Protective effect of Spirulina on lead induced deleterious changes in the lipid peroxidation and endogenous antioxidants in rats

Phytotherapy Research

Volumn 17, Issue 4, 2003, Pages 330-334

  Upasani, C D ^a   Balaraman, R ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

Catalase; GSH; Lead acetate; MDA; SOD; Spirulina

Indexed keywords

ANTIOXIDANT; CATALASE; GLUTATHIONE; LEAD; MALONALDEHYDE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLUE GREEN ALGA; BRAIN; BRAIN PROTECTION; CONTROLLED STUDY; FEMALE; HEART PROTECTION; KIDNEY; LEAD POISONING; LIPID PEROXIDATION; LIVER; LIVER PROTECTION; LUNG; MALE; NONHUMAN; RAT; SPIRULINA; SPIRULINA FUSIFORMIS;

ANIMALS; ANTIOXIDANTS; BACTERIAL PROTEINS; BRAIN; CATALASE; FEMALE; GLUTATHIONE; KIDNEY; LIPID PEROXIDATION; LIVER; LUNG; MALE; MALONDIALDEHYDE; MYOCARDIUM; ORGANOMETALLIC COMPOUNDS; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, WISTAR; SPIRULINA; SUPEROXIDE DISMUTASE;

ANIMALIA; SPIRULINA;

EID: 0037883620     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1135     Document Type: Article

References (27)

1. Allen JR, McWey PJ, Suomi SJ. 1974. Pathological and behavioral effects of lead intoxication in the infant rhesus monkey. Environ Health Perspect 7: 239-246.
2. Brawn K, Fridovich I. 1980. Superoxide radical and superoxide dismutase: threat and defense. Acta Physiol Scand Suppl 492: 9-18.
3. Ding Y, Gonic HC, Vazini ND. 2000. Lead promotes hydroxyl radical generation and lipid peroxidation in cultured aortic endothelial cells. Am J Hypertens 15: 552-555.
4. El-Missiry MA. 2000. Prophylactic effect of melatonin on lead-induced inhibition of heme biosynthesis and deterioration of antioxidant systems in male rats. J Biochem Mol Toxicol 14: 57-62.
5. Garcia-Arenas G, Caludio L, Perez-Severiano F, Rios C. 1999. Lead acetate exposure inhibits nitric oxide synthase activity in capillary and synaptosomal fractions of mouse brain. Toxicol Sci 50: 244-258.
6. Gelman BB, Michaelson IA. 1979. Neonatal lead toxicity and in vivo lipid peroxidation of rat brain. J Toxicol Environ Health 5: 671-682.
7. Goyer RA. 1993. Lead toxicity: current concerns. Environ Health Perspect 140: 177-187.
8. Greenberg AE, Clesceri LS, Eaton AD. 1992. Standard Methods, 18th edn. American Public Health Association: Washington, 3-5.
9. Gurer H, Ozgunes H, Neal R, Spitz DR, Ercal NC. 1998. Anti-oxidant effect of N-acetyl cysteine and succimer in red blood cells from lead-exposed rats. Toxicology 128: 181-189.
10. Hammond PB. 1971. The effect of chelating agents on the tissue distribution and excretion of lead. Toxicol Appl Pharmcol 18:296-310.
11. MamEation JW. 1990. Is catalase really important? Free Rad Biol Med 9: 132.
12. Meister A, Anderson ME. 1983. Glutathione. Ann Rev Biochem 52: 711-760.
13. Mano M, Lucchi I, Spano PF, Trabucchi M. 1980. Lack of correlation between neurochemical and behavioral effects induced by D-amphetamine in chronically lead treated rats. Neuropharmacology 19: 795-799.
14. Misra HP, Fridovich I. 1972. The role of superoxide anion in the autoxidation of epinephrine and a simple assay of superoxide dismutase. J Biol Chem 247: 3170-3175.
15. Monterio HP, Abdalla DSP, Augusto O, Bechar EJH. 1989. Free radical generation during delta amino laevulinic acid autoxidation: Induction by hemoglobin and connection with poryphyringathins. Arch Biochem Biophys 271: 206-261.
16. Moran MS, Defierre JW, Mannervik B. 1979. Levels of glutathione reductase and glutathione-s-transferase activities in rat lung and liver. Biochem Biophys Acta 582: 67-78.
17. Nicholls A. 1965. Activities of catalase in red cell. Biochem Biophys Acta 99: 286-297.
18. Orrenius S, Moldeus P. 1984. The multiple role of glutathione in drug metabolism. Trends Pharmac Sci 5: 432.
19. Patra RC, Swarup D. 2000. Effect of lead on erythrocytic anti- oxidant defense lipid peroxide levels and thiol groups in calves. Res Vet Sci 68: 71-74.
20. Quinlan GJ, Halliwell B, Moorhouse CP, Gutteridge JMC. 1988. Action of lead (II) and aluminium (III) ions on iron stimulated lipid peroxidation in liposomes erythrocytes and rat liver microsomal fractions. Biochem Biophys Acta 962: 196-200.
21. Schroeder HA, Vinton WH Jr, Balassa JJ. 1963. Effect of chromium cadmium and other metals on the growth and survival of mice. J Nutr 80: 39-47.
22. Shastri D, Kumar M, Kumar A. 1999. Modulations of lead toxicity by Spirulina. Phytother Res 13: 258-260.
23. Silbergeld EK, Goldberg AM. 1975. Pharmacological and neurological investigations of lead induced activity. Neuropharmacology 14: 431-444.
24. Sinha AK. 1972. Colorimetric assay of catalase. Anal Biochem 47: 389-394.
25. Six KM, Goyer RA. 1970. Experimental enhancement of lead toxicity by low dietary calcium. J Lab Clin Med 76: 933-942.
26. Slater TF, Sawyer BC. 1971. The stimulatory effect of carbon tetrachloride and other halogenoalkanes on peroxidative reactions in rat liver fractions in vitro. Biochem J 123: 805-814.
27. Uma S, Ramakrishnan CU. 1983. Studies on polyphosphoinositides in developing rat brain. J Neurochem 50: 914-916.