Luteolin attenuates hepatic steatosis and insulin resistance through the interplay between the liver and adipose tissue in mice with diet-induced obesity

Diabetes

Volumn 64, Issue 5, 2015, Pages 1658-1669

  Kwon, Eun Young ^a   Jung, Un Ju ^a   Park, Taesun ^b   Yun, Jong Won ^c   Choi, Myung Sook ^a  

^a Kyungpook National University   (South Korea)

^b Yonsei University   (South Korea)

^c Daegu University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ALANINE AMINOTRANSFERASE; APOLIPOPROTEIN A1; APOLIPOPROTEIN B100; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL ACYLTRANSFERASE; CHYLOMICRON REMNANT; FAT DROPLET; FATTY ACID SYNTHASE; FECES LIPID; GLUCOKINASE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTAMIC ACID; GLUTAMINE; GLYCOGEN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INSULIN; LOW DENSITY LIPOPROTEIN RECEPTOR; LUTEOLIN; MALATE DEHYDROGENASE (DECARBOXYLATING); PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDATE PHOSPHATASE; PHOSPHATIDYLCHOLINE; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRIACYLGLYCEROL; VALINE; FAT INTAKE; LIPID;

ADIPOSE TISSUE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET INDUCED OBESITY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; FATTY LIVER; GENE REPRESSION; GLUCOSE BLOOD LEVEL; IN VIVO STUDY; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID ABSORPTION; LIPID LIVER LEVEL; LIPOGENESIS; LIPOPROTEIN BLOOD LEVEL; LIPOTOXICITY; LIVER FUNCTION; LIVER METABOLISM; MALE; METABOLIC INHIBITION; METABOLOMICS; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE LEVEL; TRANSCRIPTOMICS; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; ADVERSE EFFECTS; ANATOMY AND HISTOLOGY; ANIMAL; BLOOD; C57BL MOUSE; CHEMISTRY; DRUG EFFECTS; FAT INTAKE; FECES; LIPID METABOLISM; LIVER; METABOLISM; OBESITY; ORGAN SIZE; PHYSIOLOGY; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE; ADIPOSE TISSUE, WHITE; ANIMALS; DIETARY FATS; FATTY LIVER; FECES; INSULIN RESISTANCE; LIPID METABOLISM; LIPIDS; LIVER; LUTEOLIN; MALE; MICE; MICE, INBRED C57BL; OBESITY; ORGAN SIZE;

EID: 84933532941     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-0631     Document Type: Article

References (36)

1. Knobler H, Schattner A, Zhornicki T, et al. Fatty liver- An additional and treatable feature of the insulin resistance syndrome. QJM 1999;92:73-79.
2. Bugianesi E, Pagotto U, Manini R, et al. Plasma adiponectin in nonalcoholic fatty liver is related to hepatic insulin resistance and hepatic fat content, not to liver disease severity. J Clin Endocrinol Metab 2005;90:3498-3504.
3. Greenberg AS, Obin MS. Obesity and the role of adipose tissue in inflammation and metabolism. Am J Clin Nutr 2006;83:461S-465S.
4. Kabir M, Catalano KJ, Ananthnarayan S, et al. Molecular evidence supporting the portal theory: A causative link between visceral adiposity and hepatic insulin resistance. Am J Physiol Endocrinol Metab 2005;288:E454- E461.
5. Lomonaco R, Ortiz-Lopez C, Orsak B, et al. Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease. Hepatology 2012;55:1389- 1397.
6. Kim SH, Shin KJ, Kim D, et al. Luteolin inhibits the nuclear factor-k B transcriptional activity in Rat-1 fibroblasts. Biochem Pharmacol 2003;66: 955-963.
7. Lim Y, Jeong Y, Tyner AL, Park JHY. Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin. Am J Physiol Gastrointest Liver Physiol 2007;292:G66-G75.
8. Zhou P, Li LP, Luo SQ, Jiang HD, Zeng S. Intestinal absorption of luteolin from peanut hull extract is more efficient than that from individual pure luteolin. J Agric Food Chem 2008;56:296-300.
9. Jang S, Dilger RN, Johnson RW. Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice. J Nutr 2010;140: 1892-1898.
10. Lee EJ, Oh SY, Sung MK. Luteolin exerts anti- Tumor activity through the suppression of epidermal growth factor receptor-mediated pathway in MDA-MB-231 ER-negative breast cancer cells. Food Chem Toxicol 2012;50: 4136-4143.
11. Kang KP, Park SK, Kim DH, et al. Luteolin ameliorates cisplatin-induced acute kidney injury in mice by regulation of p53-dependent renal tubular apoptosis. Nephrol Dial Transplant 2011;26:814-822.
12. Kim TH, Jung JW, Ha BG, et al. The effects of luteolin on osteoclast differentiation, function in vitro and ovariectomy-induced bone loss. J Nutr Biochem 2011;22:8-15.
13. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957;226: 497-509.
14. Shao R, Ring SC, Tarloff JB. Coincubation of rat renal proximal tubules with hepatic subcellular fractions potentiates the effects of para- Aminophenol. Fundam Appl Toxicol 1997;39:101-108.
15. Rudack D, Chisholm EM, Holten D. Rat liver glucose 6-phosphate dehydrogenase. Regulation by carbohydrate diet and insulin. J Biol Chem 1971; 246:1249-1254.
16. Lazarow PB. Assay of peroxisomal beta-oxidation of fatty acids. Methods Enzymol 1981;72:315-319.
17. Ochoa S. Methods Enzymology. Colowick SP, Kaplan NO, Eds. New York, Academic Press, 1955, p. 323-326.
18. Walton PA, Possmayer F. Mg2-dependent phosphatidate phosphohydrolase of rat lung: development of an assay employing a defined chemical substrate which reflects the phosphohydrolase activity measured using membrane-bound substrate. Anal Biochem 1985;151:479-486.
19. Shapiro DJ, Nordstrom JL, Mitschelen JJ, Rodwell VW, Schimke RT. Micro assay for 3-hydroxy-3-methylglutaryl-CoA reductase in rat liver and in L-cell fibroblasts. Biochim Biophys Acta 1974;370:369-377.
20. Gillies PJ, Rathgeb KA, Perri MA, Robinson CS. Regulation of acyl-CoA: cholesterol acyltransferase activity in normal and atherosclerotic rabbit aortas: Role of a cholesterol substrate pool. Exp Mol Pathol 1986;44:329- 339.
21. Alegre M, Ciudad CJ, Fillat C, Guinovart JJ. Determination of glucose-6- phosphatase activity using the glucose dehydrogenase-coupled reaction. Anal Biochem 1988;173:185-189.
22. Davidson AL, Arion WJ. Factors underlying significant underestimations of glucokinase activity in crude liver extracts: physiological implications of higher cellular activity. Arch Biochem Biophys 1987;253: 156-167.
23. Bentle LA, Lardy HA. Interaction of anions and divalent metal ions with phosphoenolpyruvate carboxykinase. J Biol Chem 1976;251:2916- 2921.
24. Seifter S, Dayton S, Muntwyler N, Muntwyler E. The estimation of glycogen with the anthrone reagent. Arch Biochem 1950;25:191-200.
25. Wolff SP. Ferrous ion oxidation in presence of ferric ion indicator xylenol orange for measurement of hydroperoxides. Methods Enzymol 1994;233: 182-189.
26. Do GM, Kwon EY, Kim E, Kim HS, Choi MS. Hepatic transcription response to high-fat treatment in mice: microarray comparison of individual vs. pooled RNA samples. Biotechnol J 2010;5:970-973.
27. Schmittgen TD, Livak KJ. Analyzing real- Time PCR data by the comparative C(T) method. Nat Protoc 2008;3:1101-1108.
28. Park HJ, Jung UJ, Lee MK, et al. Modulation of lipid metabolism by polyphenolrich grape skin extract improves liver steatosis and adiposity in high fat fed mice. Mol Nutr Food Res 2013;57:360-364.
29. Zhou L, Xu L, Ye J, et al. Cidea promotes hepatic steatosis by sensing dietary fatty acids. Hepatology 2012;56:95-107.
30. Heid HW, Moll R, Schwetlick I, Rackwitz HR, Keenan TW. Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases. Cell Tissue Res 1998;294:309-321.
31. Chen Z, Newberry EP, Norris JY, et al. ApoB100 is required for increased VLDL- Triglyceride secretion by microsomal triglyceride transfer protein in ob/ob mice. J Lipid Res 2008;49:2013-2022.
32. Huff MW, Telford DE, Barrett PH, Billheimer JT, Gillies PJ. Inhibition of hepatic ACAT decreases ApoB secretion in miniature pigs fed a cholesterol-free diet. Arterioscler Thromb 1994;14:1498-1508.
33. Wu CW, Chu ES, Lam CN, et al. PPARgamma is essential for protection against nonalcoholic steatohepatitis. Gene Ther 2010;17:790-798.
34. Valverde AM, Burks DJ, Fabregat I, et al. Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes. Diabetes 2003;52:2239-2248.
35. Walker AK, Jacobs RL, Watts JL, et al. A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Cell 2011;147: 840-852.
36. Tsunekawa S, Demozay D, Briaud I, et al. FoxO feedback control of basal IRS-2 expression in pancreatic b-cells is distinct from that in hepatocytes. Diabetes 2011;60:2883-2891.