Targeting the Late Stage of HIV-1 Entry for Antibody-Dependent Cellular Cytotoxicity: Structural Basis for Env Epitopes in the C11 Region

Structure

Volumn 25, Issue 11, 2017, Pages 1719-1731.e4

  Tolbert, William D ^a,b   Gohain, Neelakshi ^a,b   Alsahafi, Nirmin ^c,e   Van, Verna ^a,b   Orlandi, Chiara ^a,b   Ding, Shilei ^c,d   Martin, Loïc ^e   Finzi, Andrés ^c,d,f   Lewis, George K ^a,b   Ray, Krishanu ^b   Pazgier, Marzena ^a,b  

^a INSTITUTE OF HUMAN VIROLOGY   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^d UNIVERSITÉ DE MONTRÉAL   (Canada)

^e Institute Frederic Joliot   (France)

^f MCGILL UNIVERSITY   (Canada)

Author keywords

antibody dependent cellular cytotoxicity (ADCC); C11 epitope region; C11 like antibody; cluster A epitopes; crystal structure; HIV 1 entry; N12 i3 antibody

Indexed keywords

ENVELOPE PROTEIN; EPITOPE; GLYCOPROTEIN GP 120; VIRUS ANTIBODY; CD4 ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; MONOCLONAL ANTIBODY; PEPTIDE; PROTEIN BINDING;

AMINO TERMINAL SEQUENCE; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; FLOW CYTOMETRY; FLUORESCENCE CORRELATION SPECTROSCOPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOGENICITY; LIMIT OF QUANTITATION; MEMORY CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; VIRUS ENTRY; AMINO ACID SEQUENCE; BETA SHEET; BINDING SITE; CELL LINE; CHEMISTRY; DRUG EFFECT; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; MOLECULAR MIMICRY; MOLECULAR MODEL; PROTEIN DOMAIN; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SYNTHESIS; T LYMPHOCYTE; VIROLOGY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; BINDING SITES; CD4 ANTIGENS; CELL LINE; CRYSTALLOGRAPHY, X-RAY; EPITOPES; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; IMMUNITY, INNATE; MODELS, MOLECULAR; MOLECULAR MIMICRY; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION, BETA-STRAND; PROTEIN INTERACTION DOMAINS AND MOTIFS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; T-LYMPHOCYTES; VIRUS INTERNALIZATION;

EID: 85031804948     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2017.09.009     Document Type: Article

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