The Effects of Interleukin-6 Signal Blockade on Fertility, Embryo-fetal Development, and Immunization In vivo

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 95, Issue 4, 2012, Pages 304-317

  Sakurai, Takayuki ^a   Takai, Ryo ^a   Bürgin, Heinrich ^b   Ishihara, Kana ^a   Sakamoto, Yuichiro ^a   Amano, Jun ^a   Higuchi, Yoshinobu ^a   Chiba, Shuichi ^a   Singer, Thomas ^b   Kawamura, Akinori ^a   Suzuki, Masami ^a   Müller, Lutz ^b  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

development; fertility; IL 6; immunization; in vivo; mouse

Indexed keywords

HEMOCYANIN; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; KEYHOLE LIMPET HEMOCYANIN; MESSENGER RNA; MR16 1 ANTIBODY; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIRTH; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EMBRYO DEVELOPMENT; FEMALE; FEMALE FERTILITY; FERTILITY; FETUS DEVELOPMENT; IMMUNIZATION; IMPLANTATION; IN VIVO STUDY; KNOCKOUT MOUSE; MALE FERTILITY; MOUSE; NONHUMAN; POSTNATAL DEVELOPMENT; PREGNANT WOMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REPRODUCTION; SENSITIZATION; SIGNAL TRANSDUCTION;

ANIMALS; ANIMALS, NEWBORN; ANTIBODIES, NEUTRALIZING; ANTIBODY AFFINITY; BODY WEIGHT; BONE AND BONES; CROSSES, GENETIC; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; FEMALE; FERTILITY; FETUS; IMMUNIZATION; INJECTIONS, INTRAVENOUS; INTERLEUKIN-6; MALE; MEMORY; MICE; MICE, KNOCKOUT; MILK; PLACENTA; PREGNANCY; RATS; REFLEX; SERUM AMYLOID A PROTEIN; SIGNAL TRANSDUCTION;

EID: 84865107905     PISSN: 15429733     EISSN: 15429741     Source Type: Journal    
DOI: 10.1002/bdrb.21019     Document Type: Article

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