Small CD4 Mimetics Prevent HIV-1 Uninfected Bystander CD4+ T Cell Killing Mediated by Antibody-dependent Cell-mediated Cytotoxicity

EBioMedicine

Volumn 3, Issue , 2016, Pages 122-134

  Richard, Jonathan ^a,b   Veillette, Maxime ^a,b   Ding, Shilei ^a,b   Zoubchenok, Daria ^a,b   Alsahafi, Nirmin ^a,i   Coutu, Mathieu ^a,b   Brassard, Nathalie ^a   Park, Jongwoo ^c   Courter, Joel R ^c   Melillo, Bruno ^c   Smith, Amos B ^c   Shaw, George M ^d   Hahn, Beatrice H ^d   Sodroski, Joseph ^e,f   Kaufmann, Daniel E ^a,b,g,h   Finzi, Andrés ^a,b,i  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^g MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^h SCRIPPS RESEARCH INSTITUTE   (United States)

ⁱ MCGILL UNIVERSITY   (Canada)

Author keywords

ADCC; Bystander killing; CD4; CD4 bound conformation; CD4 mimetics; Envelope glycoproteins; Gp120; HIV 1; Non neutralizing antibodies

Indexed keywords

GLYCOPROTEIN GP 120; NEF PROTEIN; VIRUS ENVELOPE PROTEIN; VPU PROTEIN; CD4 ANTIGEN; PROTEIN BINDING;

ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTIGEN RECOGNITION; ARTICLE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; T CELL DEPLETION; VIRUS CELL INTERACTION; CELL COMMUNICATION; CELL LINE; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOLOGY; METABOLISM; MOLECULAR MIMICRY; PHYSIOLOGY; VIROLOGY;

ANTIBODY-DEPENDENT CELL CYTOTOXICITY; ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; CELL COMMUNICATION; CELL LINE; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; MOLECULAR MIMICRY; PROTEIN BINDING;

EID: 84958844127     PISSN: None     EISSN: 23523964     Source Type: Journal    
DOI: 10.1016/j.ebiom.2015.12.004     Document Type: Article

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