메뉴 건너뛰기




Volumn 9, Issue FEB, 2018, Pages

Interleukin (IL)-6 inhibits IL-27- and IL-30-mediated inflammatory responses in human monocytes

Author keywords

Human CD4 T cells; Human monocytes; Inflammation; Interleukin 27; Interleukin 30

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLYCOPROTEIN GP 130; INTERLEUKIN 27; INTERLEUKIN 30; INTERLEUKIN 6; STAT PROTEIN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

EID: 85042066811     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2018.00256     Document Type: Article
Times cited : (31)

References (44)
  • 1
    • 18444385868 scopus 로고    scopus 로고
    • IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells
    • Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. Immunity (2002) 16(6):779-90. doi:10.1016/S1074-7613(02)00324-2
    • (2002) Immunity , vol.16 , Issue.6 , pp. 779-790
    • Pflanz, S.1    Timans, J.C.2    Cheung, J.3    Rosales, R.4    Kanzler, H.5    Gilbert, J.6
  • 2
    • 10744222574 scopus 로고    scopus 로고
    • WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27
    • Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, et al. WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. J Immunol (2004) 172(4):2225-31. doi:10.4049/jimmunol.172.4.2225
    • (2004) J Immunol , vol.172 , Issue.4 , pp. 2225-2231
    • Pflanz, S.1    Hibbert, L.2    Mattson, J.3    Rosales, R.4    Vaisberg, E.5    Bazan, J.F.6
  • 3
    • 76249108969 scopus 로고    scopus 로고
    • The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling
    • Crabé S, Guay-Giroux A, Tormo AJ, Duluc D, Lissilaa R, Guilhot F, et al. The IL-27 p28 subunit binds cytokine-like factor 1 to form a cytokine regulating NK and T cell activities requiring IL-6R for signaling. J Immunol (2009) 183(12):7692-702. doi:10.4049/jimmunol.0901464
    • (2009) J Immunol , vol.183 , Issue.12 , pp. 7692-7702
    • Crabé, S.1    Guay-Giroux, A.2    Tormo, A.J.3    Duluc, D.4    Lissilaa, R.5    Guilhot, F.6
  • 4
    • 68249142908 scopus 로고    scopus 로고
    • The secreted form of p28 subunit of interleukin (IL)-27 inhibits biological functions of IL-27 and suppresses anti-allogeneic immune responses
    • Shimozato O, Sato A, Kawamura K, Chiyo M, Ma G, Li Q, et al. The secreted form of p28 subunit of interleukin (IL)-27 inhibits biological functions of IL-27 and suppresses anti-allogeneic immune responses. Immunology (2009) 128(1pt2):e816-25. doi:10.1111/j.1365-2567.2009.03088.x
    • (2009) Immunology , vol.128 , Issue.1 , pp. e816-e825
    • Shimozato, O.1    Sato, A.2    Kawamura, K.3    Chiyo, M.4    Ma, G.5    Li, Q.6
  • 5
    • 78449300568 scopus 로고    scopus 로고
    • A role for IL-27p28 as an antagonist of gp130-mediated signaling
    • Stumhofer JS, Tait ED, Quinn WJ III, Hosken N, Spudy B, Goenka R, et al. A role for IL-27p28 as an antagonist of gp130-mediated signaling. Nat Immunol (2010) 11(12):1119-26. doi:10.1038/ni.1957
    • (2010) Nat Immunol , vol.11 , Issue.12 , pp. 1119-1126
    • Stumhofer, J.S.1    Tait, E.D.2    Quinn, W.J.3    Hosken, N.4    Spudy, B.5    Goenka, R.6
  • 6
    • 84860338292 scopus 로고    scopus 로고
    • Coordination between TLR9 signaling in macrophages and CD3 signaling in T cells induces robust expression of IL-30
    • Dibra D, Cutrera JJ, Li S. Coordination between TLR9 signaling in macrophages and CD3 signaling in T cells induces robust expression of IL-30. J Immunol (2012) 188(8):3709-15. doi:10.4049/jimmunol.1100883
    • (2012) J Immunol , vol.188 , Issue.8 , pp. 3709-3715
    • Dibra, D.1    Cutrera, J.J.2    Li, S.3
  • 7
    • 84888043763 scopus 로고    scopus 로고
    • IFN-γ-induced IL-27 and IL-27p28 expression are differentially regulated through JNK MAPK and PI3K pathways independent of Jak/STAT in human monocytic cells
    • Blahoianu MA, Rahimi AA, Kozlowski M, Angel JB, Kumar A. IFN-γ-induced IL-27 and IL-27p28 expression are differentially regulated through JNK MAPK and PI3K pathways independent of Jak/STAT in human monocytic cells. Immunobiology (2014) 219(1):1-8. doi:10.1016/j.imbio.2013.06.001
    • (2014) Immunobiology , vol.219 , Issue.1 , pp. 1-8
    • Blahoianu, M.A.1    Rahimi, A.A.2    Kozlowski, M.3    Angel, J.B.4    Kumar, A.5
  • 8
    • 77955302693 scopus 로고    scopus 로고
    • Interleukin-27 induces a STAT1/3-and NF-κB-dependent proinflammatory cytokine profile in human monocytes
    • Guzzo C, Mat NFC, Gee K. Interleukin-27 induces a STAT1/3-and NF-κB-dependent proinflammatory cytokine profile in human monocytes. J Biol Chem (2010) 285(32):24404-11. doi:10.1074/jbc.M110.112599
    • (2010) J Biol Chem , vol.285 , Issue.32 , pp. 24404-24411
    • Guzzo, C.1    Mat, N.F.C.2    Gee, K.3
  • 9
    • 3142709474 scopus 로고    scopus 로고
    • Understanding the pro-and anti-inflammatory properties of IL-27
    • Villarino AV, Huang E, Hunter CA. Understanding the pro-and anti-inflammatory properties of IL-27. J Immunol (2004) 173(2):715-20. doi:10.4049/jimmunol.173.2.715
    • (2004) J Immunol , vol.173 , Issue.2 , pp. 715-720
    • Villarino, A.V.1    Huang, E.2    Hunter, C.A.3
  • 10
    • 23344449852 scopus 로고    scopus 로고
    • The double identity of WSX-1 (IL-27R) as an initiator and an attenuator of immune responses
    • Yoshida H, Hamano S, Miyazaki Y. The double identity of WSX-1 (IL-27R) as an initiator and an attenuator of immune responses. Curr Immunol Rev (2005) 1(1):55-60. doi:10.2174/1573395052952923
    • (2005) Curr Immunol Rev , vol.1 , Issue.1 , pp. 55-60
    • Yoshida, H.1    Hamano, S.2    Miyazaki, Y.3
  • 11
    • 84873624088 scopus 로고    scopus 로고
    • An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer
    • Garbers C, Spudy B, Aparicio-Siegmund S, Waetzig GH, Sommer J, Hölscher C, et al. An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer. J Biol Chem (2013) 288(6):4346-54. doi:10.1074/jbc.M112.432955
    • (2013) J Biol Chem , vol.288 , Issue.6 , pp. 4346-4354
    • Garbers, C.1    Spudy, B.2    Aparicio-Siegmund, S.3    Waetzig, G.H.4    Sommer, J.5    Hölscher, C.6
  • 12
    • 84856021914 scopus 로고    scopus 로고
    • IL-27 enhances LPS-induced proinflammatory cytokine production via upregulation of TLR4 expression and signaling in human monocytes
    • Guzzo C, Ayer A, Basta S, Banfield BW, Gee K. IL-27 enhances LPS-induced proinflammatory cytokine production via upregulation of TLR4 expression and signaling in human monocytes. J Immunol (2012) 188(2):864-73. doi:10.4049/jimmunol.1101912
    • (2012) J Immunol , vol.188 , Issue.2 , pp. 864-873
    • Guzzo, C.1    Ayer, A.2    Basta, S.3    Banfield, B.W.4    Gee, K.5
  • 13
    • 84862777838 scopus 로고    scopus 로고
    • Interleukin-30: a novel antiinflammatory cytokine candidate for prevention and treatment of inflammatory cytokine-induced liver injury
    • Dibra D, Cutrera J, Xia X, Kallakury B, Mishra L, Li S. Interleukin-30: a novel antiinflammatory cytokine candidate for prevention and treatment of inflammatory cytokine-induced liver injury. Hepatology (2012) 55(4):1204-14. doi:10.1002/hep.24814
    • (2012) Hepatology , vol.55 , Issue.4 , pp. 1204-1214
    • Dibra, D.1    Cutrera, J.2    Xia, X.3    Kallakury, B.4    Mishra, L.5    Li, S.6
  • 14
    • 85000360868 scopus 로고    scopus 로고
    • A high resolution method to monitor phosphorylation-dependent activation of IRF3
    • Robitaille AC, Mariani MK, Fortin A, Grandvaux N. A high resolution method to monitor phosphorylation-dependent activation of IRF3. J Visual Exp (2016) 107:e53723. doi:10.3791/53723
    • (2016) J Visual Exp , vol.107
    • Robitaille, A.C.1    Mariani, M.K.2    Fortin, A.3    Grandvaux, N.4
  • 15
    • 33750982120 scopus 로고    scopus 로고
    • Stattic: a small-molecule inhibitor of STAT3 activation and dimerization
    • Schust J, Sperl B, Hollis A, Mayer TU, Berg T. Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem Biol (2006) 13(11):1235-42. doi:10.1016/j.chembiol.2006.09.018
    • (2006) Chem Biol , vol.13 , Issue.11 , pp. 1235-1242
    • Schust, J.1    Sperl, B.2    Hollis, A.3    Mayer, T.U.4    Berg, T.5
  • 16
    • 84890116489 scopus 로고    scopus 로고
    • In silico simulations of STAT1 and STAT3 inhibitors predict SH2 domain cross-binding specificity
    • Szelag M, Sikorski K, Czerwoniec A, Szatkowska K, Wesoly J, Bluyssen HA. In silico simulations of STAT1 and STAT3 inhibitors predict SH2 domain cross-binding specificity. Eur J Pharmacol (2013) 720(1):38-48. doi:10.1016/j.ejphar.2013.10.055
    • (2013) Eur J Pharmacol , vol.720 , Issue.1 , pp. 38-48
    • Szelag, M.1    Sikorski, K.2    Czerwoniec, A.3    Szatkowska, K.4    Wesoly, J.5    Bluyssen, H.A.6
  • 17
    • 0032168152 scopus 로고    scopus 로고
    • Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
    • Heinrich PC, Behrmann I, Muller-Newen G, Schaper F, Graeve L. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J (1998) 334( Pt 2):297-314. doi:10.1042/bj3340297
    • (1998) Biochem J , vol.334 , pp. 297-314
    • Heinrich, P.C.1    Behrmann, I.2    Muller-Newen, G.3    Schaper, F.4    Graeve, L.5
  • 18
    • 84899804081 scopus 로고    scopus 로고
    • A requirement of dendritic cell-derived interleukin-27 for the tumor infiltration of regulatory T cells
    • Xia S, Wei J, Wang J, Sun H, Zheng W, Li Y, et al. A requirement of dendritic cell-derived interleukin-27 for the tumor infiltration of regulatory T cells. J Leukoc Biol (2014) 95(5):733-42. doi:10.1189/jlb.0713371
    • (2014) J Leukoc Biol , vol.95 , Issue.5 , pp. 733-742
    • Xia, S.1    Wei, J.2    Wang, J.3    Sun, H.4    Zheng, W.5    Li, Y.6
  • 19
    • 84897557081 scopus 로고    scopus 로고
    • IL-27 driven upregulation of surface HLA-E expression on monocytes inhibits IFN-gamma release by autologous NK cells
    • Morandi F, Airoldi I, Pistoia V. IL-27 driven upregulation of surface HLA-E expression on monocytes inhibits IFN-gamma release by autologous NK cells. J Immunol Res (2014) 2014:938561. doi:10.1155/2014/938561
    • (2014) J Immunol Res , vol.2014
    • Morandi, F.1    Airoldi, I.2    Pistoia, V.3
  • 20
    • 84899106289 scopus 로고    scopus 로고
    • IL-27p28 inhibits central nervous system autoimmunity by concurrently antagonizing Th1 and Th17 responses
    • Chong WP, Horai R, Mattapallil MJ, Silver PB, Chen J, Zhou R, et al. IL-27p28 inhibits central nervous system autoimmunity by concurrently antagonizing Th1 and Th17 responses. J Autoimmun (2014) 50:12-22. doi:10.1016/j.jaut.2013.08.003
    • (2014) J Autoimmun , vol.50 , pp. 12-22
    • Chong, W.P.1    Horai, R.2    Mattapallil, M.J.3    Silver, P.B.4    Chen, J.5    Zhou, R.6
  • 22
    • 25144498144 scopus 로고    scopus 로고
    • De novo folding of GFP fusion proteins: high efficiency in eukaryotes but not in bacteria
    • Chang H-C, Kaiser CM, Hartl FU, Barral JM. De novo folding of GFP fusion proteins: high efficiency in eukaryotes but not in bacteria. J Mol Biol (2005) 353(2):397-409. doi:10.1016/j.jmb.2005.08.052
    • (2005) J Mol Biol , vol.353 , Issue.2 , pp. 397-409
    • Chang, H.-C.1    Kaiser, C.M.2    Hartl, F.U.3    Barral, J.M.4
  • 23
    • 30544433196 scopus 로고    scopus 로고
    • Engineering and characterization of a superfolder green fluorescent protein
    • Pédelacq J-D, Cabantous S, Tran T, Terwilliger TC, Waldo GS. Engineering and characterization of a superfolder green fluorescent protein. Nat Biotechnol (2006) 24(1):79-88. doi:10.1038/nbt1172
    • (2006) Nat Biotechnol , vol.24 , Issue.1 , pp. 79-88
    • Pédelacq, J.-D.1    Cabantous, S.2    Tran, T.3    Terwilliger, T.C.4    Waldo, G.S.5
  • 24
    • 0038326688 scopus 로고    scopus 로고
    • Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment
    • Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, et al. Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J Immunol (2003) 170(10):4886-90. doi:10.4049/jimmunol.170.10.4886
    • (2003) J Immunol , vol.170 , Issue.10 , pp. 4886-4890
    • Takeda, A.1    Hamano, S.2    Yamanaka, A.3    Hanada, T.4    Ishibashi, T.5    Mak, T.W.6
  • 25
    • 0344304399 scopus 로고    scopus 로고
    • IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and-independent mechanisms
    • Lucas S, Ghilardi N, Li J, de Sauvage FJ. IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and-independent mechanisms. Proc Natl Acad Sci U S A (2003) 100(25):15047-52. doi:10.1073/pnas.2536517100
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.25 , pp. 15047-15052
    • Lucas, S.1    Ghilardi, N.2    Li, J.3    de Sauvage, F.J.4
  • 26
    • 0141519112 scopus 로고    scopus 로고
    • IL-27 and IFN-a signal via Stat1 and Stat3 and induce T-Bet and IL-12R β 2 in naive T cells
    • Hibbert L, Pflanz S, de Waal Malefyt R, Kastelein RA. IL-27 and IFN-a signal via Stat1 and Stat3 and induce T-Bet and IL-12R β 2 in naive T cells. J Interferon Cytokine Res (2003) 23(9):513-22. doi:10.1089/10799900360708632
    • (2003) J Interferon Cytokine Res , vol.23 , Issue.9 , pp. 513-522
    • Hibbert, L.1    Pflanz, S.2    de Waal Malefyt, R.3    Kastelein, R.A.4
  • 27
    • 4644225089 scopus 로고    scopus 로고
    • An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cells
    • Kamiya S, Owaki T, Morishima N, Fukai F, Mizuguchi J, Yoshimoto T. An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cells. J Immunol (2004) 173(6):3871-7. doi:10.4049/jimmunol.173.6.3871
    • (2004) J Immunol , vol.173 , Issue.6 , pp. 3871-3877
    • Kamiya, S.1    Owaki, T.2    Morishima, N.3    Fukai, F.4    Mizuguchi, J.5    Yoshimoto, T.6
  • 28
    • 36248951161 scopus 로고    scopus 로고
    • Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10
    • Stumhofer JS, Silver JS, Laurence A, Porrett PM, Harris TH, Turka LA, et al. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat Immunol (2007) 8(12):1363-71. doi:10.1038/ni1537
    • (2007) Nat Immunol , vol.8 , Issue.12 , pp. 1363-1371
    • Stumhofer, J.S.1    Silver, J.S.2    Laurence, A.3    Porrett, P.M.4    Harris, T.H.5    Turka, L.A.6
  • 29
    • 44449140104 scopus 로고    scopus 로고
    • IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38
    • Kalliolias GD, Ivashkiv LB. IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38. J Immunol (2008) 180(9):6325-33. doi:10.4049/jimmunol.180.9.6325
    • (2008) J Immunol , vol.180 , Issue.9 , pp. 6325-6333
    • Kalliolias, G.D.1    Ivashkiv, L.B.2
  • 30
    • 49149127436 scopus 로고    scopus 로고
    • STAT3 is indispensable to IL-27-mediated cell proliferation but not to IL-27-induced Th1 differentiation and suppression of proinflammatory cytokine production
    • Owaki T, Asakawa M, Morishima N, Mizoguchi I, Fukai F, Takeda K, et al. STAT3 is indispensable to IL-27-mediated cell proliferation but not to IL-27-induced Th1 differentiation and suppression of proinflammatory cytokine production. J Immunol (2008) 180(5):2903-11. doi:10.4049/jimmunol.180.5.2903
    • (2008) J Immunol , vol.180 , Issue.5 , pp. 2903-2911
    • Owaki, T.1    Asakawa, M.2    Morishima, N.3    Mizoguchi, I.4    Fukai, F.5    Takeda, K.6
  • 31
    • 84855272274 scopus 로고    scopus 로고
    • A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory proteins
    • Diegelmann J, Olszak T, Göke B, Blumberg RS, Brand S. A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory proteins. J Biol Chem (2012) 287(1):286-98. doi:10.1074/jbc.M111.294355
    • (2012) J Biol Chem , vol.287 , Issue.1 , pp. 286-298
    • Diegelmann, J.1    Olszak, T.2    Göke, B.3    Blumberg, R.S.4    Brand, S.5
  • 32
    • 0034623005 scopus 로고    scopus 로고
    • T-coffee: a novel method for fast and accurate multiple sequence alignment
    • Notredame C, Higgins DG, Heringa J. T-coffee: a novel method for fast and accurate multiple sequence alignment. J Mol Biol (2000) 302(1):205-17. doi:10.1006/jmbi.2000.4042
    • (2000) J Mol Biol , vol.302 , Issue.1 , pp. 205-217
    • Notredame, C.1    Higgins, D.G.2    Heringa, J.3
  • 33
    • 85016114884 scopus 로고    scopus 로고
    • Evolutionary plasticity of IL-6 cytokine family
    • Gorshkova E, Nedospasov S, Shilov E. Evolutionary plasticity of IL-6 cytokine family. Mol Biol (2016) 50(6):1039-48. doi:10.1134/S0026893316060066
    • (2016) Mol Biol , vol.50 , Issue.6 , pp. 1039-1048
    • Gorshkova, E.1    Nedospasov, S.2    Shilov, E.3
  • 34
    • 0038609651 scopus 로고    scopus 로고
    • Hexameric structure and assembly of the interleukin-6/IL-6 a-receptor/gp130 complex
    • Boulanger MJ, Chow D-C, Brevnova EE, Garcia KC. Hexameric structure and assembly of the interleukin-6/IL-6 a-receptor/gp130 complex. Science (2003) 300(5628):2101-4. doi:10.1126/science.1083901
    • (2003) Science , vol.300 , Issue.5628 , pp. 2101-2104
    • Boulanger, M.J.1    Chow, D.-C.2    Brevnova, E.E.3    Garcia, K.C.4
  • 35
    • 0031043061 scopus 로고    scopus 로고
    • Analysis of the human interleukin-6/human interleukin-6 receptor binding interface at the amino acid level: proposed mechanism of interaction
    • Kalai M, Montero-Julian FA, Görtzinger J, Fontaine V, Vandenbussche P, Deschuyteneer R, et al. Analysis of the human interleukin-6/human interleukin-6 receptor binding interface at the amino acid level: proposed mechanism of interaction. Blood (1997) 89(4):1319-33
    • (1997) Blood , vol.89 , Issue.4 , pp. 1319-1333
    • Kalai, M.1    Montero-Julian, F.A.2    Görtzinger, J.3    Fontaine, V.4    Vandenbussche, P.5    Deschuyteneer, R.6
  • 36
    • 78650602324 scopus 로고    scopus 로고
    • IL-27 structural analysis demonstrates similarities with ciliary neurotrophic factor (CNTF) and leads to the identification of antagonistic variants
    • Rousseau F, Basset L, Froger J, Dinguirard N, Chevalier S, Gascan H. IL-27 structural analysis demonstrates similarities with ciliary neurotrophic factor (CNTF) and leads to the identification of antagonistic variants. Proc Natl Acad Sci U S A (2010) 107(45):19420-5. doi:10.1073/pnas.1005793107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.45 , pp. 19420-19425
    • Rousseau, F.1    Basset, L.2    Froger, J.3    Dinguirard, N.4    Chevalier, S.5    Gascan, H.6
  • 37
    • 84869797922 scopus 로고    scopus 로고
    • IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6
    • Rose-John S. IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6. Int J Biol Sci (2012) 8(9):1237. doi:10.7150/ijbs.4989
    • (2012) Int J Biol Sci , vol.8 , Issue.9 , pp. 1237
    • Rose-John, S.1
  • 38
    • 85014835754 scopus 로고    scopus 로고
    • Meprin metalloproteases generate biologically active soluble interleukin-6 receptor to induce trans-signaling
    • Arnold P, Boll I, Rothaug M, Schumacher N, Schmidt F, Wichert R, et al. Meprin metalloproteases generate biologically active soluble interleukin-6 receptor to induce trans-signaling. Sci Rep (2017) 7:44053. doi:10.1038/srep44053
    • (2017) Sci Rep , vol.7
    • Arnold, P.1    Boll, I.2    Rothaug, M.3    Schumacher, N.4    Schmidt, F.5    Wichert, R.6
  • 39
    • 85011884641 scopus 로고    scopus 로고
    • Trans-signaling of interleukin-6 (IL-6) is mediated by the soluble IL-6 receptor, but not by soluble CD5
    • Aparicio-Siegmund S, Deseke M, Lickert A, Garbers C. Trans-signaling of interleukin-6 (IL-6) is mediated by the soluble IL-6 receptor, but not by soluble CD5. Biochem Biophys Res Commun (2017) 484(4):808-12. doi:10.1016/j.bbrc.2017.01.174
    • (2017) Biochem Biophys Res Commun , vol.484 , Issue.4 , pp. 808-812
    • Aparicio-Siegmund, S.1    Deseke, M.2    Lickert, A.3    Garbers, C.4
  • 40
    • 0027293104 scopus 로고
    • Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130
    • Narazaki M, Yasukawa K, Saito T, Ohsugi Y, Fukui H, Koishihara Y, et al. Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. Blood (1993) 82(4):1120-6
    • (1993) Blood , vol.82 , Issue.4 , pp. 1120-1126
    • Narazaki, M.1    Yasukawa, K.2    Saito, T.3    Ohsugi, Y.4    Fukui, H.5    Koishihara, Y.6
  • 41
    • 0035160256 scopus 로고    scopus 로고
    • Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses
    • Jostock T, Müllberg J, özbek S, Atreya R, Blinn G, Voltz N, et al. Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses. FEBS J (2001) 268(1):160-7. doi:10.1046/j.1432-1327.2001.01867.x
    • (2001) FEBS J , vol.268 , Issue.1 , pp. 160-167
    • Jostock, T.1    Müllberg, J.2    Özbek, S.3    Atreya, R.4    Blinn, G.5    Voltz, N.6
  • 42
    • 85013339820 scopus 로고    scopus 로고
    • Interleukin-6 "trans-signaling" and ischemic vascular disease: the important role of soluble gp130
    • Morieri ML, Passaro A, Zuliani G. Interleukin-6 "trans-signaling" and ischemic vascular disease: the important role of soluble gp130. Mediators Inflamm (2017) 2017:1396398. doi:10.1155/2017/1396398
    • (2017) Mediators Inflamm , vol.2017
    • Morieri, M.L.1    Passaro, A.2    Zuliani, G.3
  • 43
    • 0031802915 scopus 로고    scopus 로고
    • Human myeloma cells shed the interleukin-6 receptor: inhibition by tissue inhibitor of metalloproteinase-3 and a hydroxamate-based metalloproteinase inhibitor
    • Hargreaves PG, Wang F, Antcliff J, Murphy G, Lawry J, Russell RGG, et al. Human myeloma cells shed the interleukin-6 receptor: inhibition by tissue inhibitor of metalloproteinase-3 and a hydroxamate-based metalloproteinase inhibitor. Br J Haematol (1998) 101(4):694-702. doi:10.1046/j.1365-2141.1998.00754.x
    • (1998) Br J Haematol , vol.101 , Issue.4 , pp. 694-702
    • Hargreaves, P.G.1    Wang, F.2    Antcliff, J.3    Murphy, G.4    Lawry, J.5    Russell, R.G.G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.