Methanolic leaf exctract of Otostegia integrifolia Benth reduces blood glucose levels in diabetic, glucose loaded and normal rodents

BMC Complementary and Alternative Medicine

Volumn 15, Issue 1, 2015, Pages

  Shewamene, Zewdneh ^a   Abdelwuhab, Mohammedberhan ^a   Birhanu, Zewdu ^a  

^a UNIVERSITY OF GONDAR   (Ethiopia)

Author keywords

Diabetes mellitus; Ethiopia; Mice; Otostegia integrifolia; Rats; Streptozotoicn

Indexed keywords

ANTIDIABETIC AGENT; GLIBENCLAMIDE; GLUCOSE; OTOSTEGIA INTEGRIFOLIA EXTRACT; PLANT EXTRACT; POLYSORBATE 80; STREPTOZOCIN; UNCLASSIFIED DRUG; GLUCOSE BLOOD LEVEL;

ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; MALE; MEDICINAL PLANT; MOUSE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; OTOSTEGIA INTEGRIFOLIA; PHYTOCHEMISTRY; PLANT LEAF; RAT; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; TOXICITY TESTING; TREATMENT OUTCOME; ANIMAL; BLOOD; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; ETHIOPIA; GLUCOSE TOLERANCE TEST; LAMIACEAE; METABOLISM; PHYTOTHERAPY;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; ETHIOPIA; GLUCOSE; GLUCOSE TOLERANCE TEST; GLYBURIDE; HYPOGLYCEMIC AGENTS; LAMIACEAE; MALE; MICE; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; RATS;

EID: 84924330625     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-015-0535-5     Document Type: Article

References (47)

1. Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010;87:4-14.
2. Kaku K. Pathophysiology of type 2 diabetes and its treatment policy. JMAJ. 2010;53:41-6.
3. Belfiore F, Iannello S. Insulin resistance and its relevance to treatment. In: Belfiore F, Mogensen CE, editors. New Concepts in Diabetes and Its Treatment. Italy: Karger Medical and Scientific Pulblishers; 2000. p. 38-55.
4. Grover JK, Yadav S, Vats V. Medicinal plants of India with antidiabetic potential. J Ethnopharmacol. 2002;81:81-100.
5. Bnouham M, Ziyyat A, Mekhfi H, Tahri A, Legssyer A. Medicinal plants with potential antidiabetic activity-A. Review of ten years of herbal medicine research (1990-2000). Int J diabetes Met. 2006;14:1-25.
6. Gupta R, Gabrielsen B, Ferguson FM. Nature's medicines: traditional knowledge and intellectual property management. Case studies from the National Institutes of Health (NIH). USA. Current Drug Discovery Technologies. 2005;2:203-19.
7. Kesari AN, Gupta RK, Singh SK, Diwakar S, Watal G. Hypoglyceamic and antihyperglyceamic activity of Aegle marmelos seed extract in normal and diabetic rats. J thnopharmacol. 2006;107:374-9.
8. Jaouhari JT, Lazrek HB, Seddik A, Jana M. Hypoglycaemic response to Zygophyllum gaetulum extracts in patients with non-insulin dependent diabetes mellitus. J Ethnopharmacol. 1999;64:211-7.
9. Herrera-Arellano A, Aguilar-Santamaria L, Garcia-Hernandez B, Nicasio-Torres P, Tortoriello J. Clinical trial of Cecropia obtusifolia and Marrubium vulgare leaf extracts on blood glucose and serum lipids in type 2 diabetics. Phytomedicine. 2004;11:561-6.
10. Jayawardena MH, De Alwis NM, Hettigoda V, Fernando DJ. double blind randomized placebo controlled cross over study of a herbal preparation containing Salacia reticulata in the treatment of type 2 diabetes. J Ethnopharmacol. 2005;96:215-8.
11. Abate G. Etse Debdabe (Ethiopian Traditional medicine). Biology Department, Science Faculty: Addis Ababa University Addis Ababa University press; 1989. p. 97-134.
12. Tamiru W, Engidawork E, Asres K. Evaluation of the effects of 80% methanolic leaf extract of Caylusea abyssinica (fresen.) fisch. & Mey. on glucose handling in normal, glucose loaded and diabetic rodents. BMC Complemen Altern M. 2012;12:151.
13. Sebald O. Otostegia Benth. In: Hadberg I, Kelbessa E, Edward S, Demissew S, Persson E, editors. Flora of Ethiopia and Eritrea from Gentianaceae to Cyclocheilaceae, vol. 5. Addis Ababa & Uppsala: National Herbarium, Addis Ababa University; 2006. p. 538.
14. Khan S, Syed. Bioactive constituents from genus Otostegia. SARJ of physical sciences. 2013;1:15-25.
15. Bagherzade G, Dourandishana M, Malekanehb M. Antidiabetic effects of Otostegia persica root in alloxan-induced diabetic rats. Pure Appl Chem Sci. 2014;2:1-9.
16. Tofighi Z, Alipour F, Yassa N, Hadjiakhoondi A, Hadavinia H, Goodarzy S, et al. Chemical composition and antioxidant activity of Otostegia persica essential oil from Iran. Int J Esse Oil Ther. 2009;3:45-8.
17. Shrififar F, Yassa N, Shafiee A. Antioxidant activity of Otostegia persica (Labiatae) and its constituents. IJPR. 2003;2:235-9.
18. Yassa N, Sharififar F, Shafiee A. Otostegia persica as a source of natural antioxidants. Pharm Biol. 2005;43:33-8.
19. Ayatollahi M, Kobarfard F, Asgarpanah J, Choudhary I. Antiglycation activity of Otostegia persica (Burm.) Boiss. Afr J Biotechnol. 2010;9:3645-8.
20. Abebe D, Debela A, Uga K. Medicinal plants and other useful plants of Ethiopia. Camerapix Singapore. 2003
21. Tadesse S, Messele B, Seyoum A, Mazumder A, Bucar F, Asres K. Essential oil of Otostegia integrifolia benth: composition, antimicrobial and antioxidant activities. Ethip pharm J. 2011;29:1.
22. Ivorra MD, Paya M, Villar A. A review of natural products and plants as potential antidiabetic drugs. J Ethnopharmacol. 1989;27:243-75.
23. Tesso H, Koing WA. Terpenes from Otostegia integrifolia. Phytochem. 2004;65:2057-62.
24. Endale E, Bisrat D, Animut A, Bucar F, Asres K. In vivo antimalarial activity of a Labdane Diterpenoid from the leaves of Otostegia integrifolia Benth. Phytother Res. 2013;27:1805-9.
25. Jones P, Kinghorn D. Extraction of Plant Secondary Metabolites. In: Sarker D, Latif Z, Gray A, editors. Methods in Biothechnology Natural Products Isolation. 2nd ed. Totowa, New Jersey: Human Press; 2006. p. 269-73.
26. Trease GE, Evans WC. Pharmacognosy. 13th ed. London: Bailliere Tindall; 1989. p. 176-80.
27. Institute of Laboratory Animal Resources. Guide for the care and use of laboratory animals. 7th ed. Washington DC: National Academy Press; 1996.
28. Etuk EU. Animal models for studying diabetes mellitus. Agric Biol J N Am. 2010;1:130-4.
29. Raman BV, Krishna NV, Rao NB, Saradhi PM, Rao BM. Plants with antidiabetic activities and their medicinal values. Int Res J Pharm. 2012;3:11-5.
30. Joseph B, Raj SJ. Phytopharmacological properties of Ficus racemosa Linn - An overview. Int J Pharm Sci Rev Res. 2010;3:134-8.
31. Joseph B, Jini D, Ajisha SU. Phytochemical characterization of herbal drug formulation for arthritis. Res J Phytochem. 2012;6:54-60.
32. Singh U, Singh S, Kochhar A. Therapeutic potential of antidiabetic neutraceuticals. Phytopharmacol. 2012;2:144-69.
33. Joseph B, Jini D. Insight into the hypoglycaemic effect of traditional Indian herbs used in the treatment of diabetes. Res J Med Plant. 2011;5:367.
34. Abu-Abeeleh M. preliminary study of the use of human adipose tissue-derived stem cells for the treatment of streptozotocin-induced diabetes mellitus in a rat model. Comp Clin Pathol. 2010;19:1-4.
35. Arora S, Ojha SK, Vohora D. Characterization of Streptozotocin induced diabetes mellitus in Swiss albino mice. Global J Pharmacol. 2009;3:81-4.
36. Szkudelski T. The mechanism of alloxan and streptozotocin action in B-cells of the rat pancreas. Physiol Res. 2001;50:536-46.
37. Verma SM, Suresh KB, Verma A. Antidiabetic activity of leaves of Indigofera tinctoria Linn (Fabaceae). IJTPR. 2010;1:42-3.
38. Qamar F, Afroz S, Feroz Z, Siddiqui S, Ara A. Evaluation of hypoglyceamic effete of Cassia italic. J Basic Appl Sci. 2011;7:61-4.
39. Ahmed MF, Kazim SM, Ghori SS, Mehjabeen SS, Ahmed SR, Ali SM, Ibrahim M. Antidiabetic Activity of Vinca rosea Extracts in Alloxan-Induced Diabetes rats. Int J Endocrinol. 2010. doi:10.1155/2010/841090
40. Kesari AN, Gupta RK, Watal G. Hypoglyceamic effects of Murraya koenigii on normal and alloxan diabetic rabbits. J Ethnopharmacol. 2005;97:247-51.
41. Singh SK, Kwsari AN, Gupta RK, Jaiswal D, Watal G. Assessment of antidiabetic potential of Cynodon dactylon extract in streptozotocin diabetic rats. J Ethnopharmacol. 2007;114:174-9.
42. Alarcon-aguilar FJ, Jimenez-Estrada M, Reyes-Chilpa R, Roman-Ramos R. Hypoglyceamic effect of extracts and fractions from Psacalium decompositum in healthy and alloxan-diabetic mice. J Ethnopharmacol. 2000;72:21-7.
43. Beardsall K, Yuen K, Williams R, Dunger D. Applied physiology of glucose control. Current Pediatrics. 2006;16:434-8.
44. Sharma SR, Dwivedi SK, Varshney VP, Swarup D. Antihyperglycaemic and Insulin release effects of Aegle marmelos leaves in streptozotocin-diabetic rats. Phytother Res. 1996;10:426-8.
45. Jung M, Park M, Lee CH, Kang Y, Kang ES, Kim SK. Antidiabetic agents from medicinal plants. Curr Med Chem. 2006;13:1203-18.
46. Manickam M, Ramanathan M, Jahromi MA, Chansoouria JP, Ray AB. Antihyperglycaemic activity of Phenolics from Pterocarpus marsupium. J Nat Prod. 1997;60:609-10.
47. Meckes-Loaoya M, Lozoya X. Histamine response induced by the intravenous administration of Tecoma stans crude extract in the dog. Herba hungarica. 1989;28:117-22.