A., Simonis T., Marincola F.M., Wurcel A.G., Stone D.R., Russell C.J., Adolf P., Cohen D., Roach T., StJohn A., Khatri A., Davis K., Mullins J., Goulder P.J., Walker B.D., and Brander C. Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities. J. Virol. 78 (2004) 2187-2200
14. Masemola A., Mashishi T., Khoury G., Mohube P., Mokgotho P., Vardas E., Colvin M., Zijenah L., Katzenstein D., Musonda R., Allen S., Kumwenda N., Taha T., Gray G., McIntyre J., Karim S.A., Sheppard H.W., and Gray C.M. Hierarchical targeting of subtype C human immunodeficiency virus type 1 proteins by CD8+ T cells: correlation with viral load. J. Virol. 78 (2004) 3233-3243
15. Draenert R., Verrill C.L., Tang Y., Allen T.M., Wurcel A.G., Boczanowski M., Lechner A., Kim A.Y., Suscovich T., Brown N.V., Addo M.M., and Walker B.D. Persistent recognition of autologous virus by high-avidity CD8 T cells in chronic, progressive human immunodeficiency virus type 1 infection. J. Virol. 78 (2004) 630-641
16. Peretz Y., Alter G., Boisvert M.P., Hatzakis G., Tsoukas C.M., and Bernard N.F. Human immunodeficiency virus (HIV)-specific gamma interferon secretion directed against all expressed HIV genes: relationship to rate of CD4 decline. J. Virol. 79 (2005) 4908-4917
17. Zuniga R., Lucchetti A., Galvan P., Sanchez S., Sanchez C., Hernandez A., Sanchez H., Frahm N., Linde C.H., Hewitt H.S., Hildebrand W., Altfeld M., Allen T.M., Walker B.D., Korber B.T., Leitner T., Sanchez J., and Brander C. Relative dominance of Gag p24-specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control. J. Virol. 80 (2006) 3122-3125
18. Rosenberg E.S., Billingsley J.M., Caliendo A.M., Boswell S.L., Sax P.E., Kalams S.A., and Walker B.D. Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia. Science 278 (1997) 1447-1450
19. Migueles S.A., Laborico A.C., Shupert W.L., Sabbaghian M.S., Rabin R., Hallahan C.W., van Baarle D., Kostense S., Miedema F., McLaughlin M., Ehler L., Metcalf J., Liu S., and Connors M. HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors. Nat. Immunol. 3 (2002) 1061-1068
20. Boaz M.J., Waters A., Murad S., Easterbrook P.J., and Vyakarnam A. Presence of HIV-1 Gag-specific IFN-gamma + IL-2+ and CD28 + IL-2 + CD4 T cell responses is associated with nonprogression in HIV-1 infection. J. Immunol. 169 (2002) 6376-6385
21. Younes S.A., Yassine-Diab B., Dumont A.R., Boulassel M.R., Grossman Z., Routy J.P., and Sekaly R.P. HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity. J. Exp. Med. 198 (2003) 1909-1922
22. Lichterfeld M., Yu X.G., Waring M.T., Mui S.K., Johnston M.N., Cohen D., Addo M.M., Zaunders J., Alter G., Pae E., Strick D., Allen T.M., Rosenberg E.S., Walker B.D., and Altfeld M. HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8(+) T cells producing both interferon-gamma and tumor necrosis factor-alpha. Blood 104 (2004) 487-494
23. Harari A., Petitpierre S., Vallelian F., and Pantaleo G. Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: changes after antiretroviral therapy. Blood 103 (2004) 966-972
24. Zimmerli S.C., Harari A., Cellerai C., Vallelian F., Bart P.A., and Pantaleo G. HIV-1-specific IFN-gamma/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 7239-7244
25. Betts M.R., Nason M.C., West S.M., De Rosa S.C., Migueles S.A., Abraham J., Lederman M.M., Benito J.M., Goepfert P.A., Connors M., Roederer M., and Koup R.A. HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood 107 (2006) 4781-4789
26. Hoover D.R., Graham N.M., Chen B., Taylor J.M., Phair J., Zhou S.Y., and Munoz A. Effect of CD4+ cell count measurement variability on staging HIV-1 infection. J. Acquir. Immune Defic. Syndr. 5 (1992) 794-802
27. Boulassel M.R., Spurll G., Rouleau D., Tremblay C., Edwardes M., Sekaly R.P., Lalonde R., and Routy J.P. Changes in immunological and virological parameters in HIV-1 infected subjects following leukapheresis. J. Clin. Apher. 18 (2003) 55-60
28. Boulet S., Ndongala M.L., Peretz Y., Boisvert M.P., Boulassel M.R., Tremblay C., Routy J.P., Sekaly R.P., and Bernard N.F. A dual color ELISPOT method for the simultaneous detection of IL-2 and IFN-gamma HIV-specific immune responses. J. Immunol. Methods 320 (2007) 18-29
29. Currier J.R., Kuta E.G., Turk E., Earhart L.B., Loomis-Price L., Janetzki S., Ferrari G., Birx D.L., and Cox J.H. A panel of MHC class I restricted viral peptides for use as a quality control for vaccine trial ELISPOT assays. J. Immunol. Methods 260 (2002) 157-172
30. Harari A., Vallelian F., Meylan P.R., and Pantaleo G. Functional heterogeneity of memory CD4 T cell responses in different conditions of antigen exposure and persistence. J. Immunol. 174 (2005) 1037-1045
31. Wherry E.J., Blattman J.N., Murali-Krishna K., van der M.R., and Ahmed R. Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J. Virol. 77 (2003) 4911-4927
32. Shankar P., Russo M., Harnisch B., Patterson M., Skolnik P., and Lieberman J. Impaired function of circulating HIV-specific CD8(+) T cells in chronic human immunodeficiency virus infection. Blood 96 (2000) 3094-3101
33. Wherry E.J., Teichgraber V., Becker T.C., Masopust D., Kaech S.M., Antia R., and von U.H. protective immunity of memory CD8 T cell subsets. Nat. Immunol. 4 (2003) 225-234
34. Masopust D., Ha S.J., Vezys V., and Ahmed R. Stimulation history dictates memory CD8 T cell phenotype: implications for prime-boost vaccination. J. Immunol. 177 (2006) 831-839
35. Cao J., McNevin J., Holte S., Fink L., Corey L., and McElrath M.J. Comprehensive analysis of human immunodeficiency virus type 1 (HIV-1)-specific gamma interferon-secreting CD8+ T cells in primary HIV-1 infection. J. Virol. 77 (2003) 6867-6878
36. Zheng N.N., Kiviat N.B., Sow P.S., Hawes S.E., Wilson A., Diallo-Agne H., Critchlow C.W., Gottlieb G.S., Musey L., and McElrath M.J. Comparison of human immunodeficiency virus (HIV)-specific T-cell responses in HIV-1- and HIV-2-infected individuals in Senegal. J. Virol. 78 (2004) 13934-13942
37. Ramduth D., Chetty P., Mngquandaniso N.C., Nene N., Harlow J.D., Honeyborne I., Ntumba N., Gappoo S., Henry C., Jeena P., Addo M.M., Altfeld M., Brander C., Day C., Coovadia H., Kiepiela P., Goulder P., and Walker B. Differential immunogenicity of HIV-1 clade C proteins in eliciting CD8+ and CD4+ cell responses. J. Infect. Dis. 192 (2005) 1588-1596
38. Lichterfeld M., Pantaleo G., and Altfeld M. Loss of HIV-1-specific T cell proliferation in chronic HIV-1 infection: cause or consequence of viral replication?. AIDS 19 (2005) 1225-1227
39. Jansen C.A., van Baarle D., and Miedema F. HIV-specific CD4+ T cells and viremia: who's in control?. Trends Immunol. 27 (2006) 119-124
40. Jansen C.A., De Cuyper I.M., Hooibrink B., van der Bij A.K., van Baarle D., and Miedema F. Prognostic value of HIV-1 Gag-specific CD4+ T-cell responses for progression to AIDS analyzed in a prospective cohort study. Blood 107 (2006) 1427-1433