Comparative hypoglycemic activity of different fractions of Thymus serpyllum L. in alloxan induced diabetic rabbits

Pakistan Journal of Pharmaceutical Sciences

Volumn 29, Issue 5, 2016, Pages 1483-1488

  Alamgeer, ^a   Mushtaq, Muhammad Naveed ^a   Bashir, Sajid ^a   Ullah, Ikram ^b   Karim, Sabeha ^c   Rashid, Muhammad ^b   Malik, Muhammad Nasir Hayat ^a   Haroon Ur Rashid, ^a  

^a UNIVERSITY OF SARGODHA   (Pakistan)

^b UNIVERSITY OF FAISALABAD   (Pakistan)

^c UNIVERSITY OF THE PUNJAB   (Pakistan)

Author keywords

Aqueous extract; Blood glucose level; Insulin; Thymus serpyllum L

Indexed keywords

ACARBOSE; ALKALOID DERIVATIVE; ANTIDIABETIC AGENT; CARBOHYDRATE DERIVATIVE; CARDIAC GLYCOSIDE; ETHER; FLAVONOID; GLIBENCLAMIDE; GLUCOSE; HEMOGLOBIN; HEMOGLOBIN A1C; INSULIN; PLANT EXTRACT; TANNIN DERIVATIVE; TERPENOID DERIVATIVE; THYMUS SERPYLLUM EXTRACT; UNCLASSIFIED DRUG; WATER; ALLOXAN; BIOLOGICAL MARKER; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN; SOLVENT;

ADULT; ALLOXAN-INDUCED DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DRUG DOSAGE FORM COMPARISON; DRUG POTENTIATION; DRUG SCREENING; FEMALE; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; MALE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; RABBIT; THYMUS (PLANT); THYMUS SERPYLLUM; ANIMAL; BLOOD; CHEMICALLY INDUCED; CHEMISTRY; COMPARATIVE STUDY; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; FRACTIONATION; GLUCOSE TOLERANCE TEST; ISOLATION AND PURIFICATION; MEDICINAL PLANT; METABOLISM; PHYTOTHERAPY; RABBITS AND HARES; TIME FACTOR;

ALLOXAN; ANIMALS; BIOMARKERS; BLOOD GLUCOSE; CHEMICAL FRACTIONATION; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; GLUCOSE TOLERANCE TEST; HEMOGLOBIN A, GLYCOSYLATED; HYPOGLYCEMIC AGENTS; INSULIN; MALE; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; RABBITS; SOLVENTS; THYMUS PLANT; TIME FACTORS;

EID: 84989905338     PISSN: 1011601X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Ahmad M, Alamgeer and Sharif T (2009). A potential adjunct to insulin: Berberis lycium Royle.Diabetologia. Croatica., 38(1): 13-18.
2. Akhtar MS, Khan MA and Malik MT (2002).Hypoglycemic activity of Alpinia galangal rhizome and its extracts in rabbits. Fitoterapia, 73: 623-628.
3. Alamgeer, Mushtaq MN, Bashir S, Rashid M, Malik MNH, Ghumman SA, Irfan HM, Akram M, Khan AQ and Haroon-Ur-Rashid (2012). Hypoglycemic and hematological effects of aqueous extract of Thymus serpyllum Linn. in alloxan-induced diabetic rabbits.Afr. J. Pharm. Pharmacol., 6 (40): 2845-2850.
4. Andrade-Cetto A and Heinrich M (2005). Mexican plants with Hypoglycaemic effect used in the treatment of diabetes. J. Ethnopharmacol., 99: 325-348.
5. Charkravarthy BK, Gupta S, Gambir SS and Gode KD (1980). Pancreatic beta cell regeneration. A novel antidiabetic mechanism of Pterocarpus marsupium Roxb. Ind. J. Pharmacol., 12: 123-127.
6. Gholamhoseinian A, Fallah H, Sharifi-far F and Mirtajaddini M (2008). The inhibitory effect of some iranian plants extracts on the alpha glucosidase. Iran. J.Basic. Med. Sci., 11: 1-9.
7. Home P, Mant J and Turner C (2008). Management of Type 2 diabetes: Summary of updated NICE guidance.Br. Med. J., 336: 1306-1308.
8. Inwukaeme DN, Ikueybvweha TB and Asonye CC (2007). Evaluation of phytochemical constituents, antibacterial activities and effects of exhudates of Pcycanthus angolensis Weld Warb (Myrtacaceae) on corneal ulcer in rabbits. Trop. Med. J. Pharm. Res., 6: 725-730.
9. Jayaramin R, Shivakumar A, Anitha T, Joshi VD and Palei N (2009). Antidiabetic effect of petroleum ether extract of Citrullus colocynthis fruits against streptozotocininduced hyperglycemic rats. Rom. J. Biol. Plant. Biol., 54(2): 127-134.
10. Knowler WC, Connor BE and Fowler CE (2002).Diabetes prevention program research group.Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med., 346: 393-403.
11. Loew D and Kaszkin M (2002). Approaching the problems of bioequivalence of herbal medicinal products. Phytother. Res., 16: 705-711.
12. Malviya N, Jain S and Malviya S (2010). Antidiabetic potential of medicinal plants. Acta. Pol. Pharm. 67(2): 113-118.
13. Mbaka GO, Adeyemi OO, Anunobi CC, Noronha CC and Okanlawon OA (2006). Anti hyperglycaemic effects of ethanol leaf extract of sphenocentrum jollyanum in normal and alloxan-induced diabetic rabbits. Global. J.Pharmacol., 2(3): 46-51.
14. Pandey MC, Sharma JR and Dikshit AJ (1996).Antifungal evaluation of the essential oil of Cymbopogon pendulus. Flavour and Fragrance J., 11: 257-260.
15. Patel DK, Prasad SK, Kumar R and Hemalatha S (2012).An Overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac. J. Trop. Biomed., 2(4): 320-330.
16. Perfumi M, Arnold N and Tacconi (1991).Hypoglycaemic Activity of Salvia fruticosa Mill from Cyprus. J. Ethnopharmacol., 34: 135-140.
17. Qureshi LR (2007). Ethnobotanical Studies of Selected Medicinal Plants of Sudhan Gali and Ganga Chotti Hills, District, Azad Kashmir. Pak. J. Bot., 39(7): 2275-2283.
18. Sell DR, Lapolla A, Odetti P, Forgarty J and Monnier VM (1992). Pentosidine formation in skin correlates with severity of complication in individuals with long standing IDDM. Diabetes, 41: 1286-1292.
19. Signorini AM, Fondelli C, Renzoni E, Puccetti C, Gragnoli G and Giorgi G (2002). Antioxidant effect of gliclazide, glibenclamide and metformin in patients with type 2 diabetes mellitus. Curr. Ther. Res., 63: 411-420.
20. Szkudelski T (2001). The mechanism of Alloxan and Streptozotocin action in ß-cells of the rat pancreas.Physiol. Res., 50: 537-546.