Oleuropein aglycone protects against MAO-a-induced autophagy impairment and cardiomyocyte death through activation of TFEB

Oxidative Medicine and Cellular Longevity

Volumn 2018, Issue , 2018, Pages

  Miceli, Caterina ^a,b   Santin, Yohan ^b   Manzella, Nicola ^b   Coppini, Raffaele ^c   Berti, Andrea ^a   Stefani, Massimo ^a   Parini, Angelo ^b   Mialet Perez, Jeanne ^b   Nediani, Chiara ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITÉ DE TOULOUSE   (France)

^c UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELL DEATH; CHEMICAL ACTIVATION; CYTOTOXICITY; OLIVE OIL;

BENEFICIAL EFFECTS; CARDIO-VASCULAR DISEASE; CYTOTOXIC EFFECTS; MONOAMINE OXIDASE A; NEURODEGENERATION; NEURODEGENERATIVE; NUCLEAR TRANSLOCATIONS; TRANSCRIPTIONAL FACTORS;

NEURODEGENERATIVE DISEASES;

ADENOVIRUS VECTOR; AGLYCONE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; BECLIN 1; CATECHOLAMINE; HYDROGEN PEROXIDE; NUTRACEUTICAL; OLEUROPEIN; OLIVE OIL; SEROTONIN; SMALL INTERFERING RNA; AMINE OXIDASE (FLAVIN CONTAINING); BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; IRIDOID; PROTECTIVE AGENT; REACTIVE OXYGEN METABOLITE; TFEB PROTEIN, RAT; TYRAMINE;

AGING; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; CARDIAC MUSCLE CELL; CARDIOTOXICITY; CARDIOVASCULAR DISEASE; CELL DEATH; DEGLYCOSYLATION; ENZYME DEGRADATION; GENE OVEREXPRESSION; HEART PROTECTION; MTT ASSAY; NONHUMAN; OXIDATIVE STRESS; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL NUCLEUS; CYTOLOGY; DRUG EFFECT; FLUORESCENCE MICROSCOPY; GENETICS; METABOLISM; RNA INTERFERENCE;

BIODEGRADATION; DISEASES; ENZYMES; POLYPHENOLS;

ANIMALS; AUTOPHAGY; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL NUCLEUS; IRIDOIDS; MICROSCOPY, FLUORESCENCE; MONOAMINE OXIDASE; MYOCYTES, CARDIAC; PROTECTIVE AGENTS; RATS; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; TYRAMINE;

EID: 85053552305     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2018/8067592     Document Type: Article

References (57)

1. N. Ahmed, R. Mandel, and M. J. Fain, “Frailty: an emerging geriatric syndrome,” The American Journal of Medicine, vol. 120, no. 9, pp. 748-753, 2007.
2. M. E. Manni, S. Rigacci, E. Borchi et al., “Monoamine oxidase is overactivated in left and right ventricles from ischemic hearts: an intriguing therapeutic target,” Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 4375418, 10 pages, 2016.
3. C. Nediani, L. Raimondi, E. Borchi, and E. Cerbai, “Nitric oxide/reactive oxygen species generation and nitroso/redox imbalance in heart failure: from molecular mechanisms to therapeutic implications,” Antioxidants & Redox Signaling, vol. 14, no. 2, pp. 289-331, 2011.
4. C. Villeneuve, C. Guilbeau-Frugier, P. Sicard et al., “p53-PGC-1α pathway mediates oxidative mitochondrial damage and cardiomyocyte necrosis induced by monoamine oxidase-A upregulation: role in chronic left ventricular dysfunction in mice,” Antioxidants & Redox Signaling, vol. 18, no. 1, pp. 5-18, 2013.
5. Z. Tatarková, S. Kuka, P. Račay et al., “Effects of aging on activities of mitochondrial electron transport chain complexes and oxidative damage in rat heart,” Physiological Research, vol. 60, no. 2, pp. 281-289, 2011.
6. N. Kaludercic, J. Mialet-Perez, N. Paolocci, A. Parini, and F. Di Lisa, “Monoamine oxidases as sources of oxidants in the heart,” Journal of Molecular and Cellular Cardiology, vol. 73, pp. 34-42, 2014.
7. N. Kaludercic, E. Takimoto, T. Nagayama et al., “Monoamine oxidase A-mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload,” Circulation Research, vol. 106, no. 1, pp. 193-202, 2010.
8. D. Maggiorani, N. Manzella, D. E. Edmondson et al., “Monoamine oxidases, oxidative stress, and altered mitochondrial dynamics in cardiac ageing,” Oxidative Medicine and Cellular Longevity, vol. 2017, Article ID 3017947, 8 pages, 2017.
9. E. J. Anderson, J. T. Efird, S. W. Davies et al., “Monoamine oxidase is a major determinant of redox balance in human atrial myocardium and is associated with postoperative atrial fibrillation,” Journal of the American Heart Association, vol. 3, no. 1, article e000713, 2014.
10. A. Terman, T. Kurz, M. Navratil, E. A. Arriaga, and U. T. Brunk, “Mitochondrial turnover and aging of long-lived post-mitotic cells: the mitochondrial-lysosomal axis theory of aging,” Antioxidants & Redox Signaling, vol. 12, no. 4, pp. 503-535, 2010.
11. K. Nakahira and A. M. K. Choi, “Autophagy: a potential therapeutic target in lung diseases,” American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 305, no. 2, pp. L93-L107, 2013.
12. Y. Cheng, X. Ren, W. N. Hait, and J. M. Yang, “Therapeutic targeting of autophagy in disease: biology and pharmacology,” Pharmacological Reviews, vol. 65, no. 4, pp. 1162-1197, 2013.
13. Y. Santin, P. Sicard, F. Vigneron et al., “Oxidative stress by monoamine oxidase-a impairs transcription factor EB activation and autophagosome clearance, leading to cardiomyocyte necrosis and heart failure,” Antioxidants & Redox Signaling, vol. 25, no. 1, pp. 10-27, 2016.
14. D. C. Rubinsztein, P. Codogno, and B. Levine, “Autophagy modulation as a potential therapeutic target for diverse diseases,” Nature Reviews Drug Discovery, vol. 11, no. 9, pp. 709-730, 2012.
15. I. Sergin, T. D. Evans, X. Zhang et al., “Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis,” Nature Communications, vol. 8, article 15750, 2017.
16. H.-S. Kim, V. Montana, H.-J. Jang, V. Parpura, and J.-A. Kim, “Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation,” Journal of Biological Chemistry, vol. 288, no. 31, pp. 22693-22705, 2013.
17. B. Wang, Q. Yang, Y. Y. Sun et al., “Resveratrol-enhanced autophagic flux ameliorates myocardial oxidative stress injury in diabetic mice,” Journal of Cellular and Molecular Medicine, vol. 18, no. 8, pp. 1599-1611, 2014.
18. M. Stefani and S. Rigacci, “Beneficial properties of natural phenols: highlight on protection against pathological conditions associated with amyloid aggregation,” BioFactors, vol. 40, no. 5, pp. 482-493, 2014.
19. M. Brenes, A. Garcia, P. Garcia, J. J. Rios, and A. Garrido, “Phenolic compounds in Spanish olive oils,” Journal of Agricultural and Food Chemistry, vol. 47, no. 9, pp. 3535-3540, 1999.
20. K. Németh, G. W. Plumb, J. G. Berrin et al., “Deglycosylation by small intestinal epithelial cell β-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans,” European Journal of Nutrition, vol. 42, no. 1, pp. 29-42, 2003.
21. M. Servili, S. Esposto, R. Fabiani et al., “Phenolic compounds in olive oil: antioxidant, health and organoleptic activities according to their chemical structure,” Inflammopharmacol-ogy, vol. 17, no. 2, pp. 76-84, 2009.
22. S. Rigacci, “Olive oil phenols as promising multi-targeting agents against Alzheimer's disease,” Advances in Experimental Medicine and Biology, vol. 863, pp. 1-20, 2015.
23. F. Casamenti, C. Grossi, S. Rigacci, D. Pantano, I. Luccarini, and M. Stefani, “Oleuropein aglycone: a possible drug against degenerative conditions. In vivo evidence of its effectiveness against Alzheimer's disease,” Journal of Alzheimer's Disease, vol. 45, no. 3, pp. 679-688, 2015.
24. S. Rigacci and M. Stefani, “Nutraceutical properties of olive oil polyphenols. An itinerary from cultured cells through animal models to humans,” International Journal of Molecular Sciences, vol. 17, no. 12, p. 843, 2016.
25. S. Rigacci, C. Miceli, C. Nediani et al., “Oleuropein aglycone induces autophagy via the AMPK/mTOR signalling pathway: a mechanistic insight,” Oncotarget, vol. 6, no. 34, pp. 35344-35357, 2015.
26. I. Luccarini, D. Pantano, P. Nardiello et al., “The polyphenol oleuropein aglycone modulates the PARP1-SIRT1 interplay: an in vitro and in vivo study,” Journal of Alzheimer's Disease, vol. 54, no. 2, pp. 737-750, 2016.
27. C. Grossi, S. Rigacci, S. Ambrosini et al., “The polyphenol oleuropein aglycone protects TgCRND8 mice against Aß plaque pathology,” PLoS One, vol. 8, no. 8, article e71702, 2013.
28. K. Konno, C. Hirayama, H. Yasui, and M. Nakamura, “Enzymatic activation of oleuropein: a protein crosslinker used as a chemical defense in the privet tree,” Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 16, pp. 9159-9164, 1999.
29. P. Diamantakos, A. Velkou, K. I. Killday, T. Gimisis, E. Melliou, and P. Magiatis, “Oleokoronal and oleomissional: new major phenolic ingredients of extra virgin olive oil,” Olivae, vol. 122, pp. 22-33, 2015.
30. A. C. Laurent, M. Bisserier, A. Lucas et al., “Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy,” Cardiovascular Research, vol. 105, no. 1, pp. 55-64, 2015.
31. D. L. Medina, S. Di Paola, I. Peluso et al., “Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB,” Nature Cell Biology, vol. 17, no. 3, pp. 288-299, 2015.
32. I. Andreadou, F. Sigala, E. K. Iliodromitis et al., “Acute doxorubicin cardiotoxicity is successfully treated with the phytochemical oleuropein through suppression of oxidative and nitrosative stress,” Journal of Molecular and Cellular Cardiology, vol. 42, no. 3, pp. 549-558, 2007.
33. A. Petroni, M. Blasevich, M. Salami, N. Papini, G. F. Montedoro, and C. Galli, “Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil,” Thrombosis Research, vol. 78, no. 2, pp. 151-160, 1995.
34. I. Andreadou, E. K. Iliodromitis, E. Mikros et al., “The olive constituent oleuropein exhibits anti-ischemic, antioxidative, and hypolipidemic effects in anesthetized rabbits,” The Journal of Nutrition, vol. 136, no. 8, pp. 2213-2219, 2006.
35. I. Andreadou, E. Mikros, K. Ioannidis et al., “Oleuropein prevents doxorubicin-induced cardiomyopathy interfering with signaling molecules and cardiomyocyte metabolism,” Journal of Molecular and Cellular Cardiology, vol. 69, pp. 4-16, 2014.
36. Z. Janahmadi, A. A. Nekooeian, A. R. Moaref, and M. Emamghoreishi, “Oleuropein attenuates the progression of heart failure in rats by antioxidant and antiinflammatory effects,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 390, no. 3, pp. 245-252, 2017.
37. C. Manna, V. Migliardi, P. Golino et al., “Oleuropein prevents oxidative myocardial injury induced by ischemia and reperfusion,” The Journal of Nutritional Biochemistry, vol. 15, no. 8, pp. 461-466, 2004.
38. J. Zhang, J. Wang, J. Xu et al., “Curcumin targets the TFEB-lysosome pathway for induction of autophagy,” Oncotarget, vol. 7, no. 46, pp. 75659-75671, 2016.
39. L. J. Leon and Å. B. Gustafsson, “Staying young at heart: autophagy and adaptation to cardiac aging,” Journal of Molecular and Cellular Cardiology, vol. 95, pp. 78-85, 2016.
40. X. J. Zhang, S. Chen, K. X. Huang, and W. D. Le, “Why should autophagic flux be assessed?,” Acta Pharmacologica Sinica, vol. 34, no. 5, pp. 595-599, 2013.
41. Y. Zhang, X. Cao, W. Zhu et al., “Resveratrol enhances autophagic flux and promotes Ox-LDL degradation in HUVECs via upregulation of SIRT1,” Oxidative Medicine and Cellular Longevity, vol. 2016, Article ID 7589813, 13 pages, 2016.
42. X. Xie, W. Yi, P. Zhang et al., “Green tea polyphenols, mimicking the effects of dietary restriction, ameliorate high-fat diet-induced kidney injury via regulating autophagy flux,” Nutrients, vol. 9, no. 12, p. 497, 2017.
43. P. W. Zhang, C. Tian, F. Y. Xu et al., “Green tea polyphenols alleviate autophagy inhibition induced by high glucose in endothelial cells,” Biomedical and Environmental Sciences, vol. 29, no. 7, pp. 524-528, 2016.
44. M. E. Manni, M. Zazzeri, C. Musilli, E. Bigagli, M. Lodovici, and L. Raimondi, “Exposure of cardiomyocytes to angiotensin II induces over-activation of monoamine oxidase type A: implications in heart failure,” European Journal of Pharmacology, vol. 718, no. 1-3, pp. 271-276, 2013.
45. A. Maurel, C. Hernandez, O. Kunduzova et al., “Age-dependent increase in hydrogen peroxide production by cardiac monoamine oxidase A in rats,” American Journal of Physiology-Heart and Circulatory Physiology, vol. 284, no. 4, pp. H1460-H1467, 2003.
46. R. Pino, P. Failli, L. Mazzetti, and F. Buffoni, “Monoamine oxidase and semicarbazide-sensitive amine oxidase activities in isolated cardiomyocytes of spontaneously hypertensive rats,” Biochemical and Molecular Medicine, vol. 62, no. 2, pp. 188-196, 1997.
47. M. D'Archivio, C. Filesi, R. Vari, B. Scazzocchio, and R. Masella, “Bioavailability of the polyphenols: status and controversies,” International Journal of Molecular Sciences, vol. 11, no. 12, pp. 1321-1342, 2010.
48. M. N. Vissers, P. L. Zock, A. J. C. Roodenburg, R. Leenen, and M. B. Katan, “Olive oil phenols are absorbed in humans,” The Journal of Nutrition, vol. 132, no. 3, pp. 409-417, 2002.
49. T. Weinbrenner, M. Fito, R. de la Torre et al., “Olive oils high in phenolic compounds modulate oxidative/antioxidative status in men,” The Journal of Nutrition, vol. 134, no. 9, pp. 2314-2321, 2004.
50. E. Miro-Casas, M. I. Covas, M. Farre et al., “Hydroxytyrosol disposition in humans,” Clinical Chemistry, vol. 49, no. 6, pp. 945-952, 2003.
51. R. Garcia-Villalba, A. Carrasco-Pancorbo, E. Nevedomskaya et al., “Exploratory analysis of human urine by LC-ESI-TOF MS after high intake of olive oil: understanding the metabolism of polyphenols,” Analytical and Bioanalytical Chemistry, vol. 398, no. 1, pp. 463-475, 2010.
52. M. de Bock, E. B. Thorstensen, J. G. B. Derraik, H. V. Henderson, P. L. Hofman, and W. S. Cutfield, “Human absorption and metabolism of oleuropein and hydroxytyrosol ingested as olive (Olea europaea L.) leaf extract,” Molecular Nutrition & Food Research, vol. 57, no. 11, pp. 2079-2085, 2013.
53. E. Coni, R. Di Benedetto, M. Di Pasquale et al., “Protective effect of oleuropein, an olive oil biophenol, on low density lipoprotein oxidizability in rabbits,” Lipids, vol. 35, no. 1, pp. 45-54, 2000.
54. P. Lin, W. Qian, X. Wang, L. Cao, S. Li, and T. Qian, “The bio-transformation of oleuropein in rats,” Biomedical Chromatography, vol. 27, no. 9, pp. 1162-1167, 2013.
55. A. Serra, L. Rubio, X. Borras, A. Macia, M. P. Romero, and M. J. Motilva, “Distribution of olive oil phenolic compounds in rat tissues after administration of a phenolic extract from olive cake,” Molecular Nutrition & Food Research, vol. 56, no. 3, pp. 486-496, 2012.
56. F. Paiva-Martins, J. Fernandes, V. Santos et al., “Powerful protective role of 3,4-dihydroxyphenylethanol-elenolic acid dialdehyde against erythrocyte oxidative-induced hemolysis,” Journal of Agricultural and Food Chemistry, vol. 58, no. 1, pp. 135-140, 2010.
57. F. Casamenti and M. Stefani, “Olive polyphenols: new promising agents to combat aging-associated neurodegeneration,” Expert Review of Neurotherapeutics, vol. 17, no. 4, pp. 345-358, 2017.