The methanolic extract of Thymus praecox subsp. skorpilii var. skorpilii restores glucose homeostasis, ameliorates insulin resistance and improves pancreatic β-cell function on streptozotocin/nicotinamide-induced type 2 diabetic rats

Journal of Ethnopharmacology

Volumn 231, Issue , 2019, Pages 29-38

  Cam, Muhammet Emin ^a,b   Hazar Yavuz, Ayse Nur ^a   Yildiz, Sila ^a   Ertas, Busra ^a   Ayaz Adakul, Betul ^a   Taskin, Turgut ^a   Alan, Saadet ^c   Kabasakal, Levent ^a  

^a MARMARA UNIVERSITY   (Turkey)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c INONU UNIVERSITY   (Turkey)

Author keywords

AMPK; Diabetes; GLUTs; Inflammation; Medicinal plants; Metabolism; SGLTs; STZ NA; Thymus praecox

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ALPHA GLUCOSIDASE; ANTIDIABETIC AGENT; FATTY ACID; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 2; HEXOKINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; METFORMIN; METHANOL; NICOTINAMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PLANT EXTRACT; SODIUM GLUCOSE COTRANSPORTER; STREPTOZOCIN; THYMUS PRAECOX SKORPILII EXTRACT; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; CYTOKINE; SOLVENT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; ATROPHY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ELECTRIC POTENTIAL; FATTY ACID LEVEL; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HISTOPATHOLOGY; INFLAMMATION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID METABOLISM; MEDICINAL PLANT; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS; PANCREAS CELL; PANCREAS ISLET; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; THYMUS PRAECOX SUBSP SKORPILII VAR SKORPILII; AERIAL PLANT PART; ANIMAL; BLOOD; CHEMISTRY; EXPERIMENTAL DIABETES MELLITUS; HOMEOSTASIS; METABOLISM; PANCREAS ISLET BETA CELL; PHYTOTHERAPY; SPRAGUE DAWLEY RAT; THYMUS (PLANT);

ANIMALS; CYTOKINES; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; FEMALE; GLUCOSE; HOMEOSTASIS; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; METHANOL; PHYTOTHERAPY; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; RATS, SPRAGUE-DAWLEY; SOLVENTS; THYMUS PLANT;

EID: 85056621529     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2018.10.028     Document Type: Article

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