-
1
-
-
17644368573
-
Interleukin-6: from basic science to medicine-40 years in immunology
-
Kishimoto T. Interleukin-6: from basic science to medicine-40 years in immunology. Annu Rev Immunol. 2005;23:1–21.
-
(2005)
Annu Rev Immunol
, vol.23
, pp. 1-21
-
-
Kishimoto, T.1
-
2
-
-
0023942493
-
Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides
-
Houssiau FA, Devogelaer JP, Van Damme J, de Deuxchaisnes CN, Van Snick J. Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis Rheum. 1988;31(6):784–8.
-
(1988)
Arthritis Rheum
, vol.31
, Issue.6
, pp. 784-788
-
-
Houssiau, F.A.1
Devogelaer, J.P.2
Van Damme, J.3
de Deuxchaisnes, C.N.4
Van Snick, J.5
-
3
-
-
85032853779
-
Synovial fibroblasts in 2017
-
15
-
Ospelt C. Synovial fibroblasts in 2017. RMD Open. 2017;3(2):e000471.15
-
(2017)
RMD Open
, vol.3
, Issue.2
, pp. e000471
-
-
Ospelt, C.1
-
4
-
-
0030903094
-
The synovial expression and serum levels of interleukin-6, interleukin-11, leukemia inhibitory factor, and oncostatin M in rheumatoid arthritis
-
Okamoto H, Yamamura M, Morita Y, Harada S, Makino H, Ota Z. The synovial expression and serum levels of interleukin-6, interleukin-11, leukemia inhibitory factor, and oncostatin M in rheumatoid arthritis. Arthritis Rheum. 1997;40(6):1096–105.
-
(1997)
Arthritis Rheum
, vol.40
, Issue.6
, pp. 1096-1105
-
-
Okamoto, H.1
Yamamura, M.2
Morita, Y.3
Harada, S.4
Makino, H.5
Ota, Z.6
-
5
-
-
0025696128
-
Analysis of IL-1 and TNF-alpha gene expression in human rheumatoid synoviocytes and normal monocytes by in situ hybridization
-
MacNaul KL, Hutchinson NI, Parsons JN, Bayne EK, Tocci MJ. Analysis of IL-1 and TNF-alpha gene expression in human rheumatoid synoviocytes and normal monocytes by in situ hybridization. J Immunol. 1990;145:4154–66.
-
(1990)
J Immunol
, vol.145
, pp. 4154-4166
-
-
MacNaul, K.L.1
Hutchinson, N.I.2
Parsons, J.N.3
Bayne, E.K.4
Tocci, M.J.5
-
6
-
-
85018622340
-
The role of interleukin-6 signalling and its therapeutic blockage in skewing the T cell balance in rheumatoid arthritis
-
Schinnerling K, Aguillon JC, Catalan D, Soto L. The role of interleukin-6 signalling and its therapeutic blockage in skewing the T cell balance in rheumatoid arthritis. Clin Exp Immunol. 2017;189(1):12–20.
-
(2017)
Clin Exp Immunol
, vol.189
, Issue.1
, pp. 12-20
-
-
Schinnerling, K.1
Aguillon, J.C.2
Catalan, D.3
Soto, L.4
-
7
-
-
4344590199
-
Distinct contribution of IL-6, TNF-α, IL-1, and IL-10 to T cell? mediated spontaneous autoimmune arthritis in mice
-
Hata H, Sakaguchi N, Yoshitomi H, Iwakura Y, Sekikawa K, Azuma Y, et al. Distinct contribution of IL-6, TNF-α, IL-1, and IL-10 to T cell? mediated spontaneous autoimmune arthritis in mice. J Clin Invest. 2004;114(4):582–8.
-
(2004)
J Clin Invest
, vol.114
, Issue.4
, pp. 582-588
-
-
Hata, H.1
Sakaguchi, N.2
Yoshitomi, H.3
Iwakura, Y.4
Sekikawa, K.5
Azuma, Y.6
-
8
-
-
0033503152
-
Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6-deficient mice
-
Sasai M, Saeki Y, Ohshima S, Nishioka K, Mima T, Tanaka T, et al. Delayed onset and reduced severity of collagen-induced arthritis in interleukin-6-deficient mice. Arthritis Rheum. 1999;42(8):1635–43.
-
(1999)
Arthritis Rheum
, vol.42
, Issue.8
, pp. 1635-1643
-
-
Sasai, M.1
Saeki, Y.2
Ohshima, S.3
Nishioka, K.4
Mima, T.5
Tanaka, T.6
-
9
-
-
0030010969
-
Collagen-induced arthritis in CD4- or CD8-deficient mice: CD8+ T cells play a role in initiation and regulate recovery phase of collagen-induced arthritis
-
Tada Y, Ho A, Koh DR, Mak TW. Collagen-induced arthritis in CD4- or CD8-deficient mice: CD8+ T cells play a role in initiation and regulate recovery phase of collagen-induced arthritis. J Immunol. 1996;156(11):4520–6.
-
(1996)
J Immunol
, vol.156
, Issue.11
, pp. 4520-4526
-
-
Tada, Y.1
Ho, A.2
Koh, D.R.3
Mak, T.W.4
-
10
-
-
0036681846
-
The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis
-
Kagari T, Doi H, Shimozato T. The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis. J Immunol. 2002;169(3):1459–66.
-
(2002)
J Immunol
, vol.169
, Issue.3
, pp. 1459-1466
-
-
Kagari, T.1
Doi, H.2
Shimozato, T.3
-
11
-
-
0027502201
-
Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth
-
Sato K, Tsuchiya M, Saldanha J, Koishihara Y, Ohsugi Y, Kishimoto T, Bendig MM. Reshaping a human antibody to inhibit the interleukin 6-dependent tumor cell growth. Cancer Res. 1993;53(4):851–6.
-
(1993)
Cancer Res
, vol.53
, Issue.4
, pp. 851-856
-
-
Sato, K.1
Tsuchiya, M.2
Saldanha, J.3
Koishihara, Y.4
Ohsugi, Y.5
Kishimoto, T.6
Bendig, M.M.7
-
13
-
-
84927632013
-
Subcutaneous formulation of tocilizumab for treatment of rheumatoid arthritis
-
Ogata A, Morita T, Yoshida Y, Tanaka T. Subcutaneous formulation of tocilizumab for treatment of rheumatoid arthritis. Ther Deliv. 2015;6(3):283–95.
-
(2015)
Ther Deliv
, vol.6
, Issue.3
, pp. 283-295
-
-
Ogata, A.1
Morita, T.2
Yoshida, Y.3
Tanaka, T.4
-
14
-
-
80052977037
-
A mixed treatment comparison of the short-term efficacy of biologic disease modifying anti-rheumatic drugs in established rheumatoid arthritis
-
Turkstra E, Ng SK, Scuffham PA. A mixed treatment comparison of the short-term efficacy of biologic disease modifying anti-rheumatic drugs in established rheumatoid arthritis. Curr Med Res Opin. 2011;27(10):1885–97.
-
(2011)
Curr Med Res Opin
, vol.27
, Issue.10
, pp. 1885-1897
-
-
Turkstra, E.1
Ng, S.K.2
Scuffham, P.A.3
-
15
-
-
84866760268
-
Effect of biologic therapy on radiological progression in rheumatoid arthritis: what does it add to methotrexate?
-
Jones G, Darian-Smith E, Kwok M, Winzenberg T. Effect of biologic therapy on radiological progression in rheumatoid arthritis: what does it add to methotrexate? Biologics 2012;6:155–61.
-
(2012)
Biologics
, vol.6
, pp. 155-161
-
-
Jones, G.1
Darian-Smith, E.2
Kwok, M.3
Winzenberg, T.4
-
16
-
-
84891795508
-
Effectiveness and safety of tocilizumab: postmarketing surveillance of 7901 patients with rheumatoid arthritis in Japan
-
Koike T, Harigai M, Inokuma S, Ishiguro N, Ryu J, Takeuchi T. Effectiveness and safety of tocilizumab: postmarketing surveillance of 7901 patients with rheumatoid arthritis in Japan. J Rheumatol. 2014;4:15–23.
-
(2014)
J Rheumatol
, vol.4
, pp. 15-23
-
-
Koike, T.1
Harigai, M.2
Inokuma, S.3
Ishiguro, N.4
Ryu, J.5
Takeuchi, T.6
-
17
-
-
84864106582
-
Role of interleukin-6 in stress, sleep, and fatigue
-
ohleder N, Aringer M, Boentert M. Role of interleukin-6 in stress, sleep, and fatigue. Ann N Y Acad Sci. 2012;1261:88–96.
-
(2012)
Ann N Y Acad Sci
, vol.1261
, pp. 88-96
-
-
ohleder, N.1
Aringer, M.2
Boentert, M.3
-
18
-
-
0027440517
-
Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression
-
Maes M, Scharpé S, Meltzer HY, Bosmans E, Suy E, Calabrese J, Cosyns P. Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression. Psychiatry Res. 1993;49(1):11–27.
-
(1993)
Psychiatry Res
, vol.49
, Issue.1
, pp. 11-27
-
-
Maes, M.1
Scharpé, S.2
Meltzer, H.Y.3
Bosmans, E.4
Suy, E.5
Calabrese, J.6
Cosyns, P.7
-
19
-
-
84855381748
-
Sleep disturbances and interleukin 6 receptor inhibition in rheumatoid arthritis
-
Fragiadaki K, Tektonidou MG, Konsta M, Chrousos GP, Sfikakis PP. Sleep disturbances and interleukin 6 receptor inhibition in rheumatoid arthritis. J Rheumatol. 2012;39(1):60–2.
-
(2012)
J Rheumatol
, vol.39
, Issue.1
, pp. 60-62
-
-
Fragiadaki, K.1
Tektonidou, M.G.2
Konsta, M.3
Chrousos, G.P.4
Sfikakis, P.P.5
-
20
-
-
84944391205
-
Fatigue in rheumatoid arthritis: quantitative findings on the efficacy of tocilizumab and on factors associated with fatigue. The French multicentre prospective PEPS Study
-
Gossec L, Steinberg G, Rouanet S, Combe B. Fatigue in rheumatoid arthritis: quantitative findings on the efficacy of tocilizumab and on factors associated with fatigue. The French multicentre prospective PEPS Study. Clin Exp Rheumatol. 2015;33:664–70.
-
(2015)
Clin Exp Rheumatol
, vol.33
, pp. 664-670
-
-
Gossec, L.1
Steinberg, G.2
Rouanet, S.3
Combe, B.4
-
21
-
-
84866170613
-
The impact of tocilizumab on physical function and quality of life in patients with rheumatoid arthritis: a systematic literature review and interpretation
-
Townes SV, Furst DE, Thenkondar A. The impact of tocilizumab on physical function and quality of life in patients with rheumatoid arthritis: a systematic literature review and interpretation. Open Access Rheumatol. 2012;4:87–92.
-
(2012)
Open Access Rheumatol
, vol.4
, pp. 87-92
-
-
Townes, S.V.1
Furst, D.E.2
Thenkondar, A.3
-
22
-
-
85048390557
-
Impact of tocilizumab monotherapy on clinical and patient-reported quality-of-life outcomes in patients with rheumatoid arthritis
-
Harrold LR, John A, Reed GW, Haselkorn T, Karki C, Li Y, et al. Impact of tocilizumab monotherapy on clinical and patient-reported quality-of-life outcomes in patients with rheumatoid arthritis. Rheumatol Ther. 2017;4(2):405–17.
-
(2017)
Rheumatol Ther
, vol.4
, Issue.2
, pp. 405-417
-
-
Harrold, L.R.1
John, A.2
Reed, G.W.3
Haselkorn, T.4
Karki, C.5
Li, Y.6
-
23
-
-
85050262984
-
IL-6 affect the Effect of subcutaneous tocilizumab treatment on work/housework status in biologic-naïve rheumatoid arthritis patients using inverse probability of treatment weighting: FIRST ACT-SC study
-
Tanaka Y, Kameda H, Saito K, Kaneko Y, Tanaka E, Yasuda S, et al. IL-6 affect the Effect of subcutaneous tocilizumab treatment on work/housework status in biologic-naïve rheumatoid arthritis patients using inverse probability of treatment weighting: FIRST ACT-SC study. Arthritis Res Ther. 2018;20:151.
-
(2018)
Arthritis Res Ther
, vol.20
, pp. 151
-
-
Tanaka, Y.1
Kameda, H.2
Saito, K.3
Kaneko, Y.4
Tanaka, E.5
Yasuda, S.6
-
24
-
-
2342510407
-
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
-
Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004;113(9):1271–6.
-
(2004)
J Clin Invest
, vol.113
, Issue.9
, pp. 1271-1276
-
-
Nemeth, E.1
Rivera, S.2
Gabayan, V.3
Keller, C.4
Taudorf, S.5
Pedersen, B.K.6
-
25
-
-
78149324897
-
Down-regulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease
-
Nakazawa S, Tomosugi N, Kawabata H, Ishikawa T, Nishikawa T, Yoshizaki K. Down-regulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman disease. Blood 2010;116(18):3627–34.
-
(2010)
Blood
, vol.116
, Issue.18
, pp. 3627-3634
-
-
Nakazawa, S.1
Tomosugi, N.2
Kawabata, H.3
Ishikawa, T.4
Nishikawa, T.5
Yoshizaki, K.6
-
26
-
-
68549130286
-
The role of interleukins in insulin resistance and type 2 diabetes mellitus
-
Fève B, Bastard JP. The role of interleukins in insulin resistance and type 2 diabetes mellitus. Nat Rev Endocrinol. 2009;5(6):305–11.
-
(2009)
Nat Rev Endocrinol
, vol.5
, Issue.6
, pp. 305-311
-
-
Fève, B.1
Bastard, J.P.2
-
27
-
-
79955807238
-
Improvement of HbA1c during treatment with humanised anti-interleukin 6 receptor antibody, tocilizumab
-
Ogata A, Morishima A, Hirano T, Hishitani Y, Hagihara K, Shima Y, et al. Improvement of HbA1c during treatment with humanised anti-interleukin 6 receptor antibody, tocilizumab. Ann Rheum Dis. 2011;70(6):1164–5.
-
(2011)
Ann Rheum Dis
, vol.70
, Issue.6
, pp. 1164-1165
-
-
Ogata, A.1
Morishima, A.2
Hirano, T.3
Hishitani, Y.4
Hagihara, K.5
Shima, Y.6
-
28
-
-
0345743620
-
IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with proinflammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system
-
Hagihara K, Nishikawa T, Isobe T, Song J, Sugamata Y, Yoshizaki K. IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with proinflammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system. Biochem Biophys Res Commun. 2004;314:363–9.
-
(2004)
Biochem Biophys Res Commun
, vol.314
, pp. 363-369
-
-
Hagihara, K.1
Nishikawa, T.2
Isobe, T.3
Song, J.4
Sugamata, Y.5
Yoshizaki, K.6
-
29
-
-
85034978759
-
Basic and Clinical Significance of Interleukin 6 (IL-6)
-
Amyloidosis A.A., (ed), Groningen: Netherlands, May 6–10,. p
-
Yoshizaki K. Basic and Clinical Significance of Interleukin 6 (IL-6) AA, Amyloidosis. Proceedings of the XIIIth International Symposium on Amyloidosis; 2012 May 6–10, Groningen, Netherlands. p. 394–7.
-
(2012)
Proceedings of the XIIIth International Symposium on Amyloidosis;
, pp. 394-397
-
-
Yoshizaki, K.1
-
30
-
-
67549125131
-
Rapid improvement of AA amyloidosis with humanised anti-interleukin 6 receptor antibody treatment
-
Nishida S, Hagihara K, Shima Y, Kawai M, Kuwahara Y, Arimitsu J, et al. Rapid improvement of AA amyloidosis with humanised anti-interleukin 6 receptor antibody treatment. Ann Rheum Dis. 2009;68(7):1235–6.
-
(2009)
Ann Rheum Dis
, vol.68
, Issue.7
, pp. 1235-1236
-
-
Nishida, S.1
Hagihara, K.2
Shima, Y.3
Kawai, M.4
Kuwahara, Y.5
Arimitsu, J.6
-
31
-
-
58149154996
-
Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease
-
Nishimoto N, Terao K, Mima T, Nakahara H, Takagi N, Kakehi T. Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease. Blood 2008;112(10):3959–64.
-
(2008)
Blood
, vol.112
, Issue.10
, pp. 3959-3964
-
-
Nishimoto, N.1
Terao, K.2
Mima, T.3
Nakahara, H.4
Takagi, N.5
Kakehi, T.6
-
32
-
-
84942094202
-
Results of switching from intravenous to subcutaneous tocilizumab monotherapy in patients with rheumatoid arthritis: extension of the MUSASHI study
-
Ogata A, Atsumi T, Fukuda T, Hirabayashi Y, Inaba M, Ishiguro NK, et al. Results of switching from intravenous to subcutaneous tocilizumab monotherapy in patients with rheumatoid arthritis: extension of the MUSASHI study. Arthritis Care Res (Hoboken). 2015;67(10):1354–62.
-
(2015)
Arthritis Care Res (Hoboken)
, vol.67
, Issue.10
, pp. 1354-1362
-
-
Ogata, A.1
Atsumi, T.2
Fukuda, T.3
Hirabayashi, Y.4
Inaba, M.5
Ishiguro, N.K.6
-
33
-
-
85028668132
-
Successful extension of tocilizumab infusion intervals from 4 weeks to 6 or 5 weeks in 90% of RA patients with good response to 4-week intervals
-
Saiki O, Uda H. Successful extension of tocilizumab infusion intervals from 4 weeks to 6 or 5 weeks in 90% of RA patients with good response to 4-week intervals. Clin Exp Rheumatol. 2017;35(4):666–70.
-
(2017)
Clin Exp Rheumatol
, vol.35
, Issue.4
, pp. 666-670
-
-
Saiki, O.1
Uda, H.2
-
34
-
-
84940491663
-
Longterm safety and efficacy of subcutaneous tocilizumab monotherapy: results from the 2-year open-label extension of the MUSASHI study
-
Ogata A, Amano K, Dobashi H, Inoo M, Ishii T, Kasama T, et al. Longterm safety and efficacy of subcutaneous tocilizumab monotherapy: results from the 2-year open-label extension of the MUSASHI study. J Rheumatol. 2015;42(5):799–809.
-
(2015)
J Rheumatol
, vol.42
, Issue.5
, pp. 799-809
-
-
Ogata, A.1
Amano, K.2
Dobashi, H.3
Inoo, M.4
Ishii, T.5
Kasama, T.6
-
35
-
-
31044442965
-
The PREMIER study: a multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment
-
Breedveld FC, Weisman MH, Kavanaugh AF, Cohen SB, Pavelka K, van Vollenhoven R, et al. The PREMIER study: a multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. Arthritis Rheum. 2006;54:26–37.
-
(2006)
Arthritis Rheum
, vol.54
, pp. 26-37
-
-
Breedveld, F.C.1
Weisman, M.H.2
Kavanaugh, A.F.3
Cohen, S.B.4
Pavelka, K.5
van Vollenhoven, R.6
-
36
-
-
10744223002
-
Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial
-
Klareskog L, van der Heijde D, de Jager JP, Gough A, Kalden J, Malaise M, et al. Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial. Lancet. 2004;363(9410):675–81.
-
(2004)
Lancet
, vol.363
, Issue.9410
, pp. 675-681
-
-
Klareskog, L.1
van der Heijde, D.2
de Jager, J.P.3
Gough, A.4
Kalden, J.5
Malaise, M.6
-
37
-
-
73449118587
-
Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study
-
Jones G, Sebba A, Gu J, Lowenstein MB, Calvo A, Gomez-Reino JJ, et al. Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study. Ann Rheum Dis. 2010;69(1):88–96.
-
(2010)
Ann Rheum Dis
, vol.69
, Issue.1
, pp. 88-96
-
-
Jones, G.1
Sebba, A.2
Gu, J.3
Lowenstein, M.B.4
Calvo, A.5
Gomez-Reino, J.J.6
-
38
-
-
34447300492
-
Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab
-
Nishimoto N, Hashimoto J, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, et al. Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x ray reader-blinded randomised controlled trial of tocilizumab. Ann Rheum Dis. 2007;66(9):1162–7.
-
(2007)
Ann Rheum Dis
, vol.66
, Issue.9
, pp. 1162-1167
-
-
Nishimoto, N.1
Hashimoto, J.2
Miyasaka, N.3
Yamamoto, K.4
Kawai, S.5
Takeuchi, T.6
-
39
-
-
60149105639
-
Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy
-
Nishimoto N, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Azuma J, et al. Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy. Mod Rheumatol. 2009;19:12–9.
-
(2009)
Mod Rheumatol
, vol.19
, pp. 12-19
-
-
Nishimoto, N.1
Miyasaka, N.2
Yamamoto, K.3
Kawai, S.4
Takeuchi, T.5
Azuma, J.6
-
40
-
-
54949150604
-
Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: the tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study
-
Genovese MC, McKay JD, Nasonov EL, Mysler EF, da Silva NA, Alecock E, et al. Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis with inadequate response to disease-modifying antirheumatic drugs: the tocilizumab in combination with traditional disease-modifying antirheumatic drug therapy study. Arthritis Rheum. 2008;58(10):2968–80.
-
(2008)
Arthritis Rheum
, vol.58
, Issue.10
, pp. 2968-2980
-
-
Genovese, M.C.1
McKay, J.D.2
Nasonov, E.L.3
Mysler, E.F.4
da Silva, N.A.5
Alecock, E.6
-
41
-
-
52149099504
-
IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial
-
Emery P, Keystone E, Tony HP, Cantagrel A, van Vollenhoven R, Sanchez A, et al. IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial. Ann Rheum Dis.2008;67(11):1516–23.
-
(2008)
Ann Rheum Dis
, vol.67
, Issue.11
, pp. 1516-1523
-
-
Emery, P.1
Keystone, E.2
Tony, H.P.3
Cantagrel, A.4
van Vollenhoven, R.5
Sanchez, A.6
-
42
-
-
40749114497
-
Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial
-
Smolen JS, Beaulieu A, Rubbert-Roth A, Ramos-Remus C, Rovensky J, Alecock E, et al. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomised trial. Lancet 2008;371(9617):987–97.
-
(2008)
Lancet
, vol.371
, Issue.9617
, pp. 987-997
-
-
Smolen, J.S.1
Beaulieu, A.2
Rubbert-Roth, A.3
Ramos-Remus, C.4
Rovensky, J.5
Alecock, E.6
-
43
-
-
79953680176
-
Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structural joint damage at one year
-
Kremer JM, Blanco R, Brzosko M, Burgos-Vargas R, Halland AM, Vernon E, et al. Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structural joint damage at one year. Arthritis Rheum. 2011;63(3):609–21.
-
(2011)
Arthritis Rheum
, vol.63
, Issue.3
, pp. 609-621
-
-
Kremer, J.M.1
Blanco, R.2
Brzosko, M.3
Burgos-Vargas, R.4
Halland, A.M.5
Vernon, E.6
-
44
-
-
84896689880
-
Phase III study of the efficacy and safety of subcutaneous versus intravenous tocilizumab monotherapy in patients with rheumatoid arthritis
-
Ogata A, Tanimura K, Sugimoto T, Inoue H, Urata Y, Matsubara T, et al. Phase III study of the efficacy and safety of subcutaneous versus intravenous tocilizumab monotherapy in patients with rheumatoid arthritis. Arthritis Care Res (Hoboken). 2014;66(3):344–54.
-
(2014)
Arthritis Care Res (Hoboken)
, vol.66
, Issue.3
, pp. 344-354
-
-
Ogata, A.1
Tanimura, K.2
Sugimoto, T.3
Inoue, H.4
Urata, Y.5
Matsubara, T.6
-
45
-
-
84954317028
-
Efficacy and safety of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional DMARDs in patients with RA at week 97 (SUMMACTA)
-
Burmester GR, Rubbert-Roth A, Cantagrel A, Hall S, Leszczynski P, Feldman D, et al. Efficacy and safety of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional DMARDs in patients with RA at week 97 (SUMMACTA). Ann Rheum Dis. 2016;75(1):68–74.
-
(2016)
Ann Rheum Dis
, vol.75
, Issue.1
, pp. 68-74
-
-
Burmester, G.R.1
Rubbert-Roth, A.2
Cantagrel, A.3
Hall, S.4
Leszczynski, P.5
Feldman, D.6
-
46
-
-
85007277373
-
Subcutaneous tocilizumab versus placebo in combination with disease-modifying antirheumatic drugs in patients with rheumatoid arthritis
-
Kivitz A, Olech E, Borofsky M, Zazueta BM, Navarro-Sarabia F, Radominski SC, et al. Subcutaneous tocilizumab versus placebo in combination with disease-modifying antirheumatic drugs in patients with rheumatoid arthritis. Arthritis Care Res (Hoboken). 2014;66(11):1653–61.
-
(2014)
Arthritis Care Res (Hoboken)
, vol.66
, Issue.11
, pp. 1653-1661
-
-
Kivitz, A.1
Olech, E.2
Borofsky, M.3
Zazueta, B.M.4
Navarro-Sarabia, F.5
Radominski, S.C.6
-
47
-
-
85020536432
-
A randomized, double-blind, parallel-group, phase III study of shortening the dosing interval of subcutaneous tocilizumab monotherapy in patients with rheumatoid arthritis and an inadequate response to subcutaneous tocilizumab every other week: results of the 12-week double-blind period
-
Ogata A, Tanaka Y, Ishii T, Kaneko M, Miwa H, Ohsawa S, et al. A randomized, double-blind, parallel-group, phase III study of shortening the dosing interval of subcutaneous tocilizumab monotherapy in patients with rheumatoid arthritis and an inadequate response to subcutaneous tocilizumab every other week: results of the 12-week double-blind period. Mod Rheumatol. 2018;28:76–84.
-
(2018)
Mod Rheumatol
, vol.28
, pp. 76-84
-
-
Ogata, A.1
Tanaka, Y.2
Ishii, T.3
Kaneko, M.4
Miwa, H.5
Ohsawa, S.6
-
48
-
-
84871093047
-
Adding tocilizumab or switching to tocilizumab monotherapy in methotrexate inadequate responders: 24-week symptomatic and structural results of a 2-year randomised controlled strategy trial in rheumatoid arthritis (ACT-RAY)
-
Dougados M, Kissel K, Sheeran T, Tak PP, Conaghan PG, Mola EM, et al. Adding tocilizumab or switching to tocilizumab monotherapy in methotrexate inadequate responders: 24-week symptomatic and structural results of a 2-year randomised controlled strategy trial in rheumatoid arthritis (ACT-RAY). Ann Rheum Dis. 2013;72(1):43–50.
-
(2013)
Ann Rheum Dis
, vol.72
, Issue.1
, pp. 43-50
-
-
Dougados, M.1
Kissel, K.2
Sheeran, T.3
Tak, P.P.4
Conaghan, P.G.5
Mola, E.M.6
-
49
-
-
84956630876
-
Comparison of adding tocilizumab to methotrexate with switching to tocilizumab in patients with rheumatoid arthritis with inadequate response to methotrexate: 52-week results from a prospective, randomised, controlled study (SURPRISE study)
-
Kaneko Y, Atsumi T, Tanaka Y, Inoo M, Kobayashi-Haraoka H, Amano K, et al. Comparison of adding tocilizumab to methotrexate with switching to tocilizumab in patients with rheumatoid arthritis with inadequate response to methotrexate: 52-week results from a prospective, randomised, controlled study (SURPRISE study). Ann Rheum Dis. 2016;75(11):1917–23.
-
(2016)
Ann Rheum Dis
, vol.75
, Issue.11
, pp. 1917-1923
-
-
Kaneko, Y.1
Atsumi, T.2
Tanaka, Y.3
Inoo, M.4
Kobayashi-Haraoka, H.5
Amano, K.6
-
50
-
-
84946887746
-
Tocilizumab in early progressive rheumatoid arthritis: FUNCTION, a randomised controlled trial
-
Burmester GR, Rigby WF, van Vollenhoven RF, Kay J, Rubbert-Roth A, Kelman A, et al. Tocilizumab in early progressive rheumatoid arthritis: FUNCTION, a randomised controlled trial. Ann Rheum Dis. 2016;75(6):1081–91.
-
(2016)
Ann Rheum Dis
, vol.75
, Issue.6
, pp. 1081-1091
-
-
Burmester, G.R.1
Rigby, W.F.2
van Vollenhoven, R.F.3
Kay, J.4
Rubbert-Roth, A.5
Kelman, A.6
-
51
-
-
84973539391
-
Early rheumatoid arthritis treated with tocilizumab, methotrexate, or their combination (U-Act-Early): a multicentre, randomised, double-blind, double-dummy, strategy trial
-
Bijlsma JWJ, Welsing PMJ, Woodworth TG, Middelink LM, Pethö-Schramm A, Bernasconi C, et al. Early rheumatoid arthritis treated with tocilizumab, methotrexate, or their combination (U-Act-Early): a multicentre, randomised, double-blind, double-dummy, strategy trial. Lancet 2016;388(10042):343–55.
-
(2016)
Lancet
, vol.388
, Issue.10042
, pp. 343-355
-
-
Bijlsma, J.W.J.1
Welsing, P.M.J.2
Woodworth, T.G.3
Middelink, L.M.4
Pethö-Schramm, A.5
Bernasconi, C.6
-
52
-
-
84877275257
-
Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial
-
Gabay C, Emery P, van Vollenhoven R, Dikranian A, Alten R, Pavelka K, et al. Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial. Lancet. 2013;381(9877):1541–50.
-
(2013)
Lancet
, vol.381
, Issue.9877
, pp. 1541-1550
-
-
Gabay, C.1
Emery, P.2
van Vollenhoven, R.3
Dikranian, A.4
Alten, R.5
Pavelka, K.6
-
53
-
-
84897971056
-
Clinical, radiographic and immunogenic effects after 1 year of tocilizumab-based treatment strategies in rheumatoid arthritis: the ACT-RAY study
-
Dougados M, Kissel K, Conaghan PG, Mola EM, Schett G, Gerli R, et al. Clinical, radiographic and immunogenic effects after 1 year of tocilizumab-based treatment strategies in rheumatoid arthritis: the ACT-RAY study. Ann Rheum Dis. 2014;73(5):803–9.
-
(2014)
Ann Rheum Dis
, vol.73
, Issue.5
, pp. 803-809
-
-
Dougados, M.1
Kissel, K.2
Conaghan, P.G.3
Mola, E.M.4
Schett, G.5
Gerli, R.6
-
54
-
-
85019702082
-
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update
-
Smolen JS, Landewe R, Bijlsma J, Burmester G, Chatzidionysiou K, Dougados M, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update. Ann Rheum Dis. 2017;76:960–77.
-
(2017)
Ann Rheum Dis
, vol.76
, pp. 960-977
-
-
Smolen, J.S.1
Landewe, R.2
Bijlsma, J.3
Burmester, G.4
Chatzidionysiou, K.5
Dougados, M.6
-
55
-
-
85007524784
-
Low immunogenicity of tocilizumab in patients with rheumatoid arthritis
-
Burmester GR, Choy E, Kivitz A, Ogata A, Bao M, Nomura A, et al. Low immunogenicity of tocilizumab in patients with rheumatoid arthritis. Ann Rheum Dis. 2017;76(6):1078–85.
-
(2017)
Ann Rheum Dis
, vol.76
, Issue.6
, pp. 1078-1085
-
-
Burmester, G.R.1
Choy, E.2
Kivitz, A.3
Ogata, A.4
Bao, M.5
Nomura, A.6
-
56
-
-
79957630321
-
Efficacy of abatacept and tocilizumab in patients with rheumatoid arthritis treated in clinical practice: results from the nationwide Danish DANBIO registry
-
Leffers HC, Ostergaard M, Glintborg B, Krogh NS, Foged H, Tarp U, et al. Efficacy of abatacept and tocilizumab in patients with rheumatoid arthritis treated in clinical practice: results from the nationwide Danish DANBIO registry. Ann Rheum Dis. 2011;70(7):1216–22.
-
(2011)
Ann Rheum Dis
, vol.70
, Issue.7
, pp. 1216-1222
-
-
Leffers, H.C.1
Ostergaard, M.2
Glintborg, B.3
Krogh, N.S.4
Foged, H.5
Tarp, U.6
-
57
-
-
84880228981
-
Retention of tocilizumab and anti-tumour necrosis factor drugs in the treatment of rheumatoid arthritis
-
Hishitani Y, Ogata A, Shima Y, Hirano T, Ebina K, Kunugiza Y, et al. Retention of tocilizumab and anti-tumour necrosis factor drugs in the treatment of rheumatoid arthritis. Scand J Rheumatol. 2013;42(4):253–9.
-
(2013)
Scand J Rheumatol
, vol.42
, Issue.4
, pp. 253-259
-
-
Hishitani, Y.1
Ogata, A.2
Shima, Y.3
Hirano, T.4
Ebina, K.5
Kunugiza, Y.6
-
58
-
-
85028929150
-
Treatment of rheumatoid arthritis with anti-tumor necrosis factor or tocilizumab therapy as first biologic agent in a global comparative observational study
-
Choy EH, Bernasconi C, Aassi M, Molina JF, Epis OM. Treatment of rheumatoid arthritis with anti-tumor necrosis factor or tocilizumab therapy as first biologic agent in a global comparative observational study. Arthritis Care Res (Hoboken). 2017;69(10):1484–94.
-
(2017)
Arthritis Care Res (Hoboken)
, vol.69
, Issue.10
, pp. 1484-1494
-
-
Choy, E.H.1
Bernasconi, C.2
Aassi, M.3
Molina, J.F.4
Epis, O.M.5
-
59
-
-
84897569032
-
Drug free REmission/low disease activity after cessation of tocilizumab (Actemra) Monotherapy (DREAM) study
-
Nishimoto N, Amano K, Hirabayashi Y, Horiuchi T, Ishii T, Iwahashi M, et al. Drug free REmission/low disease activity after cessation of tocilizumab (Actemra) Monotherapy (DREAM) study. Mod Rheumatol. 2014;24(1):17–25.
-
(2014)
Mod Rheumatol
, vol.24
, Issue.1
, pp. 17-25
-
-
Nishimoto, N.1
Amano, K.2
Hirabayashi, Y.3
Horiuchi, T.4
Ishii, T.5
Iwahashi, M.6
-
60
-
-
84917726540
-
Clinical and radiographic outcomes at 2-years and the effect of tocilizumab discontinuation following sustained remission in the second and third year of the ACT-RAY study
-
Huizinga TW, Conaghan PG, Martin-Mola E, Schett G, Amital H, Xavier RM, et al. Clinical and radiographic outcomes at 2-years and the effect of tocilizumab discontinuation following sustained remission in the second and third year of the ACT-RAY study. Ann Rheum Dis. 2015;74(1):35–43.
-
(2015)
Ann Rheum Dis
, vol.74
, Issue.1
, pp. 35-43
-
-
Huizinga, T.W.1
Conaghan, P.G.2
Martin-Mola, E.3
Schett, G.4
Amital, H.5
Xavier, R.M.6
-
61
-
-
85048179919
-
Tocilizumab discontinuation after attaining remission in patients with rheumatoid arthritis who were treated with tocilizumab alone or in combination with methotrexate: results from a prospective randomised controlled study (the second year of the SURPRISE study)
-
Kaneko Y, Kato M, Tanaka Y, Inoo M, Kobayashi-Haraoka H, Amano K, et al. Tocilizumab discontinuation after attaining remission in patients with rheumatoid arthritis who were treated with tocilizumab alone or in combination with methotrexate: results from a prospective randomised controlled study (the second year of the SURPRISE study). Ann Rheum Dis. 2018;77(9):1268–75.
-
(2018)
Ann Rheum Dis
, vol.77
, Issue.9
, pp. 1268-1275
-
-
Kaneko, Y.1
Kato, M.2
Tanaka, Y.3
Inoo, M.4
Kobayashi-Haraoka, H.5
Amano, K.6
-
62
-
-
84904987888
-
Retreatment efficacy and safety of tocilizumab in patients with rheumatoid arthritis in recurrence (RESTORE) study
-
Nishimoto N, Amano K, Hirabayashi Y, Horiuchi T, Ishii T, Iwahashi M, et al. Retreatment efficacy and safety of tocilizumab in patients with rheumatoid arthritis in recurrence (RESTORE) study. Mod Rheumatol. 2014;24(1):26–32.
-
(2014)
Mod Rheumatol
, vol.24
, Issue.1
, pp. 26-32
-
-
Nishimoto, N.1
Amano, K.2
Hirabayashi, Y.3
Horiuchi, T.4
Ishii, T.5
Iwahashi, M.6
-
63
-
-
84926467403
-
Tocilizumab induces corticosteroid sparing in rheumatoid arthritis patients in clinical practice
-
Fortunet C, Pers YM, Lambert J, Godfrin-Valnet M, Constant E, Devilliers H, et al. Tocilizumab induces corticosteroid sparing in rheumatoid arthritis patients in clinical practice. Rheumatology (Oxford). 2015;54(4):672–7.
-
(2015)
Rheumatology (Oxford)
, vol.54
, Issue.4
, pp. 672-677
-
-
Fortunet, C.1
Pers, Y.M.2
Lambert, J.3
Godfrin-Valnet, M.4
Constant, E.5
Devilliers, H.6
-
64
-
-
85050639107
-
Sustained response following discontinuation of methotrexate in patients with rheumatoid arthritis treated with subcutaneous tocilizumab: results from a randomized, controlled trial. Arthritis
-
Kremer JM, Rigby W, Singer NG, Birchwood C, Gill D, Reiss W, et al. Sustained response following discontinuation of methotrexate in patients with rheumatoid arthritis treated with subcutaneous tocilizumab: results from a randomized, controlled trial. Arthritis Rheumatol. 2018;70(8):1200.
-
(2018)
Rheumatol
, vol.70
, Issue.8
, pp. 1200
-
-
Kremer, J.M.1
Rigby, W.2
Singer, N.G.3
Birchwood, C.4
Gill, D.5
Reiss, W.6
-
65
-
-
80052137402
-
Integrated safety in tocilizumab clinical trials
-
Schiff MH, Kremer JM, Jahreis A, Vernon E, Isaacs JD, van Vollenhoven RF. Integrated safety in tocilizumab clinical trials. Arthritis Res Ther. 2011;13(5):R141.
-
(2011)
Arthritis Res Ther
, vol.13
, Issue.5
, pp. R141
-
-
Schiff, M.H.1
Kremer, J.M.2
Jahreis, A.3
Vernon, E.4
Isaacs, J.D.5
van Vollenhoven, R.F.6
-
66
-
-
77956646068
-
Safety and efficacy profiles of tocilizumab monotherapy in Japanese patients with rheumatoid arthritis: meta-analysis of six initial trials and five long-term extensions
-
Nishimoto N, Ito K, Takagi N. Safety and efficacy profiles of tocilizumab monotherapy in Japanese patients with rheumatoid arthritis: meta-analysis of six initial trials and five long-term extensions. Mod Rheumatol. 2010;20(3):222–32.
-
(2010)
Mod Rheumatol
, vol.20
, Issue.3
, pp. 222-232
-
-
Nishimoto, N.1
Ito, K.2
Takagi, N.3
-
67
-
-
85092668353
-
Long-term safety of tocilizumab from large clinical trial and postmarketing populations
-
Mohan S, Michalska M, Yourish J, Pei J, Gale S, Birchwood C, et al. Long-term safety of tocilizumab from large clinical trial and postmarketing populations. Ann Rheum Dis. 2017;76 (suppl 2):95.
-
(2017)
Ann Rheum Dis
, vol.76
, pp. 95
-
-
Mohan, S.1
Michalska, M.2
Yourish, J.3
Pei, J.4
Gale, S.5
Birchwood, C.6
-
68
-
-
84868484220
-
Tocilizumab in patients with active rheumatoid arthritis and inadequate responses to DMARDs and/or TNF inhibitors: a large, open-label study close to clinical practice
-
Bykerk VP, Ostör AJ, Alvaro-Gracia J, Pavelka K, Ivorra JA, Graninger W, et al. Tocilizumab in patients with active rheumatoid arthritis and inadequate responses to DMARDs and/or TNF inhibitors: a large, open-label study close to clinical practice. Ann Rheum Dis. 2012;71(12):1950–4.
-
(2012)
Ann Rheum Dis
, vol.71
, Issue.12
, pp. 1950-1954
-
-
Bykerk, V.P.1
Ostör, A.J.2
Alvaro-Gracia, J.3
Pavelka, K.4
Ivorra, J.A.5
Graninger, W.6
-
69
-
-
85044762326
-
Two-year efficacy and safety of subcutaneous tocilizumab in combination with disease-modifying antirheumatic drugs including escalation to weekly dosing in rheumatoid arthritis
-
Kivitz A, Olech E, Borofsky MA, Zazueta B, Navarro-Sarabia F, Radominski SC, et al. Two-year efficacy and safety of subcutaneous tocilizumab in combination with disease-modifying antirheumatic drugs including escalation to weekly dosing in rheumatoid arthritis. J Rheumatol. 2018;45(4):456–64.
-
(2018)
J Rheumatol
, vol.45
, Issue.4
, pp. 456-464
-
-
Kivitz, A.1
Olech, E.2
Borofsky, M.A.3
Zazueta, B.4
Navarro-Sarabia, F.5
Radominski, S.C.6
-
70
-
-
85043325180
-
Subcutaneous tocilizumab in rheumatoid arthritis: findings from the common-framework phase 4 study programme TOZURA conducted in 22 countries
-
Choy E, Caporali R, Xavier R, Fautrel B, Sanmarti R, Bao M, et al. Subcutaneous tocilizumab in rheumatoid arthritis: findings from the common-framework phase 4 study programme TOZURA conducted in 22 countries. Rheumatology (Oxford). 2018;57(3):499–507.
-
(2018)
Rheumatology (Oxford)
, vol.57
, Issue.3
, pp. 499-507
-
-
Choy, E.1
Caporali, R.2
Xavier, R.3
Fautrel, B.4
Sanmarti, R.5
Bao, M.6
-
71
-
-
85040999465
-
Safety and effectiveness of subcutaneous tocilizumab in patients with rheumatoid arthritis in a real-world clinical setting
-
Atsumi T, Fujio K, Yamaoka K, Tomobe M, Kuroyanagi K, Kameda H. Safety and effectiveness of subcutaneous tocilizumab in patients with rheumatoid arthritis in a real-world clinical setting. Mod Rheumatol. 2018;28(5):780–88.
-
(2018)
Mod Rheumatol
, vol.28
, Issue.5
, pp. 780-788
-
-
Atsumi, T.1
Fujio, K.2
Yamaoka, K.3
Tomobe, M.4
Kuroyanagi, K.5
Kameda, H.6
-
72
-
-
79953018875
-
Adverse effects of biologics: a network meta-analysis and Cochrane overview
-
Singh JA, Wells GA, Christensen R, Tanjong Ghogomu E, Maxwell L, Macdonald JK, et al. Adverse effects of biologics: a network meta-analysis and Cochrane overview. Cochrane Database Syst Rev. 2011;(2):CD008794.
-
(2011)
Cochrane Database Syst Rev
, Issue.2
, pp. CD008794
-
-
Singh, J.A.1
Wells, G.A.2
Christensen, R.3
Tanjong Ghogomu, E.4
Maxwell, L.5
Macdonald, J.K.6
-
73
-
-
79952013541
-
Risk of adverse events including serious infections in rheumatoid arthritis patients treated with tocilizumab: a systematic literature review and meta-analysis of randomized controlled trials
-
Campbell L, Chen C, Bhagat SS, Parker RA, Östör AJ. Risk of adverse events including serious infections in rheumatoid arthritis patients treated with tocilizumab: a systematic literature review and meta-analysis of randomized controlled trials. Rheumatology (Oxford). 2011;50(3):552–62.
-
(2011)
Rheumatology (Oxford)
, vol.50
, Issue.3
, pp. 552-562
-
-
Campbell, L.1
Chen, C.2
Bhagat, S.S.3
Parker, R.A.4
Östör, A.J.5
-
74
-
-
84926435718
-
Head-to-head comparison of the safety of tocilizumab and tumor necrosis factor inhibitors in rheumatoid arthritis patients (RA) in clinical practice: results from the registry of Japanese RA patients on biologics for long-term safety (REAL) registry
-
Sakai R, Cho SK, Nanki T, Watanabe K, Yamazaki H, Tanaka M, et al. Head-to-head comparison of the safety of tocilizumab and tumor necrosis factor inhibitors in rheumatoid arthritis patients (RA) in clinical practice: results from the registry of Japanese RA patients on biologics for long-term safety (REAL) registry. Arthritis Res Ther. 2015;17:74.
-
(2015)
Arthritis Res Ther
, vol.17
, Issue.74
-
-
Sakai, R.1
Cho, S.K.2
Nanki, T.3
Watanabe, K.4
Yamazaki, H.5
Tanaka, M.6
-
75
-
-
60149100932
-
Masked early symptoms of pneumonia in patients with rheumatoid arthritis during tocilizumab treatment: a report of two cases
-
Fujiwara H, Nishimoto N, Hamano Y, Asanuma N, Miki S, Kasayama S, et al. Masked early symptoms of pneumonia in patients with rheumatoid arthritis during tocilizumab treatment: a report of two cases. Mod Rheumatol. 2009;19(1):64–8.
-
(2009)
Mod Rheumatol
, vol.19
, Issue.1
, pp. 64-68
-
-
Fujiwara, H.1
Nishimoto, N.2
Hamano, Y.3
Asanuma, N.4
Miki, S.5
Kasayama, S.6
-
76
-
-
85029404451
-
Prodromal signs and symptoms of serious infections with tocilizumab treatment for rheumatoid arthritis: text mining of the Japanese postmarketing adverse event-reporting database
-
Atsumi T, Ando Y, Matsuda S, Tomizawa S, Tanaka R, Takagi N, et al. Prodromal signs and symptoms of serious infections with tocilizumab treatment for rheumatoid arthritis: text mining of the Japanese postmarketing adverse event-reporting database. Mod Rheumatol. 2018;28(3):435–43.
-
(2018)
Mod Rheumatol
, vol.28
, Issue.3
, pp. 435-443
-
-
Atsumi, T.1
Ando, Y.2
Matsuda, S.3
Tomizawa, S.4
Tanaka, R.5
Takagi, N.6
-
77
-
-
84901789226
-
Biologic therapies in rheumatoid arthritis and the risk of opportunistic infections: a meta-analysis
-
Kourbeti IS, Ziakas PD, Mylonakis E. Biologic therapies in rheumatoid arthritis and the risk of opportunistic infections: a meta-analysis. Clin Infect Dis. 2014;58(12):1649–57.
-
(2014)
Clin Infect Dis
, vol.58
, Issue.12
, pp. 1649-1657
-
-
Kourbeti, I.S.1
Ziakas, P.D.2
Mylonakis, E.3
-
78
-
-
85047417783
-
Opportunistic infections in rheumatoid arthritis patients exposed to biologic therapy: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis
-
Rutherford AI, Patarata E, Subesinghe S, Hyrich KL, Galloway JB. Opportunistic infections in rheumatoid arthritis patients exposed to biologic therapy: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis. Rheumatology (Oxford). 2018;57(6):997–1001.
-
(2018)
Rheumatology (Oxford)
, vol.57
, Issue.6
, pp. 997-1001
-
-
Rutherford, A.I.1
Patarata, E.2
Subesinghe, S.3
Hyrich, K.L.4
Galloway, J.B.5
-
79
-
-
84928553933
-
Risks of herpes zoster in patients with rheumatoid arthritis according to biologic disease modifying therapy
-
Yun H, Xie F, Delzell E, Chen L, Levitan EB, Lewis JD, et al. Risks of herpes zoster in patients with rheumatoid arthritis according to biologic disease modifying therapy. Arthritis Care Res (Hoboken). 2015;67(5):731–6.
-
(2015)
Arthritis Care Res (Hoboken)
, vol.67
, Issue.5
, pp. 731-736
-
-
Yun, H.1
Xie, F.2
Delzell, E.3
Chen, L.4
Levitan, E.B.5
Lewis, J.D.6
-
80
-
-
84924842188
-
Risk of tuberculosis in patients with chronic immune-mediated inflammatory diseases treated with biologics and tofacitinib a systematic review and meta-analysis of randomized controlled trials and long-term extension studies
-
Sout A, Maneiro JR, Salgado E, Carmona L, Gomez-Reino JJ. Risk of tuberculosis in patients with chronic immune-mediated inflammatory diseases treated with biologics and tofacitinib a systematic review and meta-analysis of randomized controlled trials and long-term extension studies. Rheumatology 2014;53:1872–85.
-
(2014)
Rheumatology
, vol.53
, pp. 1872-1885
-
-
Sout, A.1
Maneiro, J.R.2
Salgado, E.3
Carmona, L.4
Gomez-Reino, J.J.5
-
81
-
-
77954761056
-
Minimal influence of tocilizumab on IFN-gamma synthesis by tuberculosis antigens
-
Ogata A, Mori M, Hashimoto S, Yano Y, Fujikawa T, Kawai M, et al. Minimal influence of tocilizumab on IFN-gamma synthesis by tuberculosis antigens. Mod Rheumatol. 2010;20(2):130–3.
-
(2010)
Mod Rheumatol
, vol.20
, Issue.2
, pp. 130-133
-
-
Ogata, A.1
Mori, M.2
Hashimoto, S.3
Yano, Y.4
Fujikawa, T.5
Kawai, M.6
-
82
-
-
84870312839
-
Pneumocystis jirovecii infection: an emerging threat to patients with rheumatoid arthritis
-
Mori S, Sugimoto M. Pneumocystis jirovecii infection: an emerging threat to patients with rheumatoid arthritis. Rheumatology (Oxford). 2012;51(12):2120–30.
-
(2012)
Rheumatology (Oxford)
, vol.51
, Issue.12
, pp. 2120-2130
-
-
Mori, S.1
Sugimoto, M.2
-
83
-
-
85012054761
-
Short-course tocilizumab increases risk of hepatitis B virus reactivation in patients with rheumatoid arthritis: a prospective clinical observation
-
Chen LF, Mo YQ, Jing J, Ma JD, Zheng DH, Dai L. Short-course tocilizumab increases risk of hepatitis B virus reactivation in patients with rheumatoid arthritis: a prospective clinical observation. Int J Rheum Dis. 2017;20(7):859–69.
-
(2017)
Int J Rheum Dis
, vol.20
, Issue.7
, pp. 859-869
-
-
Chen, L.F.1
Mo, Y.Q.2
Jing, J.3
Ma, J.D.4
Zheng, D.H.5
Dai, L.6
-
84
-
-
85045026109
-
Safety of tocilizumab in rheumatoid arthritis patients with resolved hepatitis B virus infection: data from real-world experience
-
Ahn SS, Jung SM, Song JJ, Park YB, Park JY, Lee SW. Safety of tocilizumab in rheumatoid arthritis patients with resolved hepatitis B virus infection: data from real-world experience. Yonsei Med J. 2018;59(3):452–6.
-
(2018)
Yonsei Med J
, vol.59
, Issue.3
, pp. 452-456
-
-
Ahn, S.S.1
Jung, S.M.2
Song, J.J.3
Park, Y.B.4
Park, J.Y.5
Lee, S.W.6
-
85
-
-
85017264825
-
Effect of tocilizumab on neutrophils in adult patients with rheumatoid arthritis: pooled analysis of data from phase 3 and 4 clinical trials
-
Moots RJ, Sebba A, Rigby W, Ostor A, Porter-Brown B, Donaldson F, et al. Effect of tocilizumab on neutrophils in adult patients with rheumatoid arthritis: pooled analysis of data from phase 3 and 4 clinical trials. Rheumatology (Oxford). 2017;56:541–9.
-
(2017)
Rheumatology (Oxford)
, vol.56
, pp. 541-549
-
-
Moots, R.J.1
Sebba, A.2
Rigby, W.3
Ostor, A.4
Porter-Brown, B.5
Donaldson, F.6
-
86
-
-
0028675983
-
Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system
-
Bernad A, Kopf M, Kulbacki R, Weich N, Koehler G, Gutierrez-Ramos JC. Interleukin-6 is required in vivo for the regulation of stem cells and committed progenitors of the hematopoietic system. Immunity. 1994;1(9):725–31.
-
(1994)
Immunity
, vol.1
, Issue.9
, pp. 725-731
-
-
Bernad, A.1
Kopf, M.2
Kulbacki, R.3
Weich, N.4
Koehler, G.5
Gutierrez-Ramos, J.C.6
-
87
-
-
84902959388
-
Effects of IL-6 and IL-6 blockade on neutrophil function in vitro and in vivo
-
Wright HL, Cross AL, Edwards SW, Moots RJ. Effects of IL-6 and IL-6 blockade on neutrophil function in vitro and in vivo. Rheumatology (Oxford). 2014;53(7):1321–31.
-
(2014)
Rheumatology (Oxford)
, vol.53
, Issue.7
, pp. 1321-1331
-
-
Wright, H.L.1
Cross, A.L.2
Edwards, S.W.3
Moots, R.J.4
-
88
-
-
0034537772
-
Interleukin-6 induces demargination of intravascular neutrophils and shortens their transit in marrow
-
Suwa T, Hogg JC, English D, Van Eeden SF. Interleukin-6 induces demargination of intravascular neutrophils and shortens their transit in marrow. Am J Physiol Heart Circ Physiol. 2000;279(6):H2954–60.
-
(2000)
Am J Physiol Heart Circ Physiol
, vol.279
, Issue.6
, pp. H2954-H2960
-
-
Suwa, T.1
Hogg, J.C.2
English, D.3
Van Eeden, S.F.4
-
89
-
-
0035525771
-
Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis
-
Kaser A, Brandacher G, Steurer W, Kaser S, Offner FA, Zoller H, et al. Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis. Blood. 2001;98(9):2720–5.
-
(2001)
Blood.
, vol.98
, Issue.9
, pp. 2720-2725
-
-
Kaser, A.1
Brandacher, G.2
Steurer, W.3
Kaser, S.4
Offner, F.A.5
Zoller, H.6
-
90
-
-
0034650935
-
The residual megakaryocyte and platelet production in c-mpl-deficient mice is not dependent on the actions of interleukin-6, interleukin-11, or leukemia inhibitory factor
-
Gainsford T, Nandurkar H, Metcalf D, Robb L, Begley CG, Alexander WS. The residual megakaryocyte and platelet production in c-mpl-deficient mice is not dependent on the actions of interleukin-6, interleukin-11, or leukemia inhibitory factor. Blood. 2000;95:528–34.
-
(2000)
Blood
, vol.95
, pp. 528-534
-
-
Gainsford, T.1
Nandurkar, H.2
Metcalf, D.3
Robb, L.4
Begley, C.G.5
Alexander, W.S.6
-
91
-
-
85018971196
-
Cardiovascular safety of tocilizumab versus tumor necrosis factor inhibitors in patients with rheumatoid arthritis: a multi-database cohort study. Arthritis
-
Kim SC, Solomon DH, Rogers JR, Gale S, Klearman M, Sarsour K, et al. Cardiovascular safety of tocilizumab versus tumor necrosis factor inhibitors in patients with rheumatoid arthritis: a multi-database cohort study. Arthritis Rheumatol. 2017;69:1154–64.
-
(2017)
Rheumatol
, vol.69
, pp. 1154-1164
-
-
Kim, S.C.1
Solomon, D.H.2
Rogers, J.R.3
Gale, S.4
Klearman, M.5
Sarsour, K.6
-
92
-
-
85069920453
-
Tocilizumab and the risk for cardiovascular disease: a direct comparison among biologic disease-modifying antirheumatic drugs for rheumatoid arthritis patients
-
2018 [Sep 3]. [Epub ahead of print]
-
Xie F, Yun H, Levitan EB, Muntner P, Curtis JR. Tocilizumab and the risk for cardiovascular disease: a direct comparison among biologic disease-modifying antirheumatic drugs for rheumatoid arthritis patients. Arthritis Care Res (Hoboken). 2018 [Sep 3]. [Epub ahead of print]. doi: 10.1002/acr.23737
-
Arthritis Care Res (Hoboken)
-
-
Xie, F.1
Yun, H.2
Levitan, E.B.3
Muntner, P.4
Curtis, J.R.5
-
93
-
-
84962300219
-
Response to biological treatment and subsequent risk of coronary events in rheumatoid arthritis
-
Ljung L, Rantapää-Dahlqvist S, Jacobsson LT, Askling J. Response to biological treatment and subsequent risk of coronary events in rheumatoid arthritis. Ann Rheum Dis. 2016;75(12):2087–94.
-
(2016)
Ann Rheum Dis
, vol.75
, Issue.12
, pp. 2087-2094
-
-
Ljung, L.1
Rantapää-Dahlqvist, S.2
Jacobsson, L.T.3
Askling, J.4
-
94
-
-
84987896973
-
Cardiovascular risk in rheumatoid arthritis: recent advances in the understanding of the pivotal role of inflammation, risk predictors and the impact of treatment
-
Choy E, Ganeshalingam K, Semb AG, Szekanecz Z, Nurmohamed M. Cardiovascular risk in rheumatoid arthritis: recent advances in the understanding of the pivotal role of inflammation, risk predictors and the impact of treatment. Rheumatology (Oxford). 2014;53(12):2143–54.
-
(2014)
Rheumatology (Oxford)
, vol.53
, Issue.12
, pp. 2143-2154
-
-
Choy, E.1
Ganeshalingam, K.2
Semb, A.G.3
Szekanecz, Z.4
Nurmohamed, M.5
-
95
-
-
84860331375
-
TNF-α, IL-6 and serum from RA patients each atherogenic effects of TNF-α and IL-6 via up-regulation of scavenger receptors
-
Hashizume M, Mihara M. TNF-α, IL-6 and serum from RA patients each atherogenic effects of TNF-α and IL-6 via up-regulation of scavenger receptors. Cytokine. 2012;58(3):424–30.
-
(2012)
Cytokine
, vol.58
, Issue.3
, pp. 424-430
-
-
Hashizume, M.1
Mihara, M.2
-
96
-
-
20844449693
-
Impact of interleukin-6 on plaque development and morphology in experimental atherosclerosis
-
Schieffer B, Selle T, Hilfiker A, Hilfiker-Kleiner D, Grote K, Tietge UJ, et al. Impact of interleukin-6 on plaque development and morphology in experimental atherosclerosis. Circulation. 2004;110(22):3493–500.
-
(2004)
Circulation
, vol.110
, Issue.22
, pp. 3493-3500
-
-
Schieffer, B.1
Selle, T.2
Hilfiker, A.3
Hilfiker-Kleiner, D.4
Grote, K.5
Tietge, U.J.6
-
97
-
-
85026542481
-
Transaminase levels and hepatic events during tocilizumab treatment: pooled analysis of long-term clinical trial safety data in rheumatoid arthritis
-
Genovese MC, Kremer JM, van Vollenhoven RF, Alten R, Scali JJ, Kelman A, et al. Transaminase levels and hepatic events during tocilizumab treatment: pooled analysis of long-term clinical trial safety data in rheumatoid arthritis. Arthritis Rheumatol. 2017;69(9):1751–61.
-
(2017)
Arthritis Rheumatol
, vol.69
, Issue.9
, pp. 1751-1761
-
-
Genovese, M.C.1
Kremer, J.M.2
van Vollenhoven, R.F.3
Alten, R.4
Scali, J.J.5
Kelman, A.6
-
98
-
-
85037601464
-
Sirukumab for rheumatoid arthritis: the phase III SIRROUND-D study
-
Takeuchi T, Thorne C, Karpouzas G, Sheng S, Xu W, Rao R, F, et al. Sirukumab for rheumatoid arthritis: the phase III SIRROUND-D study. Ann Rheum Dis. 2017;76(12):2001–8.
-
(2017)
Ann Rheum Dis
, vol.76
, Issue.12
, pp. 2001-2008
-
-
Takeuchi, T.1
Thorne, C.2
Karpouzas, G.3
Sheng, S.4
Xu, W.5
Rao, R.F.6
-
99
-
-
49149095841
-
Transcriptional complex formation of c-Fos, STAT3, and hepatocyte NF-1 alpha is essential for cytokine-driven C-reactive protein gene expression
-
Nishikawa T, Hagihara K, Serada S, Isobe T, Matsumura A, Song J, et al. Transcriptional complex formation of c-Fos, STAT3, and hepatocyte NF-1 alpha is essential for cytokine-driven C-reactive protein gene expression. J Immunol. 2008;180(5):3492–501.
-
(2008)
J Immunol
, vol.180
, Issue.5
, pp. 3492-3501
-
-
Nishikawa, T.1
Hagihara, K.2
Serada, S.3
Isobe, T.4
Matsumura, A.5
Song, J.6
-
100
-
-
0033928572
-
Interleukin 6 and liver regeneration
-
Streetz KL, Luedde T, Manns MP, Trautwein C. Interleukin 6 and liver regeneration. Gut. 2000;47(2):309–12.
-
(2000)
Gut
, vol.47
, Issue.2
, pp. 309-312
-
-
Streetz, K.L.1
Luedde, T.2
Manns, M.P.3
Trautwein, C.4
-
101
-
-
84992623468
-
Brief report: risk of gastrointestinal perforation among rheumatoid arthritis patients receiving tofacitinib, tocilizumab, or other biologic treatments
-
Xie F, Yun H, Bernatsky S, Curtis JR. Brief report: risk of gastrointestinal perforation among rheumatoid arthritis patients receiving tofacitinib, tocilizumab, or other biologic treatments. Arthritis Rheumatol. 2016;68(11):2612–7.
-
(2016)
Arthritis Rheumatol
, vol.68
, Issue.11
, pp. 2612-2617
-
-
Xie, F.1
Yun, H.2
Bernatsky, S.3
Curtis, J.R.4
-
102
-
-
84978805792
-
Risk for lower intestinal perforations in patients with rheumatoid arthritis treated with tocilizumab in comparison to treatment with other biologic or conventional synthetic DMARDs
-
Strangfeld A, Richter A, Siegmund B, Herzer P, Rockwitz K, Demary W, et al. Risk for lower intestinal perforations in patients with rheumatoid arthritis treated with tocilizumab in comparison to treatment with other biologic or conventional synthetic DMARDs. Ann Rheum Dis. 2017;76(3):504–10.
-
(2017)
Ann Rheum Dis
, vol.76
, Issue.3
, pp. 504-510
-
-
Strangfeld, A.1
Richter, A.2
Siegmund, B.3
Herzer, P.4
Rockwitz, K.5
Demary, W.6
-
103
-
-
77149154988
-
Interleukin-6 is an important in vivo inhibitor of intestinal epithelial cell death in mice
-
Jin X, Zimmers TA, Zhang Z, Pierce RH, Koniaris LG. Interleukin-6 is an important in vivo inhibitor of intestinal epithelial cell death in mice. Gut. 2010;59(2):186–96.
-
(2010)
Gut
, vol.59
, Issue.2
, pp. 186-196
-
-
Jin, X.1
Zimmers, T.A.2
Zhang, Z.3
Pierce, R.H.4
Koniaris, L.G.5
-
104
-
-
84918522920
-
IL-6 stimulates intestinal epithelial proliferation and repair after injury
-
Kuhn KA, Manieri NA, Liu TC, Stappenbeck TS. IL-6 stimulates intestinal epithelial proliferation and repair after injury. PLoS One. 2014;9(12):e114195.
-
(2014)
PLoS One
, vol.9
, Issue.12
-
-
Kuhn, K.A.1
Manieri, N.A.2
Liu, T.C.3
Stappenbeck, T.S.4
-
105
-
-
84939167646
-
Incidence of malignancy in adult patients with rheumatoid arthritis: a meta-analysis
-
Simon TA, Thompson A, Gandhi KK, Hochberg MC, Suissa S. Incidence of malignancy in adult patients with rheumatoid arthritis: a meta-analysis. Arthritis Res Ther. 2015;17:212.
-
(2015)
Arthritis Res Ther.
, vol.17
, pp. 212
-
-
Simon, T.A.1
Thompson, A.2
Gandhi, K.K.3
Hochberg, M.C.4
Suissa, S.5
-
106
-
-
84988417747
-
Malignancy rates in patients with rheumatoid arthritis treated with tocilizumab
-
Rubbert-Roth A, Sebba A, Brockwell L, Kelman A, Porter-Brown B, Pulley J, et al. Malignancy rates in patients with rheumatoid arthritis treated with tocilizumab. RMD Open. 2016;2(1):e000213.
-
(2016)
RMD Open
, vol.2
, Issue.1
, pp. e000213
-
-
Rubbert-Roth, A.1
Sebba, A.2
Brockwell, L.3
Kelman, A.4
Porter-Brown, B.5
Pulley, J.6
-
107
-
-
85062747274
-
No difference in the risk of malignancy in tocilizumab versus TNF inhibitor initiators in patients with rheumatoid arthritis: a multi-database cohort study
-
Kim SC, Pawar A, Desai RJ, Gale S, Klearman M, Sarsour K, et al. No difference in the risk of malignancy in tocilizumab versus TNF inhibitor initiators in patients with rheumatoid arthritis: a multi-database cohort study. Ann Rheum Dis. 2018;77(2):50.
-
(2018)
Ann Rheum Dis
, vol.77
, Issue.2
, pp. 50
-
-
Kim, S.C.1
Pawar, A.2
Desai, R.J.3
Gale, S.4
Klearman, M.5
Sarsour, K.6
-
108
-
-
84896491618
-
The IL-6 feed-forward loop: a driver of tumorigenesis
-
Chang Q, Daly L, Bromberg J. The IL-6 feed-forward loop: a driver of tumorigenesis. Semin Immunol. 2014;26(1):48–53.
-
(2014)
Semin Immunol
, vol.26
, Issue.1
, pp. 48-53
-
-
Chang, Q.1
Daly, L.2
Bromberg, J.3
-
109
-
-
85034222106
-
Immune-suppressive effects of interleukin-6 on T-cell-mediated anti-tumor immunity
-
Tsukamoto H, Fujieda K, Senju S, Ikeda T, Oshiumi H, Nishimura Y. Immune-suppressive effects of interleukin-6 on T-cell-mediated anti-tumor immunity. Cancer Sci. 2018;109(3):523–30.
-
(2018)
Cancer Sci
, vol.109
, Issue.3
, pp. 523-530
-
-
Tsukamoto, H.1
Fujieda, K.2
Senju, S.3
Ikeda, T.4
Oshiumi, H.5
Nishimura, Y.6
-
110
-
-
85019080872
-
Monocyte lineage-derived IL-6 does not affect chimeric antigen receptor T-cell function
-
Singh N, Hofmann TJ, Gershenson Z, Levine BL, Grupp SA, Teachey DT, et al. Monocyte lineage-derived IL-6 does not affect chimeric antigen receptor T-cell function. Cytotherapy. 2017;19(7):867–80.
-
(2017)
Cytotherapy.
, vol.19
, Issue.7
, pp. 867-880
-
-
Singh, N.1
Hofmann, T.J.2
Gershenson, Z.3
Levine, B.L.4
Grupp, S.A.5
Teachey, D.T.6
-
111
-
-
84977477922
-
Toxicities of chimeric antigen receptor T cells: recognition and management
-
Brudno JN, Kochenderfer JN. Toxicities of chimeric antigen receptor T cells: recognition and management. Blood. 2016;127(26):3321–30.
-
(2016)
Blood.
, vol.127
, Issue.26
, pp. 3321-3330
-
-
Brudno, J.N.1
Kochenderfer, J.N.2
-
112
-
-
0033664369
-
Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice
-
Gallucci RM, Simeonova PP, Matheson JM, Kommineni C, Guriel JL, Sugawara T, et al. Impaired cutaneous wound healing in interleukin-6-deficient and immunosuppressed mice. FASEB J. 2000;14(15):2525–31.
-
(2000)
FASEB J
, vol.14
, Issue.15
, pp. 2525-2531
-
-
Gallucci, R.M.1
Simeonova, P.P.2
Matheson, J.M.3
Kommineni, C.4
Guriel, J.L.5
Sugawara, T.6
-
113
-
-
0025494032
-
Interleukin 6 and expression of its receptor on epidermal keratinocytes
-
Yoshizaki K, Nishimoto N, Matsumoto K, Tagoh H, Taga T, Deguchi Y, et al. Interleukin 6 and expression of its receptor on epidermal keratinocytes. Cytokine. 1990;2(5):381–7.
-
(1990)
Cytokine
, vol.2
, Issue.5
, pp. 381-387
-
-
Yoshizaki, K.1
Nishimoto, N.2
Matsumoto, K.3
Tagoh, H.4
Taga, T.5
Deguchi, Y.6
-
114
-
-
85020923165
-
2017 American College of Rheumatology/American Association of hip and knee surgeons guideline for the perioperative management of antirheumatic medication in patients with rheumatic diseases undergoing elective total hip or total knee arthroplasty
-
Goodman SM, Springer B, Guyatt G, Abdel MP, Dasa V, George M, et al. 2017 American College of Rheumatology/American Association of hip and knee surgeons guideline for the perioperative management of antirheumatic medication in patients with rheumatic diseases undergoing elective total hip or total knee arthroplasty. Arthritis Care Res (Hoboken). 2017;69(8):1111–24.
-
(2017)
Arthritis Care Res (Hoboken)
, vol.69
, Issue.8
, pp. 1111-1124
-
-
Goodman, S.M.1
Springer, B.2
Guyatt, G.3
Abdel, M.P.4
Dasa, V.5
George, M.6
-
115
-
-
66149155108
-
Laboratory and febrile features after joint surgery in patients with rheumatoid arthritis treated with tocilizumab
-
Hirao M, Hashimoto J, Tsuboi H, Nampei A, Nakahara H, Yoshio N, et al. Laboratory and febrile features after joint surgery in patients with rheumatoid arthritis treated with tocilizumab. Ann Rheum Dis. 2009;68(5):654–7.
-
(2009)
Ann Rheum Dis
, vol.68
, Issue.5
, pp. 654-657
-
-
Hirao, M.1
Hashimoto, J.2
Tsuboi, H.3
Nampei, A.4
Nakahara, H.5
Yoshio, N.6
-
116
-
-
84877751661
-
Analysis of perioperative clinical features and complications after orthopaedic surgery in rheumatoid arthritis patients treated with tocilizumab in a real-world setting: results from the multicentre TOcilizumab in Perioperative Period (TOPP) study
-
Momohara S, Hashimoto J, Tsuboi H, Miyahara H, Nakagawa N, Kaneko A, et al. Analysis of perioperative clinical features and complications after orthopaedic surgery in rheumatoid arthritis patients treated with tocilizumab in a real-world setting: results from the multicentre TOcilizumab in Perioperative Period (TOPP) study. Mod Rheumatol. 2013;23(3):440–9.
-
(2013)
Mod Rheumatol
, vol.23
, Issue.3
, pp. 440-449
-
-
Momohara, S.1
Hashimoto, J.2
Tsuboi, H.3
Miyahara, H.4
Nakagawa, N.5
Kaneko, A.6
-
117
-
-
84977618703
-
Tocilizumab use in pregnancy: analysis of a global safety database including data from clinical trials and post-marketing data
-
Hoeltzenbein M, Beck E, Rajwanshi R, Gøtestam Skorpen C, Berber E, Schaefer C, et al. Tocilizumab use in pregnancy: analysis of a global safety database including data from clinical trials and post-marketing data. Semin Arthritis Rheum. 2016;46(2):238–45.
-
(2016)
Semin Arthritis Rheum
, vol.46
, Issue.2
, pp. 238-245
-
-
Hoeltzenbein, M.1
Beck, E.2
Rajwanshi, R.3
Gøtestam Skorpen, C.4
Berber, E.5
Schaefer, C.6
-
118
-
-
84961204382
-
Pregnancy outcomes after exposure to tocilizumab: a retrospective analysis of 61 patients in Japan
-
Nakajima K, Watanabe O, Mochizuki M, Nakasone A, Ishizuka N, Murashima A. Pregnancy outcomes after exposure to tocilizumab: a retrospective analysis of 61 patients in Japan. Mod Rheumatol. 2016;26(5):667–71.
-
(2016)
Mod Rheumatol
, vol.26
, Issue.5
, pp. 667-671
-
-
Nakajima, K.1
Watanabe, O.2
Mochizuki, M.3
Nakasone, A.4
Ishizuka, N.5
Murashima, A.6
-
119
-
-
0028328436
-
Impaired immune and acute-phase responses in interleukin-6-deficient mice
-
Kopf M, Baumann H, Freer G, Freudenberg M, Lamers M, Kishimoto T, et al. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature. 1994;368(6469):339–42.
-
(1994)
Nature.
, vol.368
, Issue.6469
, pp. 339-342
-
-
Kopf, M.1
Baumann, H.2
Freer, G.3
Freudenberg, M.4
Lamers, M.5
Kishimoto, T.6
-
120
-
-
84865107905
-
The effects of interleukin-6 signal blockade on fertility, embryo-fetal development, and immunization in vivo
-
Sakurai T, Takai R, Bürgin H, Ishihara K, Sakamoto Y, Amano J, et al. The effects of interleukin-6 signal blockade on fertility, embryo-fetal development, and immunization in vivo. Birth Defects Res B Dev Reprod Toxicol. 2012;95(4):304–17.
-
(2012)
Birth Defects Res B Dev Reprod Toxicol
, vol.95
, Issue.4
, pp. 304-317
-
-
Sakurai, T.1
Takai, R.2
Bürgin, H.3
Ishihara, K.4
Sakamoto, Y.5
Amano, J.6
-
122
-
-
84981243970
-
Room for more IL-6 blockade? Sarilumab for the treatment of rheumatoid arthritis
-
June RR, Olsen NJ. Room for more IL-6 blockade? Sarilumab for the treatment of rheumatoid arthritis. Expert Opin Biol Ther. 2016;16(10):1303–9.
-
(2016)
Expert Opin Biol Ther
, vol.16
, Issue.10
, pp. 1303-1309
-
-
June, R.R.1
Olsen, N.J.2
-
123
-
-
85019664560
-
Profile of sarilumab and its potential in the treatment of rheumatoid arthritis
-
Raimondo MG, Biggioggero M, Crotti C, Becciolini A, Favalli EG. Profile of sarilumab and its potential in the treatment of rheumatoid arthritis. Drug Des Devel Ther. 2017;11:1593–603.
-
(2017)
Drug Des Devel Ther
, vol.11
, pp. 1593-1603
-
-
Raimondo, M.G.1
Biggioggero, M.2
Crotti, C.3
Becciolini, A.4
Favalli, E.G.5
-
124
-
-
84930177360
-
The varying faces of IL-6: from cardiac protection to cardiac failure
-
Fontes JA, Rose NR, Čiháková D. The varying faces of IL-6: from cardiac protection to cardiac failure. Cytokine. 2015;74(1):62–8.
-
(2015)
Cytokine
, vol.74
, Issue.1
, pp. 62-68
-
-
Fontes, J.A.1
Rose, N.R.2
Čiháková, D.3
-
125
-
-
84930858136
-
Interleukin-6 mediates exercise preconditioning against myocardial ischemia reperfusion injury
-
McGinnis GR, Ballmann C, Peters B, Nanayakkara G, Roberts M, Amin R, et al. Interleukin-6 mediates exercise preconditioning against myocardial ischemia reperfusion injury. Am J Physiol Heart Circ Physiol. 2015;308(11):H1423–33.
-
(2015)
Am J Physiol Heart Circ Physiol
, vol.308
, Issue.11
, pp. H1423-H1433
-
-
McGinnis, G.R.1
Ballmann, C.2
Peters, B.3
Nanayakkara, G.4
Roberts, M.5
Amin, R.6
-
126
-
-
84873303320
-
p42/p44-MAPK and PI3K are sufficient for IL-6 family cytokines/gp130 to signal to hypertrophy and survival in cardiomyocytes in the absence of JAK/STAT activation
-
Fahmi A, Smart N, Punn A, Jabr R, Marber M, Heads R. p42/p44-MAPK and PI3K are sufficient for IL-6 family cytokines/gp130 to signal to hypertrophy and survival in cardiomyocytes in the absence of JAK/STAT activation. Cell Signal. 2013;25(4):898–909.
-
(2013)
Cell Signal
, vol.25
, Issue.4
, pp. 898-909
-
-
Fahmi, A.1
Smart, N.2
Punn, A.3
Jabr, R.4
Marber, M.5
Heads, R.6
-
127
-
-
77953645116
-
Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor
-
McFarland-Mancini MM, Funk HM, Paluch AM, Zhou M, Giridhar PV, Mercer CA, et al. Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor. J Immunol. 2010;184(12):7219–28.
-
(2010)
J Immunol
, vol.184
, Issue.12
, pp. 7219-7228
-
-
McFarland-Mancini, M.M.1
Funk, H.M.2
Paluch, A.M.3
Zhou, M.4
Giridhar, P.V.5
Mercer, C.A.6
-
128
-
-
84905048976
-
Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis
-
Sommer J, Engelowski E, Baran P, Garbers C, Floss DM, Scheller J. Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis. Int J Mol Med. 2014;34(3):651–60.
-
(2014)
Int J Mol Med
, vol.34
, Issue.3
, pp. 651-660
-
-
Sommer, J.1
Engelowski, E.2
Baran, P.3
Garbers, C.4
Floss, D.M.5
Scheller, J.6
-
129
-
-
85018585730
-
Epstein-Barr virus-induced gene 3 (EBI3) can mediate IL-6 trans-signaling
-
Chehboun S, Labrecque-Carbonneau J, Pasquin S, Meliani Y, Meddah B, Ferlin W, et al. Epstein-Barr virus-induced gene 3 (EBI3) can mediate IL-6 trans-signaling. J Biol Chem. 2017;292(16):6644–56.
-
(2017)
J Biol Chem
, vol.292
, Issue.16
, pp. 6644-6656
-
-
Chehboun, S.1
Labrecque-Carbonneau, J.2
Pasquin, S.3
Meliani, Y.4
Meddah, B.5
Ferlin, W.6
-
130
-
-
84873624088
-
An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer
-
Garbers C, Spudy B, Aparicio-Siegmund S, Waetzig GH, Sommer J, Hölscher C, et al. An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer. J Biol Chem. 2013;288(6):4346–54.
-
(2013)
J Biol Chem
, vol.288
, Issue.6
, pp. 4346-4354
-
-
Garbers, C.1
Spudy, B.2
Aparicio-Siegmund, S.3
Waetzig, G.H.4
Sommer, J.5
Hölscher, C.6
-
131
-
-
85042066811
-
Interleukin (IL)-6 inhibits IL-27- and IL-30-Mediated inflammatory responses in human monocytes
-
Petes C, Mariani MK, Yang Y, Grandvaux N, Gee K. Interleukin (IL)-6 inhibits IL-27- and IL-30-Mediated inflammatory responses in human monocytes. Front Immunol. 2018;9:256.
-
(2018)
Front Immunol
, vol.9
, pp. 256
-
-
Petes, C.1
Mariani, M.K.2
Yang, Y.3
Grandvaux, N.4
Gee, K.5
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