-
1
-
-
77955066199
-
Sipuleucel-T immunotherapy for castration-resistant prostate cancer
-
Kantoff PW, Higano CS, Shore ND, et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med. 2010;363:411-422.
-
(2010)
N Engl J Med
, vol.363
, pp. 411-422
-
-
Kantoff, P.W.1
Higano, C.S.2
Shore, N.D.3
-
2
-
-
85025693217
-
Vaccines targeting helper T cells for cancer immunotherapy
-
Melssen M, Slingluff CL Jr. Vaccines targeting helper T cells for cancer immunotherapy. Curr Opin Immunol. 2017;47:85-92.
-
(2017)
Curr Opin Immunol
, vol.47
, pp. 85-92
-
-
Melssen, M.1
Slingluff, C.L.2
-
3
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366:2443-2454.
-
(2012)
N Engl J Med
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
-
4
-
-
85028060533
-
Distinct cellular mechanisms underlie anti-CTLA-4 and anti-PD-1 checkpoint blockade
-
e17
-
Wei SC, Levine JH, Cogdill AP, et al. Distinct cellular mechanisms underlie anti-CTLA-4 and anti-PD-1 checkpoint blockade. Cell. 2017;170:1120-1133. e17.
-
(2017)
Cell
, vol.170
, pp. 1120-1133
-
-
Wei, S.C.1
Levine, J.H.2
Cogdill, A.P.3
-
5
-
-
84908073316
-
Chimeric antigen receptor T cells for sustained remissions in leukemia
-
Maude SL, Frey N, Shaw PA, et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med. 2014;371:1507-1517.
-
(2014)
N Engl J Med
, vol.371
, pp. 1507-1517
-
-
Maude, S.L.1
Frey, N.2
Shaw, P.A.3
-
6
-
-
45549099784
-
Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1
-
Hunder NN, Wallen H, Cao J, et al. Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1. N Engl J Med. 2008;358:2698-2703.
-
(2008)
N Engl J Med
, vol.358
, pp. 2698-2703
-
-
Hunder, N.N.1
Wallen, H.2
Cao, J.3
-
7
-
-
84867714627
-
Cytokines of the gamma(c) family control CD4+ T cell differentiation and function
-
Yamane H, Paul WE. Cytokines of the gamma(c) family control CD4+ T cell differentiation and function. Nat Immunol. 2012;13:1037-1044.
-
(2012)
Nat Immunol
, vol.13
, pp. 1037-1044
-
-
Yamane, H.1
Paul, W.E.2
-
8
-
-
77954096689
-
IL-6: regulator of Treg/Th17 balance
-
Kimura A, Kishimoto T. IL-6: regulator of Treg/Th17 balance. Eur J Immunol. 2010;40:1830-1835.
-
(2010)
Eur J Immunol
, vol.40
, pp. 1830-1835
-
-
Kimura, A.1
Kishimoto, T.2
-
10
-
-
84892694753
-
Inflammation amplifier, a new paradigm in cancer biology
-
Atsumi T, Singh R, Sabharwal L, et al. Inflammation amplifier, a new paradigm in cancer biology. Cancer Res. 2014;74:8-14.
-
(2014)
Cancer Res
, vol.74
, pp. 8-14
-
-
Atsumi, T.1
Singh, R.2
Sabharwal, L.3
-
11
-
-
74549167737
-
Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
-
Park EJ, Lee JH, Yu GY, et al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell. 2010;140:197-208.
-
(2010)
Cell
, vol.140
, pp. 197-208
-
-
Park, E.J.1
Lee, J.H.2
Yu, G.Y.3
-
12
-
-
0030796001
-
Role of interleukin-6 in the paraneoplastic inflammatory syndrome associated with renal-cell carcinoma
-
Blay JY, Rossi JF, Wijdenes J, et al. Role of interleukin-6 in the paraneoplastic inflammatory syndrome associated with renal-cell carcinoma. Int J Cancer. 1997;72:424-430.
-
(1997)
Int J Cancer
, vol.72
, pp. 424-430
-
-
Blay, J.Y.1
Rossi, J.F.2
Wijdenes, J.3
-
13
-
-
77957995258
-
A phase I/II study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in metastatic renal cell cancer
-
Rossi JF, Negrier S, James ND, et al. A phase I/II study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in metastatic renal cell cancer. Br J Cancer. 2010;103:1154-1162.
-
(2010)
Br J Cancer
, vol.103
, pp. 1154-1162
-
-
Rossi, J.F.1
Negrier, S.2
James, N.D.3
-
15
-
-
54249118294
-
Interleukin-6, cortisol, and depressive symptoms in ovarian cancer patients
-
Lutgendorf SK, Weinrib AZ, Penedo F, et al. Interleukin-6, cortisol, and depressive symptoms in ovarian cancer patients. J Clin Oncol. 2008;26:4820-4827.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4820-4827
-
-
Lutgendorf, S.K.1
Weinrib, A.Z.2
Penedo, F.3
-
16
-
-
77649239393
-
Serum interleukin-6 levels in colorectal cancer patients–a summary of published results
-
Knupfer H, Preiss R. Serum interleukin-6 levels in colorectal cancer patients–a summary of published results. Int J Colorectal Dis. 2010;25:135-140.
-
(2010)
Int J Colorectal Dis
, vol.25
, pp. 135-140
-
-
Knupfer, H.1
Preiss, R.2
-
17
-
-
85019024949
-
Soluble IL6R expressed by myeloid cells reduces tumor-specific Th1 differentiation and drives tumor progression
-
Tsukamoto H, Fujieda K, Hirayama M, et al. Soluble IL6R expressed by myeloid cells reduces tumor-specific Th1 differentiation and drives tumor progression. Cancer Res. 2017;77:2279-2291.
-
(2017)
Cancer Res
, vol.77
, pp. 2279-2291
-
-
Tsukamoto, H.1
Fujieda, K.2
Hirayama, M.3
-
18
-
-
84943791915
-
A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-alpha2b in patients with recurrent epithelial ovarian cancer
-
Dijkgraaf EM, Santegoets SJ, Reyners AK, et al. A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-alpha2b in patients with recurrent epithelial ovarian cancer. Ann Oncol. 2015;26:2141-2149.
-
(2015)
Ann Oncol
, vol.26
, pp. 2141-2149
-
-
Dijkgraaf, E.M.1
Santegoets, S.J.2
Reyners, A.K.3
-
19
-
-
84880062835
-
Critical role of STAT3 in IL-6-mediated drug resistance in human neuroblastoma
-
Ara T, Nakata R, Sheard MA, et al. Critical role of STAT3 in IL-6-mediated drug resistance in human neuroblastoma. Cancer Res. 2013;73:3852-3864.
-
(2013)
Cancer Res
, vol.73
, pp. 3852-3864
-
-
Ara, T.1
Nakata, R.2
Sheard, M.A.3
-
20
-
-
79953756112
-
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
-
Lesina M, Kurkowski MU, Ludes K, et al. Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell. 2011;19:456-469.
-
(2011)
Cancer Cell
, vol.19
, pp. 456-469
-
-
Lesina, M.1
Kurkowski, M.U.2
Ludes, K.3
-
21
-
-
84975709620
-
Toll-like receptor 2 activation promotes tumor dendritic cell dysfunction by regulating IL-6 and IL-10 receptor signaling
-
Tang M, Diao J, Gu H, Khatri I, Zhao J, Cattral MS. Toll-like receptor 2 activation promotes tumor dendritic cell dysfunction by regulating IL-6 and IL-10 receptor signaling. Cell Rep. 2015;13:2851-2864.
-
(2015)
Cell Rep
, vol.13
, pp. 2851-2864
-
-
Tang, M.1
Diao, J.2
Gu, H.3
Khatri, I.4
Zhao, J.5
Cattral, M.S.6
-
22
-
-
84887530424
-
Myeloid-derived suppressor cells attenuate TH1 development through IL-6 production to promote tumor progression
-
Tsukamoto H, Nishikata R, Senju S, Nishimura Y. Myeloid-derived suppressor cells attenuate TH1 development through IL-6 production to promote tumor progression. Cancer Immunol Res. 2013;1:64-76.
-
(2013)
Cancer Immunol Res
, vol.1
, pp. 64-76
-
-
Tsukamoto, H.1
Nishikata, R.2
Senju, S.3
Nishimura, Y.4
-
23
-
-
84994516325
-
IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer
-
Mace TA, Shakya R, Pitarresi JR, et al. IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer. Gut. 2016. https://doi.org/10.1136/gutjnl-2016-311585
-
(2016)
Gut
-
-
Mace, T.A.1
Shakya, R.2
Pitarresi, J.R.3
-
24
-
-
84962407508
-
A paracrine role for IL6 in prostate cancer patients: lack of production by primary or metastatic tumor cells
-
Yu SH, Zheng Q, Esopi D, et al. A paracrine role for IL6 in prostate cancer patients: lack of production by primary or metastatic tumor cells. Cancer Immunol Res. 2015;3:1175-1184.
-
(2015)
Cancer Immunol Res
, vol.3
, pp. 1175-1184
-
-
Yu, S.H.1
Zheng, Q.2
Esopi, D.3
-
25
-
-
84926523961
-
Senescence-associated inflammatory responses: aging and cancer perspectives
-
Lasry A, Ben-Neriah Y. Senescence-associated inflammatory responses: aging and cancer perspectives. Trends Immunol. 2015;36:217-228.
-
(2015)
Trends Immunol
, vol.36
, pp. 217-228
-
-
Lasry, A.1
Ben-Neriah, Y.2
-
26
-
-
84869797922
-
IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6
-
Rose-John S. IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6. Int J Biol Sci. 2012;8:1237-1247.
-
(2012)
Int J Biol Sci
, vol.8
, pp. 1237-1247
-
-
Rose-John, S.1
-
27
-
-
84862909316
-
An intermediate-risk multiple myeloma subgroup is defined by sIL-6r: levels synergistically increase with incidence of SNP rs2228145 and 1q21 amplification
-
Stephens OW, Zhang Q, Qu P, et al. An intermediate-risk multiple myeloma subgroup is defined by sIL-6r: levels synergistically increase with incidence of SNP rs2228145 and 1q21 amplification. Blood. 2012;119:503-512.
-
(2012)
Blood
, vol.119
, pp. 503-512
-
-
Stephens, O.W.1
Zhang, Q.2
Qu, P.3
-
28
-
-
77953645116
-
Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor
-
McFarland-Mancini MM, Funk HM, Paluch AM, et al. Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor. J Immunol. 2010;184:7219-7228.
-
(2010)
J Immunol
, vol.184
, pp. 7219-7228
-
-
McFarland-Mancini, M.M.1
Funk, H.M.2
Paluch, A.M.3
-
29
-
-
84938782875
-
Interleukin-6 receptor and its ligand interleukin-6 are opposite markers for survival and infiltration with mature myeloid cells in ovarian cancer
-
Wouters M, Dijkgraaf EM, Kuijjer ML, et al. Interleukin-6 receptor and its ligand interleukin-6 are opposite markers for survival and infiltration with mature myeloid cells in ovarian cancer. Oncoimmunology. 2014;3:e962397.
-
(2014)
Oncoimmunology
, vol.3
-
-
Wouters, M.1
Dijkgraaf, E.M.2
Kuijjer, M.L.3
-
30
-
-
85028561769
-
Lack of interleukin-6 in the tumor microenvironment augments type-1 immunity and increases the efficacy of cancer immunotherapy
-
Ohno Y, Toyoshima Y, Yurino H, et al. Lack of interleukin-6 in the tumor microenvironment augments type-1 immunity and increases the efficacy of cancer immunotherapy. Cancer Sci. 2017;108:1959-1966.
-
(2017)
Cancer Sci
, vol.108
, pp. 1959-1966
-
-
Ohno, Y.1
Toyoshima, Y.2
Yurino, H.3
-
31
-
-
84905987223
-
Circulating CD4+ T cells that produce IL4 or IL17 when stimulated by melan-A but not by NY-ESO-1 have negative impacts on survival of patients with stage IV melanoma
-
Zelba H, Weide B, Martens A, et al. Circulating CD4+ T cells that produce IL4 or IL17 when stimulated by melan-A but not by NY-ESO-1 have negative impacts on survival of patients with stage IV melanoma. Clin Cancer Res. 2014;20:4390-4399.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 4390-4399
-
-
Zelba, H.1
Weide, B.2
Martens, A.3
-
32
-
-
84927637387
-
IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age
-
Tsukamoto H, Senju S, Matsumura K, Swain SL, Nishimura Y. IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age. Nat Commun. 2015;6:6702.
-
(2015)
Nat Commun
, vol.6
, pp. 6702
-
-
Tsukamoto, H.1
Senju, S.2
Matsumura, K.3
Swain, S.L.4
Nishimura, Y.5
-
33
-
-
0034502224
-
Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1
-
Diehl S, Anguita J, Hoffmeyer A, et al. Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1. Immunity. 2000;13:805-815.
-
(2000)
Immunity
, vol.13
, pp. 805-815
-
-
Diehl, S.1
Anguita, J.2
Hoffmeyer, A.3
-
34
-
-
85009756462
-
Systemic immunity is required for effective cancer immunotherapy
-
e15
-
Spitzer MH, Carmi Y, Reticker-Flynn NE, et al. Systemic immunity is required for effective cancer immunotherapy. Cell. 2017;168:487-502. e15.
-
(2017)
Cell
, vol.168
, pp. 487-502
-
-
Spitzer, M.H.1
Carmi, Y.2
Reticker-Flynn, N.E.3
-
35
-
-
85029636194
-
Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer
-
Carstens JL, Correa de Sampaio P, Yang D, et al. Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer. Nat Commun. 2017;8:15095.
-
(2017)
Nat Commun
, vol.8
, pp. 15095
-
-
Carstens, J.L.1
Correa de Sampaio, P.2
Yang, D.3
-
36
-
-
78449290135
-
CD4+ T-cell help in the tumor milieu is required for recruitment and cytolytic function of CD8+ T lymphocytes
-
Bos R, Sherman LA. CD4+ T-cell help in the tumor milieu is required for recruitment and cytolytic function of CD8+ T lymphocytes. Cancer Res. 2010;70:8368-8377.
-
(2010)
Cancer Res
, vol.70
, pp. 8368-8377
-
-
Bos, R.1
Sherman, L.A.2
-
37
-
-
33645866471
-
Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction
-
Castellino F, Huang AY, Altan-Bonnet G, Stoll S, Scheinecker C, Germain RN. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature. 2006;440:890-895.
-
(2006)
Nature
, vol.440
, pp. 890-895
-
-
Castellino, F.1
Huang, A.Y.2
Altan-Bonnet, G.3
Stoll, S.4
Scheinecker, C.5
Germain, R.N.6
-
38
-
-
70849099812
-
CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help
-
Nakanishi Y, Lu B, Gerard C, Iwasaki A. CD8(+) T lymphocyte mobilization to virus-infected tissue requires CD4(+) T-cell help. Nature. 2009;462:510-513.
-
(2009)
Nature
, vol.462
, pp. 510-513
-
-
Nakanishi, Y.1
Lu, B.2
Gerard, C.3
Iwasaki, A.4
-
39
-
-
85016115393
-
Myeloid STAT3 promotes lung tumorigenesis by transforming tumor immunosurveillance into tumor-promoting inflammation
-
Zhou J, Qu Z, Sun F, et al. Myeloid STAT3 promotes lung tumorigenesis by transforming tumor immunosurveillance into tumor-promoting inflammation. Cancer Immunol Res. 2017;5:257-268.
-
(2017)
Cancer Immunol Res
, vol.5
, pp. 257-268
-
-
Zhou, J.1
Qu, Z.2
Sun, F.3
-
40
-
-
84872199075
-
The key role of IL-6-arginase cascade for inducing dendritic cell-dependent CD4(+) T cell dysfunction in tumor-bearing mice
-
Narita Y, Kitamura H, Wakita D, et al. The key role of IL-6-arginase cascade for inducing dendritic cell-dependent CD4(+) T cell dysfunction in tumor-bearing mice. J Immunol. 2013;190:812-820.
-
(2013)
J Immunol
, vol.190
, pp. 812-820
-
-
Narita, Y.1
Kitamura, H.2
Wakita, D.3
-
41
-
-
27744449724
-
IL-6-STAT3 controls intracellular MHC class II alphabeta dimer level through cathepsin S activity in dendritic cells
-
Kitamura H, Kamon H, Sawa S, et al. IL-6-STAT3 controls intracellular MHC class II alphabeta dimer level through cathepsin S activity in dendritic cells. Immunity. 2005;23:491-502.
-
(2005)
Immunity
, vol.23
, pp. 491-502
-
-
Kitamura, H.1
Kamon, H.2
Sawa, S.3
-
42
-
-
67651160649
-
CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages
-
DeNardo DG, Barreto JB, Andreu P, et al. CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell. 2009;16:91-102.
-
(2009)
Cancer Cell
, vol.16
, pp. 91-102
-
-
DeNardo, D.G.1
Barreto, J.B.2
Andreu, P.3
-
43
-
-
0033000352
-
Exposure to febrile temperature upregulates expression of pyrogenic cytokines in endotoxin-challenged mice
-
Jiang Q, Detolla L, Singh IS, et al. Exposure to febrile temperature upregulates expression of pyrogenic cytokines in endotoxin-challenged mice. Am J Physiol. 1999;276:R1653-R1660.
-
(1999)
Am J Physiol
, vol.276
, pp. R1653-R1660
-
-
Jiang, Q.1
Detolla, L.2
Singh, I.S.3
-
44
-
-
84876535364
-
Understanding immunosenescence to improve responses to vaccines
-
Goronzy JJ, Weyand CM. Understanding immunosenescence to improve responses to vaccines. Nat Immunol. 2013;14:428-436.
-
(2013)
Nat Immunol
, vol.14
, pp. 428-436
-
-
Goronzy, J.J.1
Weyand, C.M.2
-
45
-
-
70849110194
-
Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects
-
Tsukamoto H, Clise-Dwyer K, Huston GE, et al. Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects. Proc Natl Acad Sci USA. 2009;106:18333-18338.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 18333-18338
-
-
Tsukamoto, H.1
Clise-Dwyer, K.2
Huston, G.E.3
-
46
-
-
0344304396
-
CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly
-
Haynes L, Eaton SM, Burns EM, Randall TD, Swain SL. CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly. Proc Natl Acad Sci USA. 2003;100:15053-15058.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 15053-15058
-
-
Haynes, L.1
Eaton, S.M.2
Burns, E.M.3
Randall, T.D.4
Swain, S.L.5
-
47
-
-
14044268797
-
IL-6 plays a unique role in initiating c-Maf expression during early stage of CD4 T cell activation
-
Yang Y, Ochando J, Yopp A, Bromberg JS, Ding Y. IL-6 plays a unique role in initiating c-Maf expression during early stage of CD4 T cell activation. J Immunol. 2005;174:2720-2729.
-
(2005)
J Immunol
, vol.174
, pp. 2720-2729
-
-
Yang, Y.1
Ochando, J.2
Yopp, A.3
Bromberg, J.S.4
Ding, Y.5
-
48
-
-
77950554986
-
c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-beta inhibits c-Maf-induced IL-21 production in CD4+ T cells
-
Hiramatsu Y, Suto A, Kashiwakuma D, et al. c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-beta inhibits c-Maf-induced IL-21 production in CD4+ T cells. J Leukoc Biol. 2010;87:703-712.
-
(2010)
J Leukoc Biol
, vol.87
, pp. 703-712
-
-
Hiramatsu, Y.1
Suto, A.2
Kashiwakuma, D.3
-
49
-
-
33748494020
-
IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression
-
Suto A, Wurster AL, Reiner SL, Grusby MJ. IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression. J Immunol. 2006;177:3721-3727.
-
(2006)
J Immunol
, vol.177
, pp. 3721-3727
-
-
Suto, A.1
Wurster, A.L.2
Reiner, S.L.3
Grusby, M.J.4
-
50
-
-
84938739934
-
Molecular profiling of CD8 T cells in autochthonous melanoma identifies Maf as driver of exhaustion
-
Giordano M, Henin C, Maurizio J, et al. Molecular profiling of CD8 T cells in autochthonous melanoma identifies Maf as driver of exhaustion. EMBO J. 2015;34:2042-2058.
-
(2015)
EMBO J
, vol.34
, pp. 2042-2058
-
-
Giordano, M.1
Henin, C.2
Maurizio, J.3
-
51
-
-
9144220760
-
Central role of IL-6 receptor signal-transducing chain gp130 in activation of L-selectin adhesion by fever-range thermal stress
-
Chen Q, Wang WC, Bruce R, et al. Central role of IL-6 receptor signal-transducing chain gp130 in activation of L-selectin adhesion by fever-range thermal stress. Immunity. 2004;20:59-70.
-
(2004)
Immunity
, vol.20
, pp. 59-70
-
-
Chen, Q.1
Wang, W.C.2
Bruce, R.3
-
52
-
-
80053429941
-
IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells
-
Fisher DT, Chen Q, Skitzki JJ, et al. IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells. J Clin Invest. 2011;121:3846-3859.
-
(2011)
J Clin Invest
, vol.121
, pp. 3846-3859
-
-
Fisher, D.T.1
Chen, Q.2
Skitzki, J.J.3
-
53
-
-
80052236068
-
Human solid tumors contain high endothelial venules: association with T- and B-lymphocyte infiltration and favorable prognosis in breast cancer
-
Martinet L, Garrido I, Filleron T, et al. Human solid tumors contain high endothelial venules: association with T- and B-lymphocyte infiltration and favorable prognosis in breast cancer. Cancer Res. 2011;71:5678-5687.
-
(2011)
Cancer Res
, vol.71
, pp. 5678-5687
-
-
Martinet, L.1
Garrido, I.2
Filleron, T.3
-
54
-
-
17044377812
-
IL-6 increases primed cell expansion and survival
-
Rochman I, Paul WE, Ben-Sasson SZ. IL-6 increases primed cell expansion and survival. J Immunol. 2005;174:4761-4767.
-
(2005)
J Immunol
, vol.174
, pp. 4761-4767
-
-
Rochman, I.1
Paul, W.E.2
Ben-Sasson, S.Z.3
-
55
-
-
84991445529
-
Direct IL-6 signals maximize protective secondary CD4 T cell responses against influenza
-
Strutt TM, McKinstry KK, Kuang Y, et al. Direct IL-6 signals maximize protective secondary CD4 T cell responses against influenza. J Immunol. 2016;197:3260-3270.
-
(2016)
J Immunol
, vol.197
, pp. 3260-3270
-
-
Strutt, T.M.1
McKinstry, K.K.2
Kuang, Y.3
-
56
-
-
0029034740
-
Biologic effects of anti-interleukin-6 murine monoclonal antibody in advanced multiple myeloma
-
Bataille R, Barlogie B, Lu ZY, et al. Biologic effects of anti-interleukin-6 murine monoclonal antibody in advanced multiple myeloma. Blood. 1995;86:685-691.
-
(1995)
Blood
, vol.86
, pp. 685-691
-
-
Bataille, R.1
Barlogie, B.2
Lu, Z.Y.3
-
57
-
-
84876196796
-
A phase 2 multicentre study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma
-
Voorhees PM, Manges RF, Sonneveld P, et al. A phase 2 multicentre study of siltuximab, an anti-interleukin-6 monoclonal antibody, in patients with relapsed or refractory multiple myeloma. Br J Haematol. 2013;161:357-366.
-
(2013)
Br J Haematol
, vol.161
, pp. 357-366
-
-
Voorhees, P.M.1
Manges, R.F.2
Sonneveld, P.3
-
58
-
-
84937511676
-
Phase II study of personalized peptide vaccination for previously treated advanced colorectal cancer
-
Kibe S, Yutani S, Motoyama S, et al. Phase II study of personalized peptide vaccination for previously treated advanced colorectal cancer. Cancer Immunol Res. 2014;2:1154-1162.
-
(2014)
Cancer Immunol Res
, vol.2
, pp. 1154-1162
-
-
Kibe, S.1
Yutani, S.2
Motoyama, S.3
-
59
-
-
84942888151
-
STAT3 inhibition enhances the therapeutic efficacy of immunogenic chemotherapy by stimulating Type 1 interferon production by cancer cells
-
Yang H, Yamazaki T, Pietrocola F, et al. STAT3 inhibition enhances the therapeutic efficacy of immunogenic chemotherapy by stimulating Type 1 interferon production by cancer cells. Cancer Res. 2015;75:3812-3822.
-
(2015)
Cancer Res
, vol.75
, pp. 3812-3822
-
-
Yang, H.1
Yamazaki, T.2
Pietrocola, F.3
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