메뉴 건너뛰기




Volumn 19, Issue 12, 2018, Pages

Regulatory efficacy of spirulina platensis protease hydrolyzate on lipid metabolism and gut microbiota in high-fat diet-fed rats

Author keywords

Gene expression; Gut microbiota; Lipid metabolism disorder; Peptides; Spirulina platensis protease hydrolyzate

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; AGENTS AFFECTING LIPID METABOLISM; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SPIRULINA EXTRACT; SPIRULINA PLATENSIS PROTEASE HYDROLYZATE EXTRACT; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; PEPTIDE HYDROLASE; PROTEIN HYDROLYSATE;

EID: 85058880188     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms19124023     Document Type: Article
Times cited : (36)

References (81)
  • 1
    • 84895075792 scopus 로고    scopus 로고
    • Effect of Cydonia oblonga Mill. Leaf extract on serum lipids and liver function in a rat model of hyperlipidaemia
    • Abliz, A.; Aji, Q.; Abdusalam, E.; Sun, X.; Abdurahman, A.; Zhou, W.; Moore, N.; Umar, A. Effect of Cydonia oblonga Mill. leaf extract on serum lipids and liver function in a rat model of hyperlipidaemia. J. Ethnopharmacol. 2014, 151, 970–974. [CrossRef] [PubMed]
    • (2014) J. Ethnopharmacol. , vol.151 , pp. 970-974
    • Abliz, A.1    Aji, Q.2    Abdusalam, E.3    Sun, X.4    Abdurahman, A.5    Zhou, W.6    Moore, N.7    Umar, A.8
  • 2
    • 85010411093 scopus 로고    scopus 로고
    • Hypolipidemic, antioxidant and anti-atherosclerogenic effect of aqueous extract leaves of Cassia. OccidentalisLinn (Caesalpiniaceae) in diet-induced hypercholesterolemic rats
    • Fidèle, N.; Joseph, B.; Emmanuel, T.; Théophile, D. Hypolipidemic, antioxidant and anti-atherosclerogenic effect of aqueous extract leaves of Cassia. occidentalisLinn (Caesalpiniaceae) in diet-induced hypercholesterolemic rats. BMC Complement. Altern. Med. 2017, 17, 76–86. [CrossRef] [PubMed]
    • (2017) BMC Complement. Altern. Med. , vol.17 , pp. 76-86
    • Fidèle, N.1    Joseph, B.2    Emmanuel, T.3    Théophile, D.4
  • 3
    • 85040374361 scopus 로고    scopus 로고
    • Effects of green tea on lipid metabolism in overweight or obese people: A meta-analysis of randomized controlled trials
    • Yuan, F.; Dong, H.; Fang, K.; Gong, J.; Lu, F. Effects of green tea on lipid metabolism in overweight or obese people: A meta-analysis of randomized controlled trials. Mol. Nutr. Food Res. 2017, 62, 1601122–1601134. [CrossRef] [PubMed]
    • (2017) Mol. Nutr. Food Res. , vol.62 , pp. 1601122-1601134
    • Yuan, F.1    Dong, H.2    Fang, K.3    Gong, J.4    Lu, F.5
  • 4
    • 84933532941 scopus 로고    scopus 로고
    • Luteolin attenuates hepatic steatosis and insulin resistance through the interplay between the liver and adipose tissue in mice with diet-induced obesity
    • Kwon, E.Y.; Jung, U.J.; Park, T.; Yun, J.W.; Choi, M.S. Luteolin attenuates hepatic steatosis and insulin resistance through the interplay between the liver and adipose tissue in mice with diet-induced obesity. Diabetes 2015, 64, 1658–1669. [CrossRef] [PubMed]
    • (2015) Diabetes , vol.64 , pp. 1658-1669
    • Kwon, E.Y.1    Jung, U.J.2    Park, T.3    Yun, J.W.4    Choi, M.S.5
  • 5
    • 84900558046 scopus 로고    scopus 로고
    • New pharmacological treatments for the management of obesity
    • Hurt, R.T.; Edakkanambeth, V.J.; Ebbert, J.O. New pharmacological treatments for the management of obesity. Curr. Gastroenterol. Rep. 2014, 16, 394. [CrossRef] [PubMed]
    • (2014) Curr. Gastroenterol. Rep. , vol.16 , pp. 394
    • Hurt, R.T.1    Edakkanambeth, V.J.2    Ebbert, J.O.3
  • 6
    • 84865504290 scopus 로고    scopus 로고
    • Anti-obesity drugs: Past, present and future
    • Rodgers, R.J.; Tschöp, M.H.; Wilding, J.H. Anti-obesity drugs: Past, present and future. Dis. Model. Mech. 2012, 5, 621–626. [CrossRef] [PubMed]
    • (2012) Dis. Model. Mech. , vol.5 , pp. 621-626
    • Rodgers, R.J.1    Tschöp, M.H.2    Wilding, J.H.3
  • 7
    • 85039778584 scopus 로고    scopus 로고
    • Kefir Peptides Prevent Hyperlipidemia and Obesity in High Fat Diet-Induced Obese Rats via Lipid Metabolism Modulation
    • Tung, Y.T.; Chen, H.L.; Wu, H.S.; Ho, M.H.; Chong, K.Y.; Chen, C.M. Kefir Peptides Prevent Hyperlipidemia and Obesity in High Fat Diet-Induced Obese Rats via Lipid Metabolism Modulation. Mol. Nutr. Food Res. 2017, 62. [CrossRef]
    • (2017) Mol. Nutr. Food Res. , vol.62
    • Tung, Y.T.1    Chen, H.L.2    Wu, H.S.3    Ho, M.H.4    Chong, K.Y.5    Chen, C.M.6
  • 8
    • 84994669237 scopus 로고    scopus 로고
    • Glucagon-like peptide-2 treatment improves glucose dysmetabolism in mice fed a high-fat diet
    • Baldassano, S.; Amato, A.; Caldara, G.F.; Mulè, F. Glucagon-like peptide-2 treatment improves glucose dysmetabolism in mice fed a high-fat diet. Endocrine 2016, 54, 1–9. [CrossRef]
    • (2016) Endocrine , vol.54 , pp. 1-9
    • Baldassano, S.1    Amato, A.2    Caldara, G.F.3    Mulè, F.4
  • 9
  • 10
    • 84912035331 scopus 로고    scopus 로고
    • Active ingredients from natural botanicals in the treatment of obesity
    • Zhang, W.L.; Zhu, L.; Jiang, J.G. Active ingredients from natural botanicals in the treatment of obesity. Obes. Rev. 2015, 15, 957–967. [CrossRef]
    • (2015) Obes. Rev. , vol.15 , pp. 957-967
    • Zhang, W.L.1    Zhu, L.2    Jiang, J.G.3
  • 11
    • 84910068032 scopus 로고    scopus 로고
    • Anaphylaxis to Spirulina confirmed by skin prick test with ingredients of Spirulina tablets
    • Le, T.M.; Knulst, A.C.; Röckmann, H. Anaphylaxis to Spirulina confirmed by skin prick test with ingredients of Spirulina tablets. Food Chem. Toxicol. 2014, 74, 309–310. [CrossRef] [PubMed]
    • (2014) Food Chem. Toxicol. , vol.74 , pp. 309-310
    • Le, T.M.1    Knulst, A.C.2    Röckmann, H.3
  • 12
    • 0035397361 scopus 로고    scopus 로고
    • Antioxidant activity of different fractions of Spirulina platensis protean extract
    • Piñero Estrada, J.E.; Bermejo, B.P.; Am, V.D.F. Antioxidant activity of different fractions of Spirulina platensis protean extract. Farmaco 2001, 56, 497–500. [CrossRef]
    • (2001) Farmaco , vol.56 , pp. 497-500
    • Piñero Estrada, J.E.1    Bermejo, B.P.2    Am, V.D.F.3
  • 13
    • 84924795022 scopus 로고    scopus 로고
    • Pharmacodynamic interaction of Spirulina platensis and deltamethrin in freshwater fish Nile tilapia, Oreochromis niloticus: Impact on lipid peroxidation and oxidative stress
    • Abdelkhalek, N.K.; Ghazy, E.W.; Abdel-Daim, M.M. Pharmacodynamic interaction of Spirulina platensis and deltamethrin in freshwater fish Nile tilapia, Oreochromis niloticus: Impact on lipid peroxidation and oxidative stress. Environ. Sci. Pollut. Res. 2015, 22, 3023–3031. [CrossRef] [PubMed]
    • (2015) Environ. Sci. Pollut. Res. , vol.22 , pp. 3023-3031
    • Abdelkhalek, N.K.1    Ghazy, E.W.2    Abdel-Daim, M.M.3
  • 14
    • 0033748772 scopus 로고    scopus 로고
    • Effect of spirulina on the secretion of cytokines from peripheral blood mononuclear cells
    • Mao, T.K.; Van, D.W.J.; Med, M.E.J. Effect of spirulina on the secretion of cytokines from peripheral blood mononuclear cells. Food 2000, 3, 135–175. [CrossRef] [PubMed]
    • (2000) Food , vol.3 , pp. 135-175
    • Mao, T.K.1    Van, D.W.J.2    Med, M.E.J.3
  • 15
    • 27844439455 scopus 로고    scopus 로고
    • Nutritional and therapeutic potential of Spirulina
    • Khan, Z.; Bhadouria, P.; Bisen, P.S. Nutritional and therapeutic potential of Spirulina. Curr. Pharm. Biotechnol. 2005, 6, 373–379. [CrossRef] [PubMed]
    • (2005) Curr. Pharm. Biotechnol. , vol.6 , pp. 373-379
    • Khan, Z.1    Bhadouria, P.2    Bisen, P.S.3
  • 16
    • 84924704454 scopus 로고    scopus 로고
    • Anti-inflammatory and immunomodulatory effects of Spirulina platensis in comparison to Dunaliella salina in acetic acid-induced rat experimental colitis
    • Abdeldaim, M.M.; Farouk, S.M.; Madkour, F.F.; Azab, S.S. Anti-inflammatory and immunomodulatory effects of Spirulina platensis in comparison to Dunaliella salina in acetic acid-induced rat experimental colitis. Immunopharmacol. Immunotoxicol. 2015, 37, 126–139. [CrossRef]
    • (2015) Immunopharmacol. Immunotoxicol. , vol.37 , pp. 126-139
    • Abdeldaim, M.M.1    Farouk, S.M.2    Madkour, F.F.3    Azab, S.S.4
  • 17
    • 0037883620 scopus 로고    scopus 로고
    • Protective effect of Spirulina on lead induced deleterious changes in the lipid peroxidation and endogenous antioxidants in rats
    • Upasan, C.D.; Balaraman, R. Protective effect of Spirulina on lead induced deleterious changes in the lipid peroxidation and endogenous antioxidants in rats. Phytother. Res. 2010, 17, 330–334. [CrossRef]
    • (2010) Phytother. Res. , vol.17 , pp. 330-334
    • Upasan, C.D.1    Balaraman, R.2
  • 18
    • 0035131562 scopus 로고    scopus 로고
    • Effect of lead with vitamin E, C, or Spirulina on malondialdehyde, conjugated dienes and hydroperoxides in rats
    • Upasani, C.D.; Khera, A.; Balarama, R. Effect of lead with vitamin E, C, or Spirulina on malondialdehyde, conjugated dienes and hydroperoxides in rats. Indian J. Exp. Biol. 2001, 39, 70–74.
    • (2001) Indian J. Exp. Biol. , vol.39 , pp. 70-74
    • Upasani, C.D.1    Khera, A.2    Balarama, R.3
  • 19
    • 0035210651 scopus 로고    scopus 로고
    • Chemo-and radio-protective effects of polysaccharide of Spirulina platensis on hemopoietic system of mice and dogs
    • Zhang, H.Q.; Lin, A.P.; Sun, Y.; Deng, Y.M. Chemo-and radio-protective effects of polysaccharide of Spirulina platensis on hemopoietic system of mice and dogs. Acta Pharmacol. Sin. 2001, 22, 1121–1124.
    • (2001) Acta Pharmacol. Sin. , vol.22 , pp. 1121-1124
    • Zhang, H.Q.1    Lin, A.P.2    Sun, Y.3    Deng, Y.M.4
  • 20
    • 0025167821 scopus 로고
    • Effects of Spirulina platensis on plasma lipoprotein lipase activity in fructose-induced hyperlipidemic rats
    • Iwata, K.; Inayama, T.; Kato, T. Effects of Spirulina platensis on plasma lipoprotein lipase activity in fructose-induced hyperlipidemic rats. J. Nutr. Sci. Vitaminol. 1990, 36, 165. [CrossRef]
    • (1990) J. Nutr. Sci. Vitaminol. , vol.36 , pp. 165
    • Iwata, K.1    Inayama, T.2    Kato, T.3
  • 21
    • 84876709311 scopus 로고    scopus 로고
    • Release of multifunctional peptides by gastrointestinal digestion of sea cucumber (Isostichopus badionotus)
    • Pérez-Vega, J.; Olivera-Castillo, A.L.; Gómez-Rui, J.Á.; Hernández-Ledesma, B. Release of multifunctional peptides by gastrointestinal digestion of sea cucumber (Isostichopus badionotus). J. Funct. Foods 2013, 5, 869–877. [CrossRef]
    • (2013) J. Funct. Foods , vol.5 , pp. 869-877
    • Pérez-Vega, J.1    Olivera-Castillo, A.L.2    Gómez-Rui, J.Á.3    Hernández-Ledesma, B.4
  • 22
    • 67349188030 scopus 로고    scopus 로고
    • Emerging role of PPAR ligands in the management of diabetic nephropathy
    • Balakumar, P.; Balakumar, M.; Arora, K.; Singh, M. Emerging role of PPAR ligands in the management of diabetic nephropathy. Pharmacol. Res. 2009, 60, 170–173. [CrossRef] [PubMed]
    • (2009) Pharmacol. Res. , vol.60 , pp. 170-173
    • Balakumar, P.1    Balakumar, M.2    Arora, K.3    Singh, M.4
  • 23
    • 34347333419 scopus 로고    scopus 로고
    • PPAR ligands: Are they potential agents for cardiovascular disorders?
    • Balakumar, P.; Rose, M.; Singh, M. PPAR ligands: Are they potential agents for cardiovascular disorders? Pharmacology 2007, 80, 1–10. [CrossRef] [PubMed]
    • (2007) Pharmacology , vol.80 , pp. 1-10
    • Balakumar, P.1    Rose, M.2    Singh, M.3
  • 25
    • 79951791240 scopus 로고    scopus 로고
    • Ginseng Leaf Extract Prevents High Fat Diet-Induced Hyperglycemia and Hyperlipidemia through AMPK Activation
    • Yuan, H.D.; Kim, S.J.; Quan, H.Y.; Im, B.O.; Chung, S.H.; Lee, K.H.; Cho, D.H.; Cho, J.Y. Ginseng Leaf Extract Prevents High Fat Diet-Induced Hyperglycemia and Hyperlipidemia through AMPK Activation. J. Ginseng. Res. 2010, 34, 369–375. [CrossRef]
    • (2010) J. Ginseng. Res. , vol.34 , pp. 369-375
    • Yuan, H.D.1    Kim, S.J.2    Quan, H.Y.3    Im, B.O.4    Chung, S.H.5    Lee, K.H.6    Cho, D.H.7    Cho, J.Y.8
  • 27
    • 82055164131 scopus 로고    scopus 로고
    • Gut microbiota and sirtuins in obesity-related inflammation and bowel dysfunction
    • Lakhan, S.E.; Kirchgessner, A. Gut microbiota and sirtuins in obesity-related inflammation and bowel dysfunction. J. Transl. Med. 2011, 9, 202–208. [CrossRef] [PubMed]
    • (2011) J. Transl. Med. , vol.9 , pp. 202-208
    • Lakhan, S.E.1    Kirchgessner, A.2
  • 28
    • 84983784787 scopus 로고    scopus 로고
    • Linking Gut Microbiota and Inflammation to Obesity and Insulin Resistance
    • Saad, M.J.; Santos, A.; Prada, P.O. Linking Gut Microbiota and Inflammation to Obesity and Insulin Resistance. Physiology 2016, 31, 283–293. [CrossRef] [PubMed]
    • (2016) Physiology , vol.31 , pp. 283-293
    • Saad, M.J.1    Santos, A.2    Prada, P.O.3
  • 29
    • 77950669604 scopus 로고    scopus 로고
    • The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice
    • Turnbaugh, P.J.; Ridaura, V.K.; Faith, J.J.; Rey, F.E.; Knight, R.; Gordon, J.I. The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice. Sci. Transl. Med. 2009, 1, 6. [CrossRef] [PubMed]
    • (2009) Sci. Transl. Med. , vol.1 , Issue.6
    • Turnbaugh, P.J.1    Ridaura, V.K.2    Faith, J.J.3    Rey, F.E.4    Knight, R.5    Gordon, J.I.6
  • 30
    • 84879200325 scopus 로고    scopus 로고
    • LC-MS/MS coupled with QSAR modeling in characterising of angiotensin I-converting enzyme inhibitory peptides from soybean proteins
    • Gu, Y.; Wu, J. LC-MS/MS coupled with QSAR modeling in characterising of angiotensin I-converting enzyme inhibitory peptides from soybean proteins. Food Chem. 2013, 141, 2682–2690. [CrossRef] [PubMed]
    • (2013) Food Chem , vol.141 , pp. 2682-2690
    • Gu, Y.1    Wu, J.2
  • 32
    • 84902094667 scopus 로고    scopus 로고
    • Sasa borealis stem extract attenuates hepatic steatosis in high-fat diet-induced obese rats
    • Song, Y.; Lee, S.J.; Jang, S.H.; Ji, H.H.; Song, Y.M.; Ko, Y.G.; Kim, H.D.; Min, W.; Kang, S.N.; Cho, J.H. Sasa borealis stem extract attenuates hepatic steatosis in high-fat diet-induced obese rats. Nutrients 2014, 6, 2179–2195. [CrossRef] [PubMed]
    • (2014) Nutrients , vol.6 , pp. 2179-2195
    • Song, Y.1    Lee, S.J.2    Jang, S.H.3    Ji, H.H.4    Song, Y.M.5    Ko, Y.G.6    Kim, H.D.7    Min, W.8    Kang, S.N.9    Cho, J.H.10
  • 35
    • 41349090882 scopus 로고    scopus 로고
    • Anti-obesity and hypolipidemic effects of a proprietary herb and fiber combination (S&S PWH) in rats fed high-fat diet
    • Woo, M.N.; Bok, S.H.; Lee, M.K.; Kim, H.J.; Jeon, S.M.; Do, J.M.; Shin, S.K.; Ha, T.Y.; Choi, M.S. Anti-obesity and hypolipidemic effects of a proprietary herb and fiber combination (S&S PWH) in rats fed high-fat diet. J. Med. Food 2008, 11, 169–178. [CrossRef] [PubMed]
    • (2008) J. Med. Food , vol.11 , pp. 169-178
    • Woo, M.N.1    Bok, S.H.2    Lee, M.K.3    Kim, H.J.4    Jeon, S.M.5    Do, J.M.6    Shin, S.K.7    Ha, T.Y.8    Choi, M.S.9
  • 36
    • 84867626746 scopus 로고    scopus 로고
    • Endothelins reciprocally regulate VEGF-A and angiopoietin-1 production in cultured rat astrocytes: Implications on astrocytic proliferation
    • Koyama, Y.; Maebara, Y.; Hayashi, M.; Nagae, R.; Tokuyama, S.; Michinaga, S. Endothelins reciprocally regulate VEGF-A and angiopoietin-1 production in cultured rat astrocytes: Implications on astrocytic proliferation. Glia 2012, 60, 1954–1963. [CrossRef]
    • (2012) Glia , vol.60 , pp. 1954-1963
    • Koyama, Y.1    Maebara, Y.2    Hayashi, M.3    Nagae, R.4    Tokuyama, S.5    Michinaga, S.6
  • 39
    • 85027969279 scopus 로고    scopus 로고
    • Pre-procedural neutrophil-to-lymphocyte ratio and long-term cardiac outcomes after percutaneous coronary intervention for stable coronary artery disease
    • Wada, H.; Dohi, T.; Miyauchi, K.; Shitara, J.; Endo, H.; Doi, S.; Konishi, H.; Naito, R.; Tsuboi, S.; Ogita, M. et al. Pre-procedural neutrophil-to-lymphocyte ratio and long-term cardiac outcomes after percutaneous coronary intervention for stable coronary artery disease. Atherosclerosis 2017, 265, 35–40. [CrossRef] [PubMed]
    • (2017) Atherosclerosis , vol.265 , pp. 35-40
    • Wada, H.1    Dohi, T.2    Miyauchi, K.3    Shitara, J.4    Endo, H.5    Doi, S.6    Konishi, H.7    Naito, R.8    Tsuboi, S.9    Ogita, M.10
  • 40
    • 34347384676 scopus 로고    scopus 로고
    • Improvement of obesity and glucose tolerance by acetate in Type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats
    • Yamashita, H.; Fujisawa, K.; Ito, E.; Idei, S.; Kawaguchi, N.; Kimoto, M.; Hiemori, M.; Tsuji, H. Improvement of obesity and glucose tolerance by acetate in Type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Biosci. Biotechnol. Biochem. 2007, 71, 1236–1243. [CrossRef]
    • (2007) Biosci. Biotechnol. Biochem. , vol.71 , pp. 1236-1243
    • Yamashita, H.1    Fujisawa, K.2    Ito, E.3    Idei, S.4    Kawaguchi, N.5    Kimoto, M.6    Hiemori, M.7    Tsuji, H.8
  • 41
    • 33645828659 scopus 로고    scopus 로고
    • Lipid Metabolism and Liver Inflammation. II. Fatty liver disease and fatty acid oxidation
    • Reddy, J.K.; Rao, M.S. Lipid Metabolism and Liver Inflammation. II. Fatty liver disease and fatty acid oxidation. Am. J. Physiol. 2006, 290, 852–858. [CrossRef] [PubMed]
    • (2006) Am. J. Physiol. , vol.290 , pp. 852-858
    • Reddy, J.K.1    Rao, M.S.2
  • 42
    • 76749122292 scopus 로고    scopus 로고
    • Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice
    • Cho, A.S.; Jeon, S.M.; Kim, M.J.; Yeo, J.; Seo, K.I.; Choi, M.S.; Lee, M.K. Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice. Food Chem. Toxicol. 2010, 48, 937–943. [CrossRef]
    • (2010) Food Chem. Toxicol. , vol.48 , pp. 937-943
    • Cho, A.S.1    Jeon, S.M.2    Kim, M.J.3    Yeo, J.4    Seo, K.I.5    Choi, M.S.6    Lee, M.K.7
  • 43
    • 35148852985 scopus 로고    scopus 로고
    • Potential anti-obesity and lipid lowering natural products: A review
    • Bhutani, K.K.; Birari, R.B.; Kapat, K. Potential anti-obesity and lipid lowering natural products: A review. Nat. Prod. Commun. 2007, 2, 331–348.
    • (2007) Nat. Prod. Commun. , vol.2 , pp. 331-348
    • Bhutani, K.K.1    Birari, R.B.2    Kapat, K.3
  • 44
    • 77954266995 scopus 로고    scopus 로고
    • Spirulina prevents atherosclerosis by reducing hypercholesterolemia in rabbits fed a high-cholesterol diet
    • Sunhee, C.; Miyeon, K.; Daieun, S. Spirulina prevents atherosclerosis by reducing hypercholesterolemia in rabbits fed a high-cholesterol diet. Sci. Vitaminol. 2010, 56, 34–40. [CrossRef]
    • (2010) Sci. Vitaminol. , vol.56 , pp. 34-40
    • Sunhee, C.1    Miyeon, K.2    Daieun, S.3
  • 45
    • 84880510921 scopus 로고    scopus 로고
    • Antiobesity and lipid lowering effects of theaflavins on high-fat diet induced obese rats
    • Jin, D.; Xu, Y.; Mei, X.; Meng, Q.; Gao, Y.; Li, B. Antiobesity and lipid lowering effects of theaflavins on high-fat diet induced obese rats. J. Funct. Foods 2013, 5, 1142–1150. [CrossRef]
    • (2013) J. Funct. Foods , vol.5 , pp. 1142-1150
    • Jin, D.1    Xu, Y.2    Mei, X.3    Meng, Q.4    Gao, Y.5    Li, B.6
  • 46
    • 38449100865 scopus 로고    scopus 로고
    • Antihyperlipemic and antihypertensive effects of Spirulina maximain an open sample of mexican population: A preliminary report
    • Torres-Duran, P.V.; Aldo, F.H.; Juarez-Oropeza, M.A. Antihyperlipemic and antihypertensive effects of Spirulina maximain an open sample of mexican population: A preliminary report. Lipids Health Dis. 2007, 6, 33. [CrossRef] [PubMed]
    • (2007) Lipids Health Dis , vol.6 , pp. 33
    • Torres-Duran, P.V.1    Aldo, F.H.2    Juarez-Oropeza, M.A.3
  • 47
    • 0028073940 scopus 로고
    • Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia
    • Singh, R.B.; Niaz, M.A.; Ghosh, S. Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovasc. Drugs Ther. 1994, 8, 659–664. [CrossRef]
    • (1994) Cardiovasc. Drugs Ther. , vol.8 , pp. 659-664
    • Singh, R.B.1    Niaz, M.A.2    Ghosh, S.3
  • 48
    • 78549288841 scopus 로고    scopus 로고
    • Antiobesity and lipid lowering effects of Murraya koenigii (L.) Spreng leaves extracts and mahanimbine on high fat diet induced obese rats
    • Birari, R.; Javia, V.; Bhutani, K.K. Antiobesity and lipid lowering effects of Murraya koenigii (L.) Spreng leaves extracts and mahanimbine on high fat diet induced obese rats. Fitoterapia 2010, 81, 1129–1133. [CrossRef]
    • (2010) Fitoterapia , vol.81 , pp. 1129-1133
    • Birari, R.1    Javia, V.2    Bhutani, K.K.3
  • 50
    • 79960556696 scopus 로고    scopus 로고
    • Piperidine alkaloids from Piper retrofractum Vahl. Protect against high-fat diet-induced obesity by regulating lipid metabolism and activating AMP-activated protein kinase
    • Kim, K.J.; Lee, M.S.; Jo, K.; Hwang, J.K. Piperidine alkaloids from Piper retrofractum Vahl. protect against high-fat diet-induced obesity by regulating lipid metabolism and activating AMP-activated protein kinase. Biochem. Biophys. Res. Commun. 2011, 411, 219–225. [CrossRef]
    • (2011) Biochem. Biophys. Res. Commun. , vol.411 , pp. 219-225
    • Kim, K.J.1    Lee, M.S.2    Jo, K.3    Hwang, J.K.4
  • 52
    • 0030907175 scopus 로고    scopus 로고
    • Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells
    • Shimano, H.; Horton, J.D.; Shimomura, I.; EHammer, R.; Brown, M.S.; Goldstein, J.L. Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J. Clin. Investig. 1997, 99, 846–854. [CrossRef] [PubMed]
    • (1997) J. Clin. Investig. , vol.99 , pp. 846-854
    • Shimano, H.1    Horton, J.D.2    Shimomura, I.3    Ehammer, R.4    Brown, M.S.5    Goldstein, J.L.6
  • 53
    • 78649475438 scopus 로고    scopus 로고
    • Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease
    • Yang, Z.X.; Shen, W.; Sun, H. Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease. Hepatol. Int. 2010, 4, 741–748. [CrossRef] [PubMed]
    • (2010) Hepatol. Int. , vol.4 , pp. 741-748
    • Yang, Z.X.1    Shen, W.2    Sun, H.3
  • 54
    • 82955170675 scopus 로고    scopus 로고
    • Auraptene regulates gene expression involved in lipid metabolism through PPARα activation in diabetic obese mice
    • Takahashi, N.; Senda, M.; Lin, S.; Goto, T.; Yano, M.; Sasaki, T.; Murakami, S.; Kawada, T. Auraptene regulates gene expression involved in lipid metabolism through PPARα activation in diabetic obese mice. Mol. Nutr. Food Res. 2011, 55, 1791–1797. [CrossRef] [PubMed]
    • (2011) Mol. Nutr. Food Res. , vol.55 , pp. 1791-1797
    • Takahashi, N.1    Senda, M.2    Lin, S.3    Goto, T.4    Yano, M.5    Sasaki, T.6    Murakami, S.7    Kawada, T.8
  • 55
    • 33645891166 scopus 로고    scopus 로고
    • Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARδ agonist, on development of steatohepatitis in mice fed a methionine-and choline-deficient diet
    • Nagasawa, T.; Inada, Y.; Nakano, S.; Tamura, T.; Takahashi, T.; Maruyama, K.; Yamazaki, Y.; Kuroda, J.; Shibata, N. Effects of bezafibrate, PPAR pan-agonist, and GW501516, PPARδ agonist, on development of steatohepatitis in mice fed a methionine-and choline-deficient diet. Eur. J. Pharmacol. 2006, 536, 182–191. [CrossRef] [PubMed]
    • (2006) Eur. J. Pharmacol. , vol.536 , pp. 182-191
    • Nagasawa, T.1    Inada, Y.2    Nakano, S.3    Tamura, T.4    Takahashi, T.5    Maruyama, K.6    Yamazaki, Y.7    Kuroda, J.8    Shibata, N.9
  • 56
    • 0036205326 scopus 로고    scopus 로고
    • Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux
    • EAkiyama, T.; Sakai, S.; Lambert, G. Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux. Mol. Cell. Biol. 2002, 22, 2607–2619. [CrossRef]
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 2607-2619
    • Eakiyama, T.1    Sakai, S.2    Lambert, G.3
  • 57
    • 79952693613 scopus 로고    scopus 로고
    • Regulation of hepatic metabolism by AMPK
    • Foretz, M.; Viollet, B. Regulation of hepatic metabolism by AMPK. J. Hepatol. 2011, 54, 827–829. [CrossRef] [PubMed]
    • (2011) J. Hepatol. , vol.54 , pp. 827-829
    • Foretz, M.1    Viollet, B.2
  • 58
    • 0030007427 scopus 로고    scopus 로고
    • ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism
    • Kim, J.B.; Spiegelman, B.M. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev. 1996, 10, 1096–1107. [CrossRef] [PubMed]
    • (1996) Genes Dev , vol.10 , pp. 1096-1107
    • Kim, J.B.1    Spiegelman, B.M.2
  • 59
    • 0032516081 scopus 로고    scopus 로고
    • ADD1/SREBP1 activates PPARγ through the production of endogenous ligand
    • Kim, J.B.; Wright, H.M.; Wright, M.; Spiegelman, B.M. ADD1/SREBP1 activates PPARγ through the production of endogenous ligand. Proc. Natl. Acad. Sci. USA 1998, 95, 4333–4337. [CrossRef]
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 4333-4337
    • Kim, J.B.1    Wright, H.M.2    Wright, M.3    Spiegelman, B.M.4
  • 60
    • 14844335666 scopus 로고    scopus 로고
    • Role of PPARgamma, transcriptional cofactors, and adiponectin in the regulation of nutrient metabolism, adipogenesis and insulin action: View from the chair
    • Berger, J.P. Role of PPARgamma, transcriptional cofactors, and adiponectin in the regulation of nutrient metabolism, adipogenesis and insulin action: View from the chair. Int. J. Obes. 2005, 29, S3. [CrossRef]
    • (2005) Int. J. Obes. , vol.29
    • Berger, J.P.1
  • 61
    • 0036183630 scopus 로고    scopus 로고
    • The mechanism of action of PPARs
    • Berger, J.; Moller, D.E. The mechanism of action of PPARs. Ann. Rev. Med. 2002, 53, 409–444. [CrossRef] [PubMed]
    • (2002) Ann. Rev. Med. , vol.53 , pp. 409-444
    • Berger, J.1    Moller, D.E.2
  • 62
    • 34249673987 scopus 로고    scopus 로고
    • Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice
    • Lei, F.; Zhang, X.N.; Zhang, W.; Wang, D.; Xie, W.; Su, H.; Du, L.J. Evidence of anti-obesity effects of the pomegranate leaf extract in high-fat diet induced obese mice. Int. J. Obes. 2007, 31, 1023. [CrossRef] [PubMed]
    • (2007) Int. J. Obes. , vol.31 , pp. 1023
    • Lei, F.1    Zhang, X.N.2    Zhang, W.3    Wang, D.4    Xie, W.5    Su, H.6    Du, L.J.7
  • 63
    • 80054770307 scopus 로고    scopus 로고
    • Pathways of liver injury in alcoholic liver disease
    • Herbert, T.; Moschen, A.R.; Kaneider, N.C. Pathways of liver injury in alcoholic liver disease. J. Hepatol. 2011, 55, 1159–1161. [CrossRef]
    • (2011) J. Hepatol. , vol.55 , pp. 1159-1161
    • Herbert, T.1    Moschen, A.R.2    Kaneider, N.C.3
  • 64
    • 84994666611 scopus 로고    scopus 로고
    • Diet, gut microbes, and the pathogenesis of inflammatory bowel diseases
    • Dolan, K.T.; Chang, E.B. Diet, gut microbes, and the pathogenesis of inflammatory bowel diseases. Mol. Nutr. Food Res. 2016, 61, 1–38. [CrossRef]
    • (2016) Mol. Nutr. Food Res. , vol.61 , pp. 1-38
    • Dolan, K.T.1    Chang, E.B.2
  • 66
    • 85021103800 scopus 로고    scopus 로고
    • Spirulina Protects against Hepatic Inflammation in Aging: An Effect Related to the Modulation of the Gut Microbiota?
    • Neyrinck, A.M.; Taminiau, B.; Walgrave, H.; Daube, G.; Cani, P.D.; Bindels, L.B.; Delzenne, N.M. Spirulina Protects against Hepatic Inflammation in Aging: An Effect Related to the Modulation of the Gut Microbiota? Nutrients 2017, 9, 633–642. [CrossRef]
    • (2017) Nutrients , vol.9 , pp. 633-642
    • Neyrinck, A.M.1    Taminiau, B.2    Walgrave, H.3    Daube, G.4    Cani, P.D.5    Bindels, L.B.6    Delzenne, N.M.7
  • 68
    • 84874672692 scopus 로고    scopus 로고
    • Intestinal microbiota containing Barnesiella species cures vancomycin-resistant Enterococcus faecium colonization
    • Ubeda, C. Intestinal microbiota containing Barnesiella species cures vancomycin-resistant Enterococcus faecium colonization. Infect. Immun. 2013, 81, 965–973. [CrossRef]
    • (2013) Infect. Immun. , vol.81 , pp. 965-973
    • Ubeda, C.1
  • 69
    • 84999006652 scopus 로고    scopus 로고
    • Dietary fucoidan improves metabolic syndrome in association with increased Akkermansia, population in the gut microbiota of high-fat diet-fed mice
    • Shang, Q.; Song, G.; Zhang, M.; Zhang, M.F.; Shi, J.; Xu, C.; Hao, J.; Li, G.; Yu, G. Dietary fucoidan improves metabolic syndrome in association with increased Akkermansia, population in the gut microbiota of high-fat diet-fed mice. J. Funct. Foods 2017, 28, 138–146. [CrossRef]
    • (2017) J. Funct. Foods , vol.28 , pp. 138-146
    • Shang, Q.1    Song, G.2    Zhang, M.3    Zhang, M.F.4    Shi, J.5    Xu, C.6    Hao, J.7    Li, G.8    Yu, G.9
  • 73
    • 85048987243 scopus 로고    scopus 로고
    • Ethanol extract of Ganoderma lucidum ameliorates lipid metabolic disorders and modulates the gut microbiota composition in high-fat diet fed rats
    • Guo, W.L.; Pan, Y.Y.; Li, L.; Li, T.T.; Lv, X.C. Ethanol extract of Ganoderma lucidum ameliorates lipid metabolic disorders and modulates the gut microbiota composition in high-fat diet fed rats. Food Funct. 2018, 1–9. [CrossRef] [PubMed]
    • (2018) Food Funct. , pp. 1-9
    • Guo, W.L.1    Pan, Y.Y.2    Li, L.3    Li, T.T.4    Lv, X.C.5
  • 74
    • 84886304011 scopus 로고    scopus 로고
    • Optimization of Chelation of Whey Protein Hydrolysate with Calcium Using Response Surface Method
    • Zhao, L.N.; Wang, S.Y.; Huang, S.L.; Huang, Y.F. Optimization of Chelation of Whey Protein Hydrolysate with Calcium Using Response Surface Method. Adv. Mater. Res. 2013, 781–784, 1856–1860. [CrossRef]
    • (2013) Adv. Mater. Res. , vol.781-784 , pp. 1856-1860
    • Zhao, L.N.1    Wang, S.Y.2    Huang, S.L.3    Huang, Y.F.4
  • 75
    • 60149085862 scopus 로고    scopus 로고
    • Evaluation of antioxidative and hypolipidemic properties of a novel functional diet formulation of Auricularia auricula and Hawthorn
    • Luo, Y.C.; Gang, C.; Bo, L.; Guo, Y.; Yetukuri, L.; VIslam, S.; Felin, J.; Perkins, R.; Borén, J.; Oresic, M.; et al. Evaluation of antioxidative and hypolipidemic properties of a novel functional diet formulation of Auricularia auricula and Hawthorn. Innov. Food Sci. Emerg. 2009, 10, 215–221. [CrossRef]
    • (2009) Innov. Food Sci. Emerg. , vol.10 , pp. 215-221
    • Luo, Y.C.1    Gang, C.2    Bo, L.3    Guo, Y.4    Yetukuri, L.5    Vislam, S.6    Felin, J.7    Perkins, R.8    Borén, J.9    Oresic, M.10
  • 76
    • 0015348189 scopus 로고
    • Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
    • Friedewald, W.T.; Levy, R.I. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 1972, 18, 499–505. [PubMed]
    • (1972) Clin. Chem. , vol.18 , pp. 499-505
    • Friedewald, W.T.1    Levy, R.I.2
  • 77
    • 85032688202 scopus 로고    scopus 로고
    • (−)-Epicatechin regulates blood lipids and attenuates hepatic steatosis in rats fed high-fat diet
    • Cheng, H.; Xu, N.; Zhao, W.; Su, J.; Lian, M.; Xie, Z.; Wu, X.; Li, Q. (−)-Epicatechin regulates blood lipids and attenuates hepatic steatosis in rats fed high-fat diet†. Mol. Nutr. Food Res. 2017, 61, 1700303. [CrossRef]
    • (2017) Mol. Nutr. Food Res. , vol.61
    • Cheng, H.1    Xu, N.2    Zhao, W.3    Su, J.4    Lian, M.5    Xie, Z.6    Wu, X.7    Li, Q.8
  • 78
    • 84992188248 scopus 로고    scopus 로고
    • Protective effects of saffron extract and crocin supplementation on fatty liver tissue of high-fat diet-induced obese rats
    • Mashmoul, M.; Azlan, A.; Mohtarrudin, N. Protective effects of saffron extract and crocin supplementation on fatty liver tissue of high-fat diet-induced obese rats. BMC Complem. Altern. M. 2016, 16, 401–405. [CrossRef]
    • (2016) BMC Complem. Altern. M. , vol.16 , pp. 401-405
    • Mashmoul, M.1    Azlan, A.2    Mohtarrudin, N.3
  • 79
    • 85037597990 scopus 로고    scopus 로고
    • Supplementation with Docosahexaenoic Acid and Extra Virgin Olive Oil Prevents Liver Steatosis Induced by a High-Fat Diet in Mice through PPAR-α and Nrf2 Upregulation with Concomitant SREBP-1c and NF-kB Downregulation
    • Hernándezrodas, M.C.; Valenzuela, R.; Echeverría, F.; Rincón-Cervera, M.Á.; Espinosa, A.; Illesca, P.; Muñoz, P.; Corbari, A.; Romero, N.; Gonzalez-Mañan, D.; et al. Supplementation with Docosahexaenoic Acid and Extra Virgin Olive Oil Prevents Liver Steatosis Induced by a High-Fat Diet in Mice through PPAR-α and Nrf2 Upregulation with Concomitant SREBP-1c and NF-kB Downregulation. Mol. Nutr. Food Res. 2017, 61, 456–469. [CrossRef]
    • (2017) Mol. Nutr. Food Res. , vol.61 , pp. 456-469
    • Hernándezrodas, M.C.1    Valenzuela, R.2    Echeverría, F.3    Rincón-Cervera, M.Á.4    Espinosa, A.5    Illesca, P.6    Muñoz, P.7    Corbari, A.8    Romero, N.9    Gonzalez-Mañan, D.10
  • 80
    • 84988526113 scopus 로고    scopus 로고
    • Effects of Ganoderma lucidum, polysaccharides on chronic pancreatitis and intestinal microbiota in mice
    • Li, K.; Zhuo, C.; Teng, C.; Yu, S.; Wang, X.; Hu, Y.; Ren, G.; Yu, M.; Qu, J. Effects of Ganoderma lucidum, polysaccharides on chronic pancreatitis and intestinal microbiota in mice. Int. J. Biol. Macromol. 2016, 93, 904–912. [CrossRef]
    • (2016) Int. J. Biol. Macromol. , vol.93 , pp. 904-912
    • Li, K.1    Zhuo, C.2    Teng, C.3    Yu, S.4    Wang, X.5    Hu, Y.6    Ren, G.7    Yu, M.8    Qu, J.9
  • 81
    • 84946082167 scopus 로고    scopus 로고
    • Comprehensive Meta-analysis of Ontology Annotated 16S rRNA Profiles Identifies Beta Diversity Clusters of Environmental Bacterial Communities
    • Henschel, A.; Anwar, M.Z.; Manohar, V. Comprehensive Meta-analysis of Ontology Annotated 16S rRNA Profiles Identifies Beta Diversity Clusters of Environmental Bacterial Communities. PLoS Comput. Biol. 2015, 11, e1004468. [CrossRef] [PubMed]
    • (2015) Plos Comput. Biol. , vol.11
    • Henschel, A.1    Anwar, M.Z.2    Manohar, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.