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Volumn 60, Issue 5, 2014, Pages 1551-1562

Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against HCV genotypes 1a, 1b, 2a, 2b, 2c, and 3a

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN E1; GLYCOPROTEIN E2; HUMAN MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY;

EID: 84920439570     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.27298     Document Type: Article
Times cited : (75)

References (38)
  • 1
    • 84876149257 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence
    • Mohd HK, Groeger J, Flaxman AD, Wiersma ST. Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence. Hepatology 2013;57:1333-1342.
    • (2013) Hepatology , vol.57 , pp. 1333-1342
    • Mohd, H.K.1    Groeger, J.2    Flaxman, A.D.3    Wiersma, S.T.4
  • 2
    • 84880309916 scopus 로고    scopus 로고
    • Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
    • Scheel TK, Rice CM. Understanding the hepatitis C virus life cycle paves the way for highly effective therapies. Nat Med 2013;19:837-849.
    • (2013) Nat Med , vol.19 , pp. 837-849
    • Scheel, T.K.1    Rice, C.M.2
  • 3
    • 78650291306 scopus 로고    scopus 로고
    • Systematic review: anti-viral therapy of recurrent hepatitis C after liver transplantation
    • Guillouche P, Feray C. Systematic review: anti-viral therapy of recurrent hepatitis C after liver transplantation. Aliment Pharmacol Ther 2011;33:163-174.
    • (2011) Aliment Pharmacol Ther , vol.33 , pp. 163-174
    • Guillouche, P.1    Feray, C.2
  • 4
    • 0344630279 scopus 로고    scopus 로고
    • In vitro assay for neutralizing antibody to hepatitis C virus: evidence for broadly conserved neutralization epitopes
    • Bartosch B, Bukh J, Meunier JC, Granier C, Engle RE, Blackwelder WC, et al. In vitro assay for neutralizing antibody to hepatitis C virus: evidence for broadly conserved neutralization epitopes. Proc Natl Acad Sci U S A 2003;100:14199-14204.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 14199-14204
    • Bartosch, B.1    Bukh, J.2    Meunier, J.C.3    Granier, C.4    Engle, R.E.5    Blackwelder, W.C.6
  • 5
    • 79958291149 scopus 로고    scopus 로고
    • A genetically humanized mouse model for hepatitis C virus infection
    • Dorner M, Horwitz JA, Robbins JB, Barry WT, Feng Q, Mu K, et al. A genetically humanized mouse model for hepatitis C virus infection. Nature 2011;474:208-211.
    • (2011) Nature , vol.474 , pp. 208-211
    • Dorner, M.1    Horwitz, J.A.2    Robbins, J.B.3    Barry, W.T.4    Feng, Q.5    Mu, K.6
  • 6
    • 79952205644 scopus 로고    scopus 로고
    • In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus
    • Meuleman P, Bukh J, Verhoye L, Farhoudi A, Vanwolleghem T, Wang RY, et al. In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus. Hepatology 2011;53:755-762.
    • (2011) Hepatology , vol.53 , pp. 755-762
    • Meuleman, P.1    Bukh, J.2    Verhoye, L.3    Farhoudi, A.4    Vanwolleghem, T.5    Wang, R.Y.6
  • 7
    • 34347230939 scopus 로고    scopus 로고
    • Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C
    • Pestka JM, Zeisel MB, Blaser E, Schurmann P, Bartosch B, Cosset FL, et al. Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C. Proc Natl Acad Sci U S A 2007;104:6025-6030.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 6025-6030
    • Pestka, J.M.1    Zeisel, M.B.2    Blaser, E.3    Schurmann, P.4    Bartosch, B.5    Cosset, F.L.6
  • 8
    • 46249125111 scopus 로고    scopus 로고
    • Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver-chimeric mice from infection with a homologous hepatitis C virus strain
    • Vanwolleghem T, Bukh J, Meuleman P, Desombere I, Meunier JC, Alter H, et al. Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver-chimeric mice from infection with a homologous hepatitis C virus strain. Hepatology 2008;47:1846-1855.
    • (2008) Hepatology , vol.47 , pp. 1846-1855
    • Vanwolleghem, T.1    Bukh, J.2    Meuleman, P.3    Desombere, I.4    Meunier, J.C.5    Alter, H.6
  • 9
    • 84894707183 scopus 로고    scopus 로고
    • Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment Web resource
    • Smith DB, Bukh J, Kuiken C, Muerhoff AS, Rice CM, Stapleton JT, et al. Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment Web resource. Hepatology 2014;59:318-327.
    • (2014) Hepatology , vol.59 , pp. 318-327
    • Smith, D.B.1    Bukh, J.2    Kuiken, C.3    Muerhoff, A.S.4    Rice, C.M.5    Stapleton, J.T.6
  • 10
    • 84894378216 scopus 로고    scopus 로고
    • Differential sensitivity of 5'UTR-NS5A recombinants of hepatitis C virus genotypes 1-6 to protease and NS5A inhibitors
    • Li YP, Ramirez S, Humes D, Jensen SB, Gottwein JM, Bukh J. Differential sensitivity of 5'UTR-NS5A recombinants of hepatitis C virus genotypes 1-6 to protease and NS5A inhibitors. Gastroenterology 2014;146:812-821.
    • (2014) Gastroenterology , vol.146 , pp. 812-821
    • Li, Y.P.1    Ramirez, S.2    Humes, D.3    Jensen, S.B.4    Gottwein, J.M.5    Bukh, J.6
  • 11
    • 34247612265 scopus 로고    scopus 로고
    • Flying under the radar: the immunobiology of hepatitis C
    • Dustin LB, Rice CM. Flying under the radar: the immunobiology of hepatitis C. Annu Rev Immunol 2007;25:71-99.
    • (2007) Annu Rev Immunol , vol.25 , pp. 71-99
    • Dustin, L.B.1    Rice, C.M.2
  • 12
    • 84887017622 scopus 로고    scopus 로고
    • Neutralization resistance of hepatitis C virus can be overcome by recombinant human monoclonal antibodies
    • Pedersen J, Carlsen TH, Prentoe J, Ramirez S, Jensen TB, Forns X, et al. Neutralization resistance of hepatitis C virus can be overcome by recombinant human monoclonal antibodies. Hepatology 2013;58:1587-1597.
    • (2013) Hepatology , vol.58 , pp. 1587-1597
    • Pedersen, J.1    Carlsen, T.H.2    Prentoe, J.3    Ramirez, S.4    Jensen, T.B.5    Forns, X.6
  • 13
    • 84859965965 scopus 로고    scopus 로고
    • Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus
    • Giang E, Dorner M, Prentoe JC, Dreux M, Evans MJ, Bukh J, et al. Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus. Proc Natl Acad Sci U S A 2012;109:6205-6210.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 6205-6210
    • Giang, E.1    Dorner, M.2    Prentoe, J.C.3    Dreux, M.4    Evans, M.J.5    Bukh, J.6
  • 14
    • 84871990813 scopus 로고    scopus 로고
    • Cooperativity in virus neutralization by human monoclonal antibodies to two adjacent regions located at the amino terminus of hepatitis C virus E2 glycoprotein
    • Keck Z, Wang W, Wang Y, Lau P, Carlsen TH, Prentoe J, et al. Cooperativity in virus neutralization by human monoclonal antibodies to two adjacent regions located at the amino terminus of hepatitis C virus E2 glycoprotein. J Virol 2013;87:37-51.
    • (2013) J Virol , vol.87 , pp. 37-51
    • Keck, Z.1    Wang, W.2    Wang, Y.3    Lau, P.4    Carlsen, T.H.5    Prentoe, J.6
  • 15
    • 4143143121 scopus 로고    scopus 로고
    • Hepatitis C virus E2 has three immunogenic domains containing conformational epitopes with distinct properties and biological functions
    • Keck ZY, Op De BA, Hadlock KG, Xia J, Li TK, Dubuisson J, et al. Hepatitis C virus E2 has three immunogenic domains containing conformational epitopes with distinct properties and biological functions. J Virol 2004;78:9224-9232.
    • (2004) J Virol , vol.78 , pp. 9224-9232
    • Keck, Z.Y.1    Op De, B.A.2    Hadlock, K.G.3    Xia, J.4    Li, T.K.5    Dubuisson, J.6
  • 16
    • 84861205239 scopus 로고    scopus 로고
    • Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate
    • Keck ZY, Xia J, Wang Y, Wang W, Krey T, Prentoe J, et al. Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate. PLoS Pathog 2012;8:e1002653.
    • (2012) PLoS Pathog , vol.8 , pp. e1002653
    • Keck, Z.Y.1    Xia, J.2    Wang, Y.3    Wang, W.4    Krey, T.5    Prentoe, J.6
  • 17
    • 38049083122 scopus 로고    scopus 로고
    • Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge
    • Law M, Maruyama T, Lewis J, Giang E, Tarr AW, Stamataki Z, et al. Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge. Nat Med 2008;14:25-27.
    • (2008) Nat Med , vol.14 , pp. 25-27
    • Law, M.1    Maruyama, T.2    Lewis, J.3    Giang, E.4    Tarr, A.W.5    Stamataki, Z.6
  • 18
    • 82155199162 scopus 로고    scopus 로고
    • Affinity maturation to improve human monoclonal antibody neutralization potency and breadth against hepatitis C virus
    • Wang Y, Keck ZY, Saha A, Xia J, Conrad F, Lou J, et al. Affinity maturation to improve human monoclonal antibody neutralization potency and breadth against hepatitis C virus. J Biol Chem 2011;286:44218-44233.
    • (2011) J Biol Chem , vol.286 , pp. 44218-44233
    • Wang, Y.1    Keck, Z.Y.2    Saha, A.3    Xia, J.4    Conrad, F.5    Lou, J.6
  • 20
    • 79955384226 scopus 로고    scopus 로고
    • Hepatitis C patient-derived glycoproteins exhibit marked differences in susceptibility to serum neutralizing antibodies: genetic subtype defines antigenic but not neutralization serotype
    • Tarr AW, Urbanowicz RA, Hamed MR, Albecka A, McClure CP, Brown RJ, et al. Hepatitis C patient-derived glycoproteins exhibit marked differences in susceptibility to serum neutralizing antibodies: genetic subtype defines antigenic but not neutralization serotype. J Virol 2011;85:4246-4257.
    • (2011) J Virol , vol.85 , pp. 4246-4257
    • Tarr, A.W.1    Urbanowicz, R.A.2    Hamed, M.R.3    Albecka, A.4    McClure, C.P.5    Brown, R.J.6
  • 21
    • 22544470874 scopus 로고    scopus 로고
    • Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
    • Wakita T, Pietschmann T, Kato T, Date T, Miyamoto M, Zhao Z, et al. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med 2005;11:791-796.
    • (2005) Nat Med , vol.11 , pp. 791-796
    • Wakita, T.1    Pietschmann, T.2    Kato, T.3    Date, T.4    Miyamoto, M.5    Zhao, Z.6
  • 22
    • 61949320778 scopus 로고    scopus 로고
    • Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs
    • Gottwein JM, Scheel TK, Jensen TB, Lademann JB, Prentoe JC, Knudsen ML, et al. Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs. Hepatology 2009;49:364-377.
    • (2009) Hepatology , vol.49 , pp. 364-377
    • Gottwein, J.M.1    Scheel, T.K.2    Jensen, T.B.3    Lademann, J.B.4    Prentoe, J.C.5    Knudsen, M.L.6
  • 23
    • 56749131299 scopus 로고    scopus 로고
    • Highly efficient JFH1-based cell-culture system for hepatitis C virus genotype 5a: failure of homologous neutralizing-antibody treatment to control infection
    • Jensen TB, Gottwein JM, Scheel TK, Hoegh AM, Eugen-Olsen J, Bukh J. Highly efficient JFH1-based cell-culture system for hepatitis C virus genotype 5a: failure of homologous neutralizing-antibody treatment to control infection. J Infect Dis 2008;198:1756-1765.
    • (2008) J Infect Dis , vol.198 , pp. 1756-1765
    • Jensen, T.B.1    Gottwein, J.M.2    Scheel, T.K.3    Hoegh, A.M.4    Eugen-Olsen, J.5    Bukh, J.6
  • 26
    • 38949168945 scopus 로고    scopus 로고
    • Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization
    • Scheel TK, Gottwein JM, Jensen TB, Prentoe JC, Hoegh AM, Alter HJ, et al. Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization. Proc Natl Acad Sci U S A 2008;105:997-1002.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 997-1002
    • Scheel, T.K.1    Gottwein, J.M.2    Jensen, T.B.3    Prentoe, J.C.4    Hoegh, A.M.5    Alter, H.J.6
  • 27
    • 79952416361 scopus 로고    scopus 로고
    • Efficient culture adaptation of hepatitis C virus recombinants with genotype-specific core-NS2 by using previously identified mutations
    • Scheel TK, Gottwein JM, Carlsen TH, Li YP, Jensen TB, Spengler U, et al. Efficient culture adaptation of hepatitis C virus recombinants with genotype-specific core-NS2 by using previously identified mutations. J Virol 2011;85:2891-2906.
    • (2011) J Virol , vol.85 , pp. 2891-2906
    • Scheel, T.K.1    Gottwein, J.M.2    Carlsen, T.H.3    Li, Y.P.4    Jensen, T.B.5    Spengler, U.6
  • 28
    • 33846111662 scopus 로고    scopus 로고
    • Compensatory mutations in E1, p7, NS2, and NS3 enhance yields of cell culture-infectious intergenotypic chimeric hepatitis C virus
    • Yi M, Ma Y, Yates J, Lemon SM. Compensatory mutations in E1, p7, NS2, and NS3 enhance yields of cell culture-infectious intergenotypic chimeric hepatitis C virus. J Virol 2007;81:629-638.
    • (2007) J Virol , vol.81 , pp. 629-638
    • Yi, M.1    Ma, Y.2    Yates, J.3    Lemon, S.M.4
  • 29
    • 44949231397 scopus 로고    scopus 로고
    • Definition of a conserved immunodominant domain on hepatitis C virus E2 glycoprotein by neutralizing human monoclonal antibodies
    • Keck ZY, Li TK, Xia J, Gal-Tanamy M, Olson O, Li SH, et al. Definition of a conserved immunodominant domain on hepatitis C virus E2 glycoprotein by neutralizing human monoclonal antibodies. J Virol 2008;82:6061-6066.
    • (2008) J Virol , vol.82 , pp. 6061-6066
    • Keck, Z.Y.1    Li, T.K.2    Xia, J.3    Gal-Tanamy, M.4    Olson, O.5    Li, S.H.6
  • 30
    • 84860817692 scopus 로고    scopus 로고
    • Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains
    • Li YP, Ramirez S, Gottwein JM, Scheel TK, Mikkelsen L, Purcell RH, et al. Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains. Proc Natl Acad Sci U S A 2012;109:E1101-E1110.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. E1101-E1110
    • Li, Y.P.1    Ramirez, S.2    Gottwein, J.M.3    Scheel, T.K.4    Mikkelsen, L.5    Purcell, R.H.6
  • 31
    • 41949086805 scopus 로고    scopus 로고
    • Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus
    • Russell RS, Meunier JC, Takikawa S, Faulk K, Engle RE, Bukh J, et al. Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus. Proc Natl Acad Sci U S A 2008;105:4370-4375.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 4370-4375
    • Russell, R.S.1    Meunier, J.C.2    Takikawa, S.3    Faulk, K.4    Engle, R.E.5    Bukh, J.6
  • 32
    • 33847015308 scopus 로고    scopus 로고
    • Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo
    • von Hahn T, Yoon JC, Alter H, Rice CM, Rehermann B, Balfe P, et al. Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo. Gastroenterology 2007;132:667-678.
    • (2007) Gastroenterology , vol.132 , pp. 667-678
    • von Hahn, T.1    Yoon, J.C.2    Alter, H.3    Rice, C.M.4    Rehermann, B.5    Balfe, P.6
  • 34
    • 84877125433 scopus 로고    scopus 로고
    • Neutralizing antibodies in patients with chronic hepatitis C, genotype 1, against a panel of genotype 1 culture viruses: lack of correlation to treatment outcome
    • Pedersen J, Jensen TB, Carlsen TH, Schonning K, Christensen PB, Laursen AL, et al. Neutralizing antibodies in patients with chronic hepatitis C, genotype 1, against a panel of genotype 1 culture viruses: lack of correlation to treatment outcome. PLoS One 2013;8:e62674.
    • (2013) PLoS One , vol.8 , pp. e62674
    • Pedersen, J.1    Jensen, T.B.2    Carlsen, T.H.3    Schonning, K.4    Christensen, P.B.5    Laursen, A.L.6
  • 35
    • 66149117798 scopus 로고    scopus 로고
    • Mutations in hepatitis C virus E2 located outside the CD81 binding sites lead to escape from broadly neutralizing antibodies but compromise virus infectivity
    • Keck ZY, Li SH, Xia J, von HT, Balfe P, McKeating JA, et al. Mutations in hepatitis C virus E2 located outside the CD81 binding sites lead to escape from broadly neutralizing antibodies but compromise virus infectivity. J Virol 2009;83:6149-6160.
    • (2009) J Virol , vol.83 , pp. 6149-6160
    • Keck, Z.Y.1    Li, S.H.2    Xia, J.3    von, H.T.4    Balfe, P.5    McKeating, J.A.6
  • 36
    • 34547098102 scopus 로고    scopus 로고
    • The neutralizing activity of anti-hepatitis C virus antibodies is modulated by specific glycans on the E2 envelope protein
    • Helle F, Goffard A, Morel V, Duverlie G, McKeating J, Keck ZY, et al. The neutralizing activity of anti-hepatitis C virus antibodies is modulated by specific glycans on the E2 envelope protein. J Virol 2007;81:8101-8111.
    • (2007) J Virol , vol.81 , pp. 8101-8111
    • Helle, F.1    Goffard, A.2    Morel, V.3    Duverlie, G.4    McKeating, J.5    Keck, Z.Y.6
  • 37
    • 84866152584 scopus 로고    scopus 로고
    • Human monoclonal antibody HCV1 effectively prevents and treats HCV infection in chimpanzees
    • Morin TJ, Broering TJ, Leav BA, Blair BM, Rowley KJ, Boucher EN, et al. Human monoclonal antibody HCV1 effectively prevents and treats HCV infection in chimpanzees. PLoS Pathog 2012;8:e1002895.
    • (2012) PLoS Pathog , vol.8 , pp. e1002895
    • Morin, T.J.1    Broering, T.J.2    Leav, B.A.3    Blair, B.M.4    Rowley, K.J.5    Boucher, E.N.6
  • 38
    • 76549129820 scopus 로고    scopus 로고
    • Drug combination studies and their synergy quantification using the Chou-Talalay method
    • Chou TC. Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res 2010;70:440-446.
    • (2010) Cancer Res , vol.70 , pp. 440-446
    • Chou, T.C.1


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