메뉴 건너뛰기




Volumn 6, Issue 3, 2015, Pages 283-295

Subcutaneous formulation of tocilizumab for treatment of rheumatoid arthritis

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; TOCILIZUMAB; MONOCLONAL ANTIBODY;

EID: 84927632013     PISSN: 20415990     EISSN: 20416008     Source Type: Journal    
DOI: 10.4155/tde.14.118     Document Type: Article
Times cited : (13)

References (85)
  • 1
    • 84855172814 scopus 로고    scopus 로고
    • The pathogenesis of rheumatoid arthritis
    • Mclnnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N. Engl. J. Med. 365(23), 2205-2219 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , Issue.23 , pp. 2205-2219
    • McLnnes, I.B.1    Schett, G.2
  • 2
    • 84863043835 scopus 로고    scopus 로고
    • Tocilizumab for the treatment of rheumatoid arthritis and other systemic autoimmune diseases: Current perspectives and future directions
    • Ogata A, Tanaka T. Tocilizumab for the treatment of rheumatoid arthritis and other systemic autoimmune diseases: current perspectives and future directions. Int. J. Rheumatol. 2012, 946048 (2012).
    • (2012) Int. J. Rheumatol. , vol.2012 , pp. 946048
    • Ogata, A.1    Tanaka, T.2
  • 4
    • 84896495791 scopus 로고    scopus 로고
    • A new era for the treatment of inflammatory autoimmune diseases by interleukin-6 blockade strategy
    • Tanaka T, Narazaki M, Ogata A, Kishimoto T. A new era for the treatment of inflammatory autoimmune diseases by interleukin-6 blockade strategy. Semin. Immunol. 26(1), 88-96 (2014).
    • (2014) Semin. Immunol. , vol.26 , Issue.1 , pp. 88-96
    • Tanaka, T.1    Narazaki, M.2    Ogata, A.3    Kishimoto, T.4
  • 5
    • 0027502201 scopus 로고
    • Reshaping a human antibody to inhibit the interleukin-6 dependent tumor cell growth
    • Sato K, Tsuchiya M, Saldanha J et al. Reshaping a human antibody to inhibit the interleukin-6 dependent tumor cell growth. Cancer Res. 53(4), 851-856 (1993).
    • (1993) Cancer Res. , vol.53 , Issue.4 , pp. 851-856
    • Sato, K.1    Tsuchiya, M.2    Saldanha, J.3
  • 6
    • 84893772728 scopus 로고    scopus 로고
    • EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update
    • Smolen JS, Landewé R, Breedveld FC et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update. Ann. Rheum. Dis. 73(3), 492-509 (2014).
    • (2014) Ann. Rheum. Dis. , vol.73 , Issue.3 , pp. 492-509
    • Smolen, J.S.1    Landewé, R.2    Breedveld, F.C.3
  • 7
    • 84878805640 scopus 로고    scopus 로고
    • The effect of targeted rheumatoid arthritis therapies on anti-citrullinated protein autoantibody levels and B cell responses
    • Modi S, Soejima M, Levesque MC. The effect of targeted rheumatoid arthritis therapies on anti-citrullinated protein autoantibody levels and B cell responses. Clin. Exp. Immunol. 173(1), 8-17 (2013).
    • (2013) Clin. Exp. Immunol. , vol.173 , Issue.1 , pp. 8-17
    • Modi, S.1    Soejima, M.2    Levesque, M.C.3
  • 8
    • 77954096689 scopus 로고    scopus 로고
    • IL-6: Regulator of treg/Th17 balance
    • Kimura A, Kishimoto T. IL-6: regulator of Treg/Th17 balance. Eur. J. Immunol. 40(7), 1830-1835 (2010).
    • (2010) Eur. J. Immunol. , vol.40 , Issue.7 , pp. 1830-1835
    • Kimura, A.1    Kishimoto, T.2
  • 9
    • 84880084417 scopus 로고    scopus 로고
    • Can IL-6 blockade rectify imbalance between tregs and Th17 cells?
    • Tanaka T. Can IL-6 blockade rectify imbalance between Tregs and Th17 cells? Immunotherapy 5(7), 695-697 (2013).
    • (2013) Immunotherapy , vol.5 , Issue.7 , pp. 695-697
    • Tanaka, T.1
  • 10
    • 57349083145 scopus 로고    scopus 로고
    • Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses
    • Fujimoto M, Serada S, Mihara M et al. Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses. Arthritis Rheum. 58(12), 3710-3719 (2008).
    • (2008) Arthritis Rheum. , vol.58 , Issue.12 , pp. 3710-3719
    • Fujimoto, M.1    Serada, S.2    Mihara, M.3
  • 11
    • 84864481289 scopus 로고    scopus 로고
    • Brief report: Inhibition of interleukin-6 function corrects Th17/treg cell imbalance in patients with rheumatoid arthritis
    • Samson M, Audia S, Janikashvili N et al. Brief report: inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis. Arthritis Rheum. 64(8), 2499-2503 (2012).
    • (2012) Arthritis Rheum. , vol.64 , Issue.8 , pp. 2499-2503
    • Samson, M.1    Audia, S.2    Janikashvili, N.3
  • 12
    • 84866346472 scopus 로고    scopus 로고
    • Disturbed Th17/treg balance in patients with rheumatoid arthritis
    • Niu Q, Cai B, Huang ZC, Shi YY, Wang LL. Disturbed Th17/Treg balance in patients with rheumatoid arthritis. Rheumatol. Int. 32(9), 2731-2736 (2012).
    • (2012) Rheumatol. Int. , vol.32 , Issue.9 , pp. 2731-2736
    • Niu, Q.1    Cai, B.2    Huang, Z.C.3    Shi, Y.Y.4    Wang, L.L.5
  • 13
    • 0025190892 scopus 로고
    • Interleukin-6 and the acute phase response
    • Heinrich PC, Castell JV, Andus T. Interleukin-6 and the acute phase response. Biochem. J. 265(3), 621-636 (1990).
    • (1990) Biochem. J. , vol.265 , Issue.3 , pp. 621-636
    • Heinrich, P.C.1    Castell, J.V.2    Andus, T.3
  • 14
    • 84893737647 scopus 로고    scopus 로고
    • Targeting of interleukin-6 for the treatment of rheumatoid arthritis: A review and update
    • Tanaka T, Ogata A, Kishimoto T. Targeting of interleukin-6 for the treatment of rheumatoid arthritis: a review and update. Rheumatol. Curr. Res. S4 (2013). http://omicsonline.org
    • (2013) Rheumatol. Curr. Res. , vol.S4
    • Tanaka, T.1    Ogata, A.2    Kishimoto, T.3
  • 15
    • 0029060421 scopus 로고
    • Interleukin-6 (IL-6) induces the proliferation of synovial fibrotic cells in the presence of soluble IL-6 receptor
    • Mihara M, Moriya Y, Kishimoto T, Ohsugi Y. Interleukin-6 (IL-6) induces the proliferation of synovial fibrotic cells in the presence of soluble IL-6 receptor. Br. J. Rheumatol. 34(4), 321-325 (1995).
    • (1995) Br. J. Rheumatol. , vol.34 , Issue.4 , pp. 321-325
    • Mihara, M.1    Moriya, Y.2    Kishimoto, T.3    Ohsugi, Y.4
  • 16
    • 13344250490 scopus 로고    scopus 로고
    • Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclastlike cell formation
    • Kotake S, Sato K, Kim KJ et al. Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclastlike cell formation. J. Bone Miner. Res. 11(1), 88-95 (1996).
    • (1996) J. Bone Miner. Res. , vol.11 , Issue.1 , pp. 88-95
    • Kotake, S.1    Sato, K.2    Kim, K.J.3
  • 17
    • 54449101331 scopus 로고    scopus 로고
    • IL-6 transsignalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-α and IL-17
    • Hashizume M, Hayakawa N, Mihara M. IL-6 transsignalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-α and IL-17. Rheumatology (Oxford) 47(11), 1635-1640 (2008).
    • (2008) Rheumatology (Oxford) , vol.47 , Issue.11 , pp. 1635-1640
    • Hashizume, M.1    Hayakawa, N.2    Mihara, M.3
  • 18
    • 0038798085 scopus 로고    scopus 로고
    • Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis
    • Nakahara H, Song J, Sugimoto M et al. Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis. Arthritis Rheum. 48(6), 1521-1529 (2003).
    • (2003) Arthritis Rheum. , vol.48 , Issue.6 , pp. 1521-1529
    • Nakahara, H.1    Song, J.2    Sugimoto, M.3
  • 19
    • 0032577453 scopus 로고    scopus 로고
    • Interleukin (IL)-6 and its soluble receptor induce TIMP-1 expression in synoviocytes and chondrocytes, and block IL-1-induced collagenolytic activity
    • Silacci P, Dayer JM, Desgeorges A et al. Interleukin (IL)-6 and its soluble receptor induce TIMP-1 expression in synoviocytes and chondrocytes, and block IL-1-induced collagenolytic activity. J. Biol. Chem. 273(22), 13625-13629 (1998).
    • (1998) J. Biol. Chem. , vol.273 , Issue.22 , pp. 13625-13629
    • Silacci, P.1    Dayer, J.M.2    Desgeorges, A.3
  • 20
    • 77954085343 scopus 로고    scopus 로고
    • IL-6 and IL-1 synergistically enhanced the production of MMPs from synovial cells by up-regulating IL-6 production and IL-1 receptor I expression
    • Suzuki M, Hashizume M, Yoshida H, Shiina M, Mihara M. IL-6 and IL-1 synergistically enhanced the production of MMPs from synovial cells by up-regulating IL-6 production and IL-1 receptor I expression. Cytokine 51(2), 178-183 (2010).
    • (2010) Cytokine , vol.51 , Issue.2 , pp. 178-183
    • Suzuki, M.1    Hashizume, M.2    Yoshida, H.3    Shiina, M.4    Mihara, M.5
  • 21
    • 0024269961 scopus 로고
    • Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis
    • Hirano T, Matsuda T, Turne M et al. Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur. J. Immunol. 18(11), 1797-1801 (1988).
    • (1988) Eur. J. Immunol. , vol.18 , Issue.11 , pp. 1797-1801
    • Hirano, T.1    Matsuda, T.2    Turne, M.3
  • 22
    • 0023942493 scopus 로고
    • Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides
    • Houssiau FA, Devogelaer JP, Van Damme J, de Deuxchaisnes CN, Van Snick J. Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis Rheum. 31(6), 784-788 (1988).
    • (1988) Arthritis Rheum. , vol.31 , Issue.6 , pp. 784-788
    • Houssiau, F.A.1    Devogelaer, J.P.2    Van Damme, J.3    De Deuxchaisnes, C.N.4    Van Snick, J.5
  • 23
    • 0031744306 scopus 로고    scopus 로고
    • Serum levels of interleukin-6 type cytokines and soluble interleukin-6 receptor in patients with rheumatoid arthritis
    • Robak T, Gladalska A, Stepien H, Robak E. Serum levels of interleukin-6 type cytokines and soluble interleukin-6 receptor in patients with rheumatoid arthritis. Mediators Inflamm. 7(5), 347-353 (1998).
    • (1998) Mediators Inflamm. , vol.7 , Issue.5 , pp. 347-353
    • Robak, T.1    Gladalska, A.2    Stepien, H.3    Robak, E.4
  • 24
    • 0032536542 scopus 로고    scopus 로고
    • Interleukin 6 is required for the development of collagen-induced arthritis
    • Alonzi T, Fattori E, Lazzaro D et al. Interleukin 6 is required for the development of collagen-induced arthritis. J. Exp. Med. 187(4), 461-468 (1998).
    • (1998) J. Exp. Med. , vol.187 , Issue.4 , pp. 461-468
    • Alonzi, T.1    Fattori, E.2    Lazzaro, D.3
  • 25
    • 0032429668 scopus 로고    scopus 로고
    • Blockade of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis
    • Takagi N, Mihara M, Moriya Y et al. Blockade of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis. Arthritis Rheum. 41(12), 2117-2121 (1998).
    • (1998) Arthritis Rheum. , vol.41 , Issue.12 , pp. 2117-2121
    • Takagi, N.1    Mihara, M.2    Moriya, Y.3
  • 26
    • 0033503152 scopus 로고    scopus 로고
    • Delayed onset and reduced severity of collagen-induced arthritis in interleukin- 6-deficient mice
    • Sasai M, Saeki Y, Ohshima S et al. Delayed onset and reduced severity of collagen-induced arthritis in interleukin- 6-deficient mice. Arthritis Rheum. 42(8) 1635-1643 (1999).
    • (1999) Arthritis Rheum. , vol.42 , Issue.8 , pp. 1635-1643
    • Sasai, M.1    Saeki, Y.2    Ohshima, S.3
  • 27
    • 0036681846 scopus 로고    scopus 로고
    • The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis
    • Kagari T, Doi H, Shimozato T. The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis. J. Immunol. 169(3) 1459-1466 (2002).
    • (2002) J. Immunol. , vol.169 , Issue.3 , pp. 1459-1466
    • Kagari, T.1    Doi, H.2    Shimozato, T.3
  • 28
    • 0026745023 scopus 로고
    • Long-term consequences of interleukin-6 overexpression in transgenic mice
    • Woodroofe C, Muller W, Ruther U. Long-term consequences of interleukin-6 overexpression in transgenic mice. DNA Cell Biol. 11(8), 587-592 (1992).
    • (1992) DNA Cell Biol. , vol.11 , Issue.8 , pp. 587-592
    • Woodroofe, C.1    Muller, W.2    Ruther, U.3
  • 29
    • 0026039673 scopus 로고
    • Transgenic mice expressing human tumour necrosis factor: A predictive genetic model of arthritis
    • Keffer J, Probert L, Cazlaris H et al. Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J. 10(13), 4025-4031 (1991).
    • (1991) EMBO J. , vol.10 , Issue.13 , pp. 4025-4031
    • Keffer, J.1    Probert, L.2    Cazlaris, H.3
  • 30
    • 0021933846 scopus 로고
    • A systemic lymphoproliferative disorder with morphologic features of castleman's disease: Clinical findings and clinicopathologic correlations in 15 patients
    • Frizzera G, Peterson BA, Bayrd ED, Goldman A. A systemic lymphoproliferative disorder with morphologic features of Castleman's disease: clinical findings and clinicopathologic correlations in 15 patients. J. Clin. Oncol. 3(9), 1202-1216 (1985).
    • (1985) J. Clin. Oncol. , vol.3 , Issue.9 , pp. 1202-1216
    • Frizzera, G.1    Peterson, B.A.2    Bayrd, E.D.3    Goldman, A.4
  • 31
    • 84889684742 scopus 로고    scopus 로고
    • Assessment of short-term symptomatic efficacy of tocilizumab in ankylosing spondylitis: Results of randomised, placebo-controlled trials
    • Sieper J, Porter-Brown B, Thompson L, Harari O, Dougados M. Assessment of short-term symptomatic efficacy of tocilizumab in ankylosing spondylitis: results of randomised, placebo-controlled trials. Ann. Rheum. Dis. 73(1), 95-100 (2014).
    • (2014) Ann. Rheum. Dis. , vol.73 , Issue.1 , pp. 95-100
    • Sieper, J.1    Porter-Brown, B.2    Thompson, L.3    Harari, O.4    Dougados, M.5
  • 32
    • 84855716888 scopus 로고    scopus 로고
    • Psoriatic arthritis in two patients with an inadequate response to treatment with tocilizumab
    • Ogata A, Umegaki N, Katayama I, Kumanogoh A, Tanaka T. Psoriatic arthritis in two patients with an inadequate response to treatment with tocilizumab. Joint Bone Spine. 79(1), 85-87 (2012).
    • (2012) Joint Bone Spine. , vol.79 , Issue.1 , pp. 85-87
    • Ogata, A.1    Umegaki, N.2    Katayama, I.3    Kumanogoh, A.4    Tanaka, T.5
  • 33
    • 84905028422 scopus 로고    scopus 로고
    • Pathological role of interleukin-6 in psoriatic arthritis
    • Ogata A, Kumanogoh A, Tanaka T. Pathological role of interleukin-6 in psoriatic arthritis. Arthritis 2012, 713618 (2012).
    • (2012) Arthritis , vol.2012 , pp. 713618
    • Ogata, A.1    Kumanogoh, A.2    Tanaka, T.3
  • 34
    • 33749363027 scopus 로고    scopus 로고
    • CHARISMA study group. Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in european patients with rheumatoid arthritis who had an incomplete response to methotrexate
    • Maini RN, Taylor PC, Szechinski J et al. CHARISMA Study Group. Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthritis Rheum. 54(9), 2817-2829 (2006).
    • (2006) Arthritis Rheum. , vol.54 , Issue.9 , pp. 2817-2829
    • Maini, R.N.1    Taylor, P.C.2    Szechinski, J.3
  • 36
    • 34447300492 scopus 로고    scopus 로고
    • Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): Evidence of clinical and radiographic benefit from an x-ray reader-blinded randomized controlled trial of tocilizumab
    • Nishimoto N, Hashimoto J, Miyasaka N et al. Study of active controlled monotherapy used for rheumatoid arthritis, an IL-6 inhibitor (SAMURAI): evidence of clinical and radiographic benefit from an x-ray reader-blinded randomized controlled trial of tocilizumab. Ann. Rheum. Dis. 66(9), 1162-1167 (2007).
    • (2007) Ann. Rheum. Dis. , vol.66 , Issue.9 , pp. 1162-1167
    • Nishimoto, N.1    Hashimoto, J.2    Miyasaka, N.3
  • 37
    • 60149105639 scopus 로고    scopus 로고
    • Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): Significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy
    • Nishimoto N, Miyasaka N, Yamamoto K et al. Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant reduction in disease activity and serum vascular endothelial growth factor by IL-6 receptor inhibition therapy. Mod. Rheumatol. 19(1), 12-19 (2009).
    • (2009) Mod. Rheumatol. , vol.19 , Issue.1 , pp. 12-19
    • Nishimoto, N.1    Miyasaka, N.2    Yamamoto, K.3
  • 38
    • 73449118587 scopus 로고    scopus 로고
    • Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: The AMBITION study
    • Jones G, Sebba A, Gu J et al. Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study. Ann. Rheum. Dis. 69(1), 88-96 (2010).
    • (2010) Ann. Rheum. Dis. , vol.69 , Issue.1 , pp. 88-96
    • Jones, G.1    Sebba, A.2    Gu, J.3
  • 39
    • 54949150604 scopus 로고    scopus 로고
    • Interleukin-6 receptor inhibition with TCZ reduces disease activity in rheumatoid arthritis with inadequate response to diseasemodifying antirheumatic drugs: The TCZ in combination with traditional disease-modifying antirheumatic drug therapy study
    • Genovese MC, McKay JD, Nasonov EL et al. Interleukin-6 receptor inhibition with TCZ reduces disease activity in rheumatoid arthritis with inadequate response to diseasemodifying antirheumatic drugs: the TCZ in combination with traditional disease-modifying antirheumatic drug therapy study. Arthritis Rheum. 58(10), 2968-2980 (2008).
    • (2008) Arthritis Rheum. , vol.58 , Issue.10 , pp. 2968-2980
    • Genovese, M.C.1    McKay, J.D.2    Nasonov, E.L.3
  • 40
    • 40749114497 scopus 로고    scopus 로고
    • Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): A double-blind, placebo-controlled, randomized trial
    • Smolen JS, Beaulieu A, Rubbert-Roth A et al. Effect of interleukin-6 receptor inhibition with tocilizumab in patients with rheumatoid arthritis (OPTION study): a double-blind, placebo-controlled, randomized trial. Lancet 371(9617), 987-997 (2008).
    • (2008) Lancet , vol.371 , Issue.9617 , pp. 987-997
    • Smolen, J.S.1    Beaulieu, A.2    Rubbert-Roth, A.3
  • 41
    • 52149099504 scopus 로고    scopus 로고
    • IL-6 receptor inhibition with TCZ improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-TNF biologics: Results from a 24-week multicentre randomized placebo controlled trial
    • Emery P, Keystone E, Tony HP et al. IL-6 receptor inhibition with TCZ improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-TNF biologics: results from a 24-week multicentre randomized placebo controlled trial. Ann. Rheum. Dis. 67(11), 1516-1523 (2008).
    • (2008) Ann. Rheum. Dis. , vol.67 , Issue.11 , pp. 1516-1523
    • Emery, P.1    Keystone, E.2    Tony, H.P.3
  • 42
    • 79953680176 scopus 로고    scopus 로고
    • Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: Results from the double-blind treatment phase of a randomized placebocontrolled trial of tocilizumab safety and prevention of structural joint damage at one year
    • Kremer JM, Blanco R, Brzosko M et al. Tocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized placebocontrolled trial of tocilizumab safety and prevention of structural joint damage at one year. Arthritis Rheum. 63(3), 609-621 (2011).
    • (2011) Arthritis Rheum. , vol.63 , Issue.3 , pp. 609-621
    • Kremer, J.M.1    Blanco, R.2    Brzosko, M.3
  • 43
    • 84885313830 scopus 로고    scopus 로고
    • Methotrexate as combination partner of TNF inhibitors and tocilizumab: What is reasonable from an immunological viewpoint?
    • Witte T. Methotrexate as combination partner of TNF inhibitors and tocilizumab: what is reasonable from an immunological viewpoint? Z. Rheumatol. 72(3), 279-286 (2013).
    • (2013) Z. Rheumatol. , vol.72 , Issue.3 , pp. 279-286
    • Witte, T.1
  • 44
    • 84871093047 scopus 로고    scopus 로고
    • Adding tocilizumab or switching to tocilizumab monotherapy in methotrexate inadequate responders: 24-week symptomatic and structural results of a 2-year randomised controlled strategy trial in rheumatoid arthritis (ACT-RAY)
    • Dougados M, Kissel K, Sheeran T et al. Adding tocilizumab or switching to tocilizumab monotherapy in methotrexate inadequate responders: 24-week symptomatic and structural results of a 2-year randomised controlled strategy trial in rheumatoid arthritis (ACT-RAY). Ann. Rheum. Dis. 72(1), 43-50 (2013).
    • (2013) Ann. Rheum. Dis. , vol.72 , Issue.1 , pp. 43-50
    • Dougados, M.1    Kissel, K.2    Sheeran, T.3
  • 45
    • 84897971056 scopus 로고    scopus 로고
    • Adding tocilizumab or switching to tocilizumab monotherapy in methotrexate inadequate responders: 24-week symptomatic and structural results of a 2-year randomised controlled strategy trial in rheumatoid arthritis (ACT-RAY)
    • Dougados M, Kissel K, Conaghan PG et al. Adding tocilizumab or switching to tocilizumab monotherapy in methotrexate inadequate responders: 24-week symptomatic and structural results of a 2-year randomised controlled strategy trial in rheumatoid arthritis (ACT-RAY). Ann. Rheum. Dis. 73(5), 803-809 (2014).
    • (2014) Ann. Rheum. Dis. , vol.73 , Issue.5 , pp. 803-809
    • Dougados, M.1    Kissel, K.2    Conaghan, P.G.3
  • 46
    • 84893802107 scopus 로고    scopus 로고
    • Adding tocilizumab switching to tocilizumab monotherapy in RA patients with inadequate response to methotrexate: 24-week results from a randomized controlled study (SURPRISE study)
    • Takeuchi T, Kaneko Y, Atsumi T et al. Adding tocilizumab switching to tocilizumab monotherapy in RA patients with inadequate response to methotrexate: 24-week results from a randomized controlled study (SURPRISE study). Ann. Rheum. Dis. 72(Suppl. 3), 62-63 (2013).
    • (2013) Ann. Rheum. Dis. , vol.72 , pp. 62-63
    • Takeuchi, T.1    Kaneko, Y.2    Atsumi, T.3
  • 47
    • 84983803477 scopus 로고    scopus 로고
    • Clinical and radiographic effects after 52-week of adding tocilizumab or switching to tocilizumab in RA patients with inadequate response to methotrexate: Result from a prospective randomized controlled study (SURPRISE study)
    • Takeuchi T, Kaneko Y, Atsumi T et al. Clinical and radiographic effects after 52-week of adding tocilizumab or switching to tocilizumab in RA patients with inadequate response to methotrexate: result from a prospective randomized controlled study (SURPRISE study). Ann. Rheum. Dis. 73(Suppl. 2), 686 (2014).
    • (2014) Ann. Rheum. Dis. , vol.73 , pp. 686
    • Takeuchi, T.1    Kaneko, Y.2    Atsumi, T.3
  • 48
    • 84886296315 scopus 로고    scopus 로고
    • Reduction of plasma IL-6 but not TNF-α by methotrexate in patients with early rheumatoid arthritis: A potential biomarker for radiographic progression
    • Nishina N, Kaneko Y, Kameda H, Kuwana M, Takeuchi T. Reduction of plasma IL-6 but not TNF-α by methotrexate in patients with early rheumatoid arthritis: a potential biomarker for radiographic progression. Clin. Rheumatol. 32(11), 1661-1666 (2013).
    • (2013) Clin. Rheumatol. , vol.32 , Issue.11 , pp. 1661-1666
    • Nishina, N.1    Kaneko, Y.2    Kameda, H.3    Kuwana, M.4    Takeuchi, T.5
  • 49
    • 10744223002 scopus 로고    scopus 로고
    • Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: Double-blind randomised controlled trial
    • Klareskog L, van der Heijde D, de Jager JP et al. Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial. Lancet 363(9410), 675-681 (2004).
    • (2004) Lancet , vol.363 , Issue.9410 , pp. 675-681
    • Klareskog, L.1    Van Der-Heijde, D.2    De Jager, J.P.3
  • 50
    • 31044442965 scopus 로고    scopus 로고
    • The PREMIER study: A multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment
    • Breedveld FC, Weisman MH, Kavanaugh AF et al. The PREMIER study: a multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. Arthritis Rheum. 54(1), 26-37 (2006).
    • (2006) Arthritis Rheum. , vol.54 , Issue.1 , pp. 26-37
    • Breedveld, F.C.1    Weisman, M.H.2    Kavanaugh, A.F.3
  • 51
    • 84877275257 scopus 로고    scopus 로고
    • Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): A randomised, double-blind, controlled phase 4 trial
    • Gabay C, Emery P, van Vollenhoven R et al. Tocilizumab monotherapy versus adalimumab monotherapy for treatment of rheumatoid arthritis (ADACTA): a randomised, double-blind, controlled phase 4 trial. Lancet 381(9877), 1541-1550 (2013).
    • (2013) Lancet , vol.381 , Issue.9877 , pp. 1541-1550
    • Gabay, C.1    Emery, P.2    Van Vollenhoven, R.3
  • 52
    • 84880228981 scopus 로고    scopus 로고
    • Retention of tocilizumab and anti-tumour necrosis factor drugs in the treatment of rheumatoid arthritis
    • Hishitani Y, Ogata A, Shima Y et al. Retention of tocilizumab and anti-tumour necrosis factor drugs in the treatment of rheumatoid arthritis. Scand. J. Rheumatol. 42(4), 253-259 (2013).
    • (2013) Scand. J. Rheumatol. , vol.42 , Issue.4 , pp. 253-259
    • Hishitani, Y.1    Ogata, A.2    Shima, Y.3
  • 53
    • 84897569032 scopus 로고    scopus 로고
    • Drug free remission/low disease activity after cessation of tocilizumab (Actemra) monotherapy (DREAM) study
    • Nishimoto N, Amano K, Hirabayashi Y et al. Drug free remission/low disease activity after cessation of tocilizumab (Actemra) monotherapy (DREAM) study. Mod. Rheumatol. 24(1), 17-25 (2014).
    • (2014) Mod. Rheumatol. , vol.24 , Issue.1 , pp. 17-25
    • Nishimoto, N.1    Amano, K.2    Hirabayashi, Y.3
  • 54
    • 84879941145 scopus 로고    scopus 로고
    • Sustained clinical remission and rate of relapse after tocilizumab withdrawal in patients with rheumatoid arthritis
    • Aguilar-Lozano L, Castillo-Ortiz JD, Vargas-Serafin C et al. Sustained clinical remission and rate of relapse after tocilizumab withdrawal in patients with rheumatoid arthritis. J. Rheumatol. 40(7), 1069-1073 (2013).
    • (2013) J. Rheumatol. , vol.40 , Issue.7 , pp. 1069-1073
    • Aguilar-Lozano, L.1    Castillo-Ortiz, J.D.2    Vargas-Serafin, C.3
  • 55
    • 84893717334 scopus 로고    scopus 로고
    • Clinical and radiographic outcomes at two years and the effect of tocilizumab (TCZ) discontinuation following sustained remission in the second year of the ACT-RAY study
    • Dougados M, Donka T, Conaghan PG et al. Clinical and radiographic outcomes at two years and the effect of tocilizumab (TCZ) discontinuation following sustained remission in the second year of the ACT-RAY study. Ann. Rheum. Dis. 72(Suppl. 3), 63 (2013).
    • (2013) Ann. Rheum. Dis. , vol.72 , pp. 63
    • Dougados, M.1    Donka, T.2    Conaghan, P.G.3
  • 56
    • 79953018875 scopus 로고    scopus 로고
    • Adverse effects of biologics: A network meta-analysis and cochrane overview
    • Singh JA, Wells GA, Christensen R et al. Adverse effects of biologics: a network meta-analysis and Cochrane overview. Cochrane Database Syst. Rev. 2, CD008794 (2011).
    • (2011) Cochrane Database Syst. Rev. , vol.2 , pp. CD008794
    • Singh, J.A.1    Wells, G.A.2    Christensen, R.3
  • 57
    • 60149100932 scopus 로고    scopus 로고
    • Masked early symptoms of pneumonia in patients with rheumatoid arthritis during tocilizumab treatment: A report of two cases
    • Fujiwara H, Nishimoto N, Hamano Y et al. Masked early symptoms of pneumonia in patients with rheumatoid arthritis during tocilizumab treatment: a report of two cases. Mod. Rheumatol. 19(1), 64-68 (2009).
    • (2009) Mod. Rheumatol. , vol.19 , Issue.1 , pp. 64-68
    • Fujiwara, H.1    Nishimoto, N.2    Hamano, Y.3
  • 58
    • 79952614900 scopus 로고    scopus 로고
    • The impact of biologic response modifiers on hepatitis B virus infection
    • Carroll MB. The impact of biologic response modifiers on hepatitis B virus infection. Expert Opin. Biol. Ther. 11(4), 533-544 (2011).
    • (2011) Expert Opin. Biol. Ther. , vol.11 , Issue.4 , pp. 533-544
    • Carroll, M.B.1
  • 59
    • 84897352169 scopus 로고    scopus 로고
    • Reactivation of hepatitis B virus in rheumatoid arthritis patients treated with biological disease-modifying antirheumatic drugs
    • (Epub ahead of print)
    • Nakamura J, Nagashima T, Nagatani K, Yoshio T, Iwamoto M, Minota S. Reactivation of hepatitis B virus in rheumatoid arthritis patients treated with biological disease-modifying antirheumatic drugs. Int. J. Rheum. Dis. doi:10.1111/1756-185X.12359 (2014) (Epub ahead of print).
    • (2014) Int. J. Rheum. Dis.
    • Nakamura, J.1    Nagashima, T.2    Nagatani, K.3    Yoshio, T.4    Iwamoto, M.5    Minota, S.6
  • 60
    • 56649094588 scopus 로고    scopus 로고
    • Long-term tocilizumab therapy in a patient with rheumatoid arthritis and chronic hepatitis B
    • Nagashima T, Minota S. Long-term tocilizumab therapy in a patient with rheumatoid arthritis and chronic hepatitis B. Rheumatology (Oxford) 47(12), 1838-1840 (2008).
    • (2008) Rheumatology (Oxford) , vol.47 , Issue.12 , pp. 1838-1840
    • Nagashima, T.1    Minota, S.2
  • 61
    • 77954761056 scopus 로고    scopus 로고
    • Minimal influence of tocilizumab on IFN-γ synthesis by tuberculosis antigens
    • Ogata A, Mori M, Hashimoto S et al. Minimal influence of tocilizumab on IFN-γ synthesis by tuberculosis antigens. Mod. Rheumatol. 20(2) 130-133 (2010).
    • (2010) Mod. Rheumatol. , vol.20 , Issue.2 , pp. 130-133
    • Ogata, A.1    Mori, M.2    Hashimoto, S.3
  • 62
    • 84924842188 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of randomized controlled trials and long-term extension studies
    • Souto A, Maneiro JR, Salgado E, Carmona L, Gomez-Reino JJ. A systematic review and meta-analysis of randomized controlled trials and long-term extension studies. Rheumatology (Oxford) 53(10), 1872-1885 (2014).
    • (2014) Rheumatology (Oxford) , vol.53 , Issue.10 , pp. 1872-1885
    • Souto, A.1    Maneiro, J.R.2    Salgado, E.3    Carmona, L.4    Gomez-Reino, J.J.5
  • 63
    • 80755182205 scopus 로고    scopus 로고
    • Lower gastrointestinal perforation in rheumatoid arthritis patients treated with conventional DMARDs or tocilizumab: A systematic literature review
    • Gout T, Ostor AJ, Nisar MK. Lower gastrointestinal perforation in rheumatoid arthritis patients treated with conventional DMARDs or tocilizumab: a systematic literature review. Clin. Rheumatol. 30(11), 1471-1474 (2011).
    • (2011) Clin. Rheumatol. , vol.30 , Issue.11 , pp. 1471-1474
    • Gout, T.1    Ostor, A.J.2    Nisar, M.K.3
  • 64
  • 65
    • 84926433002 scopus 로고    scopus 로고
    • First experiences with pregnancies in RA patients (pts) receiving tocilizumab (TCZ) therapy
    • Rubbert-Roth A, Goupille PM, Moosavi S, Hou A. First experiences with pregnancies in RA patients (pts) receiving tocilizumab (TCZ) therapy. Arthritis Rheum. 62(10 Suppl.), S161 (2010).
    • (2010) Arthritis Rheum. , vol.62 , Issue.10 , pp. S161
    • Rubbert-Roth, A.1    Goupille, P.M.2    Moosavi, S.3    Hou, A.4
  • 66
    • 64849093693 scopus 로고    scopus 로고
    • Blockade of interleukin 6 signaling induces marked neutropenia in patients with rheumatoid arthritis
    • Nakamura I, Omata Y, Naito M, Ito K. Blockade of interleukin 6 signaling induces marked neutropenia in patients with rheumatoid arthritis. J. Rheumatol. 36(2), 459-460 (2009).
    • (2009) J. Rheumatol. , vol.36 , Issue.2 , pp. 459-460
    • Nakamura, I.1    Omata, Y.2    Naito, M.3    Ito, K.4
  • 67
    • 84902959388 scopus 로고    scopus 로고
    • Effects of IL-6 and IL-6 blockade on neutrophil function in vitro and in vivo
    • Wright HL, Cross AL, Edwards SW, Moots RJ. Effects of IL-6 and IL-6 blockade on neutrophil function in vitro and in vivo. Rheumatology (Oxford) 53(7), 1321-1331 (2014).
    • (2014) Rheumatology (Oxford) , vol.53 , Issue.7 , pp. 1321-1331
    • Wright, H.L.1    Cross, A.L.2    Edwards, S.W.3    Moots, R.J.4
  • 68
    • 84879414277 scopus 로고    scopus 로고
    • Pro-atherogenic lipid changes and decreased hepatic LDL receptor expression by tocilizumab in rheumatoid arthritis
    • Strang AC, Bisoendial RJ, Kootte RS et al. Pro-atherogenic lipid changes and decreased hepatic LDL receptor expression by tocilizumab in rheumatoid arthritis. Atherosclerosis 229(1), 174-181 (2013).
    • (2013) Atherosclerosis , vol.229 , Issue.1 , pp. 174-181
    • Strang, A.C.1    Bisoendial, R.J.2    Kootte, R.S.3
  • 69
    • 85153886025 scopus 로고    scopus 로고
    • Risk factors for major adverse cardiovascular (CV) events (MACE) in rheumatoid arthritis (RA) patients treated with tocilizumab (TCZ)
    • Rao VU, Pavlov A, Klearman M et al. Risk factors for major adverse cardiovascular (CV) events (MACE) in rheumatoid arthritis (RA) patients treated with tocilizumab (TCZ). Ann. Rheum. Dis. 71(Suppl. 3), 356 (2012).
    • (2012) Ann. Rheum. Dis. , vol.71 , pp. 356
    • Rao, V.U.1    Pavlov, A.2    Klearman, M.3
  • 70
    • 84925670384 scopus 로고    scopus 로고
    • Effect of interleukin-6 receptor blockade on surrogates of vascular risk in rheumatoid arthritis: MEASURE, a randomized, placebo-controlled study
    • (Epub ahead of print)
    • McInnes IB, Thompson L, Giles JT et al. Effect of interleukin-6 receptor blockade on surrogates of vascular risk in rheumatoid arthritis: MEASURE, a randomized, placebo-controlled study. Ann. Rheum. Dis. doi:10.1136/annrheumdis-2013-204345 (2013) (Epub ahead of print).
    • (2013) Ann. Rheum. Dis.
    • McInnes, I.B.1    Thompson, L.2    Giles, J.T.3
  • 71
    • 84859210770 scopus 로고    scopus 로고
    • Interleukin-6 receptor pathways in coronary heart disease: A collaborative meta-analysis of 82 studies
    • Sarwar N, Butterworth AS, Freitag DF et al. Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet 379(9822), 1205-1213 (2012).
    • (2012) Lancet , vol.379 , Issue.9822 , pp. 1205-1213
    • Sarwar, N.1    Butterworth, A.S.2    Freitag, D.F.3
  • 72
    • 84888057974 scopus 로고    scopus 로고
    • Mechanism-based approach using a biomarker response to evaluate tocilizumab subcutaneous injection in patients with rheumatoid arthritis with an inadequate response to synthetic DMARDs (MATSURI study)
    • Ohta S, Tsuru T, Terao K et al. Mechanism-based approach using a biomarker response to evaluate tocilizumab subcutaneous injection in patients with rheumatoid arthritis with an inadequate response to synthetic DMARDs (MATSURI study). J. Clin. Pharmacol. 54(1), 109-119 (2014).
    • (2014) J. Clin. Pharmacol. , vol.54 , Issue.1 , pp. 109-119
    • Ohta, S.1    Tsuru, T.2    Terao, K.3
  • 73
    • 84896689880 scopus 로고    scopus 로고
    • Phase III study of the efficacy and safety of subcutaneous versus intravenous tocilizumab monotherapy in patients with rheumatoid arthritis
    • Ogata A, Tanimura K, Sugimoto T et al. Phase III study of the efficacy and safety of subcutaneous versus intravenous tocilizumab monotherapy in patients with rheumatoid arthritis. Arthritis Care Res. (Hoboken) 66(3), 344-354 (2014).
    • (2014) Arthritis Care Res. (Hoboken) , vol.66 , Issue.3 , pp. 344-354
    • Ogata, A.1    Tanimura, K.2    Sugimoto, T.3
  • 74
    • 85153881991 scopus 로고    scopus 로고
    • Effectiveness and tolerability of subcutaneous tocilizumab in rheumatoid arthritis patients switched from intravenous tocilizumab: Results from the extension period of the MUSASHI study
    • Ogata A. Effectiveness and tolerability of subcutaneous tocilizumab in rheumatoid arthritis patients switched from intravenous tocilizumab: results from the extension period of the MUSASHI study. Arthritis Rheum. 64(Suppl. 10), S555 (2012).
    • (2012) Arthritis Rheum. , vol.64 , pp. S555
    • Ogata, A.1
  • 75
    • 85153876973 scopus 로고    scopus 로고
    • Safety and efficacy of subcutaneous tocilizumab monotherapy in a long-term extension study in japanese rheumatoid arthritis patients
    • Ogata A. Safety and efficacy of subcutaneous tocilizumab monotherapy in a long-term extension study in Japanese rheumatoid arthritis patients. Arthritis Rheum. 65(Suppl. 10), S605-S606 (2013).
    • (2013) Arthritis Rheum. , vol.65 , pp. S605-S606
    • Ogata, A.1
  • 76
    • 84878780747 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of tocilizumab, a humanized antiinterleukin-6 receptor monoclonal antibody, following single-dose administration by subcutaneous and intravenous routes to healthy subjects
    • Zhang X, Georgy A, Rowell L. Pharmacokinetics and pharmacodynamics of tocilizumab, a humanized antiinterleukin-6 receptor monoclonal antibody, following single-dose administration by subcutaneous and intravenous routes to healthy subjects. Int. J. Clin. Pharmacol. Ther. 51(6), 443-455 (2013).
    • (2013) Int. J. Clin. Pharmacol. Ther. , vol.51 , Issue.6 , pp. 443-455
    • Zhang, X.1    Georgy, A.2    Rowell, L.3
  • 77
    • 84880240350 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of single subcutaneous doses of tocilizumab administered with or without rHuPH20
    • Morcos PN, Zhang X, McIntyre C, Bittner B, Rowell L, Hussain Z. Pharmacokinetics and pharmacodynamics of single subcutaneous doses of tocilizumab administered with or without rHuPH20. Int. J. Clin. Pharmacol. Ther. 51(7), 537-548 (2013).
    • (2013) Int. J. Clin. Pharmacol. Ther. , vol.51 , Issue.7 , pp. 537-548
    • Morcos, P.N.1    Zhang, X.2    McIntyre, C.3    Bittner, B.4    Rowell, L.5    Hussain, Z.6
  • 78
    • 84883159838 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of tocilizumab after subcutaneous administration in patients with rheumatoid arthritis
    • Zhang X, Chen YC, Fettner S et al. Pharmacokinetics and pharmacodynamics of tocilizumab after subcutaneous administration in patients with rheumatoid arthritis. Int. J. Clin. Pharmacol. Ther. 51(8), 620-630 (2013).
    • (2013) Int. J. Clin. Pharmacol. Ther. , vol.51 , Issue.8 , pp. 620-630
    • Zhang, X.1    Chen, Y.C.2    Fettner, S.3
  • 79
    • 84889667445 scopus 로고    scopus 로고
    • A randomised, double-blind, parallel-group study of the safety and efficacy of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional diseasemodifying antirheumatic drugs in patients with moderate to severe rheumatoid arthritis (SUMMACTA study)
    • Burmester GR, Rubbert-Roth A, Cantagrel AG et al. A randomised, double-blind, parallel-group study of the safety and efficacy of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional diseasemodifying antirheumatic drugs in patients with moderate to severe rheumatoid arthritis (SUMMACTA study). Ann. Rheum. Dis. 73(1), 69-74 (2014).
    • (2014) Ann. Rheum. Dis. , vol.73 , Issue.1 , pp. 69-74
    • Burmester, G.R.1    Rubbert-Roth, A.2    Cantagrel, A.G.3
  • 80
    • 85153870134 scopus 로고    scopus 로고
    • SUMMACTA: A randomized, double-blind parallel group study of the safety and efficacy of tocilizumab SC versus tocilizumab IV, in combination with traditional DMARDs in patients with moderate to severe RA
    • Burmester GR, Rubbert-Roth A, Cantagrel A et al. SUMMACTA: a randomized, double-blind parallel group study of the safety and efficacy of tocilizumab SC versus tocilizumab IV, in combination with traditional DMARDs in patients with moderate to severe RA. Ann. Rheum. Dis. 72(Suppl. 3), 615 (2013).
    • (2013) Ann. Rheum. Dis. , vol.72 , pp. 615
    • Burmester, G.R.1    Rubbert-Roth, A.2    Cantagrel, A.3
  • 81
    • 85153889063 scopus 로고    scopus 로고
    • Burmester GR, rubbert-roth A, cantagrel AG
    • The efficacy and safety of tocilizumab subcutaneous versus tocilizumab intravenous, in combination with traditional DMARDs in patients with RA at 49 weeks (SUMMACTA). Burmester GR, Rubbert-Roth A, Cantagrel AG. Arthritis Rheum. 65(Suppl. 10), S203-S204 (2013).
    • (2013) Arthritis Rheum. , vol.65 , pp. S203-S204
  • 82
    • 84927674487 scopus 로고    scopus 로고
    • The efficacy and safety of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional DMARDs in patients with RA at week 97 (SUMMACTA)
    • Burmester G, Rubbert-Roth A, Cantagrel A et al. The efficacy and safety of subcutaneous tocilizumab versus intravenous tocilizumab in combination with traditional DMARDs in patients with RA at week 97 (SUMMACTA). Ann. Rheum. Dis. 73(Suppl. 2), 499-500 (2014).
    • (2014) Ann. Rheum. Dis. , vol.73 , pp. 499-500
    • Burmester, G.1    Rubbert-Roth, A.2    Cantagrel, A.3
  • 83
    • 85007277373 scopus 로고    scopus 로고
    • Subcutaneous tocilizumab vs placebo in combination with disease modifying antirheumatic drugs in patients with rheumatoid arthritis
    • Kivitz A, Olech E, Borofsky MA et al. Subcutaneous tocilizumab vs placebo in combination with disease modifying antirheumatic drugs in patients with Rheumatoid Arthritis. Arthritis Care Res. (Hoboken). 66(11), 1653-1661 (2014).
    • (2014) Arthritis Care Res. (Hoboken). , vol.66 , Issue.11 , pp. 1653-1661
    • Kivitz, A.1    Olech, E.2    Borofsky, M.A.3
  • 84
    • 84905579019 scopus 로고    scopus 로고
    • The safety and efficacy of tocilizumab subcutaneous in combination with traditional DMARDs in patients with moderate to severe rheumatoid arthritis up to 48 weeks (BREVACTA)
    • Kivitz A, Olech E, Borofsky MA et al. The safety and efficacy of tocilizumab subcutaneous in combination with traditional DMARDs in patients with moderate to severe rheumatoid arthritis up to 48 weeks (BREVACTA). Arthritis Rheum. 65(Suppl. 10), S604-S605 (2013).
    • (2013) Arthritis Rheum. , vol.65 , pp. S604-S605
    • Kivitz, A.1    Olech, E.2    Borofsky, M.A.3
  • 85
    • 84892529958 scopus 로고    scopus 로고
    • The role of DMARDs in reducing the immunogenicity of TNF inhibitors in chronic inflammatory diseases
    • Jani M, Barton A, Warren RB, Griffiths CE, Chinoy H. The role of DMARDs in reducing the immunogenicity of TNF inhibitors in chronic inflammatory diseases. Rheumatology (Oxford) 53(2), 213-222 (2014).
    • (2014) Rheumatology (Oxford) , vol.53 , Issue.2 , pp. 213-222
    • Jani, M.1    Barton, A.2    Warren, R.B.3    Griffiths, C.E.4    Chinoy, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.